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Volumn 45, Issue 7, 2013, Pages 767-775

Combined sequence-based and genetic mapping analysis of complex traits in outbred rats

(70)  Baud, Amelie a   Hermsen, Roel b   Guryev, Victor b,c   Stridh, Pernilla d   Graham, Delyth e   McBride, Martin W e   Foroud, Tatiana f   Calderari, Sophie g   Diez, Margarita d   Ockinger, Johan d   Beyeen, Amennai D d   Gillett, Alan d   Abdelmagid, Nada d   Guerreiro Cacais, Andre Ortlieb d   Jagodic, Maja d   Tuncel, Jonatan d   Norin, Ulrika d   Beattie, Elisabeth e   Huynh, Ngan e   Miller, William H e   more..

g INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTEGRIN; CALSYNTENIN 2; CATENIN; CATENIN DELTA2; HISTOCOMPATIBILITY ANTIGEN; INSULIN RECEPTOR; INSULIN RECEPTOR ALPHA; INSULIN RECEPTOR BETA; PHOSPHATIDATE PHOSPHATASE; PROTEIN; REPLICATION FACTOR C; TRANSCRIPTION FACTOR T BET; UDP GLUCOSE GLYCOPROTEIN GLUCOSYLTRANSFERASE 1; UNCLASSIFIED DRUG; VOLTAGE GATED POTASSIUM CHANNEL;

EID: 84879692177     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng.2644     Document Type: Article
Times cited : (149)

References (49)
  • 1
    • 57649136554 scopus 로고    scopus 로고
    • Progress and challenges in genome-wide association studies in humans
    • Donnelly, P. Progress and challenges in genome-wide association studies in humans. Nature 456, 728-731 (2008).
    • (2008) Nature , vol.456 , pp. 728-731
    • Donnelly, P.1
  • 2
    • 66049159816 scopus 로고    scopus 로고
    • Genetic architecture of quantitative traits in mice, flies, and humans
    • Flint, J. & Mackay, T.F. Genetic architecture of quantitative traits in mice, flies, and humans. Genome Res. 19, 723-733 (2009).
    • (2009) Genome Res. , vol.19 , pp. 723-733
    • Flint, J.1    Mackay, T.F.2
  • 3
    • 0021752968 scopus 로고
    • Development of the National Institutes of Health genetically heterogeneous rat stock
    • Hansen, C. & Spuhler, K. Development of the National Institutes of Health genetically heterogeneous rat stock. Alcohol. Clin. Exp. Res. 8, 477-479 (1984).
    • (1984) Alcohol. Clin. Exp. Res. , vol.8 , pp. 477-479
    • Hansen, C.1    Spuhler, K.2
  • 4
    • 80052851950 scopus 로고    scopus 로고
    • Mouse genomic variation and its effect on phenotypes and gene regulation
    • Keane, T.M. et al. Mouse genomic variation and its effect on phenotypes and gene regulation. Nature 477, 289-294 (2011).
    • (2011) Nature , vol.477 , pp. 289-294
    • Keane, T.M.1
  • 5
    • 0032979854 scopus 로고    scopus 로고
    • High-resolution mapping of quantitative trait loci in outbred mice
    • Talbot, C.J. et al. High-resolution mapping of quantitative trait loci in outbred mice. Nat. Genet. 21, 305-308 (1999).
    • (1999) Nat. Genet. , vol.21 , pp. 305-308
    • Talbot, C.J.1
  • 6
    • 31544436869 scopus 로고    scopus 로고
    • Using progenitor strain information to identify quantitative trait nucleotides in outbred mice
    • Yalcin, B., Flint, J. & Mott, R. Using progenitor strain information to identify quantitative trait nucleotides in outbred mice. Genetics 171, 673-681 (2005).
    • (2005) Genetics , vol.171 , pp. 673-681
    • Yalcin, B.1    Flint, J.2    Mott, R.3
  • 7
    • 0038282483 scopus 로고    scopus 로고
    • Measured haplotype analysis of the aldosterone synthase gene and heart size
    • Mayosi, B.M., Keavney, B., Watkins, H. & Farrall, M. Measured haplotype analysis of the aldosterone synthase gene and heart size. Eur. J. Hum. Genet. 11, 395-401 (2003).
