Curcumin attenuates diet-induced hepatic steatosis by activating AMP-activated protein kinase

Basic and Clinical Pharmacology and Toxicology

Volumn 113, Issue 3, 2013, Pages 152-157

  Um, Min Young ^a   Hwang, Kwang Hyun ^b   Ahn, Jiyun ^a   Ha, Tae Youl ^a  

^a Korea Food Research Institute   (South Korea)

^b Korea Institute of Toxicology   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; CHOLESTEROL; CURCUMIN; FATTY ACID SYNTHASE; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRIACYLGLYCEROL;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL DIET; CONTROLLED STUDY; DIET RESTRICTION; DIET SUPPLEMENTATION; DRUG EFFECT; ENZYME ACTIVATION; FATTY LIVER; FOOD INTAKE; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INSULIN SENSITIVITY; INTRAABDOMINAL FAT; LIPID DIET; LIPID LIVER LEVEL; LIPID METABOLISM; LIPID STORAGE; LIVER WEIGHT; MALE; METABOLISM; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRIACYLGLYCEROL BLOOD LEVEL;

ADIPOSE TISSUE; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; BLOOD GLUCOSE; BODY WEIGHT; CHOLESTEROL; CURCUMIN; DIET, HIGH-FAT; DISEASE MODELS, ANIMAL; FATTY LIVER; GENE EXPRESSION; INSULIN; MALE; MICE; MICE, INBRED C57BL; OBESITY; PPAR ALPHA;

CURCUMA LONGA; MUS;

EID: 84880702294     PISSN: 17427835     EISSN: 17427843     Source Type: Journal    
DOI: 10.1111/bcpt.12076     Document Type: Article

References (32)

