Pharmacopeial HPLC identification methods are not sufficient to detect adulterations in commercial bilberry (Vaccinium myrtillus) extracts. Anthocyanin profile provides additional clues

Fitoterapia

Volumn 99, Issue 1, 2014, Pages 124-138

  Govindaraghavan, Suresh ^a  

^a Network Nutrition Part of the IMCD Group   (Australia)

Author keywords

Adulteration; Anthocyanins; Bilberry; Blueberries; HPLC; methods; Pharmacopeial

Indexed keywords

ANTHOCYANIN; VACCINIUM MYRTILLUS EXTRACT; PLANT EXTRACT;

ARTICLE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MEDICAL LITERATURE; MOTIVATION; NONHUMAN; PRIORITY JOURNAL; VACCINIUM MYRTILLUS; CHEMISTRY; DRUG CONTAMINATION; STANDARDS;

VACCINIUM; VACCINIUM MYRTILLUS;

ANTHOCYANINS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG CONTAMINATION; PLANT EXTRACTS; VACCINIUM MYRTILLUS;

EID: 84907822112     PISSN: 0367326X     EISSN: 18736971     Source Type: Journal    
DOI: 10.1016/j.fitote.2014.09.007     Document Type: Article

References (79)

1. W.-K. Chu, S.C.M. Cheung, R.A.W. Lau, and I.F.F. Benzie Chapter 4. Bilberry (Vaccinium myrtillus L.) I.F.F. Benzie, S. Sachtel-Galor, Herbal medicine: biomolecular and clinical aspects 2nd ed. 2011 CRC Press Boca Raton, FL 55 72
2. B. Ursing Bilberries in North Sweden - countless opportunities http://viavasterbotten.se/wp-content/uploads/2011/03/Wild-berries-presentation-130328.pdf (accessed Nov 18, 2013)
3. A. Lindstrom, C. Ooyen, M.E. Lynch, and M. Blumenthal Herb supplement sales increases 5.5% in 2012: herbal supplement sales rice for 9th consecutive year; turmeric sales jump 40% in natural channel HerbalGram 99 2013 60 65
4. Research Report of Chinese Blueberry Extract Market 2009-2010 http://www.bloomberg.com/apps/news?pid=newsarchive&sid=aGYC90.qySpU (accessed Nov 18, 2013)
5. Invenire Bilberry Markets in Japan: Market Study Report for FoodWest http://oske-net-bin.directo.fi/@Bin/6a767d1b9e82d1973f3e9b50fb2bd076/1384728778/application/pdf/756555/Bilberry%20markets%20in%20Japan-12102012.pdf (accessed Nov 18, 2013)
6. M. Barrett, and Bilberry P.M. Coates, Encyclopedia of dietary supplements 2nd ed. 2010 CRC Press Boca Raton, FL 37 42
7. S. Foster, and M. Blumenthal The adulteration of commercial bilberry extracts HerbalGram 96 2012 64 73
8. R. Pace, P. Morazzoni, and G. Appendino Omne Ignotum pro manifico: getting bilberry out of the adulteration swamp 9th Annual Oxford International Conference on the Science of Botanicals 2010 (http://test.oxfordicsb.org/9th/presentations/Bilbery-Oxford.pdf (accessed Nov 12,2013))
9. s. dentali Adulteration: spotlight on bilberry Nutraceuticals World July/Aug. 2007 72 75
10. M.M. Giusti, and P. Jing Natural pigments of berries: functionality and application Y. Zhao, Berry fruit: value-added products for health promotion 2007 CRC Press Boca Raton, FL 105 146
11. C. Cassinese, E.D. Cambarieu, M. Falzoni, N. Fuzzati, R. Pace, and N. Sardone New liquid chromatography method with ultraviolet detection for analysis of anthocyanins and anthocyanidins in Vaccinium myrtillus fruit dry extracts and commercial preparations J AOAC Int 90 4 2007 911 919
