Undressing of phosphine gold(I) complexes as irreversible inhibitors of human disulfide reductases

Angewandte Chemie - International Edition

Volumn 45, Issue 12, 2006, Pages 1881-1886

  Urig, Sabine ^a   Fritz Wolf, Karin ^b   Réau, Régis ^c   Herold Mende, Christel ^d   Tóth, Katalin ^e   Davioud Charvet, Elisabeth ^d,f   Becker, Katja ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

^b MAX PLANCK INSTITUTE FOR MEDICAL RESEARCH   (Germany)

^c CNRS   (France)

^d UNIVERSITY OF HEIDELBERG   (Germany)

^e GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^f UNIV LILLE   (France)

Author keywords

Enzyme inhibitors; Gold; Medicinal chemistry; Platinum; Structure elucidation

Indexed keywords

MEDICINAL CHEMISTRY; STRUCTURE ELUCIDATION;

CELLS; CHEMOTHERAPY; DNA; ENZYME INHIBITION; GOLD; PLATINUM;

ENZYMES;

DNA; ENZYME INHIBITOR; GLUTATHIONE REDUCTASE; ORGANOGOLD COMPOUND; PHOSPHINE DERIVATIVE; RECOMBINANT PROTEIN; THIOREDOXIN REDUCTASE;

ARTICLE; BINDING SITE; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; HUMAN; METABOLISM; MUTATION; TUMOR CELL LINE; X RAY CRYSTALLOGRAPHY;

BINDING SITES; CELL LINE, TUMOR; CELL PROLIFERATION; CRYSTALLOGRAPHY, X-RAY; DNA; ENZYME INHIBITORS; GLUTATHIONE REDUCTASE; HUMANS; MODELS, MOLECULAR; MUTATION; ORGANOGOLD COMPOUNDS; PHOSPHINES; RECOMBINANT PROTEINS; THIOREDOXIN REDUCTASE (NADPH); THIOREDOXIN-DISULFIDE REDUCTASE;

EID: 33746315912     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200502756     Document Type: Article

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