-
1
-
-
57649136554
-
Progress and challenges in genome-wide association studies in humans
-
Donnelly, P. Progress and challenges in genome-wide association studies in humans. Nature 456, 728-731 (2008).
-
(2008)
Nature
, vol.456
, pp. 728-731
-
-
Donnelly, P.1
-
2
-
-
66049159816
-
Genetic architecture of quantitative traits in mice, flies, and humans
-
Flint, J. & Mackay, T.F. Genetic architecture of quantitative traits in mice, flies, and humans. Genome Res. 19, 723-733 (2009).
-
(2009)
Genome Res.
, vol.19
, pp. 723-733
-
-
Flint, J.1
Mackay, T.F.2
-
3
-
-
0021752968
-
Development of the National Institutes of Health genetically heterogeneous rat stock
-
Hansen, C. & Spuhler, K. Development of the National Institutes of Health genetically heterogeneous rat stock. Alcohol. Clin. Exp. Res. 8, 477-479 (1984).
-
(1984)
Alcohol. Clin. Exp. Res.
, vol.8
, pp. 477-479
-
-
Hansen, C.1
Spuhler, K.2
-
4
-
-
80052851950
-
Mouse genomic variation and its effect on phenotypes and gene regulation
-
Keane, T.M. et al. Mouse genomic variation and its effect on phenotypes and gene regulation. Nature 477, 289-294 (2011).
-
(2011)
Nature
, vol.477
, pp. 289-294
-
-
Keane, T.M.1
-
5
-
-
0032979854
-
High-resolution mapping of quantitative trait loci in outbred mice
-
Talbot, C.J. et al. High-resolution mapping of quantitative trait loci in outbred mice. Nat. Genet. 21, 305-308 (1999).
-
(1999)
Nat. Genet.
, vol.21
, pp. 305-308
-
-
Talbot, C.J.1
-
6
-
-
31544436869
-
Using progenitor strain information to identify quantitative trait nucleotides in outbred mice
-
Yalcin, B., Flint, J. & Mott, R. Using progenitor strain information to identify quantitative trait nucleotides in outbred mice. Genetics 171, 673-681 (2005).
-
(2005)
Genetics
, vol.171
, pp. 673-681
-
-
Yalcin, B.1
Flint, J.2
Mott, R.3
-
7
-
-
0038282483
-
Measured haplotype analysis of the aldosterone synthase gene and heart size
-
Mayosi, B.M., Keavney, B., Watkins, H. & Farrall, M. Measured haplotype analysis of the aldosterone synthase gene and heart size. Eur. J. Hum. Genet. 11, 395-401 (2003).
-
(2003)
Eur. J. Hum. Genet.
, vol.11
, pp. 395-401
-
-
Mayosi, B.M.1
Keavney, B.2
Watkins, H.3
Farrall, M.4
-
8
-
-
1842684068
-
Genome sequence of the Brown Norway rat yields insights into mammalian evolution
-
Gibbs, R.A. et al. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature 428, 493-521 (2004).
-
(2004)
Nature
, vol.428
, pp. 493-521
-
-
Gibbs, R.A.1
-
9
-
-
73349108077
-
National BioResource project-rat and related activities
-
Serikawa, T. et al. National BioResource Project-Rat and related activities. Exp. Anim. 58, 333-341 (2009).
-
(2009)
Exp. Anim.
, vol.58
, pp. 333-341
-
-
Serikawa, T.1
-
10
-
-
33746540478
-
Genome-wide genetic association of complex traits in heterogeneous stock mice
-
Valdar, W. et al. Genome-wide genetic association of complex traits in heterogeneous stock mice. Nat. Genet. 38, 879-887 (2006).
-
(2006)
Nat. Genet.
, vol.38
, pp. 879-887
-
-
Valdar, W.1
-
11
-
-
61449224751
-
A resource for the simultaneous high-resolution mapping of multiple quantitative trait loci in rats: The NIH heterogeneous stock
-
Johannesson, M. et al. A resource for the simultaneous high-resolution mapping of multiple quantitative trait loci in rats: the NIH heterogeneous stock. Genome Res. 19, 150-158 (2009).
