Curcumin inhibits srebp-2 expression in activated hepatic stellate cells in vitro by reducing the activity of specificity protein-1

Endocrinology

Volumn 150, Issue 12, 2009, Pages 5384-5394

  Kang, Qiaohua ^a   Chen, Anping ^a  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; CURCUMIN; LOW DENSITY LIPOPROTEIN RECEPTOR; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; TRANSCRIPTION FACTOR SP1;

ANIMAL CELL; ARTICLE; CHROMATIN IMMUNOPRECIPITATION; DRUG MECHANISM; GENE EXPRESSION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STELLATE CELL;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BINDING SITES; BLOTTING, WESTERN; CELLS, CULTURED; CHROMATIN IMMUNOPRECIPITATION; CURCUMIN; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GENE EXPRESSION; HEPATIC STELLATE CELLS; LUCIFERASES; MICE; MICE, INBRED C57BL; PPAR GAMMA; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SP1 TRANSCRIPTION FACTOR; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; TRANSFECTION;

EID: 71949103659     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2009-0517     Document Type: Article

References (53)

1. O'Brien PE, Dixon JB 2002 The extent of the problem of obesity. Am J Surg 184:4S-8S
2. Cave M, Deaciuc I, Mendez C, Song Z, Joshi-Barve S, Barve S, McClain C 2007 Nonalcoholic fatty liver disease: predisposing factors and the role of nutrition. J Nutr Biochem 18:184-195 (Pubitemid 46216810)
3. Clark JM 2006 The epidemiology of nonalcoholic fatty liver disease in adults. J Clin Gastroenterol 40(Suppl 1):S5-S10 (Pubitemid 44309537)
4. Neuschwander-Tetri BA 2001 Fatty liver and nonalcoholic steatohepatitis. Clin Cornerstone 3:47-57 (Review)
5. Bilheimer DW, Goldstein JL, Grundy SM, Starzl TE, Brown MS 1984 Liver transplantation to provide low-density-lipoprotein receptors and lower plasma cholesterol in a child with homozygous familial hypercholesterolemia. N Engl J Med 311:1658-1664
6. Brown MS, Goldstein JL 1997 The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell 89:331-340 (Pubitemid 27220877)
7. Kisseleva T, Brenner DA 2006 Hepatic stellate cells and the reversal of fibrosis. J Gastroenterol Hepatol 21(Suppl 3):S84-S87 (Pubitemid 44266558)
8. Friedman SL 2008 Mechanisms of hepatic fibrogenesis. Gastroenterology 134:1655-1669
9. O'Connell MA, Rushworth SA 2008 Curcumin: potential for hepatic fibrosis therapy? Br J Pharmacol 153:403-405
10. Shishodia S, Sethi G, Aggarwal BB 2005 Curcumin: getting back to the roots. Ann NY Acad Sci 1056:206-217
11. Arafa HM 2005 Curcumin attenuates diet-induced hypercholesterolemia in rats. Med Sci Monit 11:BR228-BR234
12. Fu Y, Zheng S, Lin J, Ryerse J, Chen A 2008 Curcumin protects the rat liver from CCl4-caused injury and fibrogenesis by attenuating oxidative stress and suppressing inflammation. Mol Pharmacol 73: 399-409 (Pubitemid 351159210)
13. Xu J, Fu Y, Chen A 2003 Activation of peroxisome proliferatoractivated receptor-γ contributes to the inhibitory effects of curcumin on rat hepatic stellate cell growth. Am J Physiol Gastrointest Liver Physiol 285:G20-G30
14. Zheng S, Chen A 2004 Activation of PPARγ is required for curcumin to induce apoptosis and to inhibit the expression of extracellular matrix genes in hepatic stellate cells in vitro. Biochem J 384:149-157 (Pubitemid 39564171)
15. Zheng S, Chen A 2006 Curcumin suppresses the expression of extracellular matrix genes in activated hepatic stellate cells by inhibiting gene expression of connective tissue growth factor. Am J Physiol Gastrointest Liver Physiol 290:G883-G893
16. Kang Q, Chen A 2009 Curcumin suppresses expression of lowdensity lipoprotein (LDL) receptor, leading to the inhibition of LDLinduced activation of hepatic stellate cells. Br J Pharmacol 157:1354-1367
17. Shin DJ, Osborne TF 2003 Thyroid hormone regulation and cholesterol metabolism are connected through sterol regulatory element- binding protein-2 (SREBP-2). J Biol Chem 278:34114-34118
