Synthesis of novel C7-aryl substituted pyrrolo[2,i- c][1,4]benzodiazepines (PBDs) via pro-N10-Troc protection and Suzuki coupling

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 21, 1998, Pages 3017-3018

  Guiotto, Andrea ^a   Howard, Philip W ^a   Giovanni Baraldi, Pier ^b   Thurston, David E ^a  

^a UNIVERSITY OF PORTSMOUTH   (United Kingdom)

^b UNIVERSITY OF FERRARA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC ANTIBIOTIC; PYRROLO[2,1 C][1,4]BENZODIAZEPINE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CYTOTOXICITY; DNA BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; GENE TARGETING; PROTEIN DNA INTERACTION;

LATEOLABRAX JAPONICUS;

EID: 0032213634     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(97)10083-X     Document Type: Article

References (8)

1. 1. Thurston, D.E., "Advances in the Study of Pyrrolo[2,1-c][1,4]benzodiazepine (PBD) Antitumour Antibiotics", In: Neidle, S. and Waring, M.J. (Eds.) Molecular Aspects of Anticancer Drug-DNA Interactions, The Macmillan Press Ltd, London, 1993, 54-88.
2. 2. Puvvada, M.S.; Hartley, J.A.; Jenkins, T.C.; Thurston, D.E. Nucleic Acids Res. 1993, 21, 3671-3675.
3. 3. Puvvada, M.S.; Forrow, S.A.; Hartley, J.A.; Stevenson, P.; Gibson, I.; Jenkins, T.C.; Thurston, D.E. Biochemistry 1997, 36, 2478-2484.
4. 4. Thurston, D.E.; Bose, D.S. Chem. Rev. 1994, 94, 433-465.
5. 5. Windholz, T.B.; Johnston, D.B.R. Tetrahedron Lett. 1967, 27, 2555-2557.
6. 6. Dong, Q.; Anderson, C.E.; Ciufolini, M. A. Tetrahedron Lett. 1995, 36, 5681-5682.
7. 7. Miyaura, N.; Suzuki, A. Chem. Rev. 1995, 95, 2457-2483.
8. 3).