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Volumn 14, Issue 1-2, 2013, Pages 25-35

Titanium dioxide nanoparticles and the oral uptake-route

Author keywords

cytotoxicity; nano Ti02; oral uptake route; translocation; uptake mechanisms

Indexed keywords


EID: 84907815710     PISSN: 21930651     EISSN: 2193066X     Source Type: Journal    
DOI: 10.1515/bnm-2013-0005     Document Type: Article
Times cited : (7)

References (87)
  • 3
    • 84905856988 scopus 로고    scopus 로고
    • Industrial ventilation: a manual of recommended practice
    • 24th ed. Ohio, USA: Cincinnati
    • ACGIH. Industrial ventilation: a manual of recommended practice. American conference of governmental industrial hygenists, 24th ed. Ohio, USA: Cincinnati, 2011.
    • (2011) American conference of governmental industrial hygenists
  • 5
    • 0003774753 scopus 로고    scopus 로고
    • US Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute of Occupational Safety and Health, DHHS (NIOSH), Cincinnati, Ohio, USA Publication No. 2002–140
    • NIOSH. National Institute for Occupational Safety and Health, NIOSH pocket guide to chemical hazards and other databases. US Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute of Occupational Safety and Health, DHHS (NIOSH), Cincinnati, Ohio, USA Publication No. 2002–140, 2002.
    • (2002) NIOSH pocket guide to chemical hazards and other databases
  • 6
    • 60649113053 scopus 로고    scopus 로고
    • Pulmonary response to intratracheal instillation of ultrafine versus fine titanium dioxide: role of particle surface area
    • DOI: 10.1186/1743–8977–5–17
    • Sager T, Kommineni C, Castranova V. Pulmonary response to intratracheal instillation of ultrafine versus fine titanium dioxide: role of particle surface area. Part Fibre Toxicol 2008;5:17. DOI: 10.1186/1743–8977–5–17.
    • (2008) Part Fibre Toxicol , vol.5 , pp. 17
    • Sager, T.1    Kommineni, C.2    Castranova, V.3
  • 8
    • 34047254664 scopus 로고    scopus 로고
    • Synthesis of TiO2 nanoparticles by hydrolysis and peptization of titanium isopropoxide solution
    • Mahshid S, Askari M, Ghamsari MS. Synthesis of TiO2 nanoparticles by hydrolysis and peptization of titanium isopropoxide solution. J Mater Process Technol 2007;189: 296–300.
    • (2007) J Mater Process Technol , vol.189 , pp. 296-300
    • Mahshid, S.1    Askari, M.2    Ghamsari, M.S.3
  • 9
    • 79960984721 scopus 로고    scopus 로고
    • Toxicological effects of titanium dioxide nanoparticles: a review of in vivo studies
    • Iavicoli L, Leso V, Bergamaschi A. Toxicological effects of titanium dioxide nanoparticles: a review of in vivo studies. J Nanomater 2011;15:481–508.
    • (2011) J Nanomater , vol.15 , pp. 481-508
    • Iavicoli, L.1    Leso, V.2    Bergamaschi, A.3
  • 10
    • 47949120856 scopus 로고    scopus 로고
    • Translocation and cellular entering mechanisms of nanoparticles in the respiratory tract
    • Mühlfeld C, Gehr P, Rothen-Rutishauser B. Translocation and cellular entering mechanisms of nanoparticles in the respiratory tract. Swiss Med Wkly 2008;138:387–391.
    • (2008) Swiss Med Wkly , vol.138 , pp. 387-391
    • Mühlfeld, C.1    Gehr, P.2    Rothen-Rutishauser, B.3
  • 11
    • 35448957273 scopus 로고    scopus 로고
    • Translocation of particles and inflammatory responses after exposure to fine particles and nanoparticles in an epithelial airway model
    • DOI: 10.1186/1743–8977–4–9
    • Rothen-Rutishauser B, Mühlfeld C, Blank F, Musso C, Gehr P. Translocation of particles and inflammatory responses after exposure to fine particles and nanoparticles in an epithelial airway model. Part Fibre Toxicol 2007;4:9. DOI: 10.1186/1743–8977–4–9.
    • (2007) Part Fibre Toxicol , vol.4 , pp. 9
    • Rothen-Rutishauser, B.1    Mühlfeld, C.2    Blank, F.3    Musso, C.4    Gehr, P.5
  • 12
    • 84155162845 scopus 로고    scopus 로고
    • Models for oral uptake of nanoparticles in consumer products
    • Fröhlich E, Roblegg E. Models for oral uptake of nanoparticles in consumer products. Toxicology 2012;291:10–17.
