Seizure exacerbation associated with inhibition of progesterone metabolism

Annals of Neurology

Volumn 53, Issue 3, 2003, Pages 390-391

  Herzog, Andrew G ^a   Frye, Cheryl A ^b  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b STATE UNIVERSITY OF NEW YORK   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

OXIDOREDUCTASE INHIBITOR; TETRAHYDROPROGESTERONE;

ADULT; ARTICLE; CASE REPORT; CHLORIDE CONDUCTANCE; CLINICAL FEATURE; DISEASE CONTROL; DISEASE EXACERBATION; DRUG ACTIVITY; DRUG MECHANISM; FEMALE; HUMAN; METABOLITE; PRIORITY JOURNAL; PROGESTERONE METABOLISM; SEIZURE;

ADULT; ENZYME INHIBITORS; FEMALE; FINASTERIDE; HUMANS; MENSTRUAL CYCLE; PREGNANOLONE; PROGESTERONE; SEIZURES; STATISTICS, NONPARAMETRIC;

EID: 0037371428     PISSN: 03645134     EISSN: None     Source Type: Journal    
DOI: 10.1002/ana.10508     Document Type: Article

References (7)

1. Frye CA, Bayon LE. Seizure activity is increased in endocrine states characterized by decline in endogenous levels of the neurosteroid 3alpha, 5alpha-THP. Neuroendocrinology 1998;68:272-280.
2. Kokate TG, Banks MK, Magee T, et al. Finasteride, a 5-reductase inhibitor blocks the anticonvulsant activity of progesterone in mice. J Pharmacol Exp Ther 1999;288:679-684.
3. Herzog AG, Friedman MN, Freund S, Pascual-Leone A. Transcranial magnetic stimulation evidence of a potential role for progesterone in the modulation of premenstrual cortico-cortical inhibition in a woman with catamenial seizure exacerbation. Epilepsy Behav 2001;2:367-369.
4. Backstrom T. Epileptic seizures in women related to plasma estrogen and progesterone during the menstrual cycle. Acta Neurol Scand 1976;54:321-347.
5. Herzog AG, Klein P, Ransil BJ. Three patterns of catamenial epilepsy. Epilepsia 1997;38:1082-1088.
6. Herzog AG. Progesterone therapy in women with epilepsy: a 3-year follow up. Neurology 1999;52:1917-1918.
7. Monaghan EP, McAuley JW, Data JL. Ganaxolone: a novel positive allostearic modulator of the GABAA receptor complex for the treatment of epilepsy. Expert Opin Invest Drugs 1999;8:1663-1671.