The interaction of human natural killer cells with either unpolarized or polarized macrophages results in different functional outcomes

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 50, 2010, Pages 21659-21664

  Bellora, Francesca ^a   Castriconi, Roberta ^a   Dondero, Alessandra ^a   Reggiardo, Giorgio ^b   Moretta, Lorenzo ^a,c   Mantovani, Alberto ^d,e   Moretta, Alessandro ^a   Bottino, Cristina ^a,c  

^a UNIVERSITY OF GENOA   (Italy)

^b Medi Service   (Italy)

^c G GASLINI INSTITUTE   (Italy)

^d HUMANITAS CLINICAL AND RESEARCH CENTER   (Italy)

^e UNIVERSITY OF MILAN   (Italy)

Author keywords

Cytolityc activity; Lypopolissacaride; Molecular interactions; Nectins' family; Proinflammatory cytokines

Indexed keywords

BCG VACCINE; CD69 ANTIGEN; CHEMOKINE RECEPTOR CCR7; GAMMA INTERFERON; HLA ANTIGEN CLASS 1; INTERLEUKIN 18; LIPOPOLYSACCHARIDE;

ANTIGEN EXPRESSION; ARTICLE; CD25+ T LYMPHOCYTE; CELL POLARITY; CYTOKINE PRODUCTION; CYTOLYSIS; CYTOTOXICITY; DENDRITIC CELL; HLA SYSTEM; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNE RESPONSE; IMMUNOMODULATION; INNATE IMMUNITY; MACROPHAGE; MOLECULAR INTERACTION; NATURAL KILLER CELL; PRIORITY JOURNAL; TUMOR CELL;

ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; CELL POLARITY; CELLS, CULTURED; COCULTURE TECHNIQUES; CYTOKINES; GENES, MHC CLASS I; HUMANS; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; K562 CELLS; KILLER CELLS, NATURAL; LECTINS, C-TYPE; LIPOPOLYSACCHARIDES; LYMPHOCYTE ACTIVATION; MACROPHAGES; RECEPTORS, CCR7;

MYCOBACTERIUM BOVIS BCG;

EID: 78650742405     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1007654108     Document Type: Article

References (44)