    • (2012) Toxicology , vol.291 , pp. 10-17
    • Fröhlich, E.1    Roblegg, E.2
  • 13
    • 72849144722 scopus 로고    scopus 로고
    • Modeled environmental concentrations of engineered nanomaterials (TiO2, ZnO, Ag, CNT, Fullerenes) for different regions
    • Gottschalk F, Sonderer T, Scholz RW, Nowack B. Modeled environmental concentrations of engineered nanomaterials (TiO2, ZnO, Ag, CNT, Fullerenes) for different regions. Environ Sci Technol 2009;43:9216–9222.
    • (2009) Environ Sci Technol , vol.43 , pp. 9216-9222
    • Gottschalk, F.1    Sonderer, T.2    Scholz, R.W.3    Nowack, B.4
  • 14
    • 77649185962 scopus 로고    scopus 로고
    • Origin and fate of dietary nanoparticles and microparticles in the gastrointestinal tract
    • Powell JJ, Faria N, Thomas-McKay E, Pele LC. Origin and fate of dietary nanoparticles and microparticles in the gastrointestinal tract. J Autoimmun 2010;34:J226–33.
    • (2010) J Autoimmun , vol.34 , pp. J226-33
    • Powell, J.J.1    Faria, N.2    Thomas-McKay, E.3    Pele, L.C.4
  • 15
    • 0034532004 scopus 로고    scopus 로고
    • Determination of titanium dioxide in foods using inductively coupled plasma optical emission spectrometry
    • Lomer MC, Thompson RP, Commisso J, Keen CL, Powell JJ. Determination of titanium dioxide in foods using inductively coupled plasma optical emission spectrometry. Analyst 2000;125:2339–2343.
    • (2000) Analyst , vol.125 , pp. 2339-2343
    • Lomer, M.C.1    Thompson, R.P.2    Commisso, J.3    Keen, C.L.4    Powell, J.J.5
  • 16
    • 11144290160 scopus 로고    scopus 로고
    • Dietary sources of inorganic microparticles and their intake in healthy subjects and patients with Crohn's disease
    • Lomer MC, Hutchinson C, Volkert S, Greenfield SM, Catterall A, Thompson RP, et al. Dietary sources of inorganic microparticles and their intake in healthy subjects and patients with Crohn's disease. Br J Nutr 2004;92:947–955.
    • (2004) Br J Nutr , vol.92 , pp. 947-955
    • Lomer, M.C.1    Hutchinson, C.2    Volkert, S.3    Greenfield, S.M.4    Catterall, A.5    Thompson, R.P.6
  • 17
    • 40149088170 scopus 로고    scopus 로고
    • On the formation and extent of uptake of silver nanoparticles by live plants
    • Harris AT, Bali R. On the formation and extent of uptake of silver nanoparticles by live plants. J Nanopart Res 2008;10:691–695.
    • (2008) J Nanopart Res , vol.10 , pp. 691-695
    • Harris, A.T.1    Bali, R.2
  • 20
    • 0023388554 scopus 로고
    • The surface area of the adult human mouth and thickness of the salivary film covering the teeth and oral mucosa
    • Collins LM, Dawes C. The surface area of the adult human mouth and thickness of the salivary film covering the teeth and oral mucosa. J Dent Res 1987;66:1300–1302.
    • (1987) J Dent Res , vol.66 , pp. 1300-1302
    • Collins, L.M.1    Dawes, C.2
  • 21
    • 0026564618 scopus 로고
    • Drug delivery via the mucous membranes of the oral cavity
    • Harris D, Robinson JR. Drug delivery via the mucous membranes of the oral cavity. J Pharm Sci 1992;81:1–10.
    • (1992) J Pharm Sci , vol.81 , pp. 1-10
    • Harris, D.1    Robinson, J.R.2
  • 22
    • 0026045125 scopus 로고
    • Cellular and molecular basis of barrier function in oral epithelium
    • Wertz PW, Squier CA. Cellular and molecular basis of barrier function in oral epithelium. Crit Rev Ther Drug Carrier Syst 1991;8:237–269.
    • (1991) Crit Rev Ther Drug Carrier Syst , vol.8 , pp. 237-269
    • Wertz, P.W.1    Squier, C.A.2
  • 23
    • 0030320982 scopus 로고    scopus 로고
    • The tissue and cell defense mechanisms of the oral mucosa]
    • Bykov VL. [The tissue and cell defense mechanisms of the oral mucosa]. Morfologiia 1996;110:14–24.
    • (1996) Morfologiia , vol.110 , pp. 14-24
    • Bykov, V.L.1
  • 24
    • 0007921761 scopus 로고    scopus 로고
    • The functional morphology of the epithelial barrier of the oral mucosa]
    • Bykov VL. [The functional morphology of the epithelial barrier of the oral mucosa]. Stomatologiia (Mosk) 1997;76:12–17.