12. A.K. Latti, K.R. Riihinen, and P.S. Kainulainen Analysis of anthocyanin variation wild populations of bilberry (Vaccinium myrtillus L.) in Finland J Agric Food Chem 56 1 2008 190 195
13. British Pharmacopoeia Vol. 4 2013 The Stationary Office MHRA, UK 3620 3622
14. A.K. Primetta, L. Jaakola, F.A. Ayaz, H. Inceer, and K.R. Riihinen Anthocyanin fingerprinting for authenticity studies of bilberry (Vaccinium myrtillus L.) Food Control 30 2 2013 662 667
15. US Pharmacopoeia The United States Pharmacopoeial Convention, Rockville, MD 2014
16. D. Müller, M. Schantz, and E. Rhichling High performance liquid chromatography analysis of anthocyanins in bilberries (Vaccinium myrtillus L.), blueberries (V. corymbosum), and corresponding juices J Food Sci 77 4 2012 C340 C345
17. 3-induced kidney damage in mice J Agric Food Chem 56 2 2008 420 425
18. D. Burdulis, L. Ivanauskas, V. Dirse, S. Kazlauskas, and A. Razukas Study of diversity of anthocyanin composition in bilberry (Vaccinium myrtillus L.) fruits Medicine (Kaunas) 43 12 2007 971 977
19. A. Bunea, D.O. Rugina, A.M. Pintea, Z. Sconta, C.I. Bunea, and C. Socaciu Comparative polyphenolic content and antioxidant activities of some wild and cultivated blueberries from Romania Not Bot Hortic Agrobot 39 2 2011 70 76
20. Y. Li, and Y. Hong The current status and future of blueberry industry in China K.E. Hummer, B.C. Strik, C.E. Finn, Proceedings of the IX International Vaccinium Symposium ISHS Acta Horticulturae 810 2009 445 456
21. K. Hayashi, and X.V. Anthocyanins Uliginosiun, a new dye from the berries of Vaccinium uliginosum Acta Phytochim 15 1949 35 39
22. O. Andersen Anthocyanins in fruits of Vaccinium uliginosum L. (bog whortleberry) J Food Sci 52 3 1987 665 680
23. A.K. Latti, L. Jaakola, K.R. Riihinen, and P.S. Kainulainen Anthocyanin and flavonol variation in bog bilberries (Vaccinium uliginosum L.) in Finland J Agric Food Chem 58 1 2010 427 433
24. L. Rui, W. Ping, G. Qing-qi, and W. Zhen-yu Anthocyanin composition and content of the Vaccinium uliginosum berry Food Chem 125 1 2011 116 120
25. J. Liu, W. Zhang, H. Jing, and D.G. Popovich Bog bilberry (Vaccinium uliginosum L.) extract reduces culture HP-G2, Caco-2 and 3T3-L1 cell viability, affects cell cycle progression and has variable effects on membrane permeability J Food Sci 75 3 2010 H103 H107
26. X. Zu, Z. Zhang, X. Zhang, M. Yoshioka, Y. Yang, and J. Li Anthocyanins extracted from Chinese blueberry (Vaccinium uliginosum L.) and its anticancer effects on DLD-1 and COLO205 cells Chin Med J 123 19 2010 2714 2719
27. G. Skrede, R.E. Wrolstad, and R.W. Durst Changes in anthocyanins and polyphenolics during juice processing of highbush blueberries (Vaccinium corymbosum L.) J Food Sci 65 2 2000 357 364
28. G.G. Yousef, A.G. Brown, Y. Funakoshi, F. Mbeunkui, M.H. Grace, J.R. Ballington, and et al. Efficient quantification of the health-relevant anthocyanin and phenolic acid profiles in commercial cultivars and breeding selections of blueberries (Vaccinium spp.) J Agric Food Chem 61 20 2013 4806 4815
29. P. Somsong Changes of anthocyanin profile in dried blueberries (Ph.D. Thesis,) 2012 The University of New South Wales
