Pyrroloquinoline quinone modulates the kinetic parameters of the mammalian selenoprotein thioredoxin reductase 1 and is an inhibitor of glutathione reductase

Biochemical Pharmacology

Volumn 83, Issue 6, 2012, Pages 815-820

  Xu, Jianqiang ^a   Arnér, Elias S J ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Glutathione reductase; Juglone; Pyrroloquinoline quinone; Redox cycling; Selenoprotein; Thioredoxin reductase

Indexed keywords

ALANINE; CYSTEINE; GLUTATHIONE REDUCTASE; INSULIN; JUGLONE; PYRROLOQUINOLINEQUINONE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SELENOPROTEIN; SERINE; THIOREDOXIN REDUCTASE 1;

ARTICLE; CATALYSIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME METABOLISM; ENZYME SUBSTRATE COMPLEX; GEL FILTRATION; IN VIVO STUDY; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN PURIFICATION; PROTEIN TARGETING; RAT;

ANIMALS; ENZYME INHIBITORS; ESCHERICHIA COLI; GLUTATHIONE REDUCTASE; HUMANS; KINETICS; MUTATION; NAPHTHOQUINONES; OXIDATION-REDUCTION; PLASMIDS; PQQ COFACTOR; RATS; SELENOPROTEINS; THIOREDOXIN REDUCTASE 1; YEASTS;

EID: 84862814291     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2011.12.028     Document Type: Article

References (40)