    • (1997) Stomatologiia (Mosk) , vol.76 , pp. 12-17
    • Bykov, V.L.1
  • 25
    • 0000966788 scopus 로고
    • Bioadhesion in drug delivery
    • Ghandi R, Robinson J. Bioadhesion in drug delivery. Ind J Pharm Sci 1988;3:145–152.
    • (1988) Ind J Pharm Sci , vol.3 , pp. 145-152
    • Ghandi, R.1    Robinson, J.2
  • 26
    • 0029421236 scopus 로고
    • Regional variation in content, composition and organization of porcine epithelial barrier lipids revealed by thin-layer chromatography and transmission electron microscopy
    • Law S, Wertz PW, Swartzendruber DC, Squier CA. Regional variation in content, composition and organization of porcine epithelial barrier lipids revealed by thin-layer chromatography and transmission electron microscopy. Arch Oral Biol 1995;40:1085–1091.
    • (1995) Arch Oral Biol , vol.40 , pp. 1085-1091
    • Law, S.1    Wertz, P.W.2    Swartzendruber, D.C.3    Squier, C.A.4
  • 27
    • 0027686847 scopus 로고
    • Regional variation in the structure and permeability of oral mucosa and skin
    • Wertz PW, Swartzendruber DC, Squier CA. Regional variation in the structure and permeability of oral mucosa and skin. Adv Drug Deliv Rev 1993;12:1–12.
    • (1993) Adv Drug Deliv Rev , vol.12 , pp. 1-12
    • Wertz, P.W.1    Swartzendruber, D.C.2    Squier, C.A.3
  • 28
    • 84860794749 scopus 로고    scopus 로고
    • Evaluation of a physiological in vitro system to study the transport of nanoparticles through the buccal mucosa
    • Roblegg E, Fröhlich E, Meindl C, Teubl B, Zaversky M, Zimmer A. Evaluation of a physiological in vitro system to study the transport of nanoparticles through the buccal mucosa. Nanotoxicology 2012;6:399–413.
    • (2012) Nanotoxicology , vol.6 , pp. 399-413
    • Roblegg, E.1    Fröhlich, E.2    Meindl, C.3    Teubl, B.4    Zaversky, M.5    Zimmer, A.6
  • 30
    • 34548279896 scopus 로고    scopus 로고
    • Toxicity of titanium dioxide nanoparticles to rainbow trout (Oncorhynchus mykiss): Gill injury, oxidative stress, and other physiological effects
    • Federici G, Shaw BJ, Handy RD. Toxicity of titanium dioxide nanoparticles to rainbow trout (Oncorhynchus mykiss): Gill injury, oxidative stress, and other physiological effects. Aquat Toxicol 2007;84:415–430.
    • (2007) Aquat Toxicol , vol.84 , pp. 415-430
    • Federici, G.1    Shaw, B.J.2    Handy, R.D.3
  • 31
    • 45849128316 scopus 로고    scopus 로고
    • Titanium dioxide nanoparticles trigger p53-mediated damage response in peripheral blood lymphocytes
    • Kang SJ, Kim BM, Lee YJ, Chung HW. Titanium dioxide nanoparticles trigger p53-mediated damage response in peripheral blood lymphocytes. Environ Mol Mutagen 2008;49:399–405.
    • (2008) Environ Mol Mutagen , vol.49 , pp. 399-405
    • Kang, S.J.1    Kim, B.M.2    Lee, Y.J.3    Chung, H.W.4
  • 32
    • 0030840483 scopus 로고    scopus 로고
    • Toxicity and cytogenetic studies of ultrafine titanium dioxide in cultured rat liver epithelial cells
    • Linnainmaa K, Kivipensas P, Vainio H. Toxicity and cytogenetic studies of ultrafine titanium dioxide in cultured rat liver epithelial cells. Toxicol in Vitro 1997;11:329–335.
    • (1997) Toxicol in Vitro , vol.11 , pp. 329-335
    • Linnainmaa, K.1    Kivipensas, P.2    Vainio, H.3
  • 33
    • 72249115549 scopus 로고    scopus 로고
    • Titanium dioxide nanoparticles induce DNA damage and genetic instability in vivo in mice
    • Trouiller B, Reliene R, Westbrook A, Solaimani P, Schiestl RH. Titanium dioxide nanoparticles induce DNA damage and genetic instability in vivo in mice. Cancer Res 2009;69:8784–8789.
    • (2009) Cancer Res , vol.69 , pp. 8784-8789
    • Trouiller, B.1    Reliene, R.2    Westbrook, A.3    Solaimani, P.4    Schiestl, R.H.5
  • 34
    • 34447321045 scopus 로고    scopus 로고
    • Development of a base set of toxicity tests using ultrafine TiO2 particles as a component of nanoparticle risk management
    • Warheit DB, Hoke RA, Finlay C, Donner EM, Reed KL, Sayes CM. Development of a base set of toxicity tests using ultrafine TiO2 particles as a component of nanoparticle risk management. Toxicol Lett 2007;171:99–110.
