Computational studies support the role of the C7-sibirosamine sugar of the pyrrolobenzodiazepine (PBD) sibiromycin in transcription factor inhibition

ACS Chemical Biology

Volumn 9, Issue 10, 2014, Pages 2432-2440

  Jackson, Paul J M ^a   James, Colin H ^b   Jenkins, Terence C ^c   Rahman, Khondaker M ^a   Thurston, David E ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF LONDON   (United Kingdom)

^c UNIVERSITY OF GREENWICH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

C7 SIBIROSAMINE; DOUBLE STRANDED DNA; HYDROXYL GROUP; MONOMER; PYRROLO[2,1 C][1,4]BENZODIAZEPINE DERIVATIVE; SIBIROMYCIN; SUGAR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GAL4; UNCLASSIFIED DRUG; AMINOGLYCOSIDE; BENZODIAZEPINE DERIVATIVE; DNA; DNA BINDING PROTEIN; GAL4 PROTEIN, S CEREVISIAE; PYRROLE DERIVATIVE; PYRROLO(2,1-C)(1,4)BENZODIAZEPINE; SACCHAROMYCES CEREVISIAE PROTEIN;

ARTICLE; BASE PAIRING; BINDING AFFINITY; BINDING SITE; DENATURATION; DNA ADDUCT; DNA BINDING; DNA HELIX; DNA REPAIR; DNA SEQUENCE; ELECTROPHILICITY; HYDROGEN BOND; IN VITRO STUDY; MOLECULAR DYNAMICS; MOLECULAR MECHANICS; NUCLEOPHILICITY; STEREOCHEMISTRY; X RAY CRYSTALLOGRAPHY; ANTAGONISTS AND INHIBITORS; BIOLOGY; CHEMICAL STRUCTURE; CHEMISTRY; METABOLISM; PROCEDURES; STRUCTURE ACTIVITY RELATION;

AMINOGLYCOSIDES; BENZODIAZEPINES; COMPUTATIONAL BIOLOGY; DNA; DNA-BINDING PROTEINS; HYDROGEN BONDING; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; PYRROLES; SACCHAROMYCES CEREVISIAE PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTION FACTORS;

EID: 84908120619     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb5002203     Document Type: Article

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