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Volumn 34, Issue 43, 2014, Pages 14181-14197

Perimenstrual-like hormonal regulation of extrasynaptic δ-containing GABAA receptors mediating tonic inhibition and neurosteroid sensitivity

Author keywords

Allopregnanolone; Epilepsy; GABA receptor; Neurosteroid; Tonic inhibition; Withdrawal

Indexed keywords

2 AMINO 5 PHOSPHONOVALERIC ACID; 3 AMINO 2 (3 CARBOXYPROPYL) 6 (4 METHOXYPHENYL) PYRIDAZINIUM BROMIDE; 3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 4 AMINOBUTYRIC ACID A RECEPTOR; ANTISENSE OLIGONUCLEOTIDE; FINASTERIDE; MESSENGER RNA; NEUROSTEROID; PROGESTERONE; STEROID 5ALPHA REDUCTASE; TETRODOTOXIN; UNCLASSIFIED DRUG; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS;

EID: 84908065126     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0596-14.2014     Document Type: Article
Times cited : (57)

References (83)
  • 2
    • 21744447595 scopus 로고    scopus 로고
    • Neurosteroids: Endogenous regulators of the GABAA receptor
    • CrossRef Medline
    • Belelli D, Lambert JJ (2005) Neurosteroids: endogenous regulators of the GABAA receptor. Nat Rev Neurosci 6:565–575. CrossRef Medline
    • (2005) Nat Rev Neurosci , vol.6 , pp. 565-575
    • Belelli, D.1    Lambert, J.J.2
  • 3
    • 0036754980 scopus 로고    scopus 로고
    • The influence of subunit composition on the interaction of neurosteroids with GABAA receptors
    • CrossRef Medline
    • Belelli D, Casula A, Ling A, Lambert JJ (2002) The influence of subunit composition on the interaction of neurosteroids with GABAA receptors. Neuropharmacology 43:651-661. CrossRef Medline
    • (2002) Neuropharmacology , vol.43 , pp. 651-661
    • Belelli, D.1    Casula, A.2    Ling, A.3    Lambert, J.J.4
  • 4
    • 0345491872 scopus 로고    scopus 로고
    • Neurosteroids shift partial agonist activation of GABAA receptor channels from low- to high-efficacy gating patterns
    • Medline
    • Bianchi MT, Macdonald RL (2003) Neurosteroids shift partial agonist activation of GABAA receptor channels from low- to high-efficacy gating patterns. J Neurosci 23:10934-10943. Medline
    • (2003) J Neurosci , vol.23 , pp. 10934-10943
    • Bianchi, M.T.1    Macdonald, R.L.2
  • 5
    • 84855729789 scopus 로고    scopus 로고
    • Extrasynaptic GABA-A receptors: Their function in the CNS and implications for disease
    • CrossRef Medline
    • Brickley SG, Mody I (2012) Extrasynaptic GABA-A receptors: their function in the CNS and implications for disease. Neuron 73:23–34. CrossRef Medline
    • (2012) Neuron , vol.73 , pp. 23-34
    • Brickley, S.G.1    Mody, I.2
  • 6
    • 78651482611 scopus 로고    scopus 로고
    • Profound desensitization by ambient GABA limits activation of d-containing GABAA receptors during spillover
    • CrossRef Medline
    • Bright DP, Renzi M, Bartram J, McGee TP, MacKenzie G, Hosie AM, Farrant M, Brickley SG (2011) Profound desensitization by ambient GABA limits activation of d-containing GABAA receptors during spillover. J Neurosci 31:753–763. CrossRef Medline
    • (2011) J Neurosci , vol.31 , pp. 753-763
    • Bright, D.P.1    Renzi, M.2    Bartram, J.3    McGee, T.P.4    Mackenzie, G.5    Hosie, A.M.6    Farrant, M.7    Brickley, S.G.8
  • 7
    • 0036024231 scopus 로고    scopus 로고
    • Pharmacological characterization of a novel cell line expressing human α4βb3d GABAA receptors
    • CrossRef Medline
    • Brown N, Kerby J, Bonnert TP, Whiting PJ, Wafford KA (2002) Pharmacological characterization of a novel cell line expressing human a4b3d GABAA receptors. Br J Pharmacol 136:965–974. CrossRef Medline
    • (2002) Br J Pharmacol , vol.136 , pp. 965-974
    • Brown, N.1    Kerby, J.2    Bonnert, T.P.3    Whiting, P.J.4    Wafford, K.A.5
  • 8
    • 84891784115 scopus 로고    scopus 로고
    • Neurosteroid interactions with synaptic and extrasynaptic GABAA receptors: Regulation of subunit plasticity, phasic and tonic inhibition, and neuronal network excitability
    • CrossRef Medline
    • Carver CM, Reddy DS (2013) Neurosteroid interactions with synaptic and extrasynaptic GABAA receptors: regulation of subunit plasticity, phasic and tonic inhibition, and neuronal network excitability. Psychopharmacology 230:151–188. CrossRef Medline
    • (2013) Psychopharmacology , vol.230 , pp. 151-188
    • Carver, C.M.1    Reddy, D.S.2
  • 9
    • 0035282615 scopus 로고    scopus 로고
    • Generating diversity at GABAergic synapses
    • CrossRef Medline
    • Cherubini E, Conti F (2001) Generating diversity at GABAergic synapses. Trends Neurosci 24:155–162. CrossRef Medline
    • (2001) Trends Neurosci , vol.24 , pp. 155-162
    • Cherubini, E.1    Conti, F.2