    • (2003) Eur. J. Hum. Genet. , vol.11 , pp. 395-401
    • Mayosi, B.M.1    Keavney, B.2    Watkins, H.3    Farrall, M.4
  • 8
    • 1842684068 scopus 로고    scopus 로고
    • Genome sequence of the Brown Norway rat yields insights into mammalian evolution
    • Gibbs, R.A. et al. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature 428, 493-521 (2004).
    • (2004) Nature , vol.428 , pp. 493-521
    • Gibbs, R.A.1
  • 9
    • 73349108077 scopus 로고    scopus 로고
    • National BioResource project-rat and related activities
    • Serikawa, T. et al. National BioResource Project-Rat and related activities. Exp. Anim. 58, 333-341 (2009).
    • (2009) Exp. Anim. , vol.58 , pp. 333-341
    • Serikawa, T.1
  • 10
    • 33746540478 scopus 로고    scopus 로고
    • Genome-wide genetic association of complex traits in heterogeneous stock mice
    • Valdar, W. et al. Genome-wide genetic association of complex traits in heterogeneous stock mice. Nat. Genet. 38, 879-887 (2006).
    • (2006) Nat. Genet. , vol.38 , pp. 879-887
    • Valdar, W.1
  • 11
    • 61449224751 scopus 로고    scopus 로고
    • A resource for the simultaneous high-resolution mapping of multiple quantitative trait loci in rats: The NIH heterogeneous stock
    • Johannesson, M. et al. A resource for the simultaneous high-resolution mapping of multiple quantitative trait loci in rats: the NIH heterogeneous stock. Genome Res. 19, 150-158 (2009).
    • (2009) Genome Res. , vol.19 , pp. 150-158
    • Johannesson, M.1
  • 12
    • 45149105926 scopus 로고    scopus 로고
    • Efficient control of population structure in model organism association mapping
    • Kang, H.M. et al. Efficient control of population structure in model organism association mapping. Genetics 178, 1709-1723 (2008).
    • (2008) Genetics , vol.178 , pp. 1709-1723
    • Kang, H.M.1
  • 13
    • 68249130288 scopus 로고    scopus 로고
    • Mapping in structured populations by resample model averaging
    • Valdar, W., Holmes, C.C., Mott, R. & Flint, J. Mapping in structured populations by resample model averaging. Genetics 182, 1263-1277 (2009).
    • (2009) Genetics , vol.182 , pp. 1263-1277
    • Valdar, W.1    Holmes, C.C.2    Mott, R.3    Flint, J.4
  • 14
  • 15
    • 4544246530 scopus 로고    scopus 로고
    • Deletion of the neuron-specific protein δ-catenin leads to severe cognitive and synaptic dysfunction
    • Israely, I. et al. Deletion of the neuron-specific protein δ-catenin leads to severe cognitive and synaptic dysfunction. Curr. Biol. 14, 1657-1663 (2004).
    • (2004) Curr. Biol. , vol.14 , pp. 1657-1663
    • Israely, I.1
  • 16
    • 77952827032 scopus 로고    scopus 로고
    • Mutations in the SHANK2 synaptic scaffolding gene in autism spectrum disorder and mental retardation
    • Berkel, S. et al. Mutations in the SHANK2 synaptic scaffolding gene in autism spectrum disorder and mental retardation. Nat. Genet. 42, 489-491 (2010).
    • (2010) Nat. Genet. , vol.42 , pp. 489-491
    • Berkel, S.1
  • 17
    • 0033954256 scopus 로고    scopus 로고
    • The protein data bank
    • Berman, H.M. et al. The Protein Data Bank. Nucleic Acids Res. 28, 235-242 (2000).
    • (2000) Nucleic Acids Res. , vol.28 , pp. 235-242
    • Berman, H.M.1
  • 18
    • 0034213588 scopus 로고    scopus 로고
    • ABC-me: A novel mitochondrial transporter induced by GATA-1 during erythroid differentiation
    • Shirihai, O.S., Gregory, T., Yu, C., Orkin, S.H. & Weiss, M.J. ABC-me: a novel mitochondrial transporter induced by GATA-1 during erythroid differentiation. EMBO J. 19, 2492-2502 (2000).