-
(2009)
Genome Res.
, vol.19
, pp. 150-158
-
-
Johannesson, M.1
-
12
-
-
45149105926
-
Efficient control of population structure in model organism association mapping
-
Kang, H.M. et al. Efficient control of population structure in model organism association mapping. Genetics 178, 1709-1723 (2008).
-
(2008)
Genetics
, vol.178
, pp. 1709-1723
-
-
Kang, H.M.1
-
13
-
-
68249130288
-
Mapping in structured populations by resample model averaging
-
Valdar, W., Holmes, C.C., Mott, R. & Flint, J. Mapping in structured populations by resample model averaging. Genetics 182, 1263-1277 (2009).
-
(2009)
Genetics
, vol.182
, pp. 1263-1277
-
-
Valdar, W.1
Holmes, C.C.2
Mott, R.3
Flint, J.4
-
14
-
-
0034619331
-
A method for fine mapping quantitative trait loci in outbred animal stocks
-
Mott, R., Talbot, C.J., Turri, M.G., Collins, A.C. & Flint, J. A method for fine mapping quantitative trait loci in outbred animal stocks. Proc. Natl. Acad. Sci. USA 97, 12649-12654 (2000).
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 12649-12654
-
-
Mott, R.1
Talbot, C.J.2
Turri, M.G.3
Collins, A.C.4
Flint, J.5
-
15
-
-
4544246530
-
Deletion of the neuron-specific protein δ-catenin leads to severe cognitive and synaptic dysfunction
-
Israely, I. et al. Deletion of the neuron-specific protein δ-catenin leads to severe cognitive and synaptic dysfunction. Curr. Biol. 14, 1657-1663 (2004).
-
(2004)
Curr. Biol.
, vol.14
, pp. 1657-1663
-
-
Israely, I.1
-
16
-
-
77952827032
-
Mutations in the SHANK2 synaptic scaffolding gene in autism spectrum disorder and mental retardation
-
Berkel, S. et al. Mutations in the SHANK2 synaptic scaffolding gene in autism spectrum disorder and mental retardation. Nat. Genet. 42, 489-491 (2010).
-
(2010)
Nat. Genet.
, vol.42
, pp. 489-491
-
-
Berkel, S.1
-
17
-
-
0033954256
-
The protein data bank
-
Berman, H.M. et al. The Protein Data Bank. Nucleic Acids Res. 28, 235-242 (2000).
-
(2000)
Nucleic Acids Res.
, vol.28
, pp. 235-242
-
-
Berman, H.M.1
-
18
-
-
0034213588
-
ABC-me: A novel mitochondrial transporter induced by GATA-1 during erythroid differentiation
-
Shirihai, O.S., Gregory, T., Yu, C., Orkin, S.H. & Weiss, M.J. ABC-me: a novel mitochondrial transporter induced by GATA-1 during erythroid differentiation. EMBO J. 19, 2492-2502 (2000).
-
(2000)
EMBO J.
, vol.19
, pp. 2492-2502
-
-
Shirihai, O.S.1
Gregory, T.2
Yu, C.3
Orkin, S.H.4
Weiss, M.J.5
-
19
-
-
84862123582
-
The mitochondrial transporter ABC-me (ABCB10), a downstream target of GATA-1, is essential for erythropoiesis in vivo
-
Hyde, B.B. et al. The mitochondrial transporter ABC-me (ABCB10), a downstream target of GATA-1, is essential for erythropoiesis in vivo. Cell Death Differ. 19, 1117-1126 (2012).
-
(2012)
Cell Death Differ.
, vol.19
, pp. 1117-1126
-
-
Hyde, B.B.1
-
20
-
-
84891459355
-
Rat models of experimental autoimmune encephalomyelitis
-
(ed. Conn, P.J.) (Humana Press, Ottawa)
-
Wallström, E.O.T. Rat models of experimental autoimmune encephalomyelitis. in Sourcebook of Models for Biomedical Research (ed. Conn, P.J.) 547-556 (Humana Press, Ottawa, 2007).