  • 10
    • 0037680161 scopus 로고    scopus 로고
    • Dentate granule cell GABAA receptors in epileptic hippocampus: Enhanced synaptic efficacy and altered pharmacology
    • CrossRef Medline
    • Cohen AS, Lin DD, Quirk GL, Coulter DA (2003) Dentate granule cell GABAA receptors in epileptic hippocampus: enhanced synaptic efficacy and altered pharmacology. Eur J Neurosci 17:1607–1616. CrossRef Medline
    • (2003) Eur J Neurosci , vol.17 , pp. 1607-1616
    • Cohen, A.S.1    Lin, D.D.2    Quirk, G.L.3    Coulter, D.A.4
  • 11
    • 34548276569 scopus 로고    scopus 로고
    • Functional regulation of the dentate gyrus by GABA-mediated inhibition
    • CrossRef Medline
    • Coulter DA, Carlson GC (2007) Functional regulation of the dentate gyrus by GABA-mediated inhibition. Prog Brain Res 163:235–243. CrossRef Medline
    • (2007) Prog Brain Res , vol.163 , pp. 235-243
    • Coulter, D.A.1    Carlson, G.C.2
  • 12
    • 84874115951 scopus 로고    scopus 로고
    • Varenicline and nicotine enhance GABAergic synaptic transmission in rat CA1 hippocampal and medial septum/diagonal band neurons
    • CrossRef Medline
    • DuBois DW, Damborsky JC, Fincher AS, Frye GD, Winzer-Serhan UH (2013) Varenicline and nicotine enhance GABAergic synaptic transmission in rat CA1 hippocampal and medial septum/diagonal band neurons. Life Sci 92:337–344. CrossRef Medline
    • (2013) Life Sci , vol.92 , pp. 337-344
    • Dubois, D.W.1    Damborsky, J.C.2    Fincher, A.S.3    Frye, G.D.4    Winzer-Serhan, U.H.5
  • 14
    • 67349158231 scopus 로고    scopus 로고
    • The optimization of TaqMan real-time RTPCR assay for transcriptional profiling of GABAA receptor subunit plasticity
    • CrossRef Medline
    • Gangisetty O, Reddy DS (2009) The optimization of TaqMan real-time RTPCR assay for transcriptional profiling of GABAA receptor subunit plasticity. J Neurosci Methods 181:58–66. CrossRef Medline
    • (2009) J Neurosci Methods , vol.181 , pp. 58-66
    • Gangisetty, O.1    Reddy, D.S.2
  • 15
    • 77956619066 scopus 로고    scopus 로고
    • Neurosteroid withdrawal regulates GABAA receptor α4-subunit expression and seizure susceptibility by activation of progesterone receptor-independent early growth response factor-3 pathway
    • CrossRef Medline
    • Gangisetty O, Reddy DS (2010) Neurosteroid withdrawal regulates GABAA receptor a4-subunit expression and seizure susceptibility by activation of progesterone receptor-independent early growth response factor-3 pathway. Neuroscience 170:865-880. CrossRef Medline
    • (2010) Neuroscience , vol.170 , pp. 865-880
    • Gangisetty, O.1    Reddy, D.S.2
  • 16
    • 38949092526 scopus 로고    scopus 로고
    • Which GABAA receptor subunits are necessary for tonic inhibition in the hippocampus?
    • CrossRef Medline
    • Glykys J, Mann EO, Mody I (2008) Which GABAA receptor subunits are necessary for tonic inhibition in the hippocampus? J Neurosci 28:1421-1426. CrossRef Medline
    • (2008) J Neurosci , vol.28 , pp. 1421-1426
    • Glykys, J.1    Mann, E.O.2    Mody, I.3
  • 17
    • 0021741846 scopus 로고
    • Modulation of the GABA receptor complex by a steroid anesthetic
    • CrossRef Medline
    • Harrison NL, Simmonds MA (1984) Modulation of the GABA receptor complex by a steroid anesthetic. Brain Res 323:287–292. CrossRef Medline
    • (1984) Brain Res , vol.323 , pp. 287-292
    • Harrison, N.L.1    Simmonds, M.A.2
  • 18
    • 0037371428 scopus 로고    scopus 로고
    • Seizure exacerbation associated with inhibition of progesterone metabolism
    • CrossRef Medline
    • Herzog AG, Frye CA (2003) Seizure exacerbation associated with inhibition of progesterone metabolism. Ann Neurol 53:390-391. CrossRef Medline
    • (2003) Ann Neurol , vol.53 , pp. 390-391
    • Herzog, A.G.1    Frye, C.A.2
  • 21
    • 34548639993 scopus 로고    scopus 로고
    • Neurosteroid binding sites on GABAA receptors
    • CrossRef Medline
    • Hosie AM, Wilkins ME, Smart TG (2007) Neurosteroid binding sites on GABAA receptors. Pharmacol Ther 116:7–19. CrossRef Medline
    • (2007) Pharmacol Ther , vol.116 , pp. 7-19
    • Hosie, A.M.1    Wilkins, M.E.2    Smart, T.G.3
  • 23
    • 42349109493 scopus 로고    scopus 로고
    • GABAA receptor trafficking and its role in the dynamic modulation of neuronal inhibition
    • CrossRef Medline
    • Jacob TC, Moss SJ, Jurd R (2008) GABAA receptor trafficking and its role in the dynamic modulation of neuronal inhibition. Nat Rev Neurosci 9:331-343. CrossRef Medline
    • (2008) Nat Rev Neurosci , vol.9 , pp. 331-343
    • Jacob, T.C.1    Moss, S.J.2    Jurd, R.3
  • 24
    • 0022501358 scopus 로고