    • (2000) EMBO J. , vol.19 , pp. 2492-2502
    • Shirihai, O.S.1    Gregory, T.2    Yu, C.3    Orkin, S.H.4    Weiss, M.J.5
  • 19
    • 84862123582 scopus 로고    scopus 로고
    • The mitochondrial transporter ABC-me (ABCB10), a downstream target of GATA-1, is essential for erythropoiesis in vivo
    • Hyde, B.B. et al. The mitochondrial transporter ABC-me (ABCB10), a downstream target of GATA-1, is essential for erythropoiesis in vivo. Cell Death Differ. 19, 1117-1126 (2012).
    • (2012) Cell Death Differ. , vol.19 , pp. 1117-1126
    • Hyde, B.B.1
  • 20
    • 84891459355 scopus 로고    scopus 로고
    • Rat models of experimental autoimmune encephalomyelitis
    • (ed. Conn, P.J.) (Humana Press, Ottawa)
    • Wallström, E.O.T. Rat models of experimental autoimmune encephalomyelitis. in Sourcebook of Models for Biomedical Research (ed. Conn, P.J.) 547-556 (Humana Press, Ottawa, 2007).
    • (2007) Sourcebook of Models for Biomedical Research , pp. 547-556
    • Wallström, E.O.T.1
  • 21
    • 80051684615 scopus 로고    scopus 로고
    • Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis
    • Sawcer, S. et al. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature 476, 214-219 (2011).
    • (2011) Nature , vol.476 , pp. 214-219
    • Sawcer, S.1
  • 22
    • 84857111200 scopus 로고    scopus 로고
    • DNase i sensitivity QTLs are a major determinant of human expression variation
    • Degner, J.F. et al. DNase I sensitivity QTLs are a major determinant of human expression variation. Nature 482, 390-394 (2012).
    • (2012) Nature , vol.482 , pp. 390-394
    • Degner, J.F.1
  • 23
    • 55449112450 scopus 로고    scopus 로고
    • High-resolution mapping of expression-QTLs yields insight into human gene regulation
    • Veyrieras, J.B. et al. High-resolution mapping of expression-QTLs yields insight into human gene regulation. PLoS Genet. 4, e1000214 (2008).
    • (2008) PLoS Genet. , vol.4
    • Veyrieras, J.B.1
  • 24
    • 66449134529 scopus 로고    scopus 로고
    • High resolution mapping of expression QTLs in heterogeneous stock mice in multiple tissues
    • Huang, G.J. et al. High resolution mapping of expression QTLs in heterogeneous stock mice in multiple tissues. Genome Res. 19, 1133-1140 (2009).
    • (2009) Genome Res. , vol.19 , pp. 1133-1140
    • Huang, G.J.1
  • 25
    • 75949096268 scopus 로고    scopus 로고
    • A role for VAV1 in experimental autoimmune encephalomyelitis and multiple sclerosis
    • Jagodic, M. et al. A role for VAV1 in experimental autoimmune encephalomyelitis and multiple sclerosis. Sci. Transl. Med. 1, 10ra21 (2009).
    • (2009) Sci. Transl. Med. , vol.1
    • Jagodic, M.1
  • 26
    • 20944445879 scopus 로고    scopus 로고
    • MHC2TA is associated with differential MHC molecule expression and susceptibility to rheumatoid arthritis, multiple sclerosis and myocardial infarction
    • Swanberg, M. et al. MHC2TA is associated with differential MHC molecule expression and susceptibility to rheumatoid arthritis, multiple sclerosis and myocardial infarction. Nat. Genet. 37, 486-494 (2005).
    • (2005) Nat. Genet. , vol.37 , pp. 486-494
    • Swanberg, M.1
  • 27
    • 82255192188 scopus 로고    scopus 로고
    • Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease
    • Trynka, G. et al. Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease. Nat. Genet. 43, 1193-1201 (2011).
    • (2011) Nat. Genet. , vol.43 , pp. 1193-1201
    • Trynka, G.1
  • 28
    • 0032919364 scopus 로고    scopus 로고
    • KEGG: Kyoto encyclopedia of genes and genomes
    • Ogata, H. et al. KEGG: Kyoto Encyclopedia of Genes and Genomes. Nucleic Acids Res. 27, 29-34 (1999).
