A gold(I) phosphine complex selectively induces apoptosis in breast cancer cells: Implications for anticancer therapeutics targeted to mitochondria

Biochemical Pharmacology

Volumn 74, Issue 7, 2007, Pages 992-1002

  Rackham, Oliver ^a   Nichols, Scott J ^a   Leedman, Peter J ^a   Berners Price, Susan J ^b   Filipovska, Aleksandra ^a,b  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^b UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

Antitumor agents; Apoptosis; Gold compounds; Mitochondria; Thioredoxin; Thioredoxin reductase

Indexed keywords

ANTINEOPLASTIC AGENT; APOPTOSIS INDUCING FACTOR; BIS[1,3 BIS(DI 2 PYRIDYLPHOSPHINO)PROPANE]GOLD CHLORIDE; CASPASE 3; CASPASE 9; GLUTATHIONE; GOLD COMPLEX; PHOSPHINE DERIVATIVE; THIOREDOXIN; THIOREDOXIN REDUCTASE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST ADENOCARCINOMA; CANCER CELL; CELL DEATH; CELL MEMBRANE DEPOLARIZATION; CONTROLLED STUDY; DEPLETION; DRUG INHIBITION; DRUG STRUCTURE; DRUG TARGETING; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LIPOPHILICITY; MITOCHONDRION; MOLECULAR DYNAMICS; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; HUMANS; MITOCHONDRIA; MOLECULAR STRUCTURE; ORGANOGOLD COMPOUNDS; PHOSPHINES; TIME FACTORS;

EID: 34548050479     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2007.07.022     Document Type: Article

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