    • Isolation of neurons suitable for patch-clamping from adult mammalian central nervous systems
    • CrossRef Medline
    • Kay AR, Wong RK (1986) Isolation of neurons suitable for patch-clamping from adult mammalian central nervous systems. J Neurosci Methods 16:227–238. CrossRef Medline
    • (1986) J Neurosci Methods , vol.16 , pp. 227-238
    • Kay, A.R.1    Wong, R.K.2
  • 25
    • 0022509201 scopus 로고
    • In vivo determination of extracellular concentration of amino acids in the rat hippocampus. A method based on brain dialysis and computerized analysis
    • CrossRef Medline
    • Lerma J, Herranz AS, Herreras O, Abraira V, Martín del Río R (1986) In vivo determination of extracellular concentration of amino acids in the rat hippocampus. A method based on brain dialysis and computerized analysis. Brain Res 384:145–155. CrossRef Medline
    • (1986) Brain Res , vol.384 , pp. 145-155
    • Lerma, J.1    Herranz, A.S.2    Herreras, O.3    Abraira, V.4    MartíN Del RíO, R.5
  • 27
    • 33847415856 scopus 로고    scopus 로고
    • Neurosteroid synthesis-mediated regulation of GABAA receptors: Relevance to the ovarian cycle and stress
    • CrossRef Medline
    • Maguire J, Mody I (2007) Neurosteroid synthesis-mediated regulation of GABAA receptors: relevance to the ovarian cycle and stress. J Neurosci 27:2155–2162. CrossRef Medline
    • (2007) J Neurosci , vol.27 , pp. 2155-2162
    • Maguire, J.1    Mody, I.2
  • 28
    • 47749083851 scopus 로고    scopus 로고
    • GABAAR plasticity during pregnancy: Relevance to postpartum depression
    • CrossRef Medline
    • Maguire J, Mody I (2008) GABAAR plasticity during pregnancy: relevance to postpartum depression. Neuron 59:207–213. CrossRef Medline
    • (2008) Neuron , vol.59 , pp. 207-213
    • Maguire, J.1    Mody, I.2
  • 29
    • 22844431788 scopus 로고    scopus 로고
    • Ovarian cycle-linked changes in GABAA receptors mediating tonic inhibition alter seizure susceptibility and anxiety
    • CrossRef Medline
    • Maguire JL, Stell BM, Rafizadeh M, Mody I (2005) Ovarian cycle-linked changes in GABAA receptors mediating tonic inhibition alter seizure susceptibility and anxiety. Nat Neurosci 8:797-804. CrossRef Medline
    • (2005) Nat Neurosci , vol.8 , pp. 797-804
    • Maguire, J.L.1    Stell, B.M.2    Rafizadeh, M.3    Mody, I.4
  • 30
    • 0022483382 scopus 로고
    • Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor
    • CrossRef Medline
    • Majewska MD, Harrison NL, Schwartz RD, Barker JL, Paul SM (1986) Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor. Science 232:1004-1007. CrossRef Medline
    • (1986) Science , vol.232 , pp. 1004-1007
    • Majewska, M.D.1    Harrison, N.L.2    Schwartz, R.D.3    Barker, J.L.4    Paul, S.M.5
  • 31
    • 14944382845 scopus 로고    scopus 로고
    • Cultured hippocampal pyramidal neurons express two kinds of GABAA receptors
    • CrossRef Medline
    • Mangan PS, Sun C, Carpenter M, Goodkin HP, Sieghart W, Kapur J (2005) Cultured hippocampal pyramidal neurons express two kinds of GABAA receptors. Mol Pharmacol 67:775–788. CrossRef Medline
    • (2005) Mol Pharmacol , vol.67 , pp. 775-788
    • Mangan, P.S.1    Sun, C.2    Carpenter, M.3    Goodkin, H.P.4    Sieghart, W.5    Kapur, J.6
  • 32
    • 80054044923 scopus 로고    scopus 로고
    • Molecular basis for the high THIP/ gaboxadol sensitivity of extrasynaptic GABAA receptors
    • CrossRef Medline
    • Meera P, Wallner M, Otis TS (2011) Molecular basis for the high THIP/ gaboxadol sensitivity of extrasynaptic GABAA receptors. J Neurophysiol 106:2057–2064. CrossRef Medline
    • (2011) J Neurophysiol , vol.106 , pp. 2057-2064
    • Meera, P.1    Wallner, M.2    Otis, T.S.3
  • 33
    • 0035663507 scopus 로고    scopus 로고
    • Biosynthesis and action of neurosteroids
    • CrossRef Medline
    • Mellon SH, Griffin LD, Compagnone NA (2001) Biosynthesis and action of neurosteroids. Brain Res Rev 37:3–12. CrossRef Medline
    • (2001) Brain Res Rev , vol.37 , pp. 3-12
    • Mellon, S.H.1    Griffin, L.D.2    Compagnone, N.A.3
  • 36
    • 0032487623 scopus 로고    scopus 로고
    • Progesterone withdrawal I: Pro-convulsant effects
    • CrossRef Medline
    • Moran MH, Smith SS (1998) Progesterone withdrawal I: pro-convulsant effects. Brain Res 807:84-90. CrossRef Medline
    • (1998) Brain Res , vol.807 , pp. 84-90
    • Moran, M.H.1    Smith, S.S.2
  • 37
    • 0032487670 scopus 로고    scopus 로고
    • Progesterone withdrawal II: Insensitivity to the sedative effects of a benzodiazepine
    • Moran MH, Goldberg M, Smith SS (1998) Progesterone withdrawal II: insensitivity to the sedative effects of a benzodiazepine. Brain Res 807:91-100.
