Integrative "omic" analysis of experimental bacteremia identifies a metabolic signature that distinguishes human sepsis from systemic inflammatory response syndromes

American Journal of Respiratory and Critical Care Medicine

Volumn 190, Issue 4, 2014, Pages 445-455

  Langley, Raymond J ^a   Tipper, Jennifer L ^a   Bruse, Shannon ^a   Baron, Rebecca M ^b   Tsalik, Ephraim L ^c,d,e   Huntley, James ^f   Rogers, Angela J ^b,g   Jaramillo, Richard J ^a   O'Donnell, Denise ^a   Mega, William M ^a   Keaton, Mignon ^h   Kensicki, Elizabeth ^h   Gazourian, Lee ^b   Fredenburgh, Laura E ^b   Massaro, Anthony F ^b   Otero, Ronny M ⁱ   Fowler, Vance G ^d,e   Rivers, Emanuel P ⁱ   Woods, Chris W ^c,d,e   Kingsmore, Stephen F ^j,k   Sopori, Mohan L ^a   Perrella, Mark A ^b   Choi, Augustine M K ^b   Harrod, Kevin S ^a   more..

^a LOVELACE RESPIRATORY RESEARCH INSTITUTE   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c DURHAM VA MEDICAL CENTER   (United States)

^d DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e DUKE UNIVERSITY   (United States)

^f UNIVERSITY OF COLORADO   (United States)

^g CHANNING LABORATORY   (United States)

^h METABOLON INC   (United States)

ⁱ HENRY FORD HEALTH SYSTEM   (United States)

^j CHILDREN S MERCY HOSPITAL   (United States)

^k UNIVERSITY OF MISSOURI KANSAS CITY SCHOOL OF MEDICINE   (United States)

more..

Author keywords

Bacteremia; Metabolomics; Mitochondrial dysfunction; Nonhuman primates; Transcriptomics

Indexed keywords

1 STEAROYL GLYCEROPHOSPHOCHOLINE; BIOLOGICAL MARKER; FATTY ACID; ISOVALERYLCARNITINE; KYNURENINE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; TAUROLITHOCHOLATE 3 SULFATE; TRANSCRIPTOME; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; AUTOPSY; BACTEREMIA; BLOOD; BLOOD SAMPLING; CATABOLISM; CONTROLLED STUDY; DEATH; EARLY DIAGNOSIS; ESCHERICHIA COLI; ESCHERICHIA COLI INFECTION; INFLAMMATION; INTRAHEPATIC CHOLESTASIS; KIDNEY; LETHARGY; LIVER FUNCTION; LUNG; LUNG EDEMA; LUNG EXTRAVASCULAR FLUID; LUNG HEMORRHAGE; LUNG INJURY; MACACA FASCICULARIS; MALE; METABOLOME; METABOLOMICS; MITOCHONDRION; MORTALITY; NONHUMAN; PNEUMONIA; PRIMATE; PRIORITY JOURNAL; RESPIRATORY DISTRESS; SEPSIS; SIGNAL TRANSDUCTION; SPLEEN; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; TISSUE INJURY; TRANSCRIPTOMICS; ANIMAL; COHORT ANALYSIS; DISEASE MODEL; FEMALE; HUMAN; MACACA; METHODOLOGY; MITOCHONDRIAL DYSFUNCTION; NONHUMAN PRIMATES; PHYSIOLOGY;

BACTEREMIA; METABOLOMICS; MITOCHONDRIAL DYSFUNCTION; NONHUMAN PRIMATES; TRANSCRIPTOMICS;

ANIMALS; BACTEREMIA; BIOLOGICAL MARKERS; COHORT STUDIES; DISEASE MODELS, ANIMAL; EARLY DIAGNOSIS; FEMALE; HUMANS; MACACA; MALE; METABOLOMICS; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; TRANSCRIPTOME;

EID: 84907821372     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201404-0624OC     Document Type: Article

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