메뉴 건너뛰기




Volumn 198, Issue 1, 2014, Pages 17-29

Identification of a novel gene for diabetic traits in rats, mice, and humans

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN; CALCIUM CHANNEL; GLUCOSE BLOOD LEVEL; TPCN2 PROTEIN, HUMAN; TPCN2 PROTEIN, MOUSE;

EID: 84907982004     PISSN: 00166731     EISSN: 19432631     Source Type: Journal    
DOI: 10.1534/genetics.114.162982     Document Type: Article
Times cited : (39)

References (76)
  • 1
    • 32844460938 scopus 로고    scopus 로고
    • Copy number polymorphism in Fcgr3 predisposes to glomerulonephritis in rats and humans
    • Aitman, T. J., R. Dong, T. J. Vyse, P. J. Norsworthy, M. D. Johnson et al., 2006 Copy number polymorphism in Fcgr3 predisposes to glomerulonephritis in rats and humans. Nature 439(7078): 851–855.
    • (2006) Nature , vol.439 , Issue.7078 , pp. 851-855
    • Aitman, T.J.1    Dong, R.2    Vyse, T.J.3    Norsworthy, P.J.4    Johnson, M.D.5
  • 2
    • 74949133820 scopus 로고    scopus 로고
    • Acute insulin signaling in pancreatic beta-cells is mediated by multiple Raf-1 dependent pathways
    • Alejandro, E. U., T. B. Kalynyak, F. Taghizadeh, K. S. Gwiazda, E. K. Rawstron et al., 2010 Acute insulin signaling in pancreatic beta-cells is mediated by multiple Raf-1 dependent pathways. Endocrinology 151(2): 502–512.
    • (2010) Endocrinology , vol.151 , Issue.2 , pp. 502-512
    • Alejandro, E.U.1    Kalynyak, T.B.2    Taghizadeh, F.3    Gwiazda, K.S.4    Rawstron, E.K.5
  • 3
    • 77957361860 scopus 로고    scopus 로고
    • An emerging role for NAADP-mediated Ca2+ signaling in the pancreatic beta-cell
    • Arredouani, A., A. M. Evans, J. Ma, J. Parrington, M. X. Zhu et al., 2010 An emerging role for NAADP-mediated Ca2+ signaling in the pancreatic beta-cell. Islets 2(5): 323–330.
    • (2010) Islets , vol.2 , Issue.5 , pp. 323-330
    • Arredouani, A.1    Evans, A.M.2    Ma, J.3    Parrington, J.4    Zhu, M.X.5
  • 4
    • 84879692177 scopus 로고    scopus 로고
    • Combined sequence-based and genetic mapping analysis of complex traits in outbred rats
    • Baud, A., R. Hermsen, V. Guryev, P. Stridh, D. Graham et al., 2013 Combined sequence-based and genetic mapping analysis of complex traits in outbred rats. Nat. Genet. 45(7): 767–775.
    • (2013) Nat. Genet , vol.45 , Issue.7 , pp. 767-775
    • Baud, A.1    Hermsen, R.2    Guryev, V.3    Stridh, P.4    Graham, D.5
  • 5
    • 42649106487 scopus 로고    scopus 로고
    • Jund is a determinant of macrophage activation and is associated with glomerulonephritis susceptibility
    • Behmoaras, J., G. Bhangal, J. Smith, K. McDonald, B. Mutch et al., 2008 Jund is a determinant of macrophage activation and is associated with glomerulonephritis susceptibility. Nat. Genet. 40(5): 553–559.
    • (2008) Nat. Genet , vol.40 , Issue.5 , pp. 553-559
    • Behmoaras, J.1    Bhangal, G.2    Smith, J.3    McDonald, K.4    Mutch, B.5
  • 6
    • 0001677717 scopus 로고
    • Controlling the false discovery rate: A practical and powerful approach to multiple testing
    • Benjamini, Y., and Y. Hochberg, 1995 Controlling the false discovery rate: a practical and powerful approach to multiple testing. J. R. Stat. Soc. B 57: 289–300.
    • (1995) J. R. Stat. Soc. B , vol.57 , pp. 289-300
    • Benjamini, Y.1    Hochberg, Y.2
  • 7
    • 67749143745 scopus 로고    scopus 로고
    • Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling
    • Brailoiu, E., D. Churamani, X. Cai, M. G. Schrlau, G. C. Brailoiu et al., 2009 Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling. J. Cell Biol. 186(2): 201–209.
    • (2009) J. Cell Biol , vol.186 , Issue.2 , pp. 201-209
    • Brailoiu, E.1    Churamani, D.2    Cai, X.3    Schrlau, M.G.4    Brailoiu, G.C.5
  • 8
    • 57049134614 scopus 로고    scopus 로고
    • Validation of simple indexes to assess insulin sensitivity during pregnancy in Wistar and Sprague-Dawley rats
    • Cacho, J., J. Sevillano, J. de Castro, E. Herrera, and M. P. Ramos, 2008 Validation of simple indexes to assess insulin sensitivity during pregnancy in Wistar and Sprague-Dawley rats. Am. J. Physiol. Endocrinol. Metab. 295(5): E1269–E1276.
    • (2008) Am. J. Physiol. Endocrinol. Metab , vol.295 , Issue.5 , pp. E1269-E1276
    • Cacho, J.1    Sevillano, J.2    De Castro, J.3    Herrera, E.4    Ramos, M.P.5
  • 9
    • 67349287016 scopus 로고    scopus 로고
    • NAADP mobilizes calcium from acidic organelles through two-pore channels
    • Calcraft, P. J., M. Ruas, Z. Pan, X. Cheng, A. Arredouani et al., 2009 NAADP mobilizes calcium from acidic organelles through two-pore channels. Nature 459(7246): 596–600.