1. R. Rucker, W. Chowanadisai, and M. Nakano Potential physiological importance of pyrroloquinoline quinone Altern Med Rev 14 2009 268 277
2. J.A. Duine, J. Frank, and J.K. van Zeeland Glucose dehydrogenase from Acinetobacter calcoaceticus: a 'quinoprotein' FEBS Lett 108 1979 443 446 (Pubitemid 10126524)
3. J. Killgore, C. Smidt, L. Duich, N. Romero-Chapman, D. Tinker, and K. Reiser Nutritional importance of pyrroloquinoline quinone Science 245 1989 850 852 (Pubitemid 19223660)
4. C. Anthony, and L.J. Zatman The microbial oxidation of methanol. The prosthetic group of the alcohol dehydrogenase of Pseudomonas sp. M27: a new oxidoreductase prosthetic group Biochem J 104 1967 960 969
5. C. Anthony Quinoprotein-catalysed reactions Biochem J 320 1996 697 711 (Pubitemid 27013781)
6. M. Ghosh, C. Anthony, K. Harlos, M.G. Goodwin, and C. Blake The refined structure of the quinoprotein methanol dehydrogenase from Methylobacterium extorquens at 1.94 Structure 3 1995 177 187
7. C. Anthony, and M. Ghosh The structure and function of the PQQ-containing quinoprotein dehydrogenases Prog Biophys Mol Biol 69 1998 1 21 (Pubitemid 28257706)
8. T. Ishii, M. Akagawa, Y. Naito, O. Handa, T. Takagi, and T. Mori Pro-oxidant action of pyrroloquinoline quinone: characterization of protein oxidative modifications Biosci Biotechnol Biochem 74 2010 663 666
9. C. Anthony Pyrroloquinoline quinone (PQQ) and quinoprotein enzymes Antioxid Redox Signal 3 2001 757 774 (Pubitemid 33131268)
10. K. He, H. Nukada, T. Urakami, and M.P. Murphy Antioxidant and pro-oxidant properties of pyrroloquinoline quinone (PQQ): implications for its function in biological systems Biochem Pharmacol 65 2003 67 74 (Pubitemid 35447840)
11. T. Kasahara, and T. Kato Nutritional biochemistry: a new redox-cofactor vitamin for mammals Nature 422 2003 832 (Pubitemid 36520027)
12. L.M. Felton, and C. Anthony Biochemistry: role of PQQ as a mammalian enzyme cofactor? Nature 433 2005 E10 (discussion E11-E12)
13. R. Rucker, D. Storms, A. Sheets, E. Tchaparian, and A. Fascetti Biochemistry: is pyrroloquinoline quinone a vitamin? Nature 433 2005 E10 E11 (discussion E11-E12)
14. E. Tchaparian, L. Marshal, G. Cutler, K. Bauerly, W. Chowanadisai, and M. Satre Identification of transcriptional networks responding to pyrroloquinoline quinone dietary supplementation and their influence on thioredoxin expression, and the JAK/STAT and MAPK pathways Biochem J 429 2010 515 526
15. E.S.J. Arnér Focus on mammalian thioredoxin reductases - important selenoproteins with versatile functions Biochim Biophys Acta 1790 2009 495 526
16. N. Cenas, H. Nivinskas, Z. Anusevicius, J. Sarlauskas, F. Lederer, and E.S.J. Arnér Interactions of quinones with thioredoxin reductase - a challenge to the antioxidant role of the mammalian selenoprotein J Biol Chem 279 2004 2583 2592 (Pubitemid 38114244)
17. Q. Cheng, W.E. Antholine, J.M. Myers, B. Kalyanaraman, E.S. Arnér, and C.R. Myers The selenium-independent inherent pro-oxidant NADPH oxidase activity of mammalian thioredoxin reductase and its selenium-dependent direct peroxidase activities J Biol Chem 285 2010 21708 21723
18. L. Zhong, E.S. Arnér, and A. Holmgren Structure and mechanism of mammalian thioredoxin reductase: the active site is a redox-active selenolthiol/selenenylsulfide formed from the conserved cysteine-selenocysteine sequence Proc Natl Acad Sci U S A 97 2000 5854 5859 (Pubitemid 30367488)
19. S. Gromer, L. Johansson, H. Bauer, L.D. Arscott, S. Rauch, and D.P. Ballou Active sites of thioredoxin reductases: why selenoproteins Proc Natl Acad Sci U S A 100 2003 12618 12623 (Pubitemid 37339948)
20. J. Lu, A. Holmgren, and Selenoproteins J Biol Chem 284 2009 723 727
21. K. Anestl, S. Prast-Nielsen, N. Cenas, and E.S.J. Arnér Cell death by SecTRAPs - thioredoxin reductase as a prooxidant killer of cells PLoS ONE 3 2008 e1846
22. L. Zhong, E.S.J. Arnér, J. Ljung, F. slund, and A. Holmgren Rat and calf thioredoxin reductase are homologous to glutathione reductase with a carboxyl-terminal elongation containing a conserved catalytically active penultimate selenocysteine residue J Biol Chem 273 1998 8581 8591 (Pubitemid 28176132)
23. E.S. Arnér, H. Sarioglu, F. Lottspeich, A. Holmgren, and A. Bock High-level expression in Escherichia coli of selenocysteine-containing rat thioredoxin reductase utilizing gene fusions with engineered bacterial-type SECIS elements and co-expression with the selA, selB and selC genes J Mol Biol 292 1999 1003 1016 (Pubitemid 29481713)
24. O. Rengby, L. Johansson, L.A. Carlson, E. Serini, A. Vlamis-Gardikas, and P. Karsnas Assessment of production conditions for efficient use of Escherichia coli in high-yield heterologous recombinant selenoprotein synthesis Appl Environ Microbiol 70 2004 5159 5167 (Pubitemid 39279585)
25. E.S. Arnér, and A. Holmgren Measurement of thioredoxin and thioredoxin reductase Curr Protoc Toxicol 2001 10.1002/0471140856.tx0704s05 Chapter 7:Unit 7.4
26. Q. Cheng, T. Sandalova, Y. Lindqvist, and E.S. Arnér Crystal structure and catalysis of the selenoprotein thioredoxin reductase 1 J Biol Chem 284 2009 3998 4008
27. N. Cenas, S. Prast, H. Nivinskas, J. Sarlauskas, and E.S. Arnér Interactions of nitroaromatic compounds with the mammalian selenoprotein thioredoxin reductase and the relation to induction of apoptosis in human cancer cells J Biol Chem 281 2006 5593 5603 (Pubitemid 43847656)
28. N. Cenas, H. Nivinskas, Z. Anusevicius, J. Sarlauskas, F. Lederer, and E.S. Arnér Interactions of quinones with thioredoxin reductase: a challenge to the antioxidant role of the mammalian selenoprotein J Biol Chem 279 2004 2583 2592 (Pubitemid 38114244)
29. W. Chowanadisai, K.A. Bauerly, E. Tchaparian, A. Wong, G.A. Cortopassi, and R.B. Rucker Pyrroloquinoline quinone stimulates mitochondrial biogenesis through cAMP response element-binding protein phosphorylation and increased PGC-1alpha expression J Biol Chem 285 2010 142 152
30. E.S. Suvorova, O. Lucas, C.M. Weisend, M.F. Rollins, G.F. Merrill, and M.R. Capecchi Cytoprotective Nrf2 pathway is induced in chronically txnrd 1-deficient hepatocytes PLoS One 4 2009 e6158
31. 2 involves KEAP1 disulfide formation J Biol Chem 285 2010 8463 8471
32. T. Kumazawa, T. Hiwasa, M. Takiguchi, O. Suzuki, and K. Sato Activation of Ras signaling pathways by pyrroloquinoline quinone in NIH3T3 mouse fibroblasts Int J Mol Med 19 2007 765 770
33. K. Nunome, S. Miyazaki, M. Nakano, S. Iguchi-Ariga, and H. Ariga Pyrroloquinoline quinone prevents oxidative stress-induced neuronal death probably through changes in oxidative status of DJ-1 Biol Pharm Bull 31 2008 1321 1326 (Pubitemid 351930640)
34. A. Holmgren, and J. Lu Thioredoxin and thioredoxin reductase: current research with special reference to human disease Biochem Biophys Res Commun 396 2010 120 124
35. C.H. Lillig, and A. Holmgren Thioredoxin and related molecules - from biology to health and disease Antioxid Redox Signal 9 2007 25 47 (Pubitemid 44901873)
36. J. Fang, J. Lu, and A. Holmgren Thioredoxin reductase is irreversibly modified by curcumin: a novel molecular mechanism for its anticancer activity J Biol Chem 280 2005 25284 25290 (Pubitemid 40934623)
37. J. Lu, L.V. Papp, J. Fang, S. Rodriguez-Nieto, B. Zhivotovsky, and A. Holmgren Inhibition of Mammalian thioredoxin reductase by some flavonoids: implications for myricetin and quercetin anticancer activity Cancer Res 66 2006 4410 4418
38. E. Aizenman, K.A. Hartnett, C. Zhong, P.M. Gallop, and P.A. Rosenberg Interaction of the putative essential nutrient pyrroloquinoline quinone with the N-methyl-d-aspartate receptor redox modulatory site J Neurosci 12 1992 2362 2369
39. E. Aizenman, F.E. Jensen, P.M. Gallop, P.A. Rosenberg, and L.H. Tang Further evidence that pyrroloquinoline quinone interacts with the N-methyl-d-aspartate receptor redox site in rat cortical neurons in vitro Neurosci Lett 168 1994 189 192
40. J. Park, and J.E. Churchich Pyrroloquinoline quinone (coenzyme PQQ) and the oxidation of SH residues in proteins Biofactors 3 1992 257 260