Inhibition of RPE cell sterile inflammatory responses and endotoxin-induced uveitis by a cell-impermeable HSP90 inhibitor

Experimental Eye Research

Volumn 93, Issue 6, 2011, Pages 889-897

  Qin, Suofu ^a   Ni, Ming ^a   Wang, Xiuyun ^a   Maurier Mahé, Florence ^b   Shurland, Dixie Lee ^a   Rodrigues, Gerard A ^a  

^a ALLERGAN INC   (United States)

^b ExonHit Therapeutics SA   (France)

Author keywords

HSP90; Inflammation; Necrosis; Retinal barrier; RPE

Indexed keywords

17 N,N DIMETHYLAMINOETHYLAMINO 17 DEMETHOXYGELDANAMYCIN N OXIDE; ALPHA ACTIN; BETA ACTIN; BRAIN DERIVED NEUROTROPHIC FACTOR; ENDOTOXIN; EOTAXIN; FERRITIN; FIBROBLAST GROWTH FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HEAT SHOCK PROTEIN 90; HEAT SHOCK PROTEIN 90 INHIBITOR; INTERLEUKIN 15; INTERLEUKIN 16; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MONOCYTE CHEMOTACTIC PROTEIN 1; RECOMBINANT HEAT SHOCK PROTEIN 90 BETA; RECOMBINANT PROTEIN; STEM CELL FACTOR; STROMELYSIN; THROMBOPLASTIN; THROMBOPOIETIN; TUMOR ANTIGEN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULOTROPIN;

ARTICLE; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; CYTOKINE RELEASE; HUMAN; HUMAN CELL; IN VITRO STUDY; INFLAMMATION; MONOLAYER CULTURE; PIGMENT EPITHELIUM; PRIORITY JOURNAL; RETINA NECROSIS; SIGNAL TRANSDUCTION; TISSUE INJURY; UVEITIS;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BENZOQUINONES; CELL LINE; CHEMOKINE CCL2; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HETEROCYCLIC COMPOUNDS, 2-RING; HSP90 HEAT-SHOCK PROTEINS; HUMANS; INFLAMMATION MEDIATORS; INTERLEUKIN-1BETA; INTERLEUKIN-8; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LACTAMS, MACROCYCLIC; LIPOPOLYSACCHARIDES; MALE; NECROSIS; PERMEABILITY; PROTEIN KINASE INHIBITORS; PYRAZOLES; RATS; RATS, INBRED LEW; RETINAL PIGMENT EPITHELIUM; SIGNAL TRANSDUCTION; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA; UVEITIS;

EID: 84855928022     PISSN: 00144835     EISSN: 10960007     Source Type: Journal    
DOI: 10.1016/j.exer.2011.10.002     Document Type: Article

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