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Volumn 29, Issue 12, 2009, Pages 3956-3968

Macrophages promote axon regeneration with concurrent neurotoxicity

Author keywords

[No Author keywords available]

Indexed keywords

GREEN FLUORESCENT PROTEIN; LIPOPOLYSACCHARIDE; ZYMOSAN;

EID: 64849114846     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3992-08.2009     Document Type: Article
Times cited : (180)

References (66)
  • 2
    • 0033747044 scopus 로고    scopus 로고
    • Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and Activate the NF-kappa b pathway
    • Basu S, Binder RJ, Suto R, Anderson KM, Srivastava PK (2000) Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-kappa B pathway. Int Immunol 12:1539-1546.
    • (2000) Int Immunol , vol.12 , pp. 1539-1546
    • Basu, S.1    Binder, R.J.2    Suto, R.3    Anderson, K.M.4    Srivastava, P.K.5
  • 3
    • 0033104019 scopus 로고    scopus 로고
    • Activated macrophages and microglia induce dopaminergic sprouting in the injured striatum sand express brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor
    • Batchelor PE, Liberatore GT, Wong JYF, Porritt MJ, Frerichs F, Donnan GA, Howells DW (1999) Activated macrophages and microglia induce dopaminergic sprouting in the injured striatum sand express brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor. J Neu-rosci 19:1708-1716.
    • (1999) J. Neu-rosci , vol.19 , pp. 1708-1716
    • Batchelor, P.E.1    Liberatore, G.T.2    Wong, J.Y.F.3    Porritt, M.J.4    Frerichs, F.5    Donnan, G.A.6    Howells, D.W.7
  • 5
    • 34547758344 scopus 로고    scopus 로고
    • Combinatorial treatments for promoting axon regeneration in the CNS: Strategies for overcoming inhibitory signals and activating neurons' intrinsic growth state
    • Benowitz LI, Yin YQ (2007) Combinatorial treatments for promoting axon regeneration in the CNS: strategies for overcoming inhibitory signals and activating neurons' intrinsic growth state. Dev Neurobiol 67:1148-1165.
    • (2007) Dev Neurobiol , vol.67 , pp. 1148-1165
    • Benowitz, L.I.1    Yin, Y.Q.2
  • 6
    • 33845951211 scopus 로고    scopus 로고
    • DAMPs, PAMPs and alarmins: All we need to know about danger
    • Bianchi ME (2007) DAMPs, PAMPs and alarmins: all we need to know about danger. J Leukoc Biol 81:1-5.
    • (2007) J. Leukoc Biol , vol.81 , pp. 1-5
    • Bianchi, M.E.1
  • 7
    • 0033591308 scopus 로고    scopus 로고
    • Quantification of neuron survival in monolayer cultures Using an enzyme-linked immunosorbent assay approach, rather than by cell counting
    • Brooke SM, Bliss TM, Franklin LR, Sapolsky RM (1999) Quantification of neuron survival in monolayer cultures using an enzyme-linked immunosorbent assay approach, rather than by cell counting. Neurosci Lett 267:21-24.
    • (1999) Neurosci Lett , vol.267 , pp. 21-24
    • Brooke, S.M.1    Bliss, T.M.2    Franklin, L.R.3    Sapolsky, R.M.4
  • 8
    • 0031875189 scopus 로고    scopus 로고
    • Acute and long-lasting changes in extracellular-matrix chondroitin-sulphate proteoglycans induced by injection of chondroitinase ABC in the adult rat brain
    • Bruckner G, Bringmann A, Hartig W, Koppe G, Delpech B, Brauer K (1998) Acute and long-lasting changes in extracellular-matrix chondroitin-sulphate proteoglycans induced by injection of chondroitinase ABC in the adult rat brain. Exp Brain Res 121:300-310.
    • (1998) Exp Brain Res , vol.121 , pp. 300-310
    • Bruckner, G.1    Bringmann, A.2    Hartig, W.3    Koppe, G.4    Delpech, B.5    Brauer, K.6
  • 9
    • 0036841178 scopus 로고    scopus 로고
    • Broad expression of Toll-like receptors in the human central nervous system
    • Bsibsi M, Ravid R, Gveric D, van Noort JM (2002) Broad expression of Toll-like receptors in the human central nervous system. J Neuropathol Exp Neurol 61:1013-1021.