    • (1999) Nucleic Acids Res. , vol.27 , pp. 29-34
    • Ogata, H.1
  • 29
    • 34547474592 scopus 로고    scopus 로고
    • Genetic regulation of T regulatory, CD4, and CD8 cell numbers by the arthritis severity loci Cia5a, Cia5d, and the MHC/Cia1 in the rat
    • Brenner, M., Laragione, T., Yarlett, N.C. & Gulko, P.S. Genetic regulation of T regulatory, CD4, and CD8 cell numbers by the arthritis severity loci Cia5a, Cia5d, and the MHC/Cia1 in the rat. Mol. Med. 13, 277-287 (2007).
    • (2007) Mol. Med. , vol.13 , pp. 277-287
    • Brenner, M.1    Laragione, T.2    Yarlett, N.C.3    Gulko, P.S.4
  • 30
    • 65749103365 scopus 로고    scopus 로고
    • The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation
    • Koch, M.A. et al. The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation. Nat. Immunol. 10, 595-602 (2009).
    • (2009) Nat. Immunol. , vol.10 , pp. 595-602
    • Koch, M.A.1
  • 31
    • 58849088509 scopus 로고    scopus 로고
    • T-bet dependent removal of Sin3A-histone deacetylase complexes at the Ifng locus drives Th1 differentiation
    • Chang, S., Collins, P.L. & Aune, T.M. T-bet dependent removal of Sin3A-histone deacetylase complexes at the Ifng locus drives Th1 differentiation. J. Immunol. 181, 8372-8381 (2008).
    • (2008) J. Immunol. , vol.181 , pp. 8372-8381
    • Chang, S.1    Collins, P.L.2    Aune, T.M.3
  • 32
    • 22344435137 scopus 로고    scopus 로고
    • The mSin3A chromatin-modifying complex is essential for embryogenesis and T-cell development
    • Cowley, S.M. et al. The mSin3A chromatin-modifying complex is essential for embryogenesis and T-cell development. Mol. Cell. Biol. 25, 6990-7004 (2005).
    • (2005) Mol. Cell. Biol. , vol.25 , pp. 6990-7004
    • Cowley, S.M.1
  • 33
    • 80051949650 scopus 로고    scopus 로고
    • Mitochondrial transporter ATP binding cassette mitochondrial erythroid is a novel gene required for cardiac recovery after ischemia/reperfusion
    • Liesa, M. et al. Mitochondrial transporter ATP binding cassette mitochondrial erythroid is a novel gene required for cardiac recovery after ischemia/reperfusion. Circulation 124, 806-813 (2011).
    • (2011) Circulation , vol.124 , pp. 806-813
    • Liesa, M.1
  • 34
    • 77953233453 scopus 로고    scopus 로고
    • Genome-wide association study of 107 phenotypes in Arabidopsis thaliana inbred lines
    • Atwell, S. et al. Genome-wide association study of 107 phenotypes in Arabidopsis thaliana inbred lines. Nature 465, 627-631 (2010).
    • (2010) Nature , vol.465 , pp. 627-631
    • Atwell, S.1
  • 35
    • 73149124061 scopus 로고    scopus 로고
    • Quantitative trait loci for CD4:CD8 lymphocyte ratio are associated with risk of type 1 diabetes and HIV-1 immune control
    • Ferreira, M.A. et al. Quantitative trait loci for CD4:CD8 lymphocyte ratio are associated with risk of type 1 diabetes and HIV-1 immune control. Am. J. Hum. Genet. 86, 88-92 (2010).
    • (2010) Am. J. Hum. Genet. , vol.86 , pp. 88-92
    • Ferreira, M.A.1
  • 36
    • 78049422154 scopus 로고    scopus 로고
    • Commercially available outbred mice for genome-wide association studies
    • Yalcin, B. et al. Commercially available outbred mice for genome-wide association studies. PLoS Genet. 6, pii: e1001085 (2010).