18. Al-Sarraj A, Day RM, Thiel G 2005 Specificity of transcriptional regulation by the zinc finger transcription factors Sp1, Sp3, and Egr-1. J Cell Biochem 94:153-167 (Pubitemid 41420333)
19. Gurnell M, Wentworth JM, Agostini M, Adams M, Collingwood TN, Provenzano C, Browne PO, Rajanayagam O, Burris TP, Schwabe JW, Lazar MA, Chatterjee VK 2000 A dominant-negative peroxisome proliferator-activated receptor γ (PPARγ) mutant is a constitutive repressor and inhibits PPARγ-mediated adipogenesis. J Biol Chem 275:5754-5759 (Pubitemid 30115218)
20. Chen A, Zhang L, Xu J, Tang J 2002 The antioxidant (-)-epigallocatechin- 3-gallate inhibits activated hepatic stellate cell growth and suppresses acetaldehyde-induced gene expression. Biochem J 368: 695-704 (Pubitemid 36042671)
21. Yumei F, Zhou Y, Zheng S, Chen A 2006 The antifibrogenic effect of (-)-epigallocatechin gallate results from the induction of de novo synthesis of glutathione in passaged rat hepatic stellate cells. Lab Invest 86:697-709 (Pubitemid 43901667)
22. Schmittgen TD, Zakrajsek BA, Mills AG, Gorn V, Singer MJ, Reed MW 2000 Quantitative reverse transcription-polymerase chain reaction to studymRNAdecay: comparison of endpoint and real-time methods. Anal Biochem 285:194-204 (Pubitemid 30783648)
23. Zheng S, Chen A 2007 Disruption of transforming growth factor-β signaling by curcumin induces gene expression of peroxisome proliferator- activated receptor-γ in rat hepatic stellate cells. Am J Physiol Gastrointest Liver Physiol 292:G113-G123 (Pubitemid 46090257)
24. Bonofiglio D, Aquila S, Catalano S, Gabriele S, Belmonte M, Middea E,QiH, Morelli C, Gentile M, Maggiolini M, Andò S2006 Peroxisome proliferator-activated receptor-γ activates p53 gene promoter binding to the nuclear factor-κB sequence in human MCF7 breast cancer cells. Mol Endocrinol 20:3083-3092
25. Hagen G, Müller S, Beato M, Suske G 1992 Cloning by recognition site screening of two novel GT box binding proteins: a family of Sp1 related genes. Nucleic Acids Res 20:5519-5525
26. Kadonaga JT, Carner KR, Masiarz FR, Tjian R 1987 Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain. Cell 51:1079-1090
27. Kingsley C, Winoto A 1992 Cloning of GT box-binding proteins: a novel Sp1 multigene family regulating T-cell receptor gene expression. Mol Cell Biol 12:4251-4261
28. Zhou Y, Zheng S, Lin J, Zhang QJ, Chen A 2007 The interruption of the PDGF and EGF signaling pathways by curcumin stimulates gene expression of PPARγ in rat activated hepatic stellate cell in vitro. Lab Invest 87:488-498 (Pubitemid 46633122)
29. Miyahara T, Schrum L, Rippe R, Xiong S, Yee Jr HF, Motomura K, Anania FA, Willson TM, Tsukamoto H 2000 Peroxisome proliferator- activated receptors and hepatic stellate cell activation. J Biol Chem 275:35715-35722 (Pubitemid 30841104)
30. Goldstein JL, DeBose-Boyd RA, Brown MS 2006 Protein sensors for membrane sterols. Cell 124:35-46
31. Horton JD, Goldstein JL, Brown MS 2002 SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest 109:1125-1131
32. Javitt NB 1995 Cholesterol homeostasis: role of the LDL receptor. FASEB J 9:1378-1381
33. Peschel D, Koerting R, Nass N 2007 Curcumin induces changes in expression of genes involved in cholesterol homeostasis. J Nutr Biochem 18:113-119 (Pubitemid 46048987)
34. Fan CL, Qian Y, Wo XD, Yan J, Gao LP 2005 [Effect of curcumin on the gene expression of low density lipoprotein receptors.]. Chin J Integr Med 11:201-204 (Chinese)
35. Liu Y, Hong XQ 2006 [Effect of three different curcumin pigments on the proliferation of vascular smooth muscle cells by ox-LDL and the expression of LDL-R]. Zhongguo Zhong Yao Za Zhi 31:500-503 (Chinese)
36. Fan C, Wo X, Qian Y, Yin J, Gao L 2006 Effect of curcumin on the expression of LDL receptor in mouse macrophages. J Ethnopharmacol 105:251-254