    • (2002) J. Neuropathol Exp Neurol , vol.61 , pp. 1013-1021
    • Bsibsi, M.1    Ravid, R.2    Gveric, D.3    Van Noort, J.M.4
  • 11
    • 0000701007 scopus 로고
    • On the composition of zymosan
    • Carlo FJD, Fiore JV (1958) On the composition of zymosan. Science 127:756-757.
    • (1958) Science , vol.127 , pp. 756-757
    • Carlo, F.J.D.1    Fiore, J.V.2
  • 12
    • 0025093295 scopus 로고
    • Macrophages can modify the nonpermissive nature of the adult mammalian central nervous system
    • David S, Bouchard C, Tsatas O, Giftochristos N (1990) Macrophages can modify the nonpermissive nature of the adult mammalian central nervous system. Neuron 5:463-469.
    • (1990) Neuron , vol.5 , pp. 463-469
    • David, S.1    Bouchard, C.2    Tsatas, O.3    Giftochristos, N.4
  • 13
    • 0031471718 scopus 로고    scopus 로고
    • Regeneration of adult axons in white matter tracts of the central nervous system
    • Davies SJA, Fitch MT, Memberg SP, Hall AK, Raisman G, Silver J (1997) Regeneration of adult axons in white matter tracts of the central nervous system. Nature 390:680-683.
    • (1997) Nature , vol.390 , pp. 680-683
    • Davies, S.J.A.1    Fitch, M.T.2    Memberg, S.P.3    Hall, A.K.4    Raisman, G.5    Silver, J.6
  • 14
    • 0033565865 scopus 로고    scopus 로고
    • Robust regeneration of adult sensory axons in degenerating white matter of the adult rat spinal cord
    • Davies SJA, Goucher DR, Doller C, Silver J (1999) Robust regeneration of adult sensory axons in degenerating white matter of the adult rat spinal cord. J Neurosci 19:5810-5822.
    • (1999) J. Neurosci , vol.19 , pp. 5810-5822
    • Davies, S.J.A.1    Goucher, D.R.2    Doller, C.3    Silver, J.4
  • 15
    • 0033216123 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of glial scarring and progressive cavitation: In vivo and in vitro analysis of inflammation-induced secondary injury after CNS trauma
    • Fitch MT, Doller C, Combs CK, Landreth GE, Silver J (1999) Cellular and molecular mechanisms of glial scarring and progressive cavitation: in vivo and in vitro analysis of inflammation-induced secondary injury after CNS trauma. J Neurosci 19:8182-8198.
    • (1999) J. Neurosci , vol.19 , pp. 8182-8198
    • Fitch, M.T.1    Doller, C.2    Combs, C.K.3    Lreth, G.E.4    Silver, J.5
  • 16
    • 0038558249 scopus 로고    scopus 로고
    • Collaborative induction of inflammatory responses by dectin-1 and Tolllike receptor 2
    • Gantner BN, Simmons RM, Canavera SJ, Akira S, Underhill DM (2003) Collaborative induction of inflammatory responses by dectin-1 and Tolllike receptor 2. J Exp Med 197:1107-1117.
    • (2003) J. Exp Med , vol.197 , pp. 1107-1117
    • Gantner, B.N.1    Simmons, R.M.2    Canavera, S.J.3    Akira, S.4    Underhill, D.M.5
  • 17
    • 33947200732 scopus 로고    scopus 로고
    • Macrophage depletion alters the blood-nerve barrier without affecting Schwann cell function after neural injury
    • Gray M, Palispis W, Popovich PG, van Rooijen N, Gupta R (2007) Macrophage depletion alters the blood-nerve barrier without affecting Schwann cell function after neural injury. J Neurosci Res 85:766-777.
    • (2007) J. Neurosci Res , vol.85 , pp. 766-777
    • Gray, M.1    Palispis, W.2    Popovich, P.G.3    Van Rooijen, N.4    Gupta, R.5
  • 18
    • 38649110471 scopus 로고    scopus 로고
    • Neuroprotective and axon growth promoting effects of intraocular inflammation do not depend on oncomodulin or the presence of large numbers of Activated macrophages
    • Hauk TG, Muller A, Lee J, Schwendener R, Fischer D (2008) Neuroprotective and axon growth promoting effects of intraocular inflammation do not depend on oncomodulin or the presence of large numbers of activated macrophages. Exp Neurol 209:469-482.