30. J. Lee, R.W. Durst, and R.E. Wrolstad Impact of juice processing on blueberry anthocyanins and polyphenolics: comparison of two pretreatments J Food Sci 67 5 2002 1660 1667
31. X. Wu, and R.L. Prior Systematic identification and characterization of anthocyanins by HPLC-ESI-MS/MS in common foods in the United States: fruits and berries J Agric Food Chem 53 7 2005 2589 2599
32. J. Nakajima, I. Tanaka, S. Seo, M. Yamazaki, and K. Saito LC/PDA/ESI-MS profiling and radical scavenging activity of anthocyanins in various berries J Biomed Biotechnol 5 2004 241 247
33. O. Anderson Chromatographic separation of anthocyanins in cowberry (Lingonberry) Vaccinium vitis-idaea L. J Food Sci 50 5 1985 1230 1232
34. M.P. Kahkonen Berry anthocyanins: isolation, identification and antioxidant activities J Sci Food Agric 83 14 2003 1403 1411
35. H.M. Lehtonen, M. Rantala, J.P. Suomela, M. Vitanen, and H. Kallio Urinary excretion of the main anthocyanin in lingonberry (Vaccinium vitis-idaea), cyanidin-3-O-galactoside, and its metabolites J Agric Food Chem 57 10 2009 4447 4451
36. A.M. Bakowska-Barczak, M. Marianchuk, and P. Kolodziejczyk Survey of bioactive components in western Canadian berries Can J Physiol Pharmacol 85 11 2007 1139 1152
37. K. Bronnum-Hansen, and S.H. Hansen High performance liquid chromatographic separation of anthocyanins of Sambucus nigra L. J Chromatogr 262 1983 385 392
38. A. Chandra, J. Rana, and Y. Li Separation, identification, quantification and method validation of anthocyanins in botanical supplement raw materials by HPLC and HPLC-MS J Agric Food Chem 49 8 2001 3515 3521
39. J. Lee, and C.E. Finn Anthocyanins and other polyphenolics in American elderberry (Sambucus canadensis) and European elderberry (S. nigra) cultivars J Sci Food Agric 87 14 2007 2665 2675
40. R. Veberic, J. Jakopic, F. Stampar, and V. Schmitzer European elderberry (Sambucus nigra L.) rich in sugars, organic acids, anthocyanins and selected polyphenols Food Chem 114 2 2009 511 515
41. W. Song, H.-J. Wang, P. Bucheli, P.-F. Zhang, D.-Z. Wei, and Y.-H. Lu Phytochemical profiles of different mulberry (Morus sp.) species from China J Agric Food Chem 57 19 2009 9133 9140
42. C. Qin, Y. Li, W. Niu, Y. Ding, R. Zhang, and X. Shang Analysis and characterization of anthocyanins in mulberry fruit Czech J Food Sci 28 2 2010 117 126
43. N.F. Engmann, Y.-K. Ma, X. Ying, and Y. Qing Investigating the effect of high hydrostatic pressure processing on anthocyanins composition of mulberry (Morus, Moraceae) juice Czech J Food Sci 31 1 2013 72 80
44. I. Khan, and E.M. Calvey Analytical methodologies to detect adulteration in dietary supplements 11th Annual Fera/JIFSAN Symposium June 16-18 2010 (http://fera.co.uk/events/pastConferences/documents/eCalvey.pdf (accessed November 12, 2013))
45. Z. Hou, P. Qin, Y. Zhang, S. Cui, and G. Ren Identification of anthocyanins isolated from black rice (Oryza sativa L.) and their degradation kinetics Food Res Int 50 2 2013 691 697