-
(2007)
Sourcebook of Models for Biomedical Research
, pp. 547-556
-
-
Wallström, E.O.T.1
-
21
-
-
80051684615
-
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis
-
Sawcer, S. et al. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature 476, 214-219 (2011).
-
(2011)
Nature
, vol.476
, pp. 214-219
-
-
Sawcer, S.1
-
22
-
-
84857111200
-
DNase i sensitivity QTLs are a major determinant of human expression variation
-
Degner, J.F. et al. DNase I sensitivity QTLs are a major determinant of human expression variation. Nature 482, 390-394 (2012).
-
(2012)
Nature
, vol.482
, pp. 390-394
-
-
Degner, J.F.1
-
23
-
-
55449112450
-
High-resolution mapping of expression-QTLs yields insight into human gene regulation
-
Veyrieras, J.B. et al. High-resolution mapping of expression-QTLs yields insight into human gene regulation. PLoS Genet. 4, e1000214 (2008).
-
(2008)
PLoS Genet.
, vol.4
-
-
Veyrieras, J.B.1
-
24
-
-
66449134529
-
High resolution mapping of expression QTLs in heterogeneous stock mice in multiple tissues
-
Huang, G.J. et al. High resolution mapping of expression QTLs in heterogeneous stock mice in multiple tissues. Genome Res. 19, 1133-1140 (2009).
-
(2009)
Genome Res.
, vol.19
, pp. 1133-1140
-
-
Huang, G.J.1
-
25
-
-
75949096268
-
A role for VAV1 in experimental autoimmune encephalomyelitis and multiple sclerosis
-
Jagodic, M. et al. A role for VAV1 in experimental autoimmune encephalomyelitis and multiple sclerosis. Sci. Transl. Med. 1, 10ra21 (2009).
-
(2009)
Sci. Transl. Med.
, vol.1
-
-
Jagodic, M.1
-
26
-
-
20944445879
-
MHC2TA is associated with differential MHC molecule expression and susceptibility to rheumatoid arthritis, multiple sclerosis and myocardial infarction
-
Swanberg, M. et al. MHC2TA is associated with differential MHC molecule expression and susceptibility to rheumatoid arthritis, multiple sclerosis and myocardial infarction. Nat. Genet. 37, 486-494 (2005).
-
(2005)
Nat. Genet.
, vol.37
, pp. 486-494
-
-
Swanberg, M.1
-
27
-
-
82255192188
-
Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease
-
Trynka, G. et al. Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease. Nat. Genet. 43, 1193-1201 (2011).
-
(2011)
Nat. Genet.
, vol.43
, pp. 1193-1201
-
-
Trynka, G.1
-
28
-
-
0032919364
-
KEGG: Kyoto encyclopedia of genes and genomes
-
Ogata, H. et al. KEGG: Kyoto Encyclopedia of Genes and Genomes. Nucleic Acids Res. 27, 29-34 (1999).
-
(1999)
Nucleic Acids Res.
, vol.27
, pp. 29-34
-
-
Ogata, H.1
-
29
-
-
34547474592
-
Genetic regulation of T regulatory, CD4, and CD8 cell numbers by the arthritis severity loci Cia5a, Cia5d, and the MHC/Cia1 in the rat
-
Brenner, M., Laragione, T., Yarlett, N.C. & Gulko, P.S. Genetic regulation of T regulatory, CD4, and CD8 cell numbers by the arthritis severity loci Cia5a, Cia5d, and the MHC/Cia1 in the rat. Mol. Med. 13, 277-287 (2007).
-
(2007)
Mol. Med.
, vol.13
, pp. 277-287
-
-
Brenner, M.1
Laragione, T.2
Yarlett, N.C.3
Gulko, P.S.4
-
30
-
-
65749103365
-
The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation
-
Koch, M.A. et al. The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation. Nat. Immunol. 10, 595-602 (2009).