    • (2008) Exp Neurol , vol.209 , pp. 469-482
    • Hauk, T.G.1    Muller, A.2    Lee, J.3    Schwendener, R.4    Fischer, D.5
  • 19
    • 56949089831 scopus 로고    scopus 로고
    • Another barrier to regeneration in the CNS: Activated macrophages induce extensive retraction of dystrophic axons through direct physical interactions
    • Horn KP, Busch SA, Hawthorne AL, van Rooijen N, Silver J (2008) Another barrier to regeneration in the CNS: activated macrophages induce extensive retraction of dystrophic axons through direct physical interactions. J Neurosci 28:9330-9341.
    • (2008) J. Neurosci , vol.28 , pp. 9330-9341
    • Horn, K.P.1    Busch, S.A.2    Hawthorne, A.L.3    Van Rooijen, N.4    Silver, J.5
  • 21
    • 34250182782 scopus 로고    scopus 로고
    • Toll-like receptor (TLR)-2 and TLR-4 regulate inflammation, gliosis, and myelin sparing after spinal cord injury
    • Kigerl KA, Lai WM, Rivest S, Hart RP, Satoskar AR, Popovich PG (2007) Toll-like receptor (TLR)-2 and TLR-4 regulate inflammation, gliosis, and myelin sparing after spinal cord injury. J Neurochem 102:37-50.
    • (2007) J. Neurochem , vol.102 , pp. 37-50
    • Kigerl, K.A.1    Lai, W.M.2    Rivest, S.3    Hart, R.P.4    Satoskar, A.R.5    Popovich, P.G.6
  • 24
    • 0034846364 scopus 로고    scopus 로고
    • Macrophage depletion impairs oligodendrocyte remyelination following lysolecithin-induced demyelination
    • Kotter MR, Setzu A, Sim FJ, van Rooijen N, Franklin RJM (2001) Macrophage depletion impairs oligodendrocyte remyelination following lysolecithin-induced demyelination. Glia 35:204-212.
    • (2001) Glia , vol.35 , pp. 204-212
    • Kotter, M.R.1    Setzu, A.2    Sim, F.J.3    Van Rooijen, N.4    Franklin, R.J.M.5
  • 25
    • 0035170282 scopus 로고    scopus 로고
    • Toll-like receptor 4: The missing link of the cerebral innate immune response triggered by circulating gram-negative bacterial cell wall components
    • Laflamme N, Rivest S (2001) Toll-like receptor 4: the missing link of the cerebral innate immune response triggered by circulating gram-negative bacterial cell wall components. FASEB J 15:155-163.
    • (2001) FASEB J , vol.15 , pp. 155-163
    • Laflamme, N.1    Rivest, S.2
  • 27
    • 0033081490 scopus 로고    scopus 로고
    • Neurotrophins support the development of diverse sensory axon morphologies
    • Lentz SI, Knudson CM, Korsmeyer SJ, Snider WD (1999) Neurotrophins support the development of diverse sensory axon morphologies. J Neurosci 19:1038-1048.
    • (1999) J. Neurosci , vol.19 , pp. 1038-1048
    • Lentz, S.I.1    Knudson, C.M.2    Korsmeyer, S.J.3    Snider, W.D.4
  • 28
    • 0034659957 scopus 로고    scopus 로고
    • Lens injury stimulates axon regeneration in the mature rat optic nerve
    • Leon S, Yin YQ, Nguyen J, Irwin N, Benowitz LI (2000) Lens injury stimulates axon regeneration in the mature rat optic nerve. J Neurosci 20:4615-4626.
    • (2000) J. Neurosci , vol.20 , pp. 4615-4626
    • Leon, S.1    Yin, Y.Q.2    Nguyen, J.3    Irwin, N.4    Benowitz, L.I.5
  • 29
    • 0035877013 scopus 로고    scopus 로고
    • An essential role of the NF-kappa B/Toll-like receptor pathway in induction of inflammatory and tissue-repair gene expression by necrotic cells
    • Li M, Carpio DF, Zheng Y, Bruzzo P, Singh V, Ouaaz F, Medzhitov RM, Beg AA (2001) An essential role of the NF-kappa B/Toll-like receptor pathway in induction of inflammatory and tissue-repair gene expression by necrotic cells. J Immunol 166:7128-7135.