    • (2007) Toxicol Lett , vol.171 , pp. 99-110
    • Warheit, D.B.1    Hoke, R.A.2    Finlay, C.3    Donner, E.M.4    Reed, K.L.5    Sayes, C.M.6
  • 35
    • 33746255334 scopus 로고    scopus 로고
    • Titanium dioxide (P25) produces reactive oxygen species in immortalized brain microglia (BV2): implications for nanoparticle neurotoxicity
    • Long TC, Saleh N, Tilton RD, Lowry GV, Veronesi B. Titanium dioxide (P25) produces reactive oxygen species in immortalized brain microglia (BV2): implications for nanoparticle neurotoxicity. Environ Sci Technol 2006;40:4346–4352.
    • (2006) Environ Sci Technol , vol.40 , pp. 4346-4352
    • Long, T.C.1    Saleh, N.2    Tilton, R.D.3    Lowry, G.V.4    Veronesi, B.5
  • 36
    • 79952748335 scopus 로고    scopus 로고
    • The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host-microbial interactions
    • Johansson MEV, Larsson JMH, Hansson GC. The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host-microbial interactions. Proc Natl Acad Sci USA 2010;108:4659–4665.
    • (2010) Proc Natl Acad Sci USA , vol.108 , pp. 4659-4665
    • Johansson, M.E.V.1    Larsson, J.M.H.2    Hansson, G.C.3
  • 37
    • 60149111908 scopus 로고    scopus 로고
    • Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues
    • Lai SK, Wang Y-Y, Hanes J. Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues. Adv Drug Deliv Rev 2009;61:158–171.
    • (2009) Adv Drug Deliv Rev , vol.61 , pp. 158-171
    • Lai, S.K.1    Wang, Y.-Y.2    Hanes, J.3
  • 39
    • 0034734982 scopus 로고    scopus 로고
    • Lectin-mediated mucosal delivery of drugs and microparticles
    • Clark MA, Hirst BH, Jepson MA. Lectin-mediated mucosal delivery of drugs and microparticles. Adv Drug Delivery Rev 2000;43:207–223.
    • (2000) Adv Drug Delivery Rev , vol.43 , pp. 207-223
    • Clark, M.A.1    Hirst, B.H.2    Jepson, M.A.3
  • 40
    • 0035026232 scopus 로고    scopus 로고
    • The adherent gastrointestinal mucus gel layer: thickness and physical state in vivo
    • Atuma C, Strugala V, Allen A, Holm L. The adherent gastrointestinal mucus gel layer: thickness and physical state in vivo. Am J Physiol-Gastr L 2001;280:G922–9.
    • (2001) Am J Physiol-Gastr L , vol.280 , pp. G922-9
    • Atuma, C.1    Strugala, V.2    Allen, A.3    Holm, L.4
  • 41
    • 0344551246 scopus 로고    scopus 로고
    • Individual variations in mucosa and total wall thickness in the stomach and rectum assessed via endoscopic ultrasound
    • Huh CH, Bhutani MS, Farfan EB, Bolch WE. Individual variations in mucosa and total wall thickness in the stomach and rectum assessed via endoscopic ultrasound. Physiol Meas 2003;24:N15–22.
    • (2003) Physiol Meas , vol.24 , pp. N15-22
    • Huh, C.H.1    Bhutani, M.S.2    Farfan, E.B.3    Bolch, W.E.4
  • 42
    • 0030471901 scopus 로고    scopus 로고
    • Gastrointestinal uptake of biodegradable microparticles: effect of particle size
    • Desai MP, Labhasetwar V, Amidon GL., Levy RJ. Gastrointestinal uptake of biodegradable microparticles: effect of particle size. Pharm Res 1996;13:1838–1845.
    • (1996) Pharm Res , vol.13 , pp. 1838-1845
    • Desai, M.P.1    Labhasetwar, V.2    Amidon, G.L.3    Levy, R.J.4
  • 43
    • 0031469673 scopus 로고    scopus 로고
    • The Mechanism of Uptake of Biodegradable Microparticles in Caco-2 Cells Is Size Dependent
    • Desai MP, Labhasetwar V, Walter E, Levy RJ, Amidon GL. The Mechanism of Uptake of Biodegradable Microparticles in Caco-2 Cells Is Size Dependent. Pharm Res 1997;14:1568–1573.