46. M.G. Choung, I.-Y. Baek, S.-T. Kang, W.-Y. Han, D.-C. Shin, H.-P. Moon, and et al. Isolation and determination of anthocyanins in seed coats of black soybean (Glycine max (L.) Merr.) J Agric Food Chem 49 12 2001 5848 5851
47. K. Yoshida, Y. Sato, R. Okuno, K. Kameda, M. Isobe, and T. Kondo Structural analysis and measurement of anthocyanins from colored seed coats of Vigna, Phaseolus, and Glycine legumes Biosci Biotechnol Biochem 60 4 1996 589 593
48. T.J. Ha, J.H. Le, S.-O. Shin, S.-H. Shin, S.I. Han, H.-T. Kim, and et al. Changes in anthocyanin and isoflavone concentrations in black seed-coated soybean at different planting locations J Crop Sci Biotechnol 12 2 2009 79 86
49. J.H. Lee, N.S. Kang, S.-O. Shin, S.-H. Shin, S.-G. Lim, D.-Y. Suh, and et al. Characterisation of anthocyanins in black soybean (Glycine max L.) by HPLC-DAD-ESI/MS analysis Food Chem 112 1 2009 226 231
50. M. Escribano-Bailon, C. Santos-Buelga, and J.C. Rivas-Gonzalo Anthocyanin in cereals J Chromatogr A 1054 1-2 2004 129 141
51. E.M. Abdel-Aal, J.C. Young, and I. Rabalski Anthocyanin composition in black, blue, pink, purple and red cereal grains J Agric Food Chem 54 13 2006 4696 4704
52. H.R. Juliani, C.R. Welch, Q. Wu, B. Diouf, D. Lalainy, and J.E. Simon Chemistry and quality of Hibiscus (Hibiscus sabdariffa) for developing the natural-product industry in Senegal J Food Sci 74 2 2009 S113 S121
53. I.C. Rodriguez-Medina, R. Beltran-Debon, V.M. Molina, C. Alonso Villaverde, J. Joven, J.A. Menendez, and et al. Direct characterization of aqueous extract of Hibiscus sabdariffa using HPLC with diode array detection coupled to ESI and ion trap MS J Sep Sci 32 20 2009 3441 3448
54. A. Segura-Carretero, M.A. Puertas-Mejia, S. Cortacero-Ramirez, R. Beltran, C. Alonso-Villaverde, J. Joven, and et al. Selective extraction, separation and identification of anthocyanins from Hibiscus sabdariffa L. using solid phase-extraction-capillary electrophoresis-mass spectrometry (time-of-flight/ion trap) Electrophoresis 29 13 2008 2852 2861
55. L. Gao, and G. Mazza Characterisation of acetylated anthocyanins in lowbush blueberries J Liq Chromatogr 18 2 1995 245 259
56. D. Fracassetti, C. Del Bo, P. Simonetti, C. Gardana, D. Klimis-Zacas, and S. Ciappellano Effect of time and storage temperature on anthocyanin decay and antioxidant activity of wild blueberry (Vaccinium angustifolium) powder J Agric Food Chem 61 12 2013 2999 3005
57. J.M. Kong, L.-S. Chia, N.-K. Goh, T.-F. Chia, and R. Brouillard Analysis and biological activities of anthocyanins Phytochemistry 64 5 2003 923 933
58. K.G. Penman, C.W. Halstead, A. Matthias, J.J. De Voss, J.M. Stuthe, and K.M. Bone Lehmann RP bilberry adulteration using the food dye amaranth J Agric Food Chem 54 19 2006 7378 7382
59. M. Jordheim, N.H. Giske, and O.M. Anderson Anthocyanins in Caprifoliaceae Biochem Syst Ecol 35 3 2007 153 159
60. M.T. Escribano-Bailon, C. Alcalde-Eon, O. Munz, J.C. Rivas-Gonzalo, and C. Santos-Buelga Anthocyanins in berries of Maqui (Aristotelia chilensis (Mol.) Stuntz.) Phytochem Anal 17 1 2006 8 14
61. Z. Su Anthocyanins and flavonoids of Vaccinium L. Pharm Crops 3 2012 7 37
62. L. Cabrita, and O.M. Anderson Anthocyanins in blue berries of Vaccinium padifolium Phytochemistry 52 8 1999 1693 1696