    • (2001) J. Immunol , vol.166 , pp. 7128-7135
    • Li, M.1    Carpio, D.F.2    Zheng, Y.3    Bruzzo, P.4    Singh, V.5    Ouaaz, F.6    Medzhitov, R.M.7    Beg, A.A.8
  • 31
    • 34547428478 scopus 로고    scopus 로고
    • Characterization and modeling of monocyte-derived macrophages after spinal cord injury
    • Longbrake EE, Lai W, Ankeny DP, Popovich PG (2007) Characterization and modeling of monocyte-derived macrophages after spinal cord injury. J Neurochem 102:1083-1094.
    • (2007) J. Neurochem , vol.102 , pp. 1083-1094
    • Longbrake, E.E.1    Lai, W.2    Ankeny, D.P.3    Popovich, P.G.4
  • 32
    • 0025936608 scopus 로고
    • Inflammation near the nerve-cell body enhances axonal regeneration
    • Lu X, Richardson PM (1991) Inflammation near the nerve-cell body enhances axonal regeneration. J Neurosci 11:972-978.
    • (1991) J. Neurosci , vol.11 , pp. 972-978
    • Lu, X.1    Richardson, P.M.2
  • 34
    • 0028065290 scopus 로고
    • Brain macrophages: Neurotoxic or neurotrophic effector cells?
    • Mallat M, Chamak B (1994) Brain macrophages: neurotoxic or neurotrophic effector cells? J Leukoc Biol 56:416-422.
    • (1994) J. Leukoc Biol , vol.56 , pp. 416-422
    • Mallat, M.1    Chamak, B.2
  • 35
    • 4944244477 scopus 로고    scopus 로고
    • The contribution of Activated phagocytes and myelin degeneration to axonal retraction/dieback following spinal cord injury
    • McPhail LT, Stirling DP, Tetzlaff W, Kwiecien JM, Ramer MS (2004) The contribution of activated phagocytes and myelin degeneration to axonal retraction/dieback following spinal cord injury. Eur J Neurosci 20:1984-1994.
    • (2004) Eur J Neurosci , vol.20 , pp. 1984-1994
    • McPhail, L.T.1    Stirling, D.P.2    Tetzlaff, W.3    Kwiecien, J.M.4    Ramer, M.S.5
  • 36
    • 36749004288 scopus 로고    scopus 로고
    • Astrocyte-derived CNTF switches mature RGCs to a regenerative state following inflammatory stimulation
    • Muller A, Hauk TG, Fischer D (2007) Astrocyte-derived CNTF switches mature RGCs to a regenerative state following inflammatory stimulation. Brain 130:3308-3320.
    • (2007) Brain , vol.130 , pp. 3308-3320
    • Muller, A.1    Hauk, T.G.2    Fischer, D.3
  • 38
    • 34248171756 scopus 로고    scopus 로고
    • Neuronal regulation by which microglia enhance the production of neurotrophic factors for GABAergic, catecholaminergic, and cholinergic neurons
    • Nakajima K, Tohyama Y, Maeda S, Kohsaka S, Kurihara T (2007) Neuronal regulation by which microglia enhance the production of neurotrophic factors for GABAergic, catecholaminergic, and cholinergic neurons. Neurochem Int 50:807-820.
    • (2007) Neurochem Int , vol.50 , pp. 807-820
    • Nakajima, K.1    Tohyama, Y.2    Maeda, S.3    Kohsaka, S.4    Kurihara, T.5
  • 39
    • 0036518997 scopus 로고    scopus 로고
    • Innate immunity: The missing link in neuroprotection and neurodegeneration?
    • Nguyen MD, Julien JP, Rivest S (2002) Innate immunity: the missing link in neuroprotection and neurodegeneration? Nat Rev Neurosci 3:216-227.
    • (2002) Nat Rev Neurosci , vol.3 , pp. 216-227
    • Nguyen, M.D.1    Julien, J.P.2    Rivest, S.3
  • 41
    • 43949114888 scopus 로고    scopus 로고
    • Perspectives-Opinion: Can the immune system be harnessed to repair the CNS?
    • Popovich PG, Longbrake EE (2008) Perspectives-Opinion: Can the immune system be harnessed to repair the CNS? Nat Rev Neurosci 9:481-493.