1. Preiss D, Sattar N. Non-alcoholic fatty liver disease: an overview of prevalence, diagnosis, pathogenesis and treatment considerations. Clin Sci (Lond) 2008;115:141-50.
2. Farrell GC, Larter CZ. Nonalcoholic fatty liver disease: from steatosis to cirrhosis. Hepatology 2006;43:S99-112.
3. Aggarwal BB, Sundaram C, Malani N, Ichikawa H. Curcumin: the Indian solid gold. The molecular targets and therapeutic uses of curcumin in health and disease. Adv Exp Med Biol 2007;595:1-75.
4. Quiles JL, Mesa MD, Ramírez-Tortosa CL, Aguilera CM, Battino M, Gil A et al. Curcuma longa extract supplementation reduces oxidative stress and attenuates aortic fatty streak development in rabbits. Arterioscler Thromb Vasc Biol 2002;22:1225-31.
5. Motterlini R, Foresti R, Bassi R, Green CJ. Curcumin, an antioxidant and anti-inflammatory agent, induces heme oxygenase-1 and protects endothelial cells against oxidative stress. Free Radic Biol Med 2000;28:1303-12.
6. Sidhu GS, Mani H, Gaddipati JP, Singh AK, Seth P, Banaudha KK et al. Curcumin enhances wound healing in streptozotocin induced diabetic rats and genetically diabetic mice. Wound Repair Regen 1999;7:362-74.
7. Ahn J, Lee H, Kim S, Ha T. Curcumin-induced suppression of adipogenic differentiation is accompanied by activation of Wnt/β-catenin signaling. Am J Physiol Cell Physiol 2010;298:C1510-6.
8. Jang EM, Choi MS, Jung UJ, Kim MJ, Kim HJ, Jeon SM et al. Beneficial effects of curcumin on hyperlipidemia and insulin resistance in high-fat-fed hamsters. Metabolism 2008;57:1576-83.
9. Li Y, Xu S, Mihaylova MM, Zheng B, Hou X, Jiang B et al. AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. Cell Metab 2011;13:376-88.
10. Carling D. The AMP-activated protein kinase cascade-a unifying system for energy control. Trends Biochem Sci 2004;29:18-24.
11. Zhang BB, Zhou G, Li C. AMPK: an emerging drug target for diabetes and the metabolic syndrome. Cell Metab 2009;9:407-16.
12. Cho IJ, Ahn JY, Kim S, Choi MS, Ha TY. Resveratrol attenuates the expression of HMG-CoA reductase mRNA in hamsters. Biochem Biophys Res Commun 2008;367:190-4.
13. Asai A, Miyazawa T. Dietary curcuminoids prevent high-fat diet-induced lipid accumulation in rat liver and epididymal adipose tissue. J Nutr 2001;131:2932-5.
14. Na LX, Zhang YL, Li Y, Liu LY, Li R, Kong T et al. Curcumin improves insulin resistance in skeletal muscle of rats. Nutr Metab Cardiovasc Dis 2011;21:526-33.
15. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985;28:412-9.
16. Folch J, Lees M, Sloane-Stanley G. A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 1957;226:497-509.
17. Samuel VT, Liu ZX, Qu X, Elder BD, Bilz S, Befroy D et al. Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease. J Biol Chem 2004;279:32345-53.
18. Oosterveer MH, Van Dijk TH, Tietge UJF, Boer T, Havinga R, Stellaard F et al. High fat feeding induces hepatic fatty acid elongation in mice. PLoS ONE 2009;4:e6066.
19. Ejaz A, Wu D, Kwan P, Meydani M. Curcumin inhibits adipogenesis in 3T3-L1 adipocytes and angiogenesis and obesity in C57/BL mice. J Nutr 2009;139:919-25.
20. Greenberg AS, Coleman RA, Kraemer FB, McManaman JL, Obin MS, Puri V et al. The role of lipid droplets in metabolic disease in rodents and humans. J Clin Invest 2011;121:2102-10.
21. Seo KI, Choi MS, Jung UJ, Kim HJ, Yeo J, Jeon SM et al. Effect of curcumin supplementation on blood glucose, plasma insulin, and glucose homeostasis related enzyme activities in diabetic db/db mice. Mol Nutr Food Res 2008;52:995-1004.
22. He HJ, Wang GY, Gao Y, Ling WH, Yu ZW, Jin TR. Curcumin attenuates Nrf2 signaling defect, oxidative stress in muscle and glucose intolerance in high fat diet-fed mice. World J Diabetes 2012;3:94-104.
23. Koonen DPY, Jacobs RL, Febbraio M, Young ME, Soltys CL, Ong H et al. Increased hepatic CD36 expression contributes to dyslipidemia associated with diet-induced obesity. Diabetes 2007;56:2863-71.
24. Greco D, Kotronen A, Westerbacka J, Puig O, Arkkila P, Kiviluoto T et al. Gene expression in human NAFLD. Am J Physiol Gastrointest Liver Physiol 2008;294:G1281-7.
25. Zhou J, Febbraio M, Wada T, Zhai Y, Kuruba R, He J et al. Hepatic fatty acid transporter Cd36 is a common target of LXR, PXR, and PPAR [gamma] in promoting steatosis. Gastroenterology 2008;134:556-7.
26. Murakami K, Tobe K, Ide T, Mochizuki T, Ohashi M, Akanuma Y et al. A novel insulin sensitizer acts as a coligand for peroxisome proliferator-activated receptor-alpha (PPAR-alpha) and PPAR-gamma: effect of PPAR-alpha activation on abnormal lipid metabolism in liver of Zucker fatty rats. Diabetes 1998;47:1841-7.
27. Hardie D. AMPK: a key regulator of energy balance in the single cell and the whole organism. Int J Obes (Lond) 2008;32:S7-12.
28. Unger RH. The Hyperleptinemia of Obesity-Regulator of Caloric Surpluses. Cell 2004;117:145-6.
29. You M, Matsumoto M, Pacold CM, Cho WK, Crabb DW. The role of AMP-activated protein kinase in the action of ethanol in the liver. Gastroenterology 2004;127:1798-808.
30. Zhou G, Myers R, Li Y, Chen Y, Shen X, Fenyk-Melody J et al. Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest 2001;108:1167-74.
31. Lee YK, Lee WS, Hwang JT, Kwon DY, Surh YJ, Park OJ. Curcumin exerts antidifferentiation effect through AMPKα-PPAR-γ in 3T3-L1 adipocytes and antiproliferatory effect through AMPKα-COX-2 in cancer cells. J Agric Food Chem 2008;57:305-10.
32. Tang Y, Chen A. Curcumin protects hepatic stellate cells against leptin-induced activation in vitro by accumulating intracellular lipids. Endocrinology 2010;151:4168-77.