The testosterone-derived neurosteroid androstanediol is a positive allosteric modulator of GABAA receptors

Journal of Pharmacology and Experimental Therapeutics

Volumn 334, Issue 3, 2010, Pages 1031-1041

  Reddy, Doodipala Samba ^a   Jian, Kuihuan ^a  

^a TEXAS A M COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 4 AMINOBUTYRIC ACID A RECEPTOR; ANDROSTANEDIOL; FLUTAMIDE; 4 AMINOBUTYRIC ACID; ANTIANDROGEN; BENZODIAZEPINE RECEPTOR AFFECTING AGENT;

ALLOSTERISM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ARTICLE; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG POTENTIATION; GABAERGIC SYSTEM; HIPPOCAMPUS; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; TEMPORAL LOBE EPILEPSY; ANIMAL; C57BL MOUSE; CYTOLOGY; DRUG EFFECTS; EVOKED RESPONSE; HIPPOCAMPAL CA1 REGION; IN VITRO STUDY; KINDLING; PHYSIOLOGY; PSYCHOMOTOR PERFORMANCE; SEIZURES; STATISTICAL ANALYSIS; TOXICITY;

ANDROGEN ANTAGONISTS; ANDROSTANE-3,17-DIOL; ANIMALS; CA1 REGION, HIPPOCAMPAL; DATA INTERPRETATION, STATISTICAL; EVOKED POTENTIALS; FLUTAMIDE; GABA MODULATORS; GAMMA-AMINOBUTYRIC ACID; HIPPOCAMPUS; IN VITRO TECHNIQUES; KINDLING, NEUROLOGIC; MALE; MICE; MICE, INBRED C57BL; PSYCHOMOTOR PERFORMANCE; PYRAMIDAL CELLS; RECEPTORS, GABA-A; SEIZURES;

EID: 77956239979     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.110.169854     Document Type: Article

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