An extended pyrrolobenzodiazepine-polyamide conjugate with selectivity for a DNA sequence containing the ICB2 transcription factor binding site

Journal of Medicinal Chemistry

Volumn 56, Issue 16, 2013, Pages 6339-6351

  Brucoli, Federico ^a,b   Hawkins, Rachel M ^b   James, Colin H ^b   Jackson, Paul J M ^c   Wells, Geoff ^b   Jenkins, Terence C ^d   Ellis, Tom ^e   Kotecha, Minal ^e   Hochhauser, Daniel ^e   Hartley, John A ^e,f   Howard, Philip W ^f   Thurston, David E ^c  

^a UNIVERSITY OF THE WEST OF SCOTLAND   (United Kingdom)

^b UNIVERSITY OF LONDON   (United Kingdom)

^c KING'S COLLEGE LONDON   (United Kingdom)

^d UNIVERSITY OF GREENWICH   (United Kingdom)

^e UNIVERSITY COLLEGE LONDON   (United Kingdom)

^f ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BENZODIAZEPINE DERIVATIVE; DEOXYRIBONUCLEASE I; DNA TOPOISOMERASE (ATP HYDROLYSING); NUCLEAR FACTOR Y; POLYAMIDE; TRANSCRIPTION FACTOR;

ARTICLE; CANCER CELL CULTURE; CELL CYCLE PROGRESSION; CELL DIFFERENTIATION; DNA ADDUCT; DNA DENATURATION; DNA FOOTPRINTING; DNA SEQUENCE; DRUG CONJUGATION; DRUG CYTOTOXICITY; DRUG SYNTHESIS; GEL MOBILITY SHIFT ASSAY; HUMAN; MOLECULAR MODEL; PROMOTER REGION;

ANIMALS; BENZODIAZEPINES; BINDING SITES; CELL LINE, TUMOR; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DNA; ELECTROPHORETIC MOBILITY SHIFT ASSAY; HUMANS; MICE; MODELS, MOLECULAR; NIH 3T3 CELLS; NYLONS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TRANSCRIPTION FACTORS;

EID: 84883173649     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm4001852     Document Type: Article

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