    • (1997) Pharm Res , vol.14 , pp. 1568-1573
    • Desai, M.P.1    Labhasetwar, V.2    Walter, E.3    Levy, R.J.4    Amidon, G.L.5
  • 45
    • 29244468833 scopus 로고    scopus 로고
    • Uptake and transport of PEG-graft-trimethyl-chitosan copolymer-insulin nanocomplexes by epithelial cells
    • Mao S, Germershaus O, Fischer D, Linn T, Schnepf R, Kissel T. Uptake and transport of PEG-graft-trimethyl-chitosan copolymer-insulin nanocomplexes by epithelial cells. Pharm Res 2005;22:2058–2068.
    • (2005) Pharm Res , vol.22 , pp. 2058-2068
    • Mao, S.1    Germershaus, O.2    Fischer, D.3    Linn, T.4    Schnepf, R.5    Kissel, T.6
  • 47
    • 34447631504 scopus 로고    scopus 로고
    • Endocytosis, oxidative stress and IL-8 expression in human lung epithelial cells upon treatment with fine and ultrafine TiO2: role of the specific surface area and of surface methylation of the particles
    • Singh S, Shi T, Duffin R, Albrecht C, van Berlo D, Höhr D, et al. Endocytosis, oxidative stress and IL-8 expression in human lung epithelial cells upon treatment with fine and ultrafine TiO2: role of the specific surface area and of surface methylation of the particles. Toxicol Appl Pharmacol 2007;222:141–151.
    • (2007) Toxicol Appl Pharmacol , vol.222 , pp. 141-151
    • Singh, S.1    Shi, T.2    Duffin, R.3    Albrecht, C.4    van Berlo, D.5    Höhr, D.6
  • 49
    • 71449088260 scopus 로고    scopus 로고
    • Cytotoxicity and oxidative DNA damage by nanoparticles in human intestinal Caco-2 cells
    • Gerloff K, Albrecht C, Boots AW, Förster I, Schins RPF. Cytotoxicity and oxidative DNA damage by nanoparticles in human intestinal Caco-2 cells. Nanotoxicology 2009;3:355–364.
    • (2009) Nanotoxicology , vol.3 , pp. 355-364
    • Gerloff, K.1    Albrecht, C.2    Boots, A.W.3    Förster, I.4    Schins, R.P.F.5
  • 52
    • 79952745367 scopus 로고    scopus 로고
    • Endocytosis of titanium dioxide nanoparticles in prostate cancer PC-3M cells
    • Thurn KT, Arora H, Paunesku T, Wu A, Brown EM, Doty C, et al. Endocytosis of titanium dioxide nanoparticles in prostate cancer PC-3M cells. Nanomedicine 2011;7:123–130.
    • (2011) Nanomedicine , vol.7 , pp. 123-130
    • Thurn, K.T.1    Arora, H.2    Paunesku, T.3    Wu, A.4    Brown, E.M.5    Doty, C.6
  • 53
    • 77951910654 scopus 로고    scopus 로고
    • Intracellular distribution, geno-and cytotoxic effects of nanosized titanium dioxide particles in the anatase crystal phase on human nasal mucosa cells
    • Hackenberg S, Friehs G, Froelich K, Ginzkey C, Koehler C, Scherzed A, et al. Intracellular distribution, geno-and cytotoxic effects of nanosized titanium dioxide particles in the anatase crystal phase on human nasal mucosa cells. Toxicol Lett 2010;195:9–14.
    • (2010) Toxicol Lett , vol.195 , pp. 9-14
    • Hackenberg, S.1    Friehs, G.2    Froelich, K.3    Ginzkey, C.4    Koehler, C.5    Scherzed, A.6
  • 54
    • 67349144664 scopus 로고    scopus 로고
    • Size-dependent toxicity of metal oxide particles-A comparison between nanoand micrometer size
    • Karlsson HL, Gustafsson J, Cronholm P, Möller L. Size-dependent toxicity of metal oxide particles-A comparison between nanoand micrometer size. Toxicol Lett 2009;188:112–118.
    • (2009) Toxicol Lett , vol.188 , pp. 112-118
    • Karlsson, H.L.1    Gustafsson, J.2    Cronholm, P.3    Möller, L.4
  • 55
  • 56
    • 70350662344 scopus 로고    scopus 로고
    • Towards a definition of inorganic nanoparticles from an environmental, health and safety perspective
    • Auffan M, Rose J, Bottero JY, Lowry GV, Jolivet J-P, Wiesner MR. Towards a definition of inorganic nanoparticles from an environmental, health and safety perspective. Nat Nanotechnol 2009;4:634–641.
