Mitochondrial oxidative stress contributes differently to rat Pancreatic islet cell apoptosis and insulin secretory defects after Prolonged culture in a low non-stimulating glucose concentration

Diabetologia

Volumn 55, Issue 8, 2012, Pages 2226-2237

  Roma, L P ^a   Pascal, S M ^a   Duprez, J ^a   Jonas, J C ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

Apoptosis; C myc; Catalytic antioxidant; Cytosolic calcium concentration; Haem oxygenase 1; Insulin secretion; Low glucose concentration; Metallothionein; Mitochondria; MnTBAP; Oxidative stress; Pancreatic beta cell; RoGFP

Indexed keywords

ACETYLCYSTEINE; CALCIUM ION; GLUCOSE; GREEN FLUORESCENT PROTEIN; HEME OXYGENASE 1; INSULIN; MANGANESE TETRAKIS(4 BENZOIC ACID)PORPHYRIN; MESSENGER RNA; METALLOTHIONEIN I; MYC PROTEIN; PORPHYRIN DERIVATIVE; POTASSIUM ION; TOLBUTAMIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL LOSS; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE TECHNIQUE; DISORDERS OF MITOCHONDRIAL FUNCTIONS; GENE; GLUCOSE METABOLISM; HMOX1 GENE; HORMONAL REGULATION; INSULIN DEFICIENCY; INSULIN RELEASE; MALE; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; MT1A GENE; NONHUMAN; ONCOGENE C MYC; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RAT; REVIEW;

ANIMALS; APOPTOSIS; CELLS, CULTURED; GLUTATHIONE; GREEN FLUORESCENT PROTEINS; INSULIN; INSULIN-SECRETING CELLS; LUMINESCENT MEASUREMENTS; MALE; METALLOPORPHYRINS; MITOCHONDRIA; OXIDATIVE STRESS; PANCREAS, EXOCRINE; RATS; RATS, WISTAR; RNA, MESSENGER;

EID: 84866405516     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-012-2581-6     Document Type: Review

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