    • (2009) Nature , vol.459 , Issue.7246 , pp. 596-600
    • Calcraft, P.J.1    Ruas, M.2    Pan, Z.3    Cheng, X.4    Arredouani, A.5
  • 10
    • 40749105508 scopus 로고    scopus 로고
    • Variations in DNA elucidate molecular networks that cause disease
    • Chen, Y., J. Zhu, P. Y. Lum, X. Yang, S. Pinto et al., 2008 Variations in DNA elucidate molecular networks that cause disease. Nature 452(7186): 429–435.
    • (2008) Nature , vol.452 , Issue.7186 , pp. 429-435
    • Chen, Y.1    Zhu, J.2    Lum, P.Y.3    Yang, X.4    Pinto, S.5
  • 11
    • 0031128599 scopus 로고    scopus 로고
    • Genetic modifiers of Leprfa associated with variability in insulin production and susceptibility to NIDDM
    • Chung, W. K., M. Zheng, M. Chua, E. Kershaw, L. Power-Kehoe et al., 1997 Genetic modifiers of Leprfa associated with variability in insulin production and susceptibility to NIDDM. Genomics 41(3): 332–344.
    • (1997) Genomics , vol.41 , Issue.3 , pp. 332-344
    • Chung, W.K.1    Zheng, M.2    Chua, M.3    Kershaw, E.4    Power-Kehoe, L.5
  • 12
    • 13944265645 scopus 로고    scopus 로고
    • Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9
    • Cohen, J., A. Pertsemlidis, I. K. Kotowski, R. Graham, C. K. Garcia et al., 2005 Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9. Nat. Genet. 37(2): 161–165.
    • (2005) Nat. Genet , vol.37 , Issue.2 , pp. 161-165
    • Cohen, J.1    Pertsemlidis, A.2    Kotowski, I.K.3    Graham, R.4    Garcia, C.K.5
  • 13
    • 0034892647 scopus 로고    scopus 로고
    • Further characterization and high-resolution mapping of quantitative trait loci for ethanol-induced locomotor activity
    • Demarest, K., J. Koyner, J. McCaughran,., L. Cipp, and R. Hitzemann, 2001 Further characterization and high-resolution mapping of quantitative trait loci for ethanol-induced locomotor activity. Behav. Genet. 31(1): 79–91.
    • (2001) Behav. Genet , vol.31 , Issue.1 , pp. 79-91
    • Demarest, K.1    Koyner, J.2    McCaughran, J.3    Cipp, L.4    Hitzemann, R.5
  • 14
    • 84895868553 scopus 로고    scopus 로고
    • Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility
    • DIAbetes Genetics Replication and Meta-analysis (DIAGRAM) Consortium, Asian Genetic Epidemiology Network Type 2 Diabetes (AGEN-T2D) Consortium, South Asian Type 2 Diabetes (SAT2D) Consortium, Mexican American Type 2 Diabetes (MAT2D) Consortium, Type 2 Diabetes Genetic Exploration by Next-Generation Sequencing in Multi-Ethnic Samples (T2D-GENES) Consortium et al., 2014 Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat. Genet. 46(3): 234–244.
    • (2014) Nat. Genet , vol.46 , Issue.3 , pp. 234-244
  • 15
    • 75749086085 scopus 로고    scopus 로고
    • New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
    • Dupuis, J., C. Langenberg, I. Prokopenko, R. Saxena, N. Soranzo et al., 2010 New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat. Genet. 42(2): 105–116.
    • (2010) Nat. Genet , vol.42 , Issue.2 , pp. 105-116
    • Dupuis, J.1    Langenberg, C.2    Prokopenko, I.3    Saxena, R.4    Soranzo, N.5
  • 16
    • 58149095143 scopus 로고    scopus 로고
    • An integrative genetics approach to identify candidate genes regulating BMD: Combining linkage, gene expression, and association
    • Farber, C. R., A. van Nas, A. Ghazalpour, J. E. Aten, S. Doss et al., 2009 An integrative genetics approach to identify candidate genes regulating BMD: combining linkage, gene expression, and association. J. Bone Miner. Res. 24(1): 105–116.
    • (2009) J. Bone Miner. Res , vol.24 , Issue.1 , pp. 105-116
    • Farber, C.R.1    Van Nas, A.2    Ghazalpour, A.3    Aten, J.E.4    Doss, S.5
  • 17
    • 84867743261 scopus 로고    scopus 로고
    • Genome-wide association studies in mice
    • Flint, J., and E. Eskin, 2012 Genome-wide association studies in mice. Nat. Rev. Genet. 13(11): 807–817.
    • (2012) Nat. Rev. Genet , vol.13 , Issue.11 , pp. 807-817
    • Flint, J.1    Eskin, E.2
  • 18
    • 84888132259 scopus 로고    scopus 로고
    • Identifying multiple causative genes at a single GWAS locus
    • Flister, M. J., S. W. Tsaih, C. C. O’Meara, B. Endres, M. J. Hoffman et al., 2013 Identifying multiple causative genes at a single GWAS locus. Genome Res. 23(12): 1996–2002.
