Prediction of multi-target networks of neuroprotective compounds with entropy indices and synthesis, assay, and theoretical study of new asymmetric 1,2-rasagiline carbamates

International Journal of Molecular Sciences

Volumn 15, Issue 9, 2014, Pages 17035-17064

  Romero Durán, Francisco J ^a   Alonso, Nerea ^a   Caamaño, Olga ^a   García Mera, Xerardo ^a   Yañez, Matilde ^a   Prado Prado, Francisco J ^a,b   González Díaz, Humberto ^c,d  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^b UNIVERSIDAD DE QUINTANA ROO   (Mexico)

^c UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^d BASQUE FOUNDATION FOR SCIENCE   (Spain)

Author keywords

Asymmetric synthesis; CHEMBL; Markov chains; Molecular information measures; Moving averages; Multi target drugs; Neuroprotective agents; Rasagiline derivatives; Shannon entropy

Indexed keywords

1,2 RASAGILINE CARBAMATE; GLUTAMIC ACID; HYDROGEN PEROXIDE; NEUROPROTECTIVE AGENT; NEUROTOXIN; RASAGILINE; UNCLASSIFIED DRUG; CARBAMIC ACID DERIVATIVE; INDAN DERIVATIVE;

ACCURACY; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BIOLOGICAL ACTIVITY; CARBAMOYLATION; CARBON NUCLEAR MAGNETIC RESONANCE; COMPUTER ANALYSIS; DRUG DESIGN; DRUG DETERMINATION; DRUG SYNTHESIS; EMBRYO; ENTROPY; FEMALE; INFRARED SPECTROSCOPY; NERVE CELL; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; SENSITIVITY AND SPECIFICITY; STATISTICAL PARAMETERS; VALIDATION PROCESS; ALGORITHM; ANIMAL; BRAIN CORTEX; CELL CULTURE; CELL SURVIVAL; CHEMICAL MODEL; CHEMICAL STRUCTURE; COMPARATIVE STUDY; CYTOLOGY; DRUG DATABASE; DRUG SCREENING; PROCEDURES; QUANTITATIVE STRUCTURE ACTIVITY RELATION; SYNTHESIS; VALIDATION STUDY;

ALGORITHMS; ANIMALS; CARBAMATES; CELL SURVIVAL; CELLS, CULTURED; CEREBRAL CORTEX; DATABASES, PHARMACEUTICAL; DRUG EVALUATION, PRECLINICAL; ENTROPY; GLUTAMIC ACID; INDANS; MODELS, CHEMICAL; MOLECULAR STRUCTURE; NEUROPROTECTIVE AGENTS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RATS;

EID: 84907863082     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms150917035     Document Type: Article

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