TOPS-MODE model of multiplexing neuroprotective effects of drugs and experimental-theoretic study of new 1,3-rasagiline derivatives potentially useful in neurodegenerative diseases

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 7, 2013, Pages 1870-1879

  Luan, Feng ^a,b   Cordeiro, M Natália D S ^b   Alonso, Nerea ^c   García Mera, Xerardo ^c   Caamaño, Olga ^c   Romero Duran, Francisco J ^c   Yañez, Matilde ^c   González Díaz, Humberto ^d,e  

^a YANTAI UNIVERSITY   (China)

^b UNIVERSITY OF PORTO   (Portugal)

^c UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^d UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^e BASQUE FOUNDATION FOR SCIENCE   (Spain)

Author keywords

CHEMBL; Moving averages; Multi target QSAR; Multiplexing assays; Neuroprotective effects; Rasagiline derivatives

Indexed keywords

1,3 RASAGILINE DERIVATIVE; 3 (N PROPARGYLAMINO) 1 INDANOL; 3 (N,N DIPROPARGYLAMINO) 1 INDANOL; 3 (N,N DIPROPARGYLAMINO) 1 INDANYL ACETIC ACID; 3 (N,N DIPROPARGYLAMINO) 1 INDANYL BENZOIC ACID; GLUTAMIC ACID; HYDROGEN PEROXIDE; RASAGILINE; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; COMPUTER MODEL; COMPUTER PROGRAM; DATA BASE; DEGENERATIVE DISEASE; DRUG IDENTIFICATION; DRUG SCREENING; DRUG STRUCTURE; HUMAN; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PREDICTION; PROTEIN TARGETING; QUANTITATIVE STRUCTURE ACTIVITY RELATION; SENSITIVITY AND SPECIFICITY; STEREOISOMERISM;

ANIMALS; COMPUTER SIMULATION; DATABASES, PHARMACEUTICAL; DRUG DISCOVERY; HUMANS; INDANS; MODELS, BIOLOGICAL; NEURODEGENERATIVE DISEASES; NEUROPROTECTIVE AGENTS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84875219025     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.01.035     Document Type: Article

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