Blockade of tissue factor-factor X binding attenuates sepsis-induced respiratory and renal failure

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 290, Issue 1, 2006, Pages

  Welty Wolf, Karen E ^a   Carraway, Martha S ^a   Ortel, Thomas L ^a   Ghio, Andrew J ^a   Idell, Steven ^b   Egan, Jack ^c   Zhu, Xiaoyun ^c   Jiao, Jin An ^c   Wong, Hing C ^c   Piantadosi, Claude A ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS AT TYLER   (United States)

^c Sunol Molecular Corporation   (United States)

Author keywords

Adult respiratory distress syndrome; Multiple organ failure; Papio; Septicemia; Thromboplastin

Indexed keywords

ANTIBIOTIC AGENT; BLOOD CLOTTING FACTOR 10; BLOOD CLOTTING FACTOR 7A; CEFTAZIDIME; FIBRINOGEN; GENTAMICIN; INTERLEUKIN 6; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; MONOCLONAL ANTIBODY; MONOCLONAT ANTIBODY CH36; THROMBOPLASTIN; UNCLASSIFIED DRUG; AUTACOID; CYTOKINE; IMMUNOGLOBULIN F(AB) FRAGMENT;

ACUTE LUNG INJURY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BABOON; CONTROLLED STUDY; DISEASE ASSOCIATION; DRUG MECHANISM; ESCHERICHIA COLI; GAS EXCHANGE; KIDNEY FAILURE; KIDNEY PRESERVATION; LUNG COMPLIANCE; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; RESPIRATORY FAILURE; SEPSIS; ANIMAL; BLOOD; CAPILLARY PERMEABILITY; CELL CULTURE; CIRCULATION; DRUG ANTAGONISM; DRUG EFFECT; ENDOTHELIUM CELL; ENTEROBACTER INFECTION; HUMAN; IMMUNOLOGY; METABOLISM; MICROBIOLOGY; PAPIO; PATHOLOGY; PATHOPHYSIOLOGY;

ANIMALS; ANTIBODIES, MONOCLONAL; BLOOD CIRCULATION; CAPILLARY PERMEABILITY; CELLS, CULTURED; CYTOKINES; ENDOTHELIAL CELLS; ESCHERICHIA COLI INFECTIONS; FACTOR X; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; INFLAMMATION MEDIATORS; KIDNEY FAILURE; LIPOPOLYSACCHARIDES; MALE; PAPIO; RESPIRATORY INSUFFICIENCY; THROMBOPLASTIN;

EID: 33644789491     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00155.2005     Document Type: Article

References (39)