    • (2008) Nat Rev Neurosci , vol.9 , pp. 481-493
    • Popovich, P.G.1    Longbrake, E.E.2
  • 42
    • 0031013236 scopus 로고    scopus 로고
    • Cellular inflammatory response after spinal cord injury in Sprague-Dawley and Lewis rats
    • Popovich PG, Wei P, Stokes BT (1997) Cellular inflammatory response after spinal cord injury in Sprague-Dawley and Lewis rats. J Comp Neurol 377:443-464.
    • (1997) J. Comp Neurol , vol.377 , pp. 443-464
    • Popovich, P.G.1    Wei, P.2    Stokes, B.T.3
  • 43
    • 0032838089 scopus 로고    scopus 로고
    • Depletion of hematogenous macrophages promotes partial hindlimb recovery and neuroanatomical repair after experimental spinal cord injury
    • Popovich PG, Guan Z, Wei P, Huitinga I, van Rooijen N, Stokes BT (1999) Depletion of hematogenous macrophages promotes partial hindlimb recovery and neuroanatomical repair after experimental spinal cord injury. Exp Neurol 158:351-365.
    • (1999) Exp Neurol , vol.158 , pp. 351-365
    • Popovich, P.G.1    Guan, Z.2    Wei, P.3    Huitinga, I.4    Van Rooijen, N.5    Stokes, B.T.6
  • 45
    • 0038807049 scopus 로고    scopus 로고
    • Hematogenous macrophages express CDS and distribute to regions of lesion cavitation after spinal cord injury
    • Popovich PG, van Rooijen N, Hickey WF, Preidis G, McGaughy V (2003) Hematogenous macrophages express CDS and distribute to regions of lesion cavitation after spinal cord injury. Exp Neurol 182:275-287.
    • (2003) Exp Neurol , vol.182 , pp. 275-287
    • Popovich, P.G.1    Van Rooijen, N.2    Hickey, W.F.3    Preidis, G.4    McGaughy, V.5
  • 48
    • 9244256719 scopus 로고    scopus 로고
    • The effect of stimulated microglia conditioned media on BDNF gene expression of striatal astrocytes: Quantification by real-time PCR
    • Savli H, Gulkac AD, Esen N (2004) The effect of stimulated microglia conditioned media on BDNF gene expression of striatal astrocytes: quantification by real-time PCR. Int J Neurosci 114:1601-1612.
    • (2004) Int J Neurosci , vol.114 , pp. 1601-1612
    • Savli, H.1    Gulkac, A.D.2    Esen, N.3
  • 49
    • 37349130280 scopus 로고    scopus 로고
    • Oligodendrocyte generation is differentially influenced by Toll-like receptor (TLR) 2 and TLR4-mediated intraspinal macrophage activation
    • Schonberg DL, Popovich PG, McTigue DM (2007) Oligodendrocyte generation is differentially influenced by Toll-like receptor (TLR) 2 and TLR4-mediated intraspinal macrophage activation. J Neuropathol Exp Neurol 66:1124-1135.
    • (2007) J. Neuropathol Exp Neurol , vol.66 , pp. 1124-1135
    • Schonberg, D.L.1    Popovich, P.G.2    McTigue, D.M.3
  • 51
    • 3543144446 scopus 로고
    • Dendritic organization in the neurons of the visual and motor cortices of the cat
    • Sholl DA (1953) Dendritic organization in the neurons of the visual and motor cortices of the cat. J Anat 87:387-406.
    • (1953) J. Anat , vol.87 , pp. 387-406
    • Sholl, D.A.1
  • 52
    • 24344470604 scopus 로고    scopus 로고
    • Chronic enhancement of the intrinsic growth capacity of sensory neurons combined with the degradation of inhibitory proteoglycans allows functional regeneration of sensory axons through the dorsal root entry zone in the mammalian spinal cord
    • Steinmetz MP, Horn KP, Tom VJ, Miller JH, Busch SA, Nair D, Silver DJ, Silver J (2005) Chronic enhancement of the intrinsic growth capacity of sensory neurons combined with the degradation of inhibitory proteoglycans allows functional regeneration of sensory axons through the dorsal root entry zone in the mammalian spinal cord. J Neurosci 25:8066-8076.