    • (2013) Genome Res , vol.23 , Issue.12 , pp. 1996-2002
    • Flister, M.J.1    Tsaih, S.W.2    O’meara, C.C.3    Endres, B.4    Hoffman, M.J.5
  • 19
    • 0030058877 scopus 로고    scopus 로고
    • Genetic analysis of non-insulin dependent diabetes mellitus in the GK rat
    • Galli, J., L. S. Li, A. Glaser, C. G. Ostenson, H. Jiao et al., 1996 Genetic analysis of non-insulin dependent diabetes mellitus in the GK rat. Nat. Genet. 12(1): 31–37.
    • (1996) Nat. Genet , vol.12 , Issue.1 , pp. 31-37
    • Galli, J.1    Li, L.S.2    Glaser, A.3    Ostenson, C.G.4    Jiao, H.5
  • 20
    • 84862001699 scopus 로고    scopus 로고
    • Increased expression of fatty-acid and calcium metabolism genes in failing human heart
    • Garcia-Rua, V., M. F. Otero, P. V. Lear, D. Rodriguez-Penas, S. Feijoo-Bandin et al., 2012 Increased expression of fatty-acid and calcium metabolism genes in failing human heart. PLoS ONE 7(6): e37505.
    • (2012) PLoS ONE , vol.7 , Issue.6 , pp. e37505
    • Garcia-Rua, V.1    Otero, M.F.2    Lear, P.V.3    Rodriguez-Penas, D.4    Feijoo-Bandin, S.5
  • 21
    • 9044247460 scopus 로고    scopus 로고
    • Chromosomal mapping of genetic loci associated with non-insulin dependent diabetes in the GK rat
    • Gauguier, D., P. Froguel, V. Parent, C. Bernard, M. T. Bihoreau et al., 1996 Chromosomal mapping of genetic loci associated with non-insulin dependent diabetes in the GK rat. Nat. Genet. 12(1): 38–43.
    • (1996) Nat. Genet , vol.12 , Issue.1 , pp. 38-43
    • Gauguier, D.1    Froguel, P.2    Parent, V.3    Bernard, C.4    Bihoreau, M.T.5
  • 22
    • 33751339484 scopus 로고    scopus 로고
    • High-resolution quantitative trait locus analysis reveals multiple diabetes susceptibility loci mapped to intervals ,800 kb in the species-conserved Niddm1i of the GK rat
    • Granhall, C., H. B. Park, H. Fakhrai-Rad, and H. Luthman, 2006 High-resolution quantitative trait locus analysis reveals multiple diabetes susceptibility loci mapped to intervals,800 kb in the species-conserved Niddm1i of the GK rat. Genetics 174: 1565–1572.
    • (2006) Genetics , vol.174 , pp. 1565-1572
    • Granhall, C.1    Park, H.B.2    Fakhrai-Rad, H.3    Luthman, H.4
  • 23
    • 0021752968 scopus 로고
    • Development of the National Institutes of Health genetically heterogeneous rat stock
    • Hansen, C., and K. Spuhler, 1984 Development of the National Institutes of Health genetically heterogeneous rat stock. Alcohol. Clin. Exp. Res. 8(5): 477–479.
    • (1984) Alcohol. Clin. Exp. Res , vol.8 , Issue.5 , pp. 477-479
    • Hansen, C.1    Spuhler, K.2
  • 24
    • 9144238154 scopus 로고    scopus 로고
    • Involvement of eotaxin, eosinophils, and pancreatic predisposition in development of type 1 diabetes mellitus in the BioBreeding rat
    • Hessner, M. J., X. Wang, L. Meyer, R. Geoffrey, S. Jia et al., 2004 Involvement of eotaxin, eosinophils, and pancreatic predisposition in development of type 1 diabetes mellitus in the BioBreeding rat. J. Immunol. 173(11): 6993–7002.
    • (2004) J. Immunol , vol.173 , Issue.11 , pp. 6993-7002
    • Hessner, M.J.1    Wang, X.2    Meyer, L.3    Geoffrey, R.4    Jia, S.5
  • 25
    • 84867745132 scopus 로고    scopus 로고
    • What have we learned from six years of GWAS in autoimmune diseases, and what is next
    • Hu, X., and M. Daly, 2012 What have we learned from six years of GWAS in autoimmune diseases, and what is next? Curr. Opin. Immunol. 24(5): 571–575.
    • (2012) Curr. Opin. Immunol , vol.24 , Issue.5 , pp. 571-575
    • Hu, X.1    Daly, M.2
  • 26
    • 66449134529 scopus 로고    scopus 로고
    • High resolution mapping of expression QTLs in heterogeneous stock mice in multiple tissues
    • Huang, G. J., S. Shifman, W. Valdar, M. Johannesson, B. Yalcin et al., 2009 High resolution mapping of expression QTLs in heterogeneous stock mice in multiple tissues. Genome Res. 19(6): 1133–1140.
    • (2009) Genome Res , vol.19 , Issue.6 , pp. 1133-1140
    • Huang, G.J.1    Shifman, S.2    Valdar, W.3    Johannesson, M.4    Yalcin, B.5
  • 27
    • 20144377218 scopus 로고    scopus 로고
    • Integrated transcriptional profiling and linkage analysis for identification of genes underlying disease
    • Hubner, N., C. A. Wallace, H. Zimdahl, E. Petretto, H. Schulz et al., 2005 Integrated transcriptional profiling and linkage analysis for identification of genes underlying disease. Nat. Genet. 37(3): 243–253.