1. Abraham E, Reinhart K, Opal S, Demeyer I, Doig C, Rodriguez AL, Beale R, Svoboda P, Laterre PF, Simon S, Light B, Spapen H, Stone J, Seibert A, Peckelsen C, De Deyne C, Postier R, Pettila V, Artigas A, Percell SR, Shu V, Zwingelstein C, Tobias J, Poole L, Stolzenbach JC, and Creasey AA. Efficacy and safety of tifacogin (recombinant tissue factor pathway inhibitor) in severe sepsis: a randomized controlled trial. JAMA 290: 238-247, 2003.
2. Ahamed J and Ruf W. Protease activated receptor 2 dependent phosphorylation of the tissue factor cytoplasmic domain. J Biol Chem 279: 23038-23044, 2004.
3. 2 release from human respiratory epithelial cells. J Immunol 168: 3577-3585, 2002.
4. Bachofen M and Weibel ER. Structural alterations of lung parenchyma in the adult respiratory distress syndrome. Clin Chest Med 3: 35-56, 1982.
5. Camerer E, Rottingen JA, Gjernes E, Larsen K, Skartlien AH, Iverson JG, and Prydz H. Coagulation factors VIIa and Xa induce cell signaling leading to up-regulation of the egr-1 gene. J Biol Chem 274: 32225-32233, 1999.
6. Camerer E, Huang W, and Coughlin SR. Tissue factor- and factor X-dependent activation of protease-activated receptor 2 by factor VIIa. Proc Natl Acad Sci USA 97: 5255-5260, 2000.
7. Camerer E, Kataoka H, Kahn M, Lease K, and Coughlin SR. Genetic evidence that protease-activated receptors mediate factor Xa signaling in endothelial cells. J Biol Chem 277: 16081-16087, 2002.
8. Carraway MS, Welty-Wolf KE, Kantrow SP, Huang YCT, Simonson SG, Que LG, Kishimoto TK, and Piantadosi CA. Antibody to E- and L-selectin does not prevent lung injury or mortality in septic baboons. Am J Respir Crit Care Med 157: 938-949, 1998.
9. Carraway MS, Welty-Wolf KE, Miller DL, Ortel TL, Idell S, Ghio AJ, Petersen LC, and Piantadosi CA. Blockade of tissue factor: treatment for organ injury in established sepsis. Am J Respir Crit Care Med 167: 1200-1209, 2003.
10. Chapman HA, Stahl M, Allen CL, Yee R, and Fair DS. Regulation of procoagulant activity within the bronchoalveolar compartment of normal human lung. Am Rev Respir Dis 137: 1417-1425, 1988.
11. Chi L, Li Y, Stehno-Bittel L, Gao J, Morrison DC, Stechschulte DJ, and Dileepan KN. Interleukin-6 production by endothelial cells via stimulation of protease-activated receptors is amplified by endotoxin and tumor necrosis factor α. J Interferon Cytokine Res 21: 231-240, 2001.
12. Cirino G, Cicala C, Bucci M, Sorrentino L, Ambrosini G, DeDominicis G, and Altieri DC. Factor Xa as an interface between coagulation and inflammation. Molecular mimicry of factor Xa association with effector cell protease receptor-1 induces acute inflammation in vivo. J Clin Invest 99: 2446-2451, 1997.
13. Colognato R, Slupsky JR, Jendrach M, Burysek L, Syrovets T, and Simmet T. Differential expression and regulation of protease-activated receptors in human peripheral monocytes and monocyte-derived antigen-presenting cells. Blood 102: 2645-2652, 2003.
14. Drake TA, Morrissey JH, and Edginton TS. Selective cellular expression of tissue factor in human tissues. Implications for disorders of hemostasis and thrombosis. Am J Pathol 134: 1087-1097, 1989.
15. Duchosal MA, Rothermal AL, McConahey PJ, Dixon FJ, and Altieri DC. In vivo immunosuppression by targeting a novel protease receptor. Nature 380: 352-356, 1996.
16. Esmon CT. Introduction: are natural anticoagulants candidates for modulating the inflammatory response to endotoxin? Blood 95: 1113-1116, 2000.
17. Herbert JM, Bono F, Herault JP, Avril C, Dol F, Mares A, and Schaeffer P. Effector protease receptor 1 mediates the mitogenic activity of factor Xa for vascular smooth muscle cells in vitro and in vivo. J Clin Invest 101: 993-1000, 1998.
18. Hjortoe GM, Petersen LC, Albrektsen T, Sorensen BB, Norby PL, Mandal SK, Pendurthi UR, and Rao LVM. Tissue factor-factor VIIa-specific up-regulation of IL-8 expression in MDA-MB-231 cells is mediated by PAR-2 and results in increased cell migration. Blood 103: 3029-3037, 2004.