-
(2009)
Nat. Immunol.
, vol.10
, pp. 595-602
-
-
Koch, M.A.1
-
31
-
-
58849088509
-
T-bet dependent removal of Sin3A-histone deacetylase complexes at the Ifng locus drives Th1 differentiation
-
Chang, S., Collins, P.L. & Aune, T.M. T-bet dependent removal of Sin3A-histone deacetylase complexes at the Ifng locus drives Th1 differentiation. J. Immunol. 181, 8372-8381 (2008).
-
(2008)
J. Immunol.
, vol.181
, pp. 8372-8381
-
-
Chang, S.1
Collins, P.L.2
Aune, T.M.3
-
32
-
-
22344435137
-
The mSin3A chromatin-modifying complex is essential for embryogenesis and T-cell development
-
Cowley, S.M. et al. The mSin3A chromatin-modifying complex is essential for embryogenesis and T-cell development. Mol. Cell. Biol. 25, 6990-7004 (2005).
-
(2005)
Mol. Cell. Biol.
, vol.25
, pp. 6990-7004
-
-
Cowley, S.M.1
-
33
-
-
80051949650
-
Mitochondrial transporter ATP binding cassette mitochondrial erythroid is a novel gene required for cardiac recovery after ischemia/reperfusion
-
Liesa, M. et al. Mitochondrial transporter ATP binding cassette mitochondrial erythroid is a novel gene required for cardiac recovery after ischemia/reperfusion. Circulation 124, 806-813 (2011).
-
(2011)
Circulation
, vol.124
, pp. 806-813
-
-
Liesa, M.1
-
34
-
-
77953233453
-
Genome-wide association study of 107 phenotypes in Arabidopsis thaliana inbred lines
-
Atwell, S. et al. Genome-wide association study of 107 phenotypes in Arabidopsis thaliana inbred lines. Nature 465, 627-631 (2010).
-
(2010)
Nature
, vol.465
, pp. 627-631
-
-
Atwell, S.1
-
35
-
-
73149124061
-
Quantitative trait loci for CD4:CD8 lymphocyte ratio are associated with risk of type 1 diabetes and HIV-1 immune control
-
Ferreira, M.A. et al. Quantitative trait loci for CD4:CD8 lymphocyte ratio are associated with risk of type 1 diabetes and HIV-1 immune control. Am. J. Hum. Genet. 86, 88-92 (2010).
-
(2010)
Am. J. Hum. Genet.
, vol.86
, pp. 88-92
-
-
Ferreira, M.A.1
-
36
-
-
78049422154
-
Commercially available outbred mice for genome-wide association studies
-
Yalcin, B. et al. Commercially available outbred mice for genome-wide association studies. PLoS Genet. 6, pii: e1001085 (2010).
-
(2010)
PLoS Genet.
, vol.6
-
-
Yalcin, B.1
-
37
-
-
67649884743
-
Fast and accurate short read alignment with Burrows-Wheeler transform
-
Li, H. & Durbin, R. Fast and accurate short read alignment with Burrows-Wheeler transform. Bioinformatics 25, 1754-1760 (2009).
-
(2009)
Bioinformatics
, vol.25
, pp. 1754-1760
-
-
Li, H.1
Durbin, R.2
-
38
-
-
68549104404
-
The sequence alignment/map format and SAMtools
-
Li, H. et al. The Sequence Alignment/Map format and SAMtools. Bioinformatics 25, 2078-2079 (2009).
-
(2009)
Bioinformatics
, vol.25
, pp. 2078-2079
-
-
Li, H.1
-
39
-
-
77955405475
-
Deriving the consequences of genomic variants with the ensembl API and SNP effect predictor
-
McLaren, W. et al. Deriving the consequences of genomic variants with the Ensembl API and SNP Effect Predictor. Bioinformatics 26, 2069-2070 (2010).
