Inducible liver-specific knockdown of protein tyrosine phosphatase 1B improves glucose and lipid homeostasis in adult mice

Diabetologia

Volumn 56, Issue 10, 2013, Pages 2286-2296

  Owen, C ^a   Lees, E K ^a   Grant, L ^a   Zimmer, D J ^b   Mody, N ^a   Bence, K K ^b   Delibegovic M ^a  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Disease; ER stress; Glucose; Insulin; Leptin; Lipid; Liver; NAFLD; Phosphatase; PTP1B

Indexed keywords

ADIPOCYTOKINE; EUKARYOTIC TRANSLATION INITIATION FACTOR 2ALPHA KINASE 3; FATTY ACID; GLUCOSE; GLYCOGEN SYNTHASE; INITIATION FACTOR; INITIATION FACTOR 2; LEPTIN; MITOGEN ACTIVATED PROTEIN KINASE 9; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PROTEIN C JUN; PROTEIN TYROSINE PHOSPHATASE 1B; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DISEASE ASSOCIATION; ENDOPLASMIC RETICULUM STRESS; FATTY ACID BLOOD LEVEL; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLUCOSE INTOLERANCE; INSULIN RESISTANCE; LIPID METABOLISM; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALS; BODY WEIGHT; GLUCOSE; GLUCOSE TOLERANCE TEST; HOMEOSTASIS; IMMUNOBLOTTING; LIPID METABOLISM; LIVER; MICE; MICE, KNOCKOUT; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1;

EID: 84890116532     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-013-2992-z     Document Type: Article

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