    • (2005) Nat. Genet , vol.37 , Issue.3 , pp. 243-253
    • Hubner, N.1    Wallace, C.A.2    Zimdahl, H.3    Petretto, E.4    Schulz, H.5
  • 28
    • 80052321622 scopus 로고    scopus 로고
    • Genome-wide and species-wide dissection of the genetics of arthritis severity in heterogeneous stock mice
    • Johnsen, A. K., W. Valdar, L. Golden, A. Ortiz-Lopez, R. Hitzemann et al., 2011 Genome-wide and species-wide dissection of the genetics of arthritis severity in heterogeneous stock mice. Arthritis Rheum. 63(9): 2630–2640.
    • (2011) Arthritis Rheum , vol.63 , Issue.9 , pp. 2630-2640
    • Johnsen, A.K.1    Valdar, W.2    Golden, L.3    Ortiz-Lopez, A.4    Hitzemann, R.5
  • 29
    • 79955016834 scopus 로고    scopus 로고
    • Effects of isoflurane on Nfkappab p65, Gadd45a and Jnk1 expression in the vital organs of CBA/CA mice
    • Kadar, B., K. Gombos, E. Szele, I. Ember, J. L. Ivanyi et al., 2011 Effects of isoflurane on Nfkappab p65, Gadd45a and Jnk1 expression in the vital organs of CBA/CA mice. In Vivo 25(2): 241–244.
    • (2011) Vivo , vol.25 , Issue.2 , pp. 241-244
    • Kadar, B.1    Gombos, K.2    Szele, E.3    Ember, I.4    Ivanyi, J.L.5
  • 30
    • 7344236791 scopus 로고    scopus 로고
    • Genetic dissection of “OLETF”, a rat model for noninsulin- dependent diabetes mellitus
    • Kanemoto, N., H. Hishigaki, A. Miyakita, K. Oga, S. Okuno et al., 1998 Genetic dissection of “OLETF”, a rat model for noninsulin- dependent diabetes mellitus. Mamm. Genome 9(6): 419–425.
    • (1998) Mamm. Genome , vol.9 , Issue.6 , pp. 419-425
    • Kanemoto, N.1    Hishigaki, H.2    Miyakita, A.3    Oga, K.4    Okuno, S.5
  • 31
    • 84874610564 scopus 로고    scopus 로고
    • Transposon-mediated transgenesis, transgenic rescue, and tissue-specific gene expression in rodents and rabbits
    • Katter, K., A. M. Geurts, O. Hoffmann, L. Mates, V. Landa et al., 2013 Transposon-mediated transgenesis, transgenic rescue, and tissue-specific gene expression in rodents and rabbits. FASEB J. 27(3): 930–941.
    • (2013) FASEB J , vol.27 , Issue.3 , pp. 930-941
    • Katter, K.1    Geurts, A.M.2    Hoffmann, O.3    Mates, L.4    Landa, V.5
  • 32
    • 0034456568 scopus 로고    scopus 로고
    • Quantitative insulin sensitivity check index: A simple, accurate method for assessing insulin sensitivity in humans
    • Katz, A., S. S. Nambi, K. Mather, A. D. Baron, D. A. Follmann et al., 2000 Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans. J. Clin. Endocrinol. Metab. 85(7): 2402–2410.
    • (2000) J. Clin. Endocrinol. Metab , vol.85 , Issue.7 , pp. 2402-2410
    • Katz, A.1    Nambi, S.S.2    Mather, K.3    Baron, A.D.4    Follmann, D.A.5
  • 33
    • 80052851950 scopus 로고    scopus 로고
    • Mouse genomic variation and its effect on phenotypes and gene regulation
    • Keane, T. M., L. Goodstadt, P. Danecek, M. A. White, K. Wong et al., 2011 Mouse genomic variation and its effect on phenotypes and gene regulation. Nature 477(7364): 289–294.
    • (2011) Nature , vol.477 , Issue.7364 , pp. 289-294
    • Keane, T.M.1    Goodstadt, L.2    Danecek, P.3    White, M.A.4    Wong, K.5
  • 34
    • 42449108189 scopus 로고    scopus 로고
    • Generation of nicotinic acid adenine dinucleotide phosphate and cyclic ADP-ribose by glucagon-like peptide-1 evokes Ca2+ signal that is essential for insulin secretion in mouse pancreatic islets
    • Kim, B. J., K. H. Park, C. Y. Yim, S. Takasawa, H. Okamoto et al., 2008 Generation of nicotinic acid adenine dinucleotide phosphate and cyclic ADP-ribose by glucagon-like peptide-1 evokes Ca2+ signal that is essential for insulin secretion in mouse pancreatic islets. Diabetes 57(4): 868–878.
    • (2008) Diabetes , vol.57 , Issue.4 , pp. 868-878
    • Kim, B.J.1    Park, K.H.2    Yim, C.Y.3    Takasawa, S.4    Okamoto, H.5
  • 35
    • 34447321852 scopus 로고    scopus 로고
    • Enhancements and modifications of primer design program Primer3
    • Koressaar, T., and M. Remm, 2007 Enhancements and modifications of primer design program Primer3. Bioinformatics 23(10): 1289–1291.
    • (2007) Bioinformatics , vol.23 , Issue.10 , pp. 1289-1291
    • Koressaar, T.1    Remm, M.2
  • 36
    • 80051824901 scopus 로고    scopus 로고
    • Integration of QTL and bioinformatic tools to identify candidate genes for triglycerides in mice
    • Leduc, M. S., R. S. Hageman, R. A. Verdugo, S. W. Tsaih, K. Walsh et al., 2011 Integration of QTL and bioinformatic tools to identify candidate genes for triglycerides in mice. J. Lipid Res. 52(9): 1672–1682.