    • (1998) Brain Res , vol.807 , pp. 91-100
    • Moran, M.H.1    Goldberg, M.2    Smith, S.S.3
  • 38
    • 77952909252 scopus 로고    scopus 로고
    • Distinct activities of GABA agonists at synaptic- and extrasynaptic-type GABAA receptors
    • CrossRef Medline
    • Mortensen M, Ebert B, Wafford K, Smart TG (2010) Distinct activities of GABA agonists at synaptic- and extrasynaptic-type GABAA receptors. J Physiol 588:1251–1268. CrossRef Medline
    • (2010) J Physiol , vol.588 , pp. 1251-1268
    • Mortensen, M.1    Ebert, B.2    Wafford, K.3    Smart, T.G.4
  • 39
    • 31044445792 scopus 로고    scopus 로고
    • High-affinity, slowly desensitizing GABAA receptors mediate tonic inhibition in hippocampal dentate granule cells
    • CrossRef Medline
    • Mtchedlishvili Z, Kapur J (2006) High-affinity, slowly desensitizing GABAA receptors mediate tonic inhibition in hippocampal dentate granule cells. Mol Pharmacol 69:564-575. CrossRef Medline
    • (2006) Mol Pharmacol , vol.69 , pp. 564-575
    • Mtchedlishvili, Z.1    Kapur, J.2
  • 40
    • 0037466765 scopus 로고    scopus 로고
    • Increased neuroste- roid sensitivity of hippocampal GABAA receptors during postnatal development
    • CrossRef Medline
    • Mtchedlishvili Z, Sun CS, Harrison MB, Kapur J (2003) Increased neuroste- roid sensitivity of hippocampal GABAA receptors during postnatal development. Neuroscience 118:655-666. CrossRef Medline
    • (2003) Neuroscience , vol.118 , pp. 655-666
    • Mtchedlishvili, Z.1    Sun, C.S.2    Harrison, M.B.3    Kapur, J.4
  • 41
    • 0030922803 scopus 로고    scopus 로고
    • Differences in synaptic GABAA receptor number underlie variation in GABA mini amplitude
    • CrossRef Medline
    • Nusser Z, Cull-Candy S, Farrant M (1997) Differences in synaptic GABAA receptor number underlie variation in GABA mini amplitude. Neuron 19:697–709. CrossRef Medline
    • (1997) Neuron , vol.19 , pp. 697-709
    • Nusser, Z.1    Cull-Candy, S.2    Farrant, M.3
  • 42
    • 80052482736 scopus 로고    scopus 로고
    • Neuroendocrinological aspects of epilepsy: Important issues and trends in future research
    • CrossRef Medline
    • Pack AM, Reddy DS, Duncan S, Herzog A (2011) Neuroendocrinological aspects of epilepsy: important issues and trends in future research. Epilepsy Behav 22:94-102. CrossRef Medline
    • (2011) Epilepsy Behav , vol.22 , pp. 94-102
    • Pack, A.M.1    Reddy, D.S.2    Duncan, S.3    Herzog, A.4
  • 44
    • 84875241327 scopus 로고    scopus 로고
    • Tonic GABAA receptor-mediated signaling in temporal lobe epilepsy
    • CrossRef Medline
    • Pavlov I, Walker MC (2013) Tonic GABAA receptor-mediated signaling in temporal lobe epilepsy. Neuropharmacology 69:55–61. CrossRef Medline
    • (2013) Neuropharmacology , vol.69 , pp. 55-61
    • Pavlov, I.1    Walker, M.C.2
  • 45
    • 80053122529 scopus 로고    scopus 로고
    • Progressive loss of phasic, but not tonic GABA(A) receptormediated inhibition in dentate granule cells in a model of post-traumatic epilepsy in rats
    • CrossRef Medline
    • Pavlov I, Huusko N, Drexel M, Kirchmair E, Sperk G, Pitkänen A, Walker MC (2011) Progressive loss of phasic, but not tonic GABA(A) receptormediated inhibition in dentate granule cells in a model of post-traumatic epilepsy in rats. Neuroscience 194:208-219. CrossRef Medline
    • (2011) Neuroscience , vol.194 , pp. 208-219
    • Pavlov, I.1    Huusko, N.2    Drexel, M.3    Kirchmair, E.4    Sperk, G.5    Pitkänen, A.6    Walker, M.C.7
  • 46
    • 0037193041 scopus 로고    scopus 로고
    • GABAA receptor changes in ăsubunit-deficient mice: altered expression of α4 and δ2 subunits in the forebrain
    • CrossRef Medline
    • Peng Z, Hauer B, Mihalek RM, Homanics GE, Sieghart W, Olsen RW, Houser CR (2002) GABAA receptor changes in d subunit-deficient mice: altered expression of a4 and g2 subunits in the forebrain. J Comp Neurol 446: 179–197. CrossRef Medline
    • (2002) J Comp Neurol , vol.446 , pp. 179-197
    • Peng, Z.1    Hauer, B.2    Mihalek, R.M.3    Homanics, G.E.4    Sieghart, W.5    Olsen, R.W.6    Houser, C.R.7
  • 47
    • 3843146088 scopus 로고    scopus 로고
    • Multiple structural features of steroids mediate subtype-selective effects on human α4β3ăGABAA receptors
