-
1
-
-
0034594978
-
A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage
-
Tanaka, H.; Arakawa, H.; Yamaguchi, T.; Shiraishi, K.; Fukuda, S.; Matsui, K.; Takei, Y.; Nakamura, Y. A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage Nature 2000, 404, 42-49
-
(2000)
Nature
, vol.404
, pp. 42-49
-
-
Tanaka, H.1
Arakawa, H.2
Yamaguchi, T.3
Shiraishi, K.4
Fukuda, S.5
Matsui, K.6
Takei, Y.7
Nakamura, Y.8
-
2
-
-
84867711090
-
Thioredoxin system in cell death progression
-
Lu, J.; Holmgren, A. Thioredoxin system in cell death progression Antioxid. Redox Signal. 2012, 17, 1738-1747
-
(2012)
Antioxid. Redox Signal.
, vol.17
, pp. 1738-1747
-
-
Lu, J.1
Holmgren, A.2
-
3
-
-
0030695172
-
Thioredoxin, A gene found overexpressed in human cancer, inhibits apoptosis in vitro and in vivo
-
Baker, A.; Payne, C. M.; Briehl, M. M.; Powis, G. Thioredoxin, A gene found overexpressed in human cancer, inhibits apoptosis in vitro and in vivo Cancer Res. 1997, 57, 5162-5167
-
(1997)
Cancer Res.
, vol.57
, pp. 5162-5167
-
-
Baker, A.1
Payne, C.M.2
Briehl, M.M.3
Powis, G.4
-
4
-
-
64049119295
-
Thioredoxin reductase: A target for gold compounds acting as potential anticancer drugs
-
Bindoli, A.; Rigobello, M. P.; Scutari, G.; Gabbiani, C.; Casini, A.; Messori, L. Thioredoxin reductase: A target for gold compounds acting as potential anticancer drugs Coord. Chem. Rev. 2009, 253, 1692-1707
-
(2009)
Coord. Chem. Rev.
, vol.253
, pp. 1692-1707
-
-
Bindoli, A.1
Rigobello, M.P.2
Scutari, G.3
Gabbiani, C.4
Casini, A.5
Messori, L.6
-
5
-
-
67649800278
-
Molecular mechanisms of thioredoxin and glutaredoxin as hydrogen donors for mammalian s phase ribonucleotide reductase
-
Avval, F. Z.; Holmgren, A. Molecular mechanisms of thioredoxin and glutaredoxin as hydrogen donors for mammalian s phase ribonucleotide reductase J. Biol. Chem. 2009, 284, 8233-8240
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 8233-8240
-
-
Avval, F.Z.1
Holmgren, A.2
-
7
-
-
0035584857
-
Reactive oxygen species, antioxidants, and the mammalian thioredoxin system
-
Nordberg, J.; Arner, E. S. Reactive oxygen species, antioxidants, and the mammalian thioredoxin system Free Radical Biol. Med. 2001, 31, 1287-1312
-
(2001)
Free Radical Biol. Med.
, vol.31
, pp. 1287-1312
-
-
Nordberg, J.1
Arner, E.S.2
-
8
-
-
70350617658
-
High levels of thioredoxin reductase 1 modulate drug-specific cytotoxic efficacy
-
Eriksson, S. E.; Prast-Nielsen, S.; Flaberg, E.; Szekely, L.; Arnér, E. S. J. High levels of thioredoxin reductase 1 modulate drug-specific cytotoxic efficacy Free Radical Biol. Med. 2009, 47, 1661-1671
-
(2009)
Free Radical Biol. Med.
