Metabolic inflexibility impairs insulin secretion and results in MODY-like diabetes in triple FoxO-deficient mice

Cell Metabolism

Volumn 20, Issue 4, 2014, Pages 593-602

  Kim Muller, Ja Young ^a   Zhao, Shangang ^d   Srivastava, Shekhar ^c   Mugabo, Yves ^d   Noh, Hye Lim ^a   Kim, Youngjung R ^b   Madiraju, S R Murthy ^d   Ferrante, Anthony W ^a   Skolnik, Edward Y ^c   Prentki, Marc ^d   Accili, Domenico ^a  

^a New York Presbyterian Morgan Stanley Children's Hospital   (United States)

^b Howard Hughes Medical Institute   (United States)

^c NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM ION; CARBOHYDRATE; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; INSULIN; LIPID; TRANSCRIPTION FACTOR FOXO; TRANSCRIPTION FACTOR PDX 1; CALCIUM; CALCIUM CHANNEL L TYPE; FORKHEAD TRANSCRIPTION FACTOR; FOXO1 PROTEIN, MOUSE; FOXO3 PROTEIN, MOUSE; FOXO4 PROTEIN, MOUSE; GLUCOSE BLOOD LEVEL; HEPATOCYTE NUCLEAR FACTOR 1ALPHA; HEPATOCYTE NUCLEAR FACTOR 4; HNF1A PROTEIN, MOUSE; HNF4A PROTEIN, MOUSE; HOMEODOMAIN PROTEIN; PANCREATIC AND DUODENAL HOMEOBOX 1 PROTEIN; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR FKHR; TRANSCRIPTION FACTOR FKHRL1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEDIFFERENTIATION; CELL FUNCTION; CONTROLLED STUDY; DISEASE COURSE; ENERGY RESOURCE; INSULIN RELEASE; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; ANALYSIS; ANIMAL; C57BL MOUSE; DEFICIENCY; DISEASE MODEL; GENE EXPRESSION PROFILING; GENETICS; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE TEST; KNOCKOUT MOUSE; METABOLISM; MITOCHONDRION; PATHOLOGY;

MUS;

ANIMALS; BLOOD GLUCOSE; CALCIUM; CALCIUM CHANNELS, L-TYPE; DIABETES MELLITUS, TYPE 2; DISEASE MODELS, ANIMAL; FORKHEAD BOX PROTEIN O1; FORKHEAD BOX PROTEIN O3; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION PROFILING; GLUCOSE TOLERANCE TEST; HEPATOCYTE NUCLEAR FACTOR 1-ALPHA; HEPATOCYTE NUCLEAR FACTOR 4; HOMEODOMAIN PROTEINS; INSULIN; INSULIN-SECRETING CELLS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOCHONDRIA; TRANS-ACTIVATORS;

EID: 84907994036     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2014.08.012     Document Type: Article

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