63. M. Yamamoto, K. Yamaura, M. Ishiwatai, M. Shimada, S. Kado, H. Seki, and et al. Degradation index for quality evaluation of commercial dietary supplements of bilberry extract J Food Sci 78 3 2013 S477 S483
64. A. Primetta Phenolic compounds in the berries of the selected Vaccinium species. The potential for authenticity analysis (Ph.D. thesis) 2014 University of Eastern Finland 104
65. T.J. Hagerand, and L.R. Howard Chapter3. Berry fruit phytochemicals Y. Zhao, Berry fruit: value-added products for health promotion 2007 CRC Press Boca Raton, FL 73 104
66. J. Lee, and R.E. Wrolstad Extraction of anthocyanins and polyphenolics from blueberry processing waste J Food Sci 69 7 2004 564 573
67. Y. Zhao Berry fruit: value-added products for health promotion 2004 CRC Press Boca Raton, FL 430
68. Y. Yoshimura, N. Zaima, T. Moriyama, and Y. Kawamura Different localization patterns of anthocyanin species in the pericarp of black rice revealed by imaging mass spectrometry PLoS One 7 2 2012 e31285 (1-9)
69. F. Shahidi, and M. Naczk Phenolics in food and nutraceuticals 2004 CRC Press Boca Raton, FL 566
70. M.G. Choung, I.-Y. Baek, S.-T. Kang, W.-Y. Han, D.-C. Shin, H.-P. Moon, and et al. Isolation and determination of anthocyanins in seed coats of black soybean (Glycine max (L.) Merr.) J Agric Food Chem 49 12 2001 5848 5851
71. J. Lee, and C.E. Finn Lingonberry (Vaccinium vitis-idaea L.) grown in the Pacific Northwest of North America: anthocyanin and free amino acid composition J Funct Foods 4 1 2012 213 218
72. A.K. Latti, L.A. Jaakola, R. Kaisu, K.R. Riihinen, and P.S. Kainulainen Anthocyanin and flavonol variation in bog bilberries (Vaccinium uliginosum L.) in Finland J Agric Food Chem 58 1 2010 427 433
73. C. Hu, J. Zawistowski, W. Ling, and D.D. Kitts Black rice (Oryza sativa L. indica) pigmented fraction suppresses both reactive oxygen species and nitric oxide in chemical and biological model systems J Agric Food Chem 51 18 2003 5271 5277
74. G. Gradinaru, C.G. Biliaderis, S. Kallithraka, P. Kefalas, and Garcia-Viguera Thermal stability of Hibiscus sabdariffa L. anthocyanins in solution and in solid state: effects of copigmentation and glass transition Food Chem 83 3 2003 423 436
75. H.R. Juliani, C.R. Welch, Q. Wu, B. Diouf, D. Malainy, and J.E. Simon Chemistry and quality of Hibiscus (Hibiscus sabdariffa) for developing the natural product industry in Senegal J Food Sci 74 2 2009 S113 S121
76. P. Aramwit, N. Bang, and T. Srichana The properties and stability of anthocyanins in mulberry fruits Food Res Int 43 4 2010 1093 1097
77. W. Yuan, L. Zhou, G. Deng, P. Wang, D. Creech, and S. Li Anthocyanins, phenolics and antioxidant capacity of Vaccinium L. in Texas, USA Pharm Crops 2 2011 11 23
78. A. Pena, G. Garcia, M. Luz Romero, and S. Capella Reversed-phase ion-pair chromatography of anthocyanins in red wines J Chromatogr Sci 35 1997 161 164
79. H. Mizuno, K. Hirano, and G. Okamoto Effect of anthocyanin composition in grape skin on anthocyanic vacuolar inclusion development and skin coloration Vitis 45 4 2006 173 177