    • (2009) Nat Nanotechnol , vol.4 , pp. 634-641
    • Auffan, M.1    Rose, J.2    Bottero, J.Y.3    Lowry, G.V.4    Jolivet, J.-P.5    Wiesner, M.R.6
  • 57
    • 79959609859 scopus 로고    scopus 로고
    • Cellular toxicity of TiO2 nanoparticles in anatase and rutile crystal phase
    • Jin C, Tang Y, Yang FG, Li XL, Xu S, Fan XY, et al. Cellular toxicity of TiO2 nanoparticles in anatase and rutile crystal phase. Biol Trace Elem Res 2011;141:3–15.
    • (2011) Biol Trace Elem Res , vol.141 , pp. 3-15
    • Jin, C.1    Tang, Y.2    Yang, F.G.3    Li, X.L.4    Xu, S.5    Fan, X.Y.6
  • 58
    • 31944451232 scopus 로고    scopus 로고
    • Toxic potential of materials at the nanolevel
    • Nel A, Xia T, Mädler L, Li N. Toxic potential of materials at the nanolevel. Science 2006;311:622–627.
    • (2006) Science , vol.311 , pp. 622-627
    • Nel, A.1    Xia, T.2    Mädler, L.3    Li, N.4
  • 59
    • 0035875977 scopus 로고    scopus 로고
    • The influence of titania/hydroxyapatite composite coatings on in vitro osteoblasts behaviour
    • Ramires PA, Romito A, Cosentino F, Milella E. The influence of titania/hydroxyapatite composite coatings on in vitro osteoblasts behaviour. Biomaterials 2001;22:1467–1474.
    • (2001) Biomaterials , vol.22 , pp. 1467-1474
    • Ramires, P.A.1    Romito, A.2    Cosentino, F.3    Milella, E.4
  • 60
    • 7044247906 scopus 로고    scopus 로고
    • Photocatalytic killing effect of TiO2 nanoparticles on Ls-174-t human colon carcinoma cells
    • Zhang AP, Sun YP. Photocatalytic killing effect of TiO2 nanoparticles on Ls-174-t human colon carcinoma cells. World J Gastroenterol 2004;10:3191–3193.
    • (2004) World J Gastroenterol , vol.10 , pp. 3191-3193
    • Zhang, A.P.1    Sun, Y.P.2
  • 61
    • 0034533082 scopus 로고    scopus 로고
    • Reactive oxygen species in cell signaling
    • Thannickal VJ, Fanburg BL. Reactive oxygen species in cell signaling. Am J Physiol-Lung C 2000;279:L1005–28.
    • (2000) Am J Physiol-Lung C , vol.279 , pp. L1005-28
    • Thannickal, V.J.1    Fanburg, B.L.2
  • 62
    • 0031709894 scopus 로고    scopus 로고
    • Cytotoxicity, pro-oxidant effects and antioxidant depletion in rat lung alveolar macrophages exposed to ultrafine titanium dioxide
    • Afaq F, Abidi P, Matin R, Rahman Q. Cytotoxicity, pro-oxidant effects and antioxidant depletion in rat lung alveolar macrophages exposed to ultrafine titanium dioxide. J Appl Toxicol 1998;18:307–312.
    • (1998) J Appl Toxicol , vol.18 , pp. 307-312
    • Afaq, F.1    Abidi, P.2    Matin, R.3    Rahman, Q.4
  • 63
    • 65649127246 scopus 로고    scopus 로고
    • Oxidative stress and proinflammatory effects of carbon black and titanium dioxide nanoparticles: role of particle surface area and internalized amount
    • Hussain S, Boland S, Baeza-Squiban A, Hamel R, Thomassen LC, Martens JA, et al. Oxidative stress and proinflammatory effects of carbon black and titanium dioxide nanoparticles: role of particle surface area and internalized amount. Toxicology 2009;260:142–149.
    • (2009) Toxicology , vol.260 , pp. 142-149
    • Hussain, S.1    Boland, S.2    Baeza-Squiban, A.3    Hamel, R.4    Thomassen, L.C.5    Martens, J.A.6
  • 64
    • 0035956929 scopus 로고    scopus 로고
    • Increased mitochondrial oxidative stress in the Sod2 (+/-) mouse results in the age-related decline of mitochondrial function culminating in increased apoptosis
    • Kokoszka JE, Coskun P, Esposito LA, Wallace DC. Increased mitochondrial oxidative stress in the Sod2 (+/-) mouse results in the age-related decline of mitochondrial function culminating in increased apoptosis. Proc Natl Acad Sci USA 2001;98:2278–2283.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 2278-2283
    • Kokoszka, J.E.1    Coskun, P.2    Esposito, L.A.3    Wallace, D.C.4
  • 65
    • 15044357362 scopus 로고    scopus 로고
    • Formation of nucleoplasmic protein aggregates impairs nuclear function in response to SiO2 nanoparticles
    • Chen M, von Mikecz, A. Formation of nucleoplasmic protein aggregates impairs nuclear function in response to SiO2 nanoparticles. Exp Cell Res 2005;305:51–62.