    • (2011) J. Lipid Res , vol.52 , Issue.9 , pp. 1672-1682
    • Leduc, M.S.1    Hageman, R.S.2    Verdugo, R.A.3    Tsaih, S.W.4    Walsh, K.5
  • 37
    • 84878649483 scopus 로고    scopus 로고
    • High-precision genetic mapping of behavioral traits in the diversity outbred mouse population
    • Logan, R. W., R. F. Robledo, J. M. Recla, V. M. Philip, J. A. Bubier et al., 2013 High-precision genetic mapping of behavioral traits in the diversity outbred mouse population. Genes Brain Behav. 12(4): 424–437.
    • (2013) Genes Brain Behav , vol.12 , Issue.4 , pp. 424-437
    • Logan, R.W.1    Robledo, R.F.2    Recla, J.M.3    Philip, V.M.4    Bubier, J.A.5
  • 38
    • 0035861942 scopus 로고    scopus 로고
    • Mice lacking Ca(v)2.3 (alpha1E) calcium channel exhibit hyperglycemia
    • Matsuda, Y., H. Saegusa, S. Zong, T. Noda, and T. Tanabe, 2001 Mice lacking Ca(v)2.3 (alpha1E) calcium channel exhibit hyperglycemia. Biochem. Biophys. Res. Commun. 289(4): 791–795.
    • (2001) Biochem. Biophys. Res. Commun , vol.289 , Issue.4 , pp. 791-795
    • Matsuda, Y.1    Saegusa, H.2    Zong, S.3    Noda, T.4    Tanabe, T.5
  • 39
    • 0021813187 scopus 로고
    • Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
    • Matthews, D. R., J. P. Hosker, A. S. Rudenski, B. A. Naylor, D. F. Treacher et al., 1985 Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28(7): 412–419.
    • (1985) Diabetologia , vol.28 , Issue.7 , pp. 412-419
    • Matthews, D.R.1    Hosker, J.P.2    Rudenski, A.S.3    Naylor, B.A.4    Treacher, D.F.5
  • 40
    • 84868337361 scopus 로고    scopus 로고
    • Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
    • Morris, A. P., B. F. Voight, T. M. Teslovich, T. Ferreira, A. V. Segre et al., 2012 Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat. Genet. 44(9): 981–990.
    • (2012) Nat. Genet , vol.44 , Issue.9 , pp. 981-990
    • Morris, A.P.1    Voight, B.F.2    Teslovich, T.M.3    Ferreira, T.4    Segre, A.V.5
  • 41
    • 80855140431 scopus 로고    scopus 로고
    • Integrated genomic approaches to identification of candidate genes underlying metabolic and cardiovascular phenotypes in the spontaneously hypertensive rat
    • Morrissey, C., I. C. Grieve, M. Heinig, S. Atanur, E. Petretto et al., 2011 Integrated genomic approaches to identification of candidate genes underlying metabolic and cardiovascular phenotypes in the spontaneously hypertensive rat. Physiol. Genomics 43(21): 1207–1218.
    • (2011) Physiol. Genomics , vol.43 , Issue.21 , pp. 1207-1218
    • Morrissey, C.1    Grieve, I.C.2    Heinig, M.3    Atanur, S.4    Petretto, E.5
  • 42
    • 0034619331 scopus 로고    scopus 로고
    • A method for fine mapping quantitative trait loci in outbred animal stocks
    • Mott, R., C. J. Talbot, M. G. Turri, A. C. Collins, and J. Flint, 2000 A method for fine mapping quantitative trait loci in outbred animal stocks. Proc. Natl. Acad. Sci. USA 97(23): 12649–12654.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , Issue.23 , pp. 12649-12654
    • Mott, R.1    Talbot, C.J.2    Turri, M.G.3    Collins, A.C.4    Flint, J.5
  • 43
  • 44
    • 70349102137 scopus 로고    scopus 로고
    • Distinct genetic regulation of progression of diabetes and renal disease in the Goto-Kakizaki rat
    • Nobrega, M. A., L. C. Woods, S. Fleming, and H. J. Jacob, 2009 Distinct genetic regulation of progression of diabetes and renal disease in the Goto-Kakizaki rat. Physiol. Genomics 39(1): 38–46.
    • (2009) Physiol. Genomics , vol.39 , Issue.1 , pp. 38-46
    • Nobrega, M.A.1    Woods, L.C.2    Fleming, S.3    Jacob, H.J.4
  • 45
    • 84860427618 scopus 로고    scopus 로고
    • Calcium signaling through CaMKII regulates hepatic glucose production in fasting and obesity
    • Ozcan, L., C. C. Wong, G. Li, T. Xu, U. Pajvani et al., 2012 Calcium signaling through CaMKII regulates hepatic glucose production in fasting and obesity. Cell Metab. 15(5): 739–751.
    • (2012) Cell Metab , vol.15 , Issue.5 , pp. 739-751
    • Ozcan, L.1    Wong, C.C.2    Li, G.3    Xu, T.4    Pajvani, U.5
  • 46
    • 84890284562 scopus 로고    scopus 로고
    • Autocrine/paracrine function of nicotinic acid adenine dinucleotide phosphate (NAADP) for glucose homeostasis in pancreatic beta-cells and adipocytes
    • Park, K. H., B. J. Kim, A. I. Shawl, M. K. Han, H. C. Lee et al., 2013 Autocrine/paracrine function of nicotinic acid adenine dinucleotide phosphate (NAADP) for glucose homeostasis in pancreatic beta-cells and adipocytes. J. Biol. Chem. 288(49): 35548–35558.