, vol.47
, pp. 1661-1671
-
-
Eriksson, S.E.1
Prast-Nielsen, S.2
Flaberg, E.3
Szekely, L.4
Arnér, E.S.J.5
-
9
-
-
44449119080
-
Regulated protein denitrosylation by cytosolic and mitochondrial thioredoxins
-
Benhar, M.; Forrester, M. T.; Hess, D. T.; Stamler, J. S. Regulated protein denitrosylation by cytosolic and mitochondrial thioredoxins Science 2008, 320, 1050-1054
-
(2008)
Science
, vol.320
, pp. 1050-1054
-
-
Benhar, M.1
Forrester, M.T.2
Hess, D.T.3
Stamler, J.S.4
-
10
-
-
0035918571
-
Up-regulation of thioredoxin and thioredoxin reductase in human malignant pleural mesothelioma
-
Kahlos, K.; Soini, Y.; Säily, M.; Koistinen, P.; Kakko, S.; Pääkkö, P.; Holmgren, A.; Kinnula, V. L. Up-regulation of thioredoxin and thioredoxin reductase in human malignant pleural mesothelioma Int. J. Cancer 2001, 95, 198-204
-
(2001)
Int. J. Cancer
, vol.95
, pp. 198-204
-
-
Kahlos, K.1
Soini, Y.2
Säily, M.3
Koistinen, P.4
Kakko, S.5
Pääkkö, P.6
Holmgren, A.7
Kinnula, V.L.8
-
11
-
-
70449730274
-
P53-dependent inhibition of TrxR1 contributes to the tumor-specific induction of apoptosis by RITA
-
Hedström, E.; Eriksson, S.; Zawacka-Pankau, J.; Arnér, E. S. J.; Selivanova, G. p53-dependent inhibition of TrxR1 contributes to the tumor-specific induction of apoptosis by RITA Cell Cycle 2009, 8, 3584-3591
-
(2009)
Cell Cycle
, vol.8
, pp. 3584-3591
-
-
Hedström, E.1
Eriksson, S.2
Zawacka-Pankau, J.3
Arnér, E.S.J.4
Selivanova, G.5
-
12
-
-
33747355805
-
Selenite induces apoptosis in sarcomatoid malignant mesothelioma cells through oxidative stress
-
Nilsonne, G.; Sun, X.; Nyström, C.; Rundlöf, A.-K.; Potamitou Fernandes, A.; Björnstedt, M.; Dobra, K. Selenite induces apoptosis in sarcomatoid malignant mesothelioma cells through oxidative stress Free Radical Biol. Med. 2006, 41, 874-885
-
(2006)
Free Radical Biol. Med.
, vol.41
, pp. 874-885
-
-
Nilsonne, G.1
Sun, X.2
Nyström, C.3
Rundlöf, A.-K.4
Potamitou, F.A.5
Björnstedt, M.6
Dobra, K.7
-
13
-
-
0032562519
-
Thioredoxin redox control of cell growth and death and the effects of inhibitors
-
Powis, G.; Kirkpatrick, D. L.; Angulo, M.; Baker, A. Thioredoxin redox control of cell growth and death and the effects of inhibitors Chem. Biol. Interact. 1998, 111-112, 23-34
-
(1998)
Chem. Biol. Interact.
, vol.111-112
, pp. 23-34
-
-
Powis, G.1
Kirkpatrick, D.L.2
Angulo, M.3
Baker, A.4
-
14
-
-
23444435104
-
Inhibition of thioredoxin reductase but not of glutathione reductase by the major classes of alkylating and platinum-containing anticancer compounds
-
Witte, A.-B.; Anestal, K.; Jerremalm, E.; Ehrsson, H.; Arnér, E. S. J. Inhibition of thioredoxin reductase but not of glutathione reductase by the major classes of alkylating and platinum-containing anticancer compounds Free Radical Biol. Med. 2005, 39, 696-703
-
(2005)
Free Radical Biol. Med.
, vol.39
, pp. 696-703
-
-
Witte, A.-B.1
Anestal, K.2
Jerremalm, E.3
Ehrsson, H.4
Arnér, E.S.J.5
-
15
-
-
78049398585
-
Noble metal targeting of thioredoxin reductase - Covalent complexes with thioredoxin and thioredoxin-related protein of 14 kDa triggered by cisplatin
-
Prast-Nielsen, S.; Cebula, M.; Pader, I.; Arnér, E. S. J. Noble metal targeting of thioredoxin reductase - covalent complexes with thioredoxin and thioredoxin-related protein of 14 kDa triggered by cisplatin Free Radical Biol. Med. 2010, 49, 1765-1778
-
(2010)
Free Radical Biol. Med.
, vol.49
, pp. 1765-1778
-
-
Prast-Nielsen, S.1
Cebula, M.2
Pader, I.3
Arnér, E.S.J.4
-
16
-
-
34547644483
-
Targeting thioredoxin reductase is a basis for cancer therapy by arsenic trioxide
-
Lu, J.; Chew, E. H.; Holmgren, A. Targeting thioredoxin reductase is a basis for cancer therapy by arsenic trioxide Proc. Natl. Acad. Sci. U.S.A. 2007, 104, 12288-12293
-
(2007)
Proc. Natl. Acad. Sci. U.S.A.