    • (2005) Exp Cell Res , vol.305 , pp. 51-62
    • Chen, M.1    von Mikecz, A.2
  • 66
    • 77957948204 scopus 로고    scopus 로고
    • Possible genotoxic mechanisms of nanoparticles: Criteria for improved test strategies
    • Donaldson K, Poland CA, Schins RPF. Possible genotoxic mechanisms of nanoparticles: Criteria for improved test strategies. Nanotoxicology 2010;4:414–420.
    • (2010) Nanotoxicology , vol.4 , pp. 414-420
    • Donaldson, K.1    Poland, C.A.2    Schins, R.P.F.3
  • 67
    • 43349098455 scopus 로고    scopus 로고
    • Impact and mechanism of TiO2 nanoparticles on DNA synthesis in vitro
    • Li S, Zhu H, Zhu R, Sun XY, Yao S, Wang S. Impact and mechanism of TiO2 nanoparticles on DNA synthesis in vitro. Sci China Ser B 2008;51:367–372.
    • (2008) Sci China Ser B , vol.51 , pp. 367-372
    • Li, S.1    Zhu, H.2    Zhu, R.3    Sun, X.Y.4    Yao, S.5    Wang, S.6
  • 68
    • 34548065681 scopus 로고    scopus 로고
    • A novel toxicological evaluation of TiO2 nanoparticles on DNA structure
    • Zhu R-R, Wang S-L, Zhang R, Sun X-Y, Yao S-D. A novel toxicological evaluation of TiO2 nanoparticles on DNA structure. Chinese J Chem 2007;25:958–961.
    • (2007) Chinese J Chem , vol.25 , pp. 958-961
    • Zhu, R.-R.1    Wang, S.-L.2    Zhang, R.3    Sun, X.-Y.4    Yao, S.-D.5
  • 69
    • 23944463473 scopus 로고    scopus 로고
    • Ultrafine titanium dioxide particles in the absence of photoactivation can induce oxidative damage to human bronchial epithelial cells
    • Gurr JR, Wang AS, Chen CH, Jan KY. Ultrafine titanium dioxide particles in the absence of photoactivation can induce oxidative damage to human bronchial epithelial cells. Toxicology 2005;213:66–73.
    • (2005) Toxicology , vol.213 , pp. 66-73
    • Gurr, J.R.1    Wang, A.S.2    Chen, C.H.3    Jan, K.Y.4
  • 70
    • 33947413465 scopus 로고    scopus 로고
    • Cytokine responses of human lung cells (BEAS-2B) treated with micron-sized and nanoparticles of metal oxides compared to soil dusts
    • DOI: 10.1186/1743–8977–4–2
    • Veranth JM, Kaser EG, Veranth MM, Koch M, Yost GS. Cytokine responses of human lung cells (BEAS-2B) treated with micron-sized and nanoparticles of metal oxides compared to soil dusts. Part Fibre Toxicol 2007;4:2. DOI: 10.1186/1743–8977–4–2.
    • (2007) Part Fibre Toxicol , vol.4 , pp. 2
    • Veranth, J.M.1    Kaser, E.G.2    Veranth, M.M.3    Koch, M.4    Yost, G.S.5
  • 71
    • 33845642987 scopus 로고    scopus 로고
    • Titanium dioxide nanoparticles induce emphysema-like lung injury in mice
    • Chen H-W, Su S-F, Chien C-T, Lin WH, Yu SL, Chou CC, et al. Titanium dioxide nanoparticles induce emphysema-like lung injury in mice. FASEB J 2006;20:2393–2395.
    • (2006) FASEB J , vol.20 , pp. 2393-2395
    • Chen, H.-W.1    Su, S.-F.2    Chien, C.-T.3    Lin, W.H.4    Yu, S.L.5    Chou, C.C.6
  • 72
    • 33750567127 scopus 로고    scopus 로고
    • Ultrafine but not fine particulate matter causes airway inflammation and allergic airway sensitization to co-administered antigen in mice
    • de Haar C, Hassing I, Bol M, Bleumink R, Pieters R. Ultrafine but not fine particulate matter causes airway inflammation and allergic airway sensitization to co-administered antigen in mice. Clin Exp Allergy 2006;36:1469–1479.
    • (2006) Clin Exp Allergy , vol.36 , pp. 1469-1479
    • de Haar, C.1    Hassing, I.2    Bol, M.3    Bleumink, R.4    Pieters, R.5
  • 74
    • 0028104529 scopus 로고
    • Correlation between particle size, in vivo particle persistence, and lung injury
    • Oberdörster G, Ferin J, Lehnert BE. Correlation between particle size, in vivo particle persistence, and lung injury. Environ Health Perspect 1994;5:173–179.