    • (2013) J. Biol. Chem , vol.288 , Issue.49 , pp. 35548-35558
    • Park, K.H.1    Kim, B.J.2    Shawl, A.I.3    Han, M.K.4    Lee, H.C.5
  • 47
    • 42649125570 scopus 로고    scopus 로고
    • Integrated genomic approaches implicate osteoglycin (Ogn) in the regulation of left ventricular mass
    • Petretto, E., R. Sarwar, I. Grieve, H. Lu, M. K. Kumaran et al., 2008 Integrated genomic approaches implicate osteoglycin (Ogn) in the regulation of left ventricular mass. Nat. Genet. 40(5): 546–552.
    • (2008) Nat. Genet , vol.40 , Issue.5 , pp. 546-552
    • Petretto, E.1    Sarwar, R.2    Grieve, I.3    Lu, H.4    Kumaran, M.K.5
  • 48
    • 17344392308 scopus 로고    scopus 로고
    • A new mathematical model for relative quantification in real-time RT-PCR
    • Pfaffl, M. W., 2001 A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 29(9): e45.
    • (2001) Nucleic Acids Res , vol.29 , Issue.9 , pp. e45
    • Pfaffl, M.W.1
  • 49
    • 42649140561 scopus 로고    scopus 로고
    • SNP and haplotype mapping for genetic analysis in the rat
    • Saar, K., A. Beck, M. T. Bihoreau, E. Birney, D. Brocklebank et al., 2008 SNP and haplotype mapping for genetic analysis in the rat. Nat. Genet. 40(5): 560–566.
    • (2008) Nat. Genet , vol.40 , Issue.5 , pp. 560-566
    • Saar, K.1    Beck, A.2    Bihoreau, M.T.3    Birney, E.4    Brocklebank, D.5
  • 50
    • 34547537530 scopus 로고    scopus 로고
    • Rat Mcs5a is a compound quantitative trait locus with orthologous human loci that associate with breast cancer risk
    • Samuelson, D. J., S. E. Hesselson, B. A. Aperavich, Y. Zan, J. D. Haag et al., 2007 Rat Mcs5a is a compound quantitative trait locus with orthologous human loci that associate with breast cancer risk. Proc. Natl. Acad. Sci. USA 104(15): 6299–6304.
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , Issue.15 , pp. 6299-6304
    • Samuelson, D.J.1    Hesselson, S.E.2    Aperavich, B.A.3    Zan, Y.4    Haag, J.D.5
  • 51
    • 77954359777 scopus 로고    scopus 로고
    • Characterization of two-pore channel 2 (TPCN2)- mediated Ca2+ currents in isolated lysosomes
    • Schieder, M., K. Rotzer, A. Bruggemann, M. Biel, and C. A. Wahl- Schott, 2010 Characterization of two-pore channel 2 (TPCN2)- mediated Ca2+ currents in isolated lysosomes. J. Biol. Chem. 285(28): 21219–21222.
    • (2010) J. Biol. Chem , vol.285 , Issue.28 , pp. 21219-21222
    • Schieder, M.1    Rotzer, K.2    Bruggemann, A.3    Biel, M.4    Wahl-Schott, C.A.5
  • 52
    • 84865693929 scopus 로고    scopus 로고
    • Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways
    • Scott, R. A., V. Lagou, R. P. Welch, E. Wheeler, M. E. Montasser et al., 2012 Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat. Genet. 44(9): 991–1005.
    • (2012) Nat. Genet , vol.44 , Issue.9 , pp. 991-1005
    • Scott, R.A.1    Lagou, V.2    Welch, R.P.3    Wheeler, E.4    Montasser, M.E.5
  • 53
    • 79953295227 scopus 로고    scopus 로고
    • Insulin receptor signaling for the proliferation of pancreatic beta-cells: Involvement of Ca2+ second messengers, IP3, NAADP and cADPR
    • Shawl, A. I., K. H. Park, and U. H. Kim, 2009 Insulin receptor signaling for the proliferation of pancreatic beta-cells: involvement of Ca2+ second messengers, IP3, NAADP and cADPR. Islets 1(3): 216–223.
    • (2009) Islets , vol.1 , Issue.3 , pp. 216-223
    • Shawl, A.I.1    Park, K.H.2    Kim, U.H.3
  • 54
    • 79955841697 scopus 로고    scopus 로고
    • Evaluating the heritability explained by known susceptibility variants: A survey of ten complex diseases
    • So, H. C., A. H. Gui, S. S. Cherny, and P. C. Sham, 2011 Evaluating the heritability explained by known susceptibility variants: a survey of ten complex diseases. Genet. Epidemiol. 35(5): 310–317.
    • (2011) Genet. Epidemiol , vol.35 , Issue.5 , pp. 310-317
    • So, H.C.1    Gui, A.H.2    Cherny, S.S.3    Sham, P.C.4
  • 55
    • 84893343029 scopus 로고    scopus 로고
    • QTL mapping in outbred populations: Successes and challenges
    • Solberg Woods, L. C., 2014 QTL mapping in outbred populations: successes and challenges. Physiol. Genomics 46(3): 81–90.
