Induction of mitochondrial permeability transition by auranofin, a Gold(I)-phosphine derivative

British Journal of Pharmacology

Volumn 136, Issue 8, 2002, Pages 1162-1168

  Rigobello, Maria Pia ^a   Scutari, Guido ^a   Boscolo, Rita ^a   Bindoli, Alberto ^a  

^a UNIVERSITY OF PADOVA   (Italy)

Author keywords

Auranofin; Calcium; Gold(I) complexes; Mitochondrial permeability transition; Selenium; Thiol groups; Thioredoxin reductase

Indexed keywords

ANTIRHEUMATIC AGENT; AURANOFIN; CALCIUM; ISOENZYME; THIOREDOXIN REDUCTASE; CALCIUM ION; CYCLOSPORIN A; DIMETHYLSULFIDE GOLD; GLUTATHIONE REDUCTASE; GOLD COMPLEX; SELENIUM DERIVATIVE; SUCCINIC ACID; THIOL DERIVATIVE; TRIETHYLPHOSPHINE GOLD; UNCLASSIFIED DRUG;

ANIMAL; ARTICLE; CELL MEMBRANE POTENTIAL; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; IN VITRO STUDY; INTRACELLULAR MEMBRANE; LIVER MITOCHONDRION; METABOLISM; MITOCHONDRION SWELLING; OXYGEN CONSUMPTION; PERMEABILITY; RAT; ULTRASTRUCTURE; ANIMAL CELL; CONTROLLED STUDY; DRUG MECHANISM; ENZYME INHIBITION; MEMBRANE PERMEABILITY; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; NONHUMAN; OXIDATION REDUCTION STATE; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS;

ANIMALS; ANTIRHEUMATIC AGENTS; AURANOFIN; CALCIUM; INTRACELLULAR MEMBRANES; ISOENZYMES; MEMBRANE POTENTIALS; MITOCHONDRIA, LIVER; MITOCHONDRIAL SWELLING; OXYGEN CONSUMPTION; PERMEABILITY; RATS; THIOREDOXIN REDUCTASE (NADPH);

EID: 0036688034     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704823     Document Type: Article

References (52)

1. Discriminatory effects of gold compounds and carriers on mitochondria isolated from different tissues
2. Preparation and assay of mammalian thioredoxin and thioredoxin reductase
3. Type I iodothyronine deiodinase is a selenocysteine-containing enzyme
4. Influence of the redox state of pyridine nucleotides on mitochondrial sulfhydryl groups and permeability transition
5. Glutathione reductase
6. Personal computer control of electrochemical detectors utilized for mitochondrial studies
7. Interaction of gold(I) with the active site of selenium-glutathione peroxidase
8. The cellular and molecular pharmacology of auranofin and related gold complexes
9. ET-18-OCH3 inhibits nuclear factor kappa B activation by 12-o-tetradecanoylphorbol-13-acetate but not by tumor necrosis factor-alpha or interleukin 1 alpha
10. Serine protease inhibition and mitochondrial dysfunction associated with cisplatin resistance in human tumor cell lines: Targets for therapy
11. Mitochondrial respiratory control and the polarographic measurement of ADP:O ratios
12. Action of cyclosporine on mitochondrial calcium fluxes
13. 2+ transport in mitochondria
14. Determination of serum proteins by means of the biuret reaction
15. Human placenta thioredoxin reductase. Isolation of the selenoenzyme, steady-state kinetics, and inhibition by therapeutic gold compounds
16. A hypothesis on the catalytic mechanism of the selenoenzyme thioredoxin reductase
17. Control of oxidative damage in rheumatoid arthritis by Gold(I)-thiolate drugs
18. Mechanisms by which mitochondria transport calcium
19. Inhibition of AP-1 binding and transcription by gold and selenium involving conserved cysteine residues in Jun and Fos
20. Thioredoxin reductase activity is decreased by selenium deficiency
21. Mechanism of alterations in isolated rat liver mitochondrial function induced by gold complexes of bidentate phosphines
22. The mechanism of acute cytotoxicity of triethylphosphine gold(I) complexes. III. Chlortriethylphosphine gold(I)-induced alterations in isolated rat liver mitochondrial functions
23. Structure and mechanism of mammalian selenium-dependent thioredoxin reductases
24. Membrane potential of mitochondria measured with an electrode sensitive to tetraphenyl phosphonium and relationship between proton electrochemical potential and phosphorylation potential in steady state
25. Auranofin
26. Antioxidant enzymes; possible mechanism of gold compound treatment in rheumatoid arthritis
27. 2+ transport by dopamine oxidation
28. Mitochondrial permeability transition and oxidative stress
29. Molecular cloning and characterization of a mitochondrial selenocysteine-containing thioredoxin reductase from rat liver
30. Water uptake and extrusion by mitochondria in relation to oxidative phosphorylation
31. Effect of auranofin, an antirheumatic drug, on neutrophil apoptosis
32. Protein measurement with the Folin phenol reagent
33. ++ transport by ruthenium red
34. The enzymatic hydrolysis of adenosine triphosphate by rat liver mitochondria. I. Activities at different pH values
35. Reactive oxygen species, antioxidants, and the mammalian thioredoxin system
36. Purification of mitochondrial thioredoxin reductase and its involvement in the redox regulation of membrane permeability
37. Mitochondrial permeability transition and release of cytochrome c induced by retinoic acids
38. Inhibition of erythrocyte selenium-glutathione peroxidase by auranofin analogues and metabolites
39. The mechanism of acute cytotoxicity of triethylphosphine gold (I) complexes. I. Characterization of triethylphosphine gold chloride-induced biochemical and morphological changes in isolated hepatocytes
40. The mechanism of acute cytotoxicity of triethylphosphine gold(I) complexes. II. Triethylphosphine gold chloride-induced alterations in mitochondrial function
41. Alloxan-induced mitochondrial permeability transition triggered by calcium, thiol oxidation, and matrix ATP
42. The stereospecific suicide inhibition of human melanoma thioredoxin reductase by 13-cis-retinoic acid
43. Ebselen, a selenoorganic compound as glutathione peroxidase mimic
44. Effect of oxidation of glutathione and membrane thiol groups on mitochondrial functions
45. Screening trial with the coordinated gold compound auranofin using mouse lymphocyte leukemia p388
46. Aurothioglucose inhibits murine thioredoxin reductase in vivo
47. Cellular association, intracellular distribution, and efflux of auranofin via sequential ligand exchange reactions
48. Role of mitochondria in the handling of gold by the kidney
49. A new selenoprotein from human lung adenocarcinoma cells: Purificatoin, properties, and thioredoxin reductase activity
50. Relation between the activities of reducing disulfides and the protection against membrane permeability transition in rat liver mitochondria
51. Rat and calf thioredoxin reductase are homologous to glutathione reductase with a carboxyl-terminal elongation containing a conserved catalytically active penultimate selenocysteine residue
52. The mitochondrial permeability transition