, vol.104
, pp. 12288-12293
-
-
Lu, J.1
Chew, E.H.2
Holmgren, A.3
-
17
-
-
34250652117
-
Targeting the mitochondrial cell death pathway with gold compounds
-
Barnard, P. J.; Berners-Price, S. J. Targeting the mitochondrial cell death pathway with gold compounds Coord. Chem. Rev. 2007, 251, 1889-1902
-
(2007)
Coord. Chem. Rev.
, vol.251
, pp. 1889-1902
-
-
Barnard, P.J.1
Berners-Price, S.J.2
-
18
-
-
33847014053
-
Inhibition of thioredoxin reductase by auranofin induces apoptosis in cisplatin-resistant human ovarian cancer cells
-
Marzano, C.; Gandin, V.; Folda, A.; Scutari, G.; Bindoli, A.; Rigobello, M. P. Inhibition of thioredoxin reductase by auranofin induces apoptosis in cisplatin-resistant human ovarian cancer cells Free Radical Biol. Med. 2007, 42, 872-881
-
(2007)
Free Radical Biol. Med.
, vol.42
, pp. 872-881
-
-
Marzano, C.1
Gandin, V.2
Folda, A.3
Scutari, G.4
Bindoli, A.5
Rigobello, M.P.6
-
19
-
-
53649092133
-
The thioredoxin reductase inhibitor auranofin triggers apoptosis through a Bax/Bak-dependent process that involves peroxiredoxin 3 oxidation
-
Cox, A. G.; Brown, K. K.; Arner, E. S. J.; Hampton, M. B. The thioredoxin reductase inhibitor auranofin triggers apoptosis through a Bax/Bak-dependent process that involves peroxiredoxin 3 oxidation Biochem. Pharmacol. 2008, 76, 1097-1109
-
(2008)
Biochem. Pharmacol.
, vol.76
, pp. 1097-1109
-
-
Cox, A.G.1
Brown, K.K.2
Arner, E.S.J.3
Hampton, M.B.4
-
20
-
-
0036688034
-
Induction of mitochondrial permeability transition by auranofin, a Gold(I)-phosphine derivative
-
Rigobello, M. P.; Scutari, G.; Boscolo, R.; Bindoli, A. Induction of mitochondrial permeability transition by auranofin, a Gold(I)-phosphine derivative Br. J. Pharmacol. 2002, 136, 1162-1168
-
(2002)
Br. J. Pharmacol.
, vol.136
, pp. 1162-1168
-
-
Rigobello, M.P.1
Scutari, G.2
Boscolo, R.3
Bindoli, A.4
-
21
-
-
33744956073
-
Motexafin Gadolinium, A tumor-selective drug targeting thioredoxin reductase and ribonucleotide reductase
-
Hashemy, S. I.; Ungerstedt, J. S.; Avval, F. Z.; Holmgren, A. Motexafin Gadolinium, A tumor-selective drug targeting thioredoxin reductase and ribonucleotide reductase J. Biol. Chem. 2006, 281, 10691-10697
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 10691-10697
-
-
Hashemy, S.I.1
Ungerstedt, J.S.2
Avval, F.Z.3
Holmgren, A.4
-
22
-
-
33746315912
-
Undressing of phosphine gold(I) complexes as irreversible inhibitors of human disulfide reductases
-
Urig, S.; Fritz-Wolf, K.; Réau, R.; Herold-Mende, C.; Toith, K.; Davioud-Charvet, E.; Becker, K. Undressing of phosphine gold(I) complexes as irreversible inhibitors of human disulfide reductases Angew. Chem., Int. Ed. 2006, 45, 1881-1886
-
(2006)
Angew. Chem., Int. Ed.
, vol.45
, pp. 1881-1886
-
-
Urig, S.1
Fritz-Wolf, K.2
Réau, R.3
Herold-Mende, C.4
Toth, K.5
Davioud-Charvet, E.6
Becker, K.7
-
23
-
-
84865407721
-
On the biological properties of alkynyl phosphine gold (I) complexes
-
Meyer, A.; Bagowski, C. P.; Kokoschka, M.; Stefanopoulou, M.; Alborzinia, H.; Can, S.; Vlecken, D. H.; Sheldrick, W. S.; Wölfl, S.; Ott, I. On the biological properties of alkynyl phosphine gold (I) complexes Angew. Chem., Int. Ed. 2012, 51, 8895-8899
-
(2012)
Angew. Chem., Int. Ed.