37. Philipsen S, Suske G 1999 A tale of three fingers: the family of mammalian Sp/XKLF transcription factors. Nucleic Acids Res 27: 2991-3000 (Pubitemid 29355710)
38. Tan NY, Khachigian LM 2009 Sp1 Phosphorylation and its Regulation of Gene Transcription. Mol Cell Biol 29:2483-2488
39. Chadalapaka G, Jutooru I, Chintharlapalli S, Papineni S, Smith 3rd R, Li X, Safe S 2008 Curcumin decreases specificity protein expression in bladder cancer cells. Cancer Res 68:5345-5354
40. Athanikar JN, Sanchez HB, Osborne TF 1997 Promoter selective transcriptional synergy mediated by sterol regulatory element binding protein and Sp1: a critical role for the Btd domain of Sp1. Mol Cell Biol 17:5193-5200
41. Bennett MK, Ngo TT, Athanikar JN, Rosenfeld JM, Osborne TF 1999 Co-stimulation of promoter for low density lipoprotein receptor gene by sterol regulatory element-binding protein and Sp1 is specifically disrupted by the yin yang 1 protein. J Biol Chem 274: 13025-13032 (Pubitemid 129518501)
42. Sanchez HB, Yieh L, Osborne TF 1995 Cooperation by sterol regulatory element-binding protein and Sp1 in sterol regulation of low density lipoprotein receptor gene. J Biol Chem 270:1161-1169
43. García-Ruiz I, de la Torre P, Díaz T, Esteban E, Fernández I,Muñoz- Yagüe T, Solís-Herruzo JA 2002 Sp1 and Sp3 transcription factors mediate malondialdehyde-induced collagen alpha 1(I) gene expression in cultured hepatic stellate cells. J Biol Chem 277:30551-30558
44. Inagaki Y, Nemoto T, Nakao A, Dijke Pt, Kobayashi K, Takehara K, Greenwel P 2001 Interaction between GC box binding factors and Smad proteins modulates cell lineage-specific α2(I) collagen gene transcription. J Biol Chem 276:16573-16579 (Pubitemid 37391710)
45. Lefterova MI, Zhang Y, Steger DJ, Schupp M, Schug J, Cristancho A, Feng D, Zhuo D, Stoeckert Jr CJ, Liu XS, Lazar MA 2008 PPARγ and C/EBP factors orchestrate adipocyte biology via adjacent binding on a genome-wide scale. Genes Dev 22:2941-2952
46. Lehrke M, Pascual G, Glass CK, Lazar MA 2005 Gaining weight: the Keystone Symposium on PPAR and LXR. Genes Dev 19: 1737-1742 (Pubitemid 41126910)
47. Necela BM, Su W, Thompson EA 2008 Peroxisome proliferatoractivated receptorγ down-regulates follistatin in intestinal epithelial cells through SP1. J Biol Chem 283:29784-29794
48. Sugawara A, Takeuchi K, Uruno A, Ikeda Y, Arima S, Kudo M, Sato K, Taniyama Y, Ito S 2001 Transcriptional suppression of type 1 angiotensin II receptor gene expression by peroxisome proliferatoractivated receptor-γ in vascular smooth muscle cells. Endocrinology 142:3125-3134 (Pubitemid 32575551)
49. Sugawara A, Uruno A, Kudo M, Ikeda Y, Sato K, Taniyama Y, Ito S, Takeuchi K 2002 Transcription suppression of thromboxane receptor gene by peroxisome proliferator-activated receptor-γ via an interaction with Sp1 in vascular smooth muscle cells. J Biol Chem 277:9676-9683 (Pubitemid 34968066)
50. Joe B, Vijaykumar M, Lokesh BR 2004 Biological properties of curcumin-cellular and molecular mechanisms of action. Crit Rev Food Sci Nutr 44:97-111 (Pubitemid 38552286)
51. Singh S, Khar A 2006 Biological effects of curcumin and its role in cancer chemoprevention and therapy. Anticancer Agents Med Chem 6:259-270 (Pubitemid 43796643)
52. Galli A, Crabb D, Price D, Ceni E, Salzano R, Surrenti C, Casini A 2000 Peroxisome proliferator-activated receptor γ transcriptional regulation is involved in platelet-derived growth factorinduced proliferation of human hepatic stellate cells. Hepatology 31:101-108 (Pubitemid 30033695)
53. Marra F, Efsen E, Romanelli RG, Caligiuri A, Pastacaldi S, Batignani G, Bonacchi A, Caporale R, Laffi G, Pinzani M, Gentilini P 2000 Ligands of peroxisome proliferator-activated receptor γ modulate profibrogenic and proinflammatory actions in hepatic stellate cells. Gastroenterology 119:466-478 (Pubitemid 30621997)