    • CrossRef Medline
    • Pillai GV, Smith AJ, Hunt PA, Simpson PB (2004) Multiple structural features of steroids mediate subtype-selective effects on human a4b3d GABAA receptors. Biochem Pharmacol 68:819–831. CrossRef Medline
    • (2004) Biochem Pharmacol , vol.68 , pp. 819-831
    • Pillai, G.V.1    Smith, A.J.2    Hunt, P.A.3    Simpson, P.B.4
  • 48
    • 0034736184 scopus 로고    scopus 로고
    • GABA(A) receptors: Immunocytochemical distribution of 13 subunits in the adult rat brain
    • CrossRef Medline
    • Pirker S, Schwarzer C, Wieselthaler A, Sieghart W, Sperk G (2000) GABA(A) receptors: immunocytochemical distribution of 13 subunits in the adult rat brain. Neuroscience 101:815-850. CrossRef Medline
    • (2000) Neuroscience , vol.101 , pp. 815-850
    • Pirker, S.1    Schwarzer, C.2    Wieselthaler, A.3    Sieghart, W.4    Sperk, G.5
  • 49
    • 0015309163 scopus 로고
    • Modification of seizure activity by electrical stimulation. II. Motor seizure
    • CrossRef Medline
    • Racine RJ (1972) Modification of seizure activity by electrical stimulation. II. Motor seizure. Electroencephalogr Clin Neurophysiol 32:281–294. CrossRef Medline
    • (1972) Electroencephalogr Clin Neurophysiol , vol.32 , pp. 281-294
    • Racine, R.J.1
  • 50
    • 67349176702 scopus 로고    scopus 로고
    • The role of neurosteroids in the pathophysiology and treatment of catamenial epilepsy
    • CrossRef Medline
    • Reddy DS (2009) The role of neurosteroids in the pathophysiology and treatment of catamenial epilepsy. Epilepsy Res 85:1–30. CrossRef Medline
    • (2009) Epilepsy Res , vol.85 , pp. 1-30
    • Reddy, D.S.1
  • 51
    • 84861554984 scopus 로고    scopus 로고
    • Role of anticonvulsant and antiepileptogenic neurosteroids in the pathophysiology and treatment of epilepsy
    • CrossRef Medline
    • Reddy DS (2011) Role of anticonvulsant and antiepileptogenic neurosteroids in the pathophysiology and treatment of epilepsy. Front Endocrinol (Lausanne) 2:38. CrossRef Medline
    • (2011) Front Endocrinol (Lausanne) , vol.2 , pp. 38
    • Reddy, D.S.1
  • 52
    • 84872845083 scopus 로고    scopus 로고
    • Neuroendocrine aspects of catamenial epilepsy
    • CrossRef Medline
    • Reddy DS (2013) Neuroendocrine aspects of catamenial epilepsy. Horm Behav 63:254-266. CrossRef Medline
    • (2013) Horm Behav , vol.63 , pp. 254-266
    • Reddy, D.S.1
  • 53
    • 77956239979 scopus 로고    scopus 로고
    • The testosterone-derived neurosteroid androstanediol is a positive allosteric modulator of GABAA receptors
    • CrossRef Medline
    • Reddy DS, Jian K (2010) The testosterone-derived neurosteroid androstanediol is a positive allosteric modulator of GABAA receptors. J Pharmacol Exp Ther 334:1031–1041. CrossRef Medline
    • (2010) J Pharmacol Exp Ther , vol.334 , pp. 1031-1041
    • Reddy, D.S.1    Jian, K.2
  • 54
    • 78651512827 scopus 로고    scopus 로고
    • Development and persistence of limbic epileptogenesis are impaired in mice lacking progesterone receptors
    • CrossRef Medline
    • Reddy DS, Mohan A (2011) Development and persistence of limbic epileptogenesis are impaired in mice lacking progesterone receptors. J Neurosci 31:650–658. CrossRef Medline
    • (2011) J Neurosci , vol.31 , pp. 650-658
    • Reddy, D.S.1    Mohan, A.2
  • 55
    • 0033842656 scopus 로고    scopus 로고
    • Enhanced anticonvulsant activity of ganaxolone after neurosteroid withdrawal in a rat model of catamenial epilepsy
    • Medline
    • Reddy DS, Rogawski MA (2000) Enhanced anticonvulsant activity of ganaxolone after neurosteroid withdrawal in a rat model of catamenial epilepsy. J Pharmacol Exp Ther 294:909-915. Medline
    • (2000) J Pharmacol Exp Ther , vol.294 , pp. 909-915
    • Reddy, D.S.1    Rogawski, M.A.2
  • 56
    • 0035060229 scopus 로고    scopus 로고
    • Enhanced anticonvulsant activity of neuroactive steroids in a rat model of catamenial epilepsy
    • CrossRef Medline
    • Reddy DS, Rogawski MA (2001) Enhanced anticonvulsant activity of neuroactive steroids in a rat model of catamenial epilepsy. Epilepsia 42:337-344. CrossRef Medline
    • (2001) Epilepsia , vol.42 , pp. 337-344
    • Reddy, D.S.1    Rogawski, M.A.2
  • 57
    • 0036582315 scopus 로고    scopus 로고