, vol.51
, pp. 8895-8899
-
-
Meyer, A.1
Bagowski, C.P.2
Kokoschka, M.3
Stefanopoulou, M.4
Alborzinia, H.5
Can, S.6
Vlecken, D.H.7
Sheldrick, W.S.8
Wölfl, S.9
Ott, I.10
-
24
-
-
34548050479
-
A gold (I) phosphine complex selectively induces apoptosis in breast cancer cells: Implications for anticancer therapeutics targeted to mitochondria
-
Rackham, O.; Nichols, S. J.; Leedman, P. J.; Berners-Price, S. J.; Filipovska, A. A gold (I) phosphine complex selectively induces apoptosis in breast cancer cells: Implications for anticancer therapeutics targeted to mitochondria Biochem. Pharmacol. 2007, 74, 992-1002
-
(2007)
Biochem. Pharmacol.
, vol.74
, pp. 992-1002
-
-
Rackham, O.1
Nichols, S.J.2
Leedman, P.J.3
Berners-Price, S.J.4
Filipovska, A.5
-
25
-
-
1642452655
-
Mitochondrial thioredoxin reductase inhibition by gold(I) compounds and concurrent stimulation of permeability transition and release of cytochrome c
-
Rigobello, M. P.; Scutari, G.; Folda, A.; Bindoli, A. Mitochondrial thioredoxin reductase inhibition by gold(I) compounds and concurrent stimulation of permeability transition and release of cytochrome c Biochem. Pharmacol. 2004, 67, 689-696
-
(2004)
Biochem. Pharmacol.
, vol.67
, pp. 689-696
-
-
Rigobello, M.P.1
Scutari, G.2
Folda, A.3
Bindoli, A.4
-
26
-
-
52449114832
-
Mitochondria-targeted chemotherapeutics: The rational design of gold(I) N-heterocyclic carbene complexes that are selectively toxic to cancer cells and target protein selenols in preference to thiols
-
Hickey, J. L.; Ruhayel, R. A.; Barnard, P. J.; Baker, M. V.; Berners-Price, S. J.; Filipovska, A. Mitochondria-targeted chemotherapeutics: the rational design of gold(I) N-heterocyclic carbene complexes that are selectively toxic to cancer cells and target protein selenols in preference to thiols J. Am. Chem. Soc. 2008, 130, 12570-12571
-
(2008)
J. Am. Chem. Soc.
, vol.130
, pp. 12570-12571
-
-
Hickey, J.L.1
Ruhayel, R.A.2
Barnard, P.J.3
Baker, M.V.4
Berners-Price, S.J.5
Filipovska, A.6
-
27
-
-
77649206626
-
Stable anticancer gold (III)-porphyrin complexes: Effects of porphyrin structure
-
Sun, R. W.-Y.; Li, C. K.-L.; Ma, D.-L.; Yan, J. J.; Lok, C.-N.; Leung, C.-H.; Zhu, N.; Che, C.-M. Stable anticancer gold (III)-porphyrin complexes: effects of porphyrin structure Chem. - Eur. J. 2010, 16, 3097-3113
-
(2010)
Chem. - Eur. J.
, vol.16
, pp. 3097-3113
-
-
Sun, R.W.-Y.1
Li, C.K.-L.2
Ma, D.-L.3
Yan, J.J.4
Lok, C.-N.5
Leung, C.-H.6
Zhu, N.7
Che, C.-M.8
-
28
-
-
33644855554
-
Gold(III) Dithiocarbamate derivatives for the treatment of cancer: Solution chemistry, DNA binding, and hemolytic properties
-
Ronconi, L.; Marzano, C.; Zanello, P.; Corsini, M.; Miolo, G.; Maccai, C.; Trevisan, A.; Fregona, D. Gold(III) Dithiocarbamate derivatives for the treatment of cancer: solution chemistry, DNA binding, and hemolytic properties J. Med. Chem. 2006, 49, 1648-1657
-
(2006)
J. Med. Chem.
, vol.49
, pp. 1648-1657
-
-
Ronconi, L.1
Marzano, C.2
Zanello, P.3
Corsini, M.4
Miolo, G.5
Macca, C.6
Trevisan, A.7
Fregona, D.8
-
29
-
-
0034699549
-
Gold(III) Complexes as potential antitumor agents: Solution chemistry and cytotoxic properties of some selected gold(III) compounds
-
Messori, L.; Abbate, F.; Marcon, G.; Orioli, P.; Fontani, M.; Mini, E.; Mazzei, T.; Carotti, S.; O'Connell, T.; Zanello, P. Gold(III) Complexes as potential antitumor agents: solution chemistry and cytotoxic properties of some selected gold(III) compounds J. Med. Chem. 2000, 43, 3541-3548
-
(2000)