-
(2010)
Bioinformatics
, vol.26
, pp. 2069-2070
-
-
McLaren, W.1
-
40
-
-
0036226603
-
BLAT-the BLAST-like alignment tool
-
Kent, W.J. BLAT-the BLAST-like alignment tool. Genome Res. 12, 656-664 (2002).
-
(2002)
Genome Res.
, vol.12
, pp. 656-664
-
-
Kent, W.J.1
-
41
-
-
33646547251
-
An integrated system for genetic analysis
-
Fiddy, S., Cattermole, D., Xie, D., Duan, X.Y. & Mott, R. An integrated system for genetic analysis. BMC Bioinformatics 7, 210 (2006).
-
(2006)
BMC Bioinformatics
, vol.7
, pp. 210
-
-
Fiddy, S.1
Cattermole, D.2
Xie, D.3
Duan, X.Y.4
Mott, R.5
-
42
-
-
34548292504
-
PLINK: A tool set for whole-genome association and population-based linkage analyses
-
Purcell, S. et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am. J. Hum. Genet. 81, 559-575 (2007).
-
(2007)
Am. J. Hum. Genet.
, vol.81
, pp. 559-575
-
-
Purcell, S.1
-
43
-
-
33644874573
-
The UCSC genome browser database: Update 2006
-
Hinrichs, A.S. et al. The UCSC Genome Browser Database: update 2006. Nucleic Acids Res. 34, D590-D598 (2006).
-
(2006)
Nucleic Acids Res.
, vol.34
-
-
Hinrichs, A.S.1
-
44
-
-
84855199947
-
-
R Core Development Team. (R Foundation for Statistical Computing, Vienna)
-
R Core Development Team. A Language and Environment for Statistical Computing (R Foundation for Statistical Computing, Vienna, 2004).
-
(2004)
A Language and Environment for Statistical Computing
-
-
-
45
-
-
79960976768
-
UniProt Knowledgebase: A hub of integrated protein data
-
bar009
-
Magrane, M. & Consortium, U. UniProt Knowledgebase: a hub of integrated protein data. Database (Oxford) 2011, bar009 (2011).
-
(2011)
Database (Oxford) 2011
-
-
Magrane, M.1
Consortium, U.2
-
46
-
-
23144452044
-
The HHpred interactive server for protein homology detection and structure prediction
-
Söding, J., Biegert, A. & Lupas, A.N. The HHpred interactive server for protein homology detection and structure prediction. Nucleic Acids Res. 33, W244-W248 (2005).
-
(2005)
Nucleic Acids Res.
, vol.33
-
-
Söding, J.1
Biegert, A.2
Lupas, A.N.3
-
47
-
-
49649114605
-
Protein structure modeling with MODELLER
-
Eswar, N., Eramian, D., Webb, B., Shen, M.Y. & Sali, A. Protein structure modeling with MODELLER. Methods Mol. Biol. 426, 145-159 (2008).
-
(2008)
Methods Mol. Biol.
, vol.426
, pp. 145-159
-
-
Eswar, N.1
Eramian, D.2
Webb, B.3
Shen, M.Y.4
Sali, A.5
-
48
-
-
84858314394
-
BioMart: Driving a paradigm change in biological data management
-
bar049
-
Kasprzyk, A. BioMart: driving a paradigm change in biological data management. Database (Oxford) 2011, bar049 (2011).
-
(2011)
Database (Oxford) 2011
-
-
Kasprzyk, A.1
-
49
-
-
84863987483
-
INRICH: Interval-based enrichment analysis for genome-wide association studies
-
Lee, P.H., O'Dushlaine, C., Thomas, B. & Purcell, S.M. INRICH: interval-based enrichment analysis for genome-wide association studies. Bioinformatics 28, 1797-1799 (2012).
-
(2012)
Bioinformatics
, vol.28
, pp. 1797-1799
-
-
Lee, P.H.1
O'dushlaine, C.2
Thomas, B.3
Purcell, S.M.4
|