ANN multiplexing model of drugs effect on macrophages; Theoretical and flow cytometry study on the cytotoxicity of the anti-microbial drug G1 in spleen

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 20, 2012, Pages 6181-6194

  Tenorio Borroto, Esvieta ^a,b   Peñuelas Rivas, Claudia G ^b   Vásquez Chagoyán, Juan C ^b   Castañedo, Nilo ^c   Prado Prado, Francisco J ^a   García Mera, Xerardo ^a   González Díaz, Humberto ^a  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^b UNIVERSIDAD AUTÓNOMA DEL ESTADO DE MÉXICO   (Mexico)

^c CENTRAL UNIVERSITY OF LAS VILLAS   (Cuba)

Author keywords

Anti parasite anti microbial drug; Artificial Neural Networks; CHEMBL; Drug cytotoxicity; Flow cytometry; Multi target versus multiplexing QSAR; Multiplexing assay endpoints; Spleen macrophage

Indexed keywords

1 5 BROMOFUR 2 IL 2 BROMO 2 NITROETHENE; ANTIBIOTIC AGENT; UNCLASSIFIED DRUG;

ACCURACY; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ARTIFICIAL NEURAL NETWORK; COMPUTER MODEL; COMPUTER PROGRAM; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY TEST; DRUG DETERMINATION; FEMALE; FLOW CYTOMETRY; LINEAR NEURAL NETWORK; MACROPHAGE; MOUSE; MULTI LAYER PERCEPTRON; NONHUMAN; PREDICTION; PROBABILISTIC NEURAL NETWORK; RADIAL BASIS FUNCTION; SPLEEN; VALIDATION PROCESS;

ANIMALS; ANTI-INFECTIVE AGENTS; CELLS, CULTURED; DATABASES, CHEMICAL; FEMALE; FLOW CYTOMETRY; HUMANS; MACROPHAGES; MICE; MICE, INBRED BALB C; MODELS, THEORETICAL; NEURAL NETWORKS (COMPUTER); ROC CURVE;

EID: 84866900119     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.07.020     Document Type: Article

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