    • (2010) PLoS Genet. , vol.6
    • Yalcin, B.1
  • 37
    • 67649884743 scopus 로고    scopus 로고
    • Fast and accurate short read alignment with Burrows-Wheeler transform
    • Li, H. & Durbin, R. Fast and accurate short read alignment with Burrows-Wheeler transform. Bioinformatics 25, 1754-1760 (2009).
    • (2009) Bioinformatics , vol.25 , pp. 1754-1760
    • Li, H.1    Durbin, R.2
  • 38
    • 68549104404 scopus 로고    scopus 로고
    • The sequence alignment/map format and SAMtools
    • Li, H. et al. The Sequence Alignment/Map format and SAMtools. Bioinformatics 25, 2078-2079 (2009).
    • (2009) Bioinformatics , vol.25 , pp. 2078-2079
    • Li, H.1
  • 39
    • 77955405475 scopus 로고    scopus 로고
    • Deriving the consequences of genomic variants with the ensembl API and SNP effect predictor
    • McLaren, W. et al. Deriving the consequences of genomic variants with the Ensembl API and SNP Effect Predictor. Bioinformatics 26, 2069-2070 (2010).
    • (2010) Bioinformatics , vol.26 , pp. 2069-2070
    • McLaren, W.1
  • 40
    • 0036226603 scopus 로고    scopus 로고
    • BLAT-the BLAST-like alignment tool
    • Kent, W.J. BLAT-the BLAST-like alignment tool. Genome Res. 12, 656-664 (2002).
    • (2002) Genome Res. , vol.12 , pp. 656-664
    • Kent, W.J.1
  • 42
    • 34548292504 scopus 로고    scopus 로고
    • PLINK: A tool set for whole-genome association and population-based linkage analyses
    • Purcell, S. et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am. J. Hum. Genet. 81, 559-575 (2007).
    • (2007) Am. J. Hum. Genet. , vol.81 , pp. 559-575
    • Purcell, S.1
  • 43
    • 33644874573 scopus 로고    scopus 로고
    • The UCSC genome browser database: Update 2006
    • Hinrichs, A.S. et al. The UCSC Genome Browser Database: update 2006. Nucleic Acids Res. 34, D590-D598 (2006).
    • (2006) Nucleic Acids Res. , vol.34
    • Hinrichs, A.S.1
  • 44
    • 84855199947 scopus 로고    scopus 로고
    • R Core Development Team. (R Foundation for Statistical Computing, Vienna)
    • R Core Development Team. A Language and Environment for Statistical Computing (R Foundation for Statistical Computing, Vienna, 2004).
    • (2004) A Language and Environment for Statistical Computing
  • 45
    • 79960976768 scopus 로고    scopus 로고
    • UniProt Knowledgebase: A hub of integrated protein data
    • bar009
    • Magrane, M. & Consortium, U. UniProt Knowledgebase: a hub of integrated protein data. Database (Oxford) 2011, bar009 (2011).
    • (2011) Database (Oxford) 2011
    • Magrane, M.1    Consortium, U.2
  • 46
    • 23144452044 scopus 로고    scopus 로고
    • The HHpred interactive server for protein homology detection and structure prediction
    • Söding, J., Biegert, A. & Lupas, A.N. The HHpred interactive server for protein homology detection and structure prediction. Nucleic Acids Res. 33, W244-W248 (2005).
    • (2005) Nucleic Acids Res. , vol.33
    • Söding, J.1    Biegert, A.2    Lupas, A.N.3
  • 48
    • 84858314394 scopus 로고    scopus 로고
    • BioMart: Driving a paradigm change in biological data management
    • bar049
    • Kasprzyk, A. BioMart: driving a paradigm change in biological data management. Database (Oxford) 2011, bar049 (2011).
    • (2011) Database (Oxford) 2011
    • Kasprzyk, A.1
  • 49
    • 84863987483 scopus 로고    scopus 로고
    • INRICH: Interval-based enrichment analysis for genome-wide association studies
    • Lee, P.H., O'Dushlaine, C., Thomas, B. & Purcell, S.M. INRICH: interval-based enrichment analysis for genome-wide association studies. Bioinformatics 28, 1797-1799 (2012).
    • (2012) Bioinformatics , vol.28 , pp. 1797-1799
    • Lee, P.H.1    O'dushlaine, C.2    Thomas, B.3    Purcell, S.M.4


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