J. Med. Chem.
, vol.43
, pp. 3541-3548
-
-
Messori, L.1
Abbate, F.2
Marcon, G.3
Orioli, P.4
Fontani, M.5
Mini, E.6
Mazzei, T.7
Carotti, S.8
O'Connell, T.9
Zanello, P.10
-
30
-
-
0038639859
-
Gold(iii) porphyrins as a new class of anticancer drugs: Cytotoxicity, DNA binding and induction of apoptosis in human cervix epitheloid cancer cells
-
Che, C.-M.; Sun, R. W.-Y.; Yu, W.-Y.; Ko, C.-B.; Zhu, N.; Sun, H. Gold(iii) porphyrins as a new class of anticancer drugs: cytotoxicity, DNA binding and induction of apoptosis in human cervix epitheloid cancer cells Chem. Commun. 2003, 1718-1719
-
(2003)
Chem. Commun.
, pp. 1718-1719
-
-
Che, C.-M.1
Sun, R.W.-Y.2
Yu, W.-Y.3
Ko, C.-B.4
Zhu, N.5
Sun, H.6
-
31
-
-
77951999997
-
Gold compounds as anticancer agents: Chemistry, cellular pharmacology, and preclinical studies
-
Nobili, S.; Mini, E.; Landini, I.; Gabbiani, C.; Casini, A.; Messori, L. Gold compounds as anticancer agents: chemistry, cellular pharmacology, and preclinical studies Med. Res. Rev. 2010, 30, 550-580
-
(2010)
Med. Res. Rev.
, vol.30
, pp. 550-580
-
-
Nobili, S.1
Mini, E.2
Landini, I.3
Gabbiani, C.4
Casini, A.5
Messori, L.6
-
32
-
-
77956414155
-
A versatile gold synthon for acetylene C-H bond activation
-
Fortman, G. C.; Poater, A.; Levell, J. W.; Gaillard, S.; Slawin, A. M.; Samuel, I. D.; Cavallo, L.; Nolan, S. P. A versatile gold synthon for acetylene C-H bond activation Dalton Trans. 2010, 39, 10382-10390
-
(2010)
Dalton Trans.
, vol.39
, pp. 10382-10390
-
-
Fortman, G.C.1
Poater, A.2
Levell, J.W.3
Gaillard, S.4
Slawin, A.M.5
Samuel, I.D.6
Cavallo, L.7
Nolan, S.P.8
-
33
-
-
84862814291
-
Pyrroloquinoline quinone modulates the kinetic parameters of the mammalian selenoprotein thioredoxin reductase 1 and is an inhibitor of glutathione reductase
-
Xu, J.; Arnér, E. S. J. Pyrroloquinoline quinone modulates the kinetic parameters of the mammalian selenoprotein thioredoxin reductase 1 and is an inhibitor of glutathione reductase Biochem. Pharmacol. 2012, 83, 815-820
-
(2012)
Biochem. Pharmacol.
, vol.83
, pp. 815-820
-
-
Xu, J.1
Arnér, E.S.J.2
-
34
-
-
1642535437
-
Interactions of quinones with thioredoxin reductase: A challenge to the antioxidant role of the mammalian selenoprotein
-
Cenas, N.; Nivinskas, H.; Anusevicius, Z.; Sarlauskas, J.; Lederer, F.; Arnér, E. S. J. Interactions of quinones with thioredoxin reductase: a challenge to the antioxidant role of the mammalian selenoprotein J. Biol. Chem. 2004, 279, 2583-2592
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 2583-2592
-
-
Cenas, N.1
Nivinskas, H.2
Anusevicius, Z.3
Sarlauskas, J.4
Lederer, F.5
Arnér, E.S.J.6
-
35
-
-
77954355103
-
The selenium-independent inherent pro-oxidant NADPH oxidase activity of mammalian thioredoxin reductase and its selenium-dependent direct peroxidase activities
-
Cheng, Q.; Antholine, W. E.; Myers, J. M.; Kalyanaraman, B.; Arnér, E. S. J.; Myers, C. R. The selenium-independent inherent pro-oxidant NADPH oxidase activity of mammalian thioredoxin reductase and its selenium-dependent direct peroxidase activities J. Biol. Chem. 2010, 285, 21708-21723
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 21708-21723
-
-
Cheng, Q.1
Antholine, W.E.2
Myers, J.M.3
Kalyanaraman, B.4
Arnér, E.S.J.5
Myers, C.R.6
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