1. Caligiuri MA (2008) Human natural killer cells. Blood 112:461-469.
2. Moretta A, Locatelli F, Moretta L (2008) Human NK cells: From HLA class I-specific killer Ig-like receptors to the therapy of acute leukemias. Immunol Rev 224:58-69.
3. Lanier LL (2008) Up on the tightrope: Natural killer cell activation and inhibition. Nat Immunol 9:495-502.
4. Ma CS, Nichols KE, Tangye SG (2007) Regulation of cellular and humoral immune responses by the SLAM and SAP families of molecules. Annu Rev Immunol 25:337-379.
5. Bottino C, Castriconi R, Moretta L, Moretta A (2005) Cellular ligands of activating NK receptors. Trends Immunol 26:221-226.
6. Pende D, et al. (2005) Analysis of the receptor-ligand interactions in the natural killermediated lysis of freshly isolated myeloid or lymphoblastic leukemias: Evidence for the involvement of the Poliovirus receptor (CD155) and Nectin-2 (CD112). Blood 105: 2066-2073.
7. Castriconi R, et al. (2009) NK cells recognize and kill human glioblastoma cells with stem cell-like properties. J Immunol 182:3530-3539.
8. Welte S, Kuttruff S, Waldhauer I, Steinle A (2006) Mutual activation of natural killer cells and monocytes mediated by NKp80-AICL interaction. Nat Immunol 7:1334-1342.
9. Brandt CS, et al. (2009) The B7 family member B7-H6 is a tumor cell ligand for the activating natural killer cell receptor NKp30 in humans. J Exp Med 206:1495-1503.
10. Long EO (2008) Negative signaling by inhibitory receptors: The NK cell paradigm. Immunol Rev 224:70-84.
11. Bryceson YT, Ljunggren HG (2008) Tumor cell recognition by the NK cell activating receptor NKG2D. Eur J Immunol 38:2957-2961.
12. Carlsten M, et al. (2009) Primary human tumor cells expressing CD155 impair tumor targeting by down-regulating DNAM-1 on NK cells. J Immunol 183:4921-4930.
13. Moretta A, et al. (2005) Early liaisons between cells of the innate immune system in inflamed peripheral tissues. Trends Immunol 26:668-675.
14. Ferlazzo G, Münz C (2009) Dendritic cell interactions with NK cells from different tissues. J Clin Immunol 29:265-273.
15. Martinez FO, Gordon S, Locati M, Mantovani A (2006) Transcriptional profiling of the human monocyte-to-macrophage differentiation and polarization: New molecules and patterns of gene expression. J Immunol 177:7303-7311.
16. Mosser DM, Edwards JP (2008) Exploring the full spectrum of macrophage activation.Nat Rev Immunol 8:958-969.
17. Mantovani A, Allavena P, Sica A, Balkwill F (2008) Cancer-related inflammation. Nature 454:436-444.
18. Sozzani S, Rusnati M, Riboldi E, Mitola S, Presta M (2007) Dendritic cell-endothelial cell cross-talk in angiogenesis. Trends Immunol 28:385-392.
19. Pende D, et al. (2006) Expression of the DNAM-1 ligands, Nectin-2 (CD112) and poliovirus receptor (CD155), on dendritic cells: Relevance for natural killer-dendritic cell interaction. Blood 107:2030-2036.
20. Moretta A (2002) Natural killer cells and dendritic cells: Rendezvous in abused tissues. Nat Rev Immunol 2:957-964.
21. Campbell JJ, et al. (2001) Unique subpopulations of CD56+ NK and NK-T peripheral blood lymphocytes identified by chemokine receptor expression repertoire. J Immunol 166:6477-6482.
22. Inngjerdingen M, Damaj B, Maghazachi AA (2001) Expression and regulation of chemokine receptors in human natural killer cells. Blood 97:367-375.
23. Della Chiesa M, et al. (2010) GPR56 as a novel marker identifying the CD56dull CD16+ NK cell subset both in blood stream and in inflamed peripheral tissues. Int Immunol 22:91-100.
24. Baratin M, et al. (2005) Natural killer cell and macrophage cooperation in MyD88-dependent innate responses to Plasmodium falciparum. Proc Natl Acad Sci USA 102: 14747-14752.
25. Lapaque N, Walzer T, Méresse S, Vivier E, Trowsdale J (2009) Interactions between human NK cells and macrophages in response to Salmonella infection. J Immunol 182: 4339-4348.
26. Biswas SK, Lopez-Collazo E (2009) Endotoxin tolerance: New mechanisms, molecules and clinical significance. Trends Immunol 30:475-487.
27. Porta C, et al. (2009) Tolerance and M2 (alternative) macrophage polarization are related processes orchestrated by p50 nuclear factor kappaB. Proc Natl Acad Sci USA 106:14978-14983.
28. Mailliard RB, et al. (2005) IL-18-induced CD83+CCR7+ NK helper cells. J Exp Med 202: 941-953.
29. Marcenaro E, et al. (2009) Uptake of CCR7 and acquisition of migratory properties by human KIR+ NK cells interacting with monocyte-derived DC or EBV cell lines: Regulation by KIR/HLA-class I interaction. Blood 114:4108-4116.
30. Nedvetzki S, et al. (2007) Reciprocal regulation of human natural killer cells and macrophages associated with distinct immune synapses. Blood 109:3776-3785.
31. Arend WP, Palmer G, Gabay C (2008) IL-1, IL-18, and IL-33 families of cytokines. Immunol Rev 223:20-38.
32. Martín-Fontecha A, et al. (2004) Induced recruitment of NK cells to lymph nodes provides IFN-gamma for T(H)1 priming. Nat Immunol 5:1260-1265.
33. Bajénoff M, et al. (2006) Natural killer cell behavior in lymph nodes revealed by static and real-time imaging. J Exp Med 203:619-631.
34. Lucas M, Schachterle W, Oberle K, Aichele P, Diefenbach A (2007) Dendritic cells prime natural killer cells by trans-presenting interleukin 15. Immunity 26:503-517.
35. Ferlazzo G, et al. (2004) The abundant NK cells in human secondary lymphoid tissues require activation to express killer cell Ig-like receptors and become cytolytic. J Immunol 172:1455-1462.
36. Parolini S, et al. (2007) The role of chemerin in the colocalization of NK and dendritic cell subsets into inflamed tissues. Blood 109:3625-3632.
37. Maghazachi AA (2005) Compartmentalization of human natural killer cells. Mol Immunol 42:523-529.
38. Frankel TL, et al. (2010) Identification and characterization of a tumor infiltrating CD56(+)/CD16(-) NK cell subset with specificity for pancreatic and prostate cancer cell lines. Cancer Immunol Immunother 59:1757-1769.
39. Le Maux Chansac B, et al. (2005) NK cells infiltrating a MHC class I-deficient lung adenocarcinoma display impaired cytotoxic activity toward autologous tumor cells associated with altered NK cell-triggering receptors. J Immunol 175:5790-5798.
40. Agaugué S, Marcenaro E, Ferranti B, Moretta L, Moretta A (2008) Human natural killer cells exposed to IL-2, IL-12, IL-18, or IL-4 differently modulate priming of naive T cells by monocyte-derived dendritic cells. Blood 112:1776-1783.
41. Staretz-Haham O, et al. (2003) Interleukin-12 receptor beta1 deficiency presenting as recurrent Salmonella infection. Clin Infect Dis 37:137-140.
42. Guiducci C, Vicari AP, Sangaletti S, Trinchieri G, Colombo MP (2005) Redirecting in vivo elicited tumor infiltrating macrophages and dendritic cells towards tumor rejection. Cancer Res 65:3437-3446.
43. Hayashi A, et al. (2009) Immunotherapy of ovarian cancer with cell wall skeleton of Mycobacterium bovis Bacillus Calmette-Guérin: Effect of lymphadenectomy. Cancer Sci 100:1991-1995.
44. Kim YJ, et al. (2010) Gene signatures for the prediction of response to Bacillus Calmette-Guerin immunotherapy in primary pT1 bladder cancers. Clin Cancer Res 16: 2131-2137.