19. Idell S, James KK, Levin EG, Schwartz BS, Manchanda N, Maunder RJ, Martin TR, McLarty J, and Fair DS. Local abnormalities in coagulation and fibrinolytic pathways predispose to alveolar fibrin deposition in the adult respiratory distress syndrome. J Clin Invest 84: 695-705, 1989.
20. Idell S. Extravascular coagulation and fibrin deposition in acute lung injury. New Horiz 2: 566-574, 1994.
21. Levi M, van der Poll T, ten Cate H, Kuipers B, Biemond BJ, Jansen HM, and ten Cate JW. Differential effects of anti-cytokine treatment on bronchoalveolar hemostasis in endotoxemic chimpanzees. Am J Respir Crit Care Med 158: 92-98, 1998.
22. McGee MP and Rothberger H. Tissue factor in bronchoalveolar lavage fluids. Evidence for an alveolar macrophage source. Am Rev Respir Dis 131: 331-336, 1985.
23. Nicholson AC, Nachman RL, Altieri DC, Summers BD, Ruf W, Edgington TS, and Hajjar DP. Effector cell protease receptor 1 is a vascular receptor for coagulation factor Xa. J Biol Chem 271: 28407-28413, 1996.
24. Ossovskaa VS and Bunnett NW. Protease-activated receptors: contribution to physiology and disease. Physiol Rev 84: 579-621, 2003.
25. Pawlinski R, Pedersen B, Schabbauer G, Tencati M, Holscher T, Boisvert W, Andrade-Gordon P, Frank RD, and Mackman N. Role of tissue factor and protease-activated receptors in a mouse model of endotoxemia. Blood 103: 1342-1347, 2004.
26. Peterson LC, Freskgard PO, and Ezban M. Tissue factor-dependent factor VIIa signaling. Trends Cardiovasc Med 10: 47-52, 2000.
27. Riewald M, Kravchenko VV, Petrovan RJ, O'Brien PJ, Brass LF, Ulevitch RJ, and Ruf W. Gene induction by coagulation factor Xa is mediated by activation of protease-activated receptor 1. Blood 97: 3109-3116, 2001.
28. Riewald M and Ruf W. Mechanistic coupling of protease signaling and initiation of coagulation by tissue factor. Proc Natl Acad Sci USA 98: 7743-7747, 2001.
29. Ruf W and Reiwald M. Tissue factor-dependent coagulation protease signaling in acute lung injury. Crit Care Med 31: S231-S237, 2003.
30. Ruf W, Dorfleutner A, and Riewald M. Specificity of coagulation factor signaling. J Thromb Haemost 1: 1495-1503, 2003.
31. Simonson SG, Huang YCT, Fracica PJ, Welty-Wolf KE, Moon RE, Young SL, and Piantadosi CA. Changes in the lung after prolonged positive pressure ventilation in normal baboons. J Crit Care 12: 72-82, 1997.
32. Taylor FB Jr, Chang ACK, Peer G, Mather T, Blick K, Catlett R, Lockhart MS, and Esmon CT. DEGR-factor Xa blocks disseminated intravascular coagulation initiated by Escherichia coli without preventing shock or organ damage. Blood 78: 362-368, 1991.
33. Vogel SM, Gao X, Mehta D, Ye RD, John TA, Andrade-Gordon P, Tiruppathi C, and Malik AB. Abrogation of thrombin-induced increase in pulmonary microvascular permeability in PAR-1 knockout mice. Physiol Genomics 4: 137-145, 2000.
34. Warren BL, Eid A, Singer P, Pillay SS, Carl P, Novak I, Chalupa P, Atherstone A, Penzes I, Kubler A, Knaub S, Keinecke HO, Heinrichs H, Schindel F, Juers M, Bone R, and Opal S. High-dose antithrombin III in severe sepsis: a randomized controlled trial. JAMA 286: 1869-1878, 2001.
35. Welty-Wolf KE, Carraway MS, Huang YCT, Simonson SG, Kantrow SP, and Piantadosi CA. Bacterial priming increases lung injury in gram negative sepsis. Am J Respir Crit Care Med 158: 610-619, 1998.
36. Welty-Wolf KE, Carraway MS, Ghio A, Kantrow SP, Huang YCT, and Piantadosi CA. Pro-inflammatory cytokines increase in sepsis after anti-adhesion molecule therapy. Shock 13: 404-409, 2000.
37. Welty-Wolf KE, Carraway MS, Huang YCT, Simonson SG, Kantrow SP, Kishimoto TK, and Piantadosi CA. Antibody to intercellular molecule-1 (CD54) decreases survival and not lung injury in baboons with sepsis. Am J Respir Crit Care Med 163: 665-673, 2001.
38. Welty-Wolf KE, Carraway MS, Miller DL, Ortel TL, Ezban M, Ghio AJ, Idell S, and Piantadosi CA. Coagulation blockade prevents sepsis-induced respiratory and renal failure in baboons. Am J Respir Crit Care Med 164: 1988-1996, 2001.
39. Welty-Wolf KE, Carraway MS, Ortel TL, and Piantadosi CA. Coagulation and inflammation in acute lung injury. Thromb Haemost 88: 17-25, 2002.