    • (2014) Physiol. Genomics , vol.46 , Issue.3 , pp. 81-90
    • Solberg Woods, L.C.1
  • 56
    • 70349855190 scopus 로고    scopus 로고
    • Identification of genetic loci involved in diabetes using a rat model of depression
    • Solberg Woods, L. C., N. Ahmadiyeh, A. Baum, K. Shimomura, Q. Li et al., 2009 Identification of genetic loci involved in diabetes using a rat model of depression. Mamm. Genome 20(8): 486–497.
    • (2009) Mamm. Genome , vol.20 , Issue.8 , pp. 486-497
    • Solberg Woods, L.C.1    Ahmadiyeh, N.2    Baum, A.3    Shimomura, K.4    Li, Q.5
  • 57
    • 77949706465 scopus 로고    scopus 로고
    • Fine-mapping a locus for glucose tolerance using heterogeneous stock rats
    • Solberg Woods, L. C., K. Holl, M. Tschannen, and W. Valdar, 2010 Fine-mapping a locus for glucose tolerance using heterogeneous stock rats. Physiol. Genomics 41(1): 102–108.
    • (2010) Physiol. Genomics , vol.41 , Issue.1 , pp. 102-108
    • Solberg Woods, L.C.1    Holl, K.2    Tschannen, M.3    Valdar, W.4
  • 58
    • 84868566945 scopus 로고    scopus 로고
    • Fine-mapping diabetes-related traits, including insulin resistance, in heterogeneous stock rats
    • Solberg Woods, L. C., K. L. Holl, D. Oreper, Y. Xie, S. W. Tsaih et al., 2012 Fine-mapping diabetes-related traits, including insulin resistance, in heterogeneous stock rats. Physiol. Genomics 44(21): 1013–1026.
    • (2012) Physiol. Genomics , vol.44 , Issue.21 , pp. 1013-1026
    • Solberg Woods, L.C.1    Holl, K.L.2    Oreper, D.3    Xie, Y.4    Tsaih, S.W.5
  • 59
    • 84895858002 scopus 로고    scopus 로고
    • Identification of low-frequency and rare sequence variants associated with elevated or reduced risk of type 2 diabetes
    • Steinthorsdottir, V., G. Thorleifsson, P. Sulem, H. Helgason, N. Grarup et al., 2014 Identification of low-frequency and rare sequence variants associated with elevated or reduced risk of type 2 diabetes. Nat. Genet. 46(3): 294–298.
    • (2014) Nat. Genet , vol.46 , Issue.3 , pp. 294-298
    • Steinthorsdottir, V.1    Thorleifsson, G.2    Sulem, P.3    Helgason, H.4    Grarup, N.5
  • 60
    • 84857410370 scopus 로고    scopus 로고
    • High-resolution genetic mapping using the Mouse Diversity outbred population
    • Svenson, K. L., D. M. Gatti, W. Valdar, C. E. Welsh, R. Cheng et al., 2012 High-resolution genetic mapping using the Mouse Diversity outbred population. Genetics 190: 437–447.
    • (2012) Genetics , vol.190 , pp. 437-447
    • Svenson, K.L.1    Gatti, D.M.2    Valdar, W.3    Welsh, C.E.4    Cheng, R.5
  • 61
    • 20944445879 scopus 로고    scopus 로고
    • MHC2TA is associated with differential MHC molecule expression and susceptibility to rheumatoid arthritis, multiple sclerosis and myocardial infarction
    • Swanberg, M., O. Lidman, L. Padyukov, P. Eriksson, E. Akesson et al., 2005 MHC2TA is associated with differential MHC molecule expression and susceptibility to rheumatoid arthritis, multiple sclerosis and myocardial infarction. Nat. Genet. 37(5): 486–494.
    • (2005) Nat. Genet , vol.37 , Issue.5 , pp. 486-494
    • Swanberg, M.1    Lidman, O.2    Padyukov, L.3    Eriksson, P.4    Akesson, E.5
  • 62
    • 0032979854 scopus 로고    scopus 로고
    • High-resolution mapping of quantitative trait loci in outbred mice
    • Talbot, C. J., A. Nicod, S. S. Cherny, D. W. Fulker, A. C. Collins et al., 1999 High-resolution mapping of quantitative trait loci in outbred mice. Nat. Genet. 21(3): 305–308.
    • (1999) Nat. Genet , vol.21 , Issue.3 , pp. 305-308
    • Talbot, C.J.1    Nicod, A.2    Cherny, S.S.3    Fulker, D.W.4    Collins, A.C.5
  • 64
    • 79951693222 scopus 로고    scopus 로고
    • Regulation of gene expression by carbon dioxide
    • Taylor, C. T., and E. P. Cummins, 2011 Regulation of gene expression by carbon dioxide. J. Physiol. 589(Pt. 4): 797–803.
    • (2011) J. Physiol , vol.589 , pp. 797-803
    • Taylor, C.T.1    Cummins, E.P.2
  • 66
    • 33746540478 scopus 로고    scopus 로고
    • Genome-wide genetic association of complex traits in heterogeneous stock mice
    • Valdar, W., L. C. Solberg, D. Gauguier, S. Burnett, P. Klenerman et al., 2006 Genome-wide genetic association of complex traits in heterogeneous stock mice. Nat. Genet. 38(8): 879–887.
    • (2006) Nat. Genet , vol.38 , Issue.8 , pp. 879-887
    • Valdar, W.1    Solberg, L.C.2    Gauguier, D.3    Burnett, S.4    Klenerman, P.5
  • 67
    • 68249130288 scopus 로고    scopus 로고
    • Mapping in structured populations by resample model averaging
    • Valdar, W., C. C. Holmes, R. Mott, and J. Flint, 2009 Mapping in structured populations by resample model averaging. Genetics 182(4): 1263–1277.
