Genetic dissection of 'OLETF', a rat model for non-insulin-dependent diabetes mellitus

Mammalian Genome

Volumn 9, Issue 6, 1998, Pages 419-425

  Kanemoto, Naohide ^a   Hishigaki, Haretsugu ^a   Miyakita, Ayako ^a   Oga, Keiko ^a   Okuno, Shiro ^a   Tsuji, Atsushi ^a   Takagi, Toshihisa ^b   Takahashi, Ei Ichi ^a   Nakamura, Yusuke ^b   Watanabe, Takeshi K ^a  

^a OTSUKA PHARMACEUTICAL CO LTD   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHROMOSOME 10; CHROMOSOME 11; CHROMOSOME 16; GENE LOCUS; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PHENOTYPE; QUANTITATIVE DIAGNOSIS; QUANTITATIVE TRAIT; RAT;

ANIMALIA;

EID: 7344236791     PISSN: 09388990     EISSN: None     Source Type: Journal    
DOI: 10.1007/s003359900789     Document Type: Article

References (28)

1. Barnett AH, Eff C, Leslie RD, Pyke DA (1981) Diabetes in identical twins. A study of 200 pairs. Diabetologia 20, 87-93
2. Bihoreau M-T, Gauguier D, Kato N, Hyne G, Lindpainter K et al. (1997) A linkage map of the rat genome derived from three F2 crosses. Genome Res 7, 434-440
3. fa associated with variability in insulin production and susceptibility to NIDDM. Genomics 41, 332-344
4. Du Y, Remmers EF, Goldmuntz EA, Zha H, Mathem P et al. (1996) Linkage maps of rat chromosomes 15, 16, 17, 19 and X. Genomics 32, 113-116
5. Funakoshi A, Miyasaka K, Shinozaki H, Masuda M, Kawanami T et al. (1995) An animal model of congenital deffect of gene expression of cholecystokinin (CCK)-A receptor. Biochem Biophys Res Commun 210, 787-796
6. Galli J, Li L-S, Glaser A, Ostenson C-G, Jiao H et al. (1996) Genetic analysis of non-insulin dependent diabetes mellitus in the GK rat. Nat Genet 12, 31-37
7. Gauguier D, Froguel P, Parent V, Bernard C, Bihoreau M-T et al. (1996) Chromosomal mapping of genetic loci associated with non-insulin dependent diabetes in the GK rat. Nat Genet 12, 38-43
8. Hanis CL, Boerwinkle E, Chakraborty, Ellsworth DL, Concannon P et al. (1996) A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2. Nat Genet 13, 161-166
9. Hirashima T, Kawano K, Mori S, Matsumoto K, Natori T (1995) A diabetogenic (ODB-1) assigned to the X-chromosome in OLETF rats. Diabetes Res Clin Pract 27, 91-96
10. Hirashima T, Kawano K, Mori S, Natori T (1996) A diabetogenic gene, ODB-2, identified on chromosome 14 of the OLETF rat and its synergistic action with ODB-1. Biochem Biophys Res Commun 224, 420-425
11. Jacob HJ, Brown DM, Bunker RK, Daly MJ, Dzau VJ et al. (1995) A genetic linkage map of the laboratory rat, Rattus norvegicus. Nat Genet 9, 63-69
12. Kawano K, Hirashima T, Mori S, Kurosumi M, Saitoh Y (1991) A new rat strain with non insulin dependent diabetes mellitus, "OLETF". Rat News Lett 25, 24-26
13. Kawano K, Hirashima T, Mori S, Kurosumi M, Natori T (1992) Spontaneous long-term hyperglycemic rat with diabetic complication: Otsuka Long-Evans Tokushima Fatty (OLETF) strain. Diabetes 41, 1422-1428
14. Lander ES, Botstein D (1989) Mapping mendelian factors underlying quantitative traits using RFLP linkage maps. Genetics 121, 185-199
15. Lander ES, Kruglyak L (1995) Genetic dissection of complex traits: guidelines for interpreting and reporting linkage result. Nat Genet 11, 241-247
16. Mahtani MM, Widen E, Lehto M, Thomas J, McCarthy M et al. (1996) Mapping of a gene for type 2 diabetes associated with an insulin secretion defect by a genome scan in Finish families. Nat Genet 14, 90-94
17. Nabiki T, Ito T, Kitada K, Serikawa T, Mashimo T et al. (1997) Comparative mapping of novel simple sequence repeat markers in a hypertension-related region on rat chromosome 1. Mamm Genome 8, 215-217
18. Okauchi N, Mizuno A, Yoshimoto S, Zhu M, Sano T et al. (1995a) Is caloric restriction effective in preventing diabetes mellitus in the Otsuka Long Evans Tokushima Fatty rat, a model of spontaneous non-insulin-dependent diabetes mellitus? Diabetes Res Clin Pract 27, 97-106
19. Okauchi N, Mizuno A, Zhu M, Ishida K, Sano T et al. (1995b) Effects of obesity and inheritance on the development of non-insulin-dependent diabetes mellitus in Otsuka-Long-Evans-Tokushima Fatty rats. Diabetes Res Clin Pract 29, 1-10
20. Sato T, Asahi Y, Nakayama N (1995) Insulin resistance in skeletal muscle of the male Otsuka Long-Evans Tokushima Fatty, a new model of NIDDM. Diabetologia 38, 1033-1041
21. Stam P (1995) Construction of integrated genetic linkage maps by means of a computer package: JoinMap. Plant J 3, 739-744
22. Stam P, Van Ooijan JW (1995) JoinMap (tm) version 2.0: software for the calculation of genetic linkage maps. DLO-Centre for Plant Breeding and Reproduction Research, Wageningen, The Netherlands
23. Takiguchi S, Takata Y, Funakoshi A, Miyasaka K, Kataoka K et al. (1997) Disrupted cholecystokinin type-A receptor (CCKAR) gene in OLETF rats. Gene 197, 169-175
24. Van Ooijen JW (1992) Accuracy of mapping quantitative trait loci in autogamous species. Theor Appl Genet 84, 803-811
25. Van Ooijan JW, Maliepaard C (1996) MapQTL (tm) version 3.0: Software for the calculation of QTL position on genetics maps. DLO-Centre for Plant Breeding and Reproduction Research, Wageningen, The Netherlands
26. Vionnet N, Stoffel M, Takeda J, Yasuda K, Bell GI et al. (1992) Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes mellitus. Nature 356, 721-722
27. Yamagata K, Oda N, Kaisaki PJ, Menzel S, Furuta H et al. (1996a) Mutations in the hepatocyte nuclear factor-1-alpha gene in maturity-onset diabetes of the young (MODY3). Nature 384, 455-457
28. Yamagata K, Furuta H, Oda N, Kaisaki PJ, Menzel S et al. (1996b) Mutations in the hepatocyte nuclear factor-4-alpha gene in maturity-onset diabetes of the young (MODY1). Nature 384, 458-460