    • (2005) J. Neurosci , vol.25 , pp. 8066-8076
    • Steinmetz, M.P.1    Horn, K.P.2    Tom, V.J.3    Miller, J.H.4    Busch, S.A.5    Nair, D.6    Silver, D.J.7    Silver, J.8
  • 53
    • 0036935538 scopus 로고    scopus 로고
    • Detrimental and beneficial effects of injury-induced inflammation and cytokine expression in the nervous system
    • Stoll G, Jander S, Schroeter M (2002) Detrimental and beneficial effects of injury-induced inflammation and cytokine expression in the nervous system. Mol Cell Biol 513:87-113.
    • (2002) Mol. Cell. Biol , vol.513 , pp. 87-113
    • Stoll, G.1    Jander, S.2    Schroeter, M.3
  • 54
    • 17644414137 scopus 로고    scopus 로고
    • The CNS role of Toll-like receptor 4 in innate neuroimmunity and painful neuropathy
    • Tanga FY, Nutile-McMenemy N, Deleo JA (2005) The CNS role of Toll-like receptor 4 in innate neuroimmunity and painful neuropathy. Proc Natl. Acad. Sci. U S A 102:5856-5861.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 5856-5861
    • Tanga, F.Y.1    Nutile-McMenemy, N.2    Deleo, J.A.3
  • 57
    • 0038006797 scopus 로고    scopus 로고
    • Macrophage recognition of zymosan particles
    • Underhill DM (2003) Macrophage recognition of zymosan particles. J Endotoxin Res 9:176-180.
    • (2003) J. Endotoxin Res , vol.9 , pp. 176-180
    • Underhill, D.M.1
  • 58
    • 30444447683 scopus 로고    scopus 로고
    • Systemic injections of li-popolysaccharide accelerates myelin phagocytosis during Wallerian degeneration in the injured mouse spinal cord
    • Vallieres N, Berard JL, David S, Lacroix S (2006) Systemic injections of li-popolysaccharide accelerates myelin phagocytosis during Wallerian degeneration in the injured mouse spinal cord. Glia 53:103-113.
    • (2006) Glia , vol.53 , pp. 103-113
    • Vallieres, N.1    Berard, J.L.2    David, S.3    Lacroix, S.4
  • 59
    • 0028111256 scopus 로고
    • Liposome-mediated depletion of macrophages-mechanism of action, preparation of liposomes and applications
    • van Rooijen N, Sanders A (1994) Liposome-mediated depletion of macrophages-mechanism of action, preparation of liposomes and applications. J Immunol Methods 174:83-93.
    • (1994) J. Immunol Methods , vol.174 , pp. 83-93
    • Van Rooijen, N.1    Sers, A.2
  • 60
    • 0021164231 scopus 로고
    • Elimination of phagocytic cells in the spleen after intravenous injection of liposome-encapsulated dichlo-romethylene diphosphonate-an enzyme-histochemical study
    • van Rooijen N, Vannieuwmegen R (1984) Elimination of phagocytic cells in the spleen after intravenous injection of liposome-encapsulated dichlo-romethylene diphosphonate-an enzyme-histochemical study. Cell Tissue Res 238:355-358.
    • (1984) Cell Tissue Res , vol.238 , pp. 355-358
    • Van Rooijen, N.1    Vannieuwmegen, R.2
  • 65
    • 0036019158 scopus 로고    scopus 로고
    • The clinical course of experimental autoimmune encephalomyelitis is associated with a profound and sustained transcriptional activation of the genes encoding Toll-like receptor 2 and CD14 in the mouse CNS
    • Zekki H, Feinstein DL, Rivest S (2002) The clinical course of experimental autoimmune encephalomyelitis is associated with a profound and sustained transcriptional activation of the genes encoding Toll-like receptor 2 and CD14 in the mouse CNS. Brain Pathol 12:308-319.
    • (2002) Brain Pathol , vol.12 , pp. 308-319
    • Zekki, H.1    Feinstein, D.L.2    Rivest, S.3
  • 66
    • 33846035724 scopus 로고    scopus 로고
    • Mammalian Toll-like receptors: From endogenous ligands to tissue regeneration
    • Zhang Z, Schluesener HJ (2006) Mammalian Toll-like receptors: from endogenous ligands to tissue regeneration. Cell Mol Life Sci 63:2901-2907.
    • (2006) Cell Mol Life Sci , vol.63 , pp. 2901-2907
    • Zhang, Z.1    Schluesener, H.J.2


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