    • (2009) Genetics , vol.182 , Issue.4 , pp. 1263-1277
    • Valdar, W.1    Holmes, C.C.2    Mott, R.3    Flint, J.4
  • 68
    • 77954143522 scopus 로고    scopus 로고
    • Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
    • Voight, B. F., L. J. Scott, V. Steinthorsdottir, A. P. Morris, C. Dina et al., 2010 Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat. Genet. 42(7): 579–589.
    • (2010) Nat. Genet , vol.42 , Issue.7 , pp. 579-589
    • Voight, B.F.1    Scott, L.J.2    Steinthorsdottir, V.3    Morris, A.P.4    Dina, C.5
  • 69
    • 64649083363 scopus 로고    scopus 로고
    • Type 1 diabetes in the BB rat: A polygenic disease
    • Wallis, R. H., K. Wang, L. Marandi, E. Hsieh, T. Ning et al., 2009 Type 1 diabetes in the BB rat: a polygenic disease. Diabetes 58(4): 1007–1017.
    • (2009) Diabetes , vol.58 , Issue.4 , pp. 1007-1017
    • Wallis, R.H.1    Wang, K.2    Marandi, L.3    Hsieh, E.4    Ning, T.5
  • 70
    • 0032805994 scopus 로고    scopus 로고
    • Mapping and characterization of quantitative trait loci for non-insulin-dependent diabetes mellitus with an improved genetic map in the Otsuka Long-Evans Tokushima fatty rat
    • Wei, S., K. Wei, D. H. Moralejo, T. Ogino, G. Koike et al., 1999 Mapping and characterization of quantitative trait loci for non-insulin-dependent diabetes mellitus with an improved genetic map in the Otsuka Long-Evans Tokushima fatty rat. Mamm. Genome 10(3): 249–258.
    • (1999) Mamm. Genome , vol.10 , Issue.3 , pp. 249-258
    • Wei, S.1    Wei, K.2    Moralejo, D.H.3    Ogino, T.4    Koike, G.5
  • 71
    • 3042840998 scopus 로고    scopus 로고
    • Unexpected complexity in the haplotypes of commonly used inbred strains of laboratory mice
    • Yalcin, B., J. Fullerton, S. Miller, D. A. Keays, S. Brady et al., 2004a Unexpected complexity in the haplotypes of commonly used inbred strains of laboratory mice. Proc. Natl. Acad. Sci. USA 101(26): 9734–9739.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , Issue.26 , pp. 9734-9739
    • Yalcin, B.1    Fullerton, J.2    Miller, S.3    Keays, D.A.4    Brady, S.5
  • 72
    • 11844254278 scopus 로고    scopus 로고
    • Genetic dissection of a behavioral quantitative trait locus shows that Rgs2 modulates anxiety in mice
    • Yalcin, B., S. A. Willis-Owen, J. Fullerton, A. Meesaq, R. M. Deacon et al., 2004b Genetic dissection of a behavioral quantitative trait locus shows that Rgs2 modulates anxiety in mice. Nat. Genet. 36(11): 1197–1202.
    • (2004) Nat. Genet , vol.36 , Issue.11 , pp. 1197-1202
    • Yalcin, B.1    Willis-Owen, S.A.2    Fullerton, J.3    Meesaq, A.4    Deacon, R.M.5
  • 73
    • 31544436869 scopus 로고    scopus 로고
    • Using progenitor strain information to identify quantitative trait nucleotides in outbred mice
    • Yalcin, B., J. Flint, and R. Mott, 2005 Using progenitor strain information to identify quantitative trait nucleotides in outbred mice. Genetics 171: 673–681.
    • (2005) Genetics , vol.171 , pp. 673-681
    • Yalcin, B.1    Flint, J.2    Mott, R.3
  • 74
    • 78049422154 scopus 로고    scopus 로고
    • Commercially available outbred mice for genome-wide association studies
    • Yalcin, B., J. Nicod, A. Bhomra, S. Davidson, J. Cleak et al., 2010 Commercially available outbred mice for genome-wide association studies. PLoS Genet. 6(9): e1001085.
    • (2010) PLoS Genet , vol.6 , Issue.9 , pp. e1001085
    • Yalcin, B.1    Nicod, J.2    Bhomra, A.3    Davidson, S.4    Cleak, J.5
  • 75
    • 42349106044 scopus 로고    scopus 로고
    • Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
    • Zeggini, E., L. J. Scott, R. Saxena, B. F. Voight, J. L. Marchini et al., 2008 Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat. Genet. 40(5): 638–645.
    • (2008) Nat. Genet , vol.40 , Issue.5 , pp. 638-645
    • Zeggini, E.1    Scott, L.J.2    Saxena, R.3    Voight, B.F.4    Marchini, J.L.5
  • 76
    • 84893378179 scopus 로고    scopus 로고
    • Searching for missing heritability: Designing rare variant association studies
    • Zuk, O., S. F. Schaffner, K. Samocha, R. Do, E. Hechter et al., 2014 Searching for missing heritability: designing rare variant association studies. Proc. Natl. Acad. Sci. USA 111(4): E455–E464.
    • (2014) Proc. Natl. Acad. Sci. USA , vol.111 , Issue.4 , pp. E455-E464
    • Zuk, O.1    Schaffner, S.F.2    Samocha, K.3    Do, R.4    Hechter, E.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.