    • Stress-induced deoxycorticosterone-derived neurosteroids modulate GABA(A) receptor function and seizure susceptibility
    • Medline
    • Reddy DS, Rogawski MA (2002) Stress-induced deoxycorticosterone-derived neurosteroids modulate GABA(A) receptor function and seizure susceptibility. J Neurosci 22:3795–3805. Medline
    • (2002) J Neurosci , vol.22 , pp. 3795-3805
    • Reddy, D.S.1    Rogawski, M.A.2
  • 58
    • 63149166858 scopus 로고    scopus 로고
    • Neurosteroid replacement therapy for catamenial epilepsy
    • CrossRef Medline
    • Reddy DS, Rogawski MA (2009) Neurosteroid replacement therapy for catamenial epilepsy. Neurotherapeutics 6:392-401. CrossRef Medline
    • (2009) Neurotherapeutics , vol.6 , pp. 392-401
    • Reddy, D.S.1    Rogawski, M.A.2
  • 59
    • 67349219168 scopus 로고    scopus 로고
    • Effect of neurosteroid withdrawal on spontaneous recurrent seizures in a rat model of catamenial epilepsy
    • Medline
    • Reddy DS, Zeng YC (2007) Effect of neurosteroid withdrawal on spontaneous recurrent seizures in a rat model of catamenial epilepsy. FASEB J 21:885.14. Medline
    • (2007) FASEB J , vol.21 , pp. 885
    • Reddy, D.S.1    Zeng, Y.C.2
  • 60
    • 0035057345 scopus 로고    scopus 로고
    • Neurosteroid withdrawal model of perimenstrual catamenial epilepsy
    • CrossRef Medline
    • Reddy DS, Kim HY, Rogawski MA (2001) Neurosteroid withdrawal model of perimenstrual catamenial epilepsy. Epilepsia 42:328-336. CrossRef Medline
    • (2001) Epilepsia , vol.42 , pp. 328-336
    • Reddy, D.S.1    Kim, H.Y.2    Rogawski, M.A.3
  • 61
    • 3042552746 scopus 로고    scopus 로고
    • Anticonvulsant activity of progesterone and neurosteroids in progesterone receptor knockout mice
    • CrossRef Medline
    • Reddy DS, Castaneda DC, O’Malley BW, Rogawski MA (2004) Anticonvulsant activity of progesterone and neurosteroids in progesterone receptor knockout mice. J Pharmacol Exp Ther 310:230-239. CrossRef Medline
    • (2004) J Pharmacol Exp Ther , vol.310 , pp. 230-239
    • Reddy, D.S.1    Castaneda, D.C.2    O’malley, B.W.3    Rogawski, M.A.4
  • 62
    • 77958113561 scopus 로고    scopus 로고
    • Disease-modifying activity of progesterone in the hippocampus kindling model of epileptogenesis
    • CrossRef Medline
    • Reddy DS, Gangisetty O, Briyal S (2010) Disease-modifying activity of progesterone in the hippocampus kindling model of epileptogenesis. Neuropharmacology 59:573–581. CrossRef Medline
    • (2010) Neuropharmacology , vol.59 , pp. 573-581
    • Reddy, D.S.1    Gangisetty, O.2    Briyal, S.3
  • 63
    • 84861563818 scopus 로고    scopus 로고
    • A mouse kindling model of perimenstrual catamenial epilepsy
    • CrossRef Medline
    • Reddy DS, Gould J, Gangisetty O (2012) A mouse kindling model of perimenstrual catamenial epilepsy. J Pharmacol Exp Ther 341:784-793. CrossRef Medline
    • (2012) J Pharmacol Exp Ther , vol.341 , pp. 784-793
    • Reddy, D.S.1    Gould, J.2    Gangisetty, O.3
  • 64
    • 84866299415 scopus 로고    scopus 로고
    • Finasteride inhibits the disease-modifying activity of progesterone in the hippocampus kindling model of epileptogenesis
    • CrossRef Medline
    • Reddy D, Ramanathan G (2012) Finasteride inhibits the disease-modifying activity of progesterone in the hippocampus kindling model of epileptogenesis. Epilepsy Behav 25:92–97. CrossRef Medline
    • (2012) Epilepsy Behav , vol.25 , pp. 92-97
    • Reddy, D.1    Ramanathan, G.2
  • 65
    • 60849131485 scopus 로고    scopus 로고
    • Changes in expression and function of extrasynaptic GABAA receptors in rat hippocampus during pregnancy and after delivery
    • CrossRef Medline
    • Sanna E, Mostallino MC, Murru L, Carta M, Talani G, Zucca S, Mura ML, Maciocco E, Biggio G (2009) Changes in expression and function of extrasynaptic GABAA receptors in rat hippocampus during pregnancy and after delivery. J Neurosci 29:1755–1765. CrossRef Medline
    • (2009) J Neurosci , vol.29 , pp. 1755-1765
    • Sanna, E.1    Mostallino, M.C.2    Murru, L.3    Carta, M.4    Talani, G.5    Zucca, S.6    Mura, M.L.7    Maciocco, E.8    Biggio, G.9
  • 66
    • 1942501006 scopus 로고    scopus 로고
    • Tonically active GABAA receptors: Modulating gain and maintaining the tone
    • CrossRef Medline
