Effects of isoflurane on Nfκb p65, Gadd45a and Jnk1 expression in the vital organs of CBA/CA mice

In Vivo

Volumn 25, Issue 2, 2011, Pages 241-244

  Kádár, Balázs ^a   Gombos, Katalin ^b   Szele, Eszter ^b   Ember, István ^b   Iványi, János László ^c   Csejtei, Rás ^c   Pajkos, Gábor ^d  

^a Borsod County Teaching Hospital   (Hungary)

^b UNIVERSITY OF PÉCS   (Hungary)

^c University Teaching Hospital of Vas County   (Hungary)

^d BÁCS KISKUN COUNTY TEACHING HOSPITAL   (Hungary)

Author keywords

Gadd45 ; Gene expression; Isoflurane; Jnk1; Nf b p65; Volatile anaesthetic

Indexed keywords

GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; ISOFLURANE; STRESS ACTIVATED PROTEIN KINASE 1; TRANSCRIPTION FACTOR RELA;

ANESTHESIA LEVEL; ANESTHESIA MECHANISM; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG EXPOSURE; GENE EXPRESSION; GENE INDUCTION; GENE OVEREXPRESSION; GENERAL ANESTHESIA; KIDNEY; LIVER; MOUSE; NONHUMAN; REAL TIME POLYMERASE CHAIN REACTION; RNA ISOLATION;

EID: 79955016834     PISSN: 0258851X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Eger EI II, Eisenkraft JB and Weiskopf RB: The Pharmacology of Inhaled Anesthetics. Baxter Healthcare Corporation, USA, 2002.
2. Kim H, Oh E, Im H, Mun J, Yang M, Khim JY, Lee E, Lim SH, Kong MH, Lee M and SuI D: Oxidative damage in the DNA, lipids, and proteins of rats exposed to isofluranes and alcohols. Toxicology 220(2-3): 169-178, 2006. (Pubitemid 43276406)
3. Wade JG and Stevens WC: Isoflurane: an anesthetic for the eighties? Anesth Analg 60(9): 666-682, 1981.
4. Stachnik J: Formulary review, inhaled anaesthetic agents. Am J Health Syst Pharm 63: 623-634, 2006.
5. Holaday DA, Rudofsky S and Treuhaft PS: The metabolic degradation of methoxyflurane in man. Anesthesiology 33(6): 589-593, 1970.
6. Holaday DA, Fiserova-Bergerova V, Latto IP and Zumbiel MA: Resistance of isoflurane to biotransformation in man. Anesthesiology 43(3): 325-332, 1975.
7. Mazze RI, Cousins MJ and Barr GA: Renal effects and metabolism of isoflurane in man. Anesthesiology 40(6): 536-542, 1974.
8. Goldberg ME, Cantillo J, Larijani GE, Torjman M, Vekeman D and Schieren H: Sevoflurane versus isoflurane for maintenance of anesthesia: Are serum inorganic fluoride ion concentrations of concern? Anesth Analg 82(6): 1268-1272, 1996.
9. Culley DJ, Yukhananov RY, Xie Z, Gali RR, Tanzi RE and Crosby G: Altered hippocampal gene expression 2 days after general anesthesia in rats. Eur J Pharmacol 549(1-3): 71-78, 2006. (Pubitemid 44441270)
10. Rampil IJ, Moller DH and Bell AH: Isoflurane modulates genomic expression in rat Amygdala. Anesth Analg 102: 1431-1438, 2006.
11. Kádár B, Gombos K, Szele E, Beregi A, Varga Z, Sebestyén A and Ember I: Effects of isoflurane exposure on oncogene and tumour suppressor gene expressions in vital organs of CBA/CA mice. In Vivo 21(5): 861-865, 2007.
12. Kotani N, Hashimoto H, Sessler DI, Yasuda T, Ebina T, Muraoka M and Matsuki A: Expression of genes for proinflammatory cytokines in alveolar macrophages during propofol and isoflurane anesthesia. Anesth Analg 89(5): 1250-1256, 1999. (Pubitemid 29521949)
13. Hamaya Y, Takeda T, Dohi S, Nakashima S and Nozawa Y: The effects of pentobarbital, isoflurane, and propofol on immediate-early gene expression in the vital organs of the rat. Anesth Analg 90(5): 1177-1183, 2000. (Pubitemid 30253473)
14. Boost KA, Leipold T, Scheiermann P, Hoegl S, Sadik CD, Hofstetter C and Zwissler B: Sevoflurane and isoflurane decrease TNF-alpha-induced gene expression in human monocytic THP-1 cells: potential role of intracellular IkappaBalpha regulation. Int J Mol Med 23(5): 665-671, 2009.
15. Greten FR and Karin M: The IKK/NF-kappaB activation pathway-a target for prevention and treatment of cancer. Cancer Lett 206(2): 193-199, 2004. (Pubitemid 38317289)
16. Pelech SL, Charest DL and Mordret GP: Networking with mitogen-activated protein kinases. Mol Cell Biochem 128: 157-169, 1993.
17. Song L, Li J, Zhang D, Liu ZG, Ye J, Zhan Q, Shen HM, Whiteman M and Huang C: IKKβ programs to turn on the GADD45α -MKK4-JNK apoptotic cascade specifically via p50 NFκBI in arsenite response. J Cell Biol 175: 607-617, 2006. (Pubitemid 44790614)
18. Ghosh S and Karin M: Missing pieces in the NF-kappaB puzzle. Cell 109: 81-96, 2002.
19. Solan NJ, Miyoshi H, Carmona EM, Bren GD and Paya CV: RelB cellular regulation and transcriptional activity are regulated by p100. J Biol Chem 277(2): 1405-1418, 2002. (Pubitemid 34968896)
20. Sanchez-Perez I, Benitah SA, Martinez-Gomariz M, Lacal JC and Perona R: Cell stress and MEKK1-mediated c-Jun activation modulate NFκB1 activity and cell viability. Mol Biol Cell 13: 2933-2945, 2002.
21. Hoerauf KH, Hartmann T, Acimovic S, Kopp A, Wiesner G, Gustorff B, Jellinek H and Krafft P: Waste gas exposure to sevoflurane and nitrous oxide during anaesthesia using the oesophageal-tracheal Combitube small adult. Br J Anaesth 86(1): 124-126, 2001. (Pubitemid 32014132)
22. Hoerauf KH, Schrögendorfer KF, Wiesner G, Gruber M, Spacek A, Kress HG and Rüdiger HW: Sister chromatid exchange in human lymphocytes exposed to isoflurane and nitrous oxide in vitro. Br J Anaesth 82(2): 268-270, 1999. (Pubitemid 29057628)