    • Semyanov A, Walker MC, Kullmann DM, Silver RA (2004) Tonically active GABAA receptors: modulating gain and maintaining the tone. Trends Neurosci 27:262–269. CrossRef Medline
    • (2004) Trends Neurosci , vol.27 , pp. 262-269
    • Semyanov, A.1    Walker, M.C.2    Kullmann, D.M.3    Silver, R.A.4
  • 67
    • 23944441957 scopus 로고    scopus 로고
    • Short-term steroid treatment increases _ GABAA receptor subunit expression in rat CA1 hippocampus: Pharmacological and behavioral effects
    • CrossRef Medline
    • Shen H, Gong QH, Yuan M, Smith SS (2005) Short-term steroid treatment increases _ GABAA receptor subunit expression in rat CA1 hippocampus: pharmacological and behavioral effects. Neuropharmacology 49:573-586. CrossRef Medline
    • (2005) Neuropharmacology , vol.49 , pp. 573-586
    • Shen, H.1    Gong, Q.H.2    Yuan, M.3    Smith, S.S.4
  • 68
    • 33947659009 scopus 로고    scopus 로고
    • Reversal of neurosteroid effects at α4β2ăGABAA receptors triggers anxiety at puberty
    • CrossRef Medline
    • Shen H, Gong QH, Aoki C, Yuan M, Ruderman Y, Dattilo M, Williams K, Smith SS (2007) Reversal of neurosteroid effects at a4b2d GABAA receptors triggers anxiety at puberty. Nat Neurosci 10:469–477. CrossRef Medline
    • (2007) Nat Neurosci , vol.10 , pp. 469-477
    • Shen, H.1    Gong, Q.H.2    Aoki, C.3    Yuan, M.4    Ruderman, Y.5    Dattilo, M.6    Williams, K.7    Smith, S.S.8
  • 69
    • 17844406662 scopus 로고    scopus 로고
    • Neurosteroid administration and withdrawal alter GABAA receptor kinetics in CA1 hippocampus of female rats
    • CrossRef Medline
    • Smith SS, Gong QH (2005) Neurosteroid administration and withdrawal alter GABAA receptor kinetics in CA1 hippocampus of female rats. J Physiol 564:421-436. CrossRef Medline
    • (2005) J Physiol , vol.564 , pp. 421-436
    • Smith, S.S.1    Gong, Q.H.2
  • 70
    • 0032580125 scopus 로고    scopus 로고
    • GABAA receptor α4 subunit suppression prevents withdrawal properties of an endogenous steroid
    • CrossRef Medline
    • Smith SS, Gong QH, Hsu FC, Markowitz RS, ffrench-Mullen JM, Li X (1998a) GABAA receptor a4 subunit suppression prevents withdrawal properties of an endogenous steroid. Nature 392:926–930. CrossRef Medline
    • (1998) Nature , vol.392 , pp. 926-930
    • Smith, S.S.1    Gong, Q.H.2    Hsu, F.C.3    Markowitz, R.S.4    Ffrench-Mullen, J.M.5    Li, X.6
  • 71
    • 0032527128 scopus 로고    scopus 로고
    • Withdrawal from 3α-OH-5α-pregnan-20-one using a pseudopregnancy model alters the kinetics of hippocampal GABAA-gated current and increases the GABAA receptor α4 subunit in association with increased anxiety
    • Medline
    • Smith SS, Gong QH, Li X, Moran MH, Bitran D, Frye CA, Hsu FC (1998b) Withdrawal from 3a-OH-5a-pregnan-20-one using a pseudopregnancy model alters the kinetics of hippocampal GABAA-gated current and increases the GABAA receptor a4 subunit in association with increased anxiety. J Neurosci 18:5275–5284. Medline
    • (1998) J Neurosci , vol.18 , pp. 5275-5284
    • Smith, S.S.1    Gong, Q.H.2    Li, X.3    Moran, M.H.4    Bitran, D.5    Frye, C.A.6    Hsu, F.C.7
  • 72
    • 34548588448 scopus 로고    scopus 로고
    • Neurosteroid regulation of GABAA receptors: Focus on the α4 and δsubunits
    • CrossRef Medline
    • Smith SS, Shen H, Gong QH, Zhou X (2007) Neurosteroid regulation of GABAA receptors: focus on the a4 and dsubunits. Pharmacol Ther 116: 58–76. CrossRef Medline
    • (2007) Pharmacol Ther , vol.116 , pp. 58-76
    • Smith, S.S.1    Shen, H.2    Gong, Q.H.3    Zhou, X.4
  • 73
    • 0042817889 scopus 로고    scopus 로고
    • Reduced inhibition and sensitivity to neurosteroids in hippocampus of mice lacking the GABAA receptor ăsubunit
    • CrossRef Medline
    • Spigelman I, Li Z, Liang J, Cagetti E, Samzadeh S, Mihalek RM, Homanics GE, Olsen RW (2003) Reduced inhibition and sensitivity to neurosteroids in hippocampus of mice lacking the GABAA receptor d subunit. J Neurophysiol 90:903–910. CrossRef Medline
    • (2003) J Neurophysiol , vol.90 , pp. 903-910
    • Spigelman, I.1    Li, Z.2    Liang, J.3    Cagetti, E.4    Samzadeh, S.5    Mihalek, R.M.6    Homanics, G.E.7    Olsen, R.W.8
  • 74
    • 0344630208 scopus 로고    scopus 로고
    • Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by _ subunit-containing GABAA receptors
    • CrossRef Medline
    • Stell BM, Brickley SG, Tang CY, Farrant M, Mody I (2003) Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by _ subunit-containing GABAA receptors. Proc Natl Acad Sci U S A 100:14439-14444. CrossRef Medline
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 14439-14444
    • Stell, B.M.1    Brickley, S.G.2    Tang, C.Y.3    Farrant, M.4    Mody, I.5
  • 75
    • 33644772587 scopus 로고    scopus 로고
    • Pharmacological characterization of agonists at δ-containing GABAA receptors: Functional selectivity for extrasynaptic receptors is dependent on the absence of δ2
    • CrossRef Medline
    • Stórustovu SI, Ebert B (2006) Pharmacological characterization of agonists at d-containing GABAA receptors: functional selectivity for extrasynaptic receptors is dependent on the absence of g2. J Pharmacol Exp Ther 316: 1351–1359. CrossRef Medline
    • (2006) J Pharmacol Exp Ther , vol.316 , pp. 1351-1359
    • Stórustovu, S.I.1    Ebert, B.2
  • 76
    • 7944226960 scopus 로고    scopus 로고
    • Distribution of α1, δ2, and ăsubunits of GABAA receptors in hippocampal granule cells
    • CrossRef Medline
    • Sun C, Sieghart W, Kapur J (2004) Distribution of a1, g2, and d subunits of GABAA receptors in hippocampal granule cells. Brain Res 1029:207–216. CrossRef Medline
    • (2004) Brain Res , vol.1029 , pp. 207-216
    • Sun, C.1    Sieghart, W.2    Kapur, J.3
  • 77
    • 36248971747 scopus 로고    scopus 로고
    • Diminished neurosteroid sensitivity of synaptic inhibition and altered location of the α4 subunit of GABA-A receptors in an animal model of epilepsy
    • CrossRef Medline
    • Sun C, Mtchedlishvili Z, Erisir A, Kapur J (2007) Diminished neurosteroid sensitivity of synaptic inhibition and altered location of the a4 subunit of GABA-A receptors in an animal model of epilepsy. J Neurosci 27:12641-12650. CrossRef Medline
    • (2007) J Neurosci , vol.27 , pp. 12641-12650
    • Sun, C.1    Mtchedlishvili, Z.2    Erisir, A.3    Kapur, J.4
  • 80
    • 0344442662 scopus 로고    scopus 로고
    • Perisynaptic localization of ăsubunit-containing GABAA receptors and their activation by GABA spillover in the mouse dentate gyrus
    • Medline
    • Wei W, Zhang N, Peng Z, Houser CR, Mody I (2003) Perisynaptic localization of d subunit-containing GABAA receptors and their activation by GABA spillover in the mouse dentate gyrus. J Neurosci 23:10650-10661. Medline
    • (2003) J Neurosci , vol.23 , pp. 10650-10661
    • Wei, W.1    Zhang, N.2    Peng, Z.3    Houser, C.R.4    Mody, I.5
  • 81
    • 0036522966 scopus 로고    scopus 로고
    • Enhanced neurosteroid potentiation of ternary GABAA receptors containing the ăsubunit
    • Medline
    • Wohlfarth KM, Bianchi MT, Macdonald RL (2002) Enhanced neurosteroid potentiation of ternary GABAA receptors containing the d subunit. J Neurosci 22:1541–1549. Medline
    • (2002) J Neurosci , vol.22 , pp. 1541-1549
    • Wohlfarth, K.M.1    Bianchi, M.T.2    Macdonald, R.L.3
  • 82
    • 84879304927 scopus 로고    scopus 로고
    • Estrous cycle regulation of extrasynaptic δ-containing GABAA receptor-mediated tonic inhibition and limbic epileptogenesis
    • CrossRef Medline
    • Wu X, Gangisetty O, Carver CM, Reddy DS (2013) Estrous cycle regulation of extrasynaptic d-containing GABAA receptor-mediated tonic inhibition and limbic epileptogenesis. J Pharmacol Exp Ther 346:146-160. CrossRef Medline
    • (2013) J Pharmacol Exp Ther , vol.346 , pp. 146-160
    • Wu, X.1    Gangisetty, O.2    Carver, C.M.3    Reddy, D.S.4
  • 83
    • 34447503741 scopus 로고    scopus 로고
    • Altered localization of GABAA receptor subunits on dentate granule cell dendrites influences tonic and phasic inhibition in a mouse model of epilepsy
    • CrossRef Medline
    • Zhang N, Wei W, Mody I, Houser CR (2007) Altered localization of GABAA receptor subunits on dentate granule cell dendrites influences tonic and phasic inhibition in a mouse model of epilepsy. J Neurosci 27:7520-7531. CrossRef Medline
    • (2007) J Neurosci , vol.27 , pp. 7520-7531
    • Zhang, N.1    Wei, W.2    Mody, I.3    Houser, C.R.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.