    • (1994) Environ Health Perspect , vol.5 , pp. 173-179
    • Oberdörster, G.1    Ferin, J.2    Lehnert, B.E.3
  • 75
    • 0002524169 scopus 로고    scopus 로고
    • Surface free radical activity of PM10 and ultrafine titanium dioxide: a unifying factor in their toxicity?
    • Gilmour P, Brown DM, Beswick PH, Benton E, MacNee W, Donaldson K. Surface free radical activity of PM10 and ultrafine titanium dioxide: a unifying factor in their toxicity? Ann Occup Hyg 1997;41:32–38.
    • (1997) Ann Occup Hyg , vol.41 , pp. 32-38
    • Gilmour, P.1    Brown, D.M.2    Beswick, P.H.3    Benton, E.4    MacNee, W.5    Donaldson, K.6
  • 76
    • 33847256798 scopus 로고    scopus 로고
    • Cyto-and genotoxicity of ultrafine TiO2 particles in cultured human lymphoblastoid cells
    • Wang JJ, Sanderson BJS, Wang H. Cyto-and genotoxicity of ultrafine TiO2 particles in cultured human lymphoblastoid cells. Mutat Res-Gen Tox En 2007;628:99–106.
    • (2007) Mutat Res-Gen Tox En , vol.628 , pp. 99-106
    • Wang, J.J.1    Sanderson, B.J.S.2    Wang, H.3
  • 77
    • 77956012861 scopus 로고    scopus 로고
    • Neurotoxicological effects and the impairment of spatial recognition memory in mice caused by exposure to TiO2 nanoparticles
    • Hu R, Gong X, Duan Y, Li N, Che Y, Cui Y, et al. Neurotoxicological effects and the impairment of spatial recognition memory in mice caused by exposure to TiO2 nanoparticles. Biomaterials 2010;31:8043–8050.
    • (2010) Biomaterials , vol.31 , pp. 8043-8050
    • Hu, R.1    Gong, X.2    Duan, Y.3    Li, N.4    Che, Y.5    Cui, Y.6
  • 78
    • 84875352123 scopus 로고    scopus 로고
    • Intragastric exposure to titanium dioxide nanoparticles induced nephrotoxicity in mice, assessed by physiological and gene expression modifications
    • Gui S, Sang X, Zheng L, Ze Y, Zhao Xi, Sheng L, et al. Intragastric exposure to titanium dioxide nanoparticles induced nephrotoxicity in mice, assessed by physiological and gene expression modifications. Part. Fibre Toxicol. 2013;10:4.
    • (2013) Part. Fibre Toxicol , vol.10 , pp. 4
    • Gui, S.1    Sang, X.2    Zheng, L.3    Ze, Y.4    Xi, Z.5    Sheng, L.6
  • 79
    • 77949399860 scopus 로고    scopus 로고
    • NMR-based metabonomic study of the sub-acute toxicity of titanium dioxide nanoparticles in rats after oral administration
    • Bu Q, Yan G, Deng P, Peng F, Lin H, Xu Y, et al. NMR-based metabonomic study of the sub-acute toxicity of titanium dioxide nanoparticles in rats after oral administration. Nanotechnology 2010;21:125105.
    • (2010) Nanotechnology , vol.21 , pp. 125105
    • Bu, Q.1    Yan, G.2    Deng, P.3    Peng, F.4    Lin, H.5    Xu, Y.6
  • 80
    • 70649101217 scopus 로고    scopus 로고
    • Toxicological characteristics of nanoparticulate anatase titanium dioxide in mice
    • Duan Y, Liu J, Ma L, Li N, Liu H, Wang J, et al. Toxicological characteristics of nanoparticulate anatase titanium dioxide in mice. Biomaterials 2010;31:894–899.
    • (2010) Biomaterials , vol.31 , pp. 894-899
    • Duan, Y.1    Liu, J.2    Ma, L.3    Li, N.4    Liu, H.5    Wang, J.6
  • 81
    • 78649604711 scopus 로고    scopus 로고
    • Signaling pathway of inflammatory responses in the mouse liver caused by TiO2 nanoparticles
    • Cui Y, Liu H, Zhou M, Duan Y, Li N, Gong X, et al. Signaling pathway of inflammatory responses in the mouse liver caused by TiO2 nanoparticles. J Biomed Mater Res A 2011;96A:221–229.
    • (2011) J Biomed Mater Res A , vol.96A , pp. 221-229
    • Cui, Y.1    Liu, H.2    Zhou, M.3    Duan, Y.4    Li, N.5    Gong, X.6
  • 82
    • 77956446944 scopus 로고    scopus 로고
    • Hepatocyte apoptosis and its molecular mechanisms in mice caused by titanium dioxide nanoparticles
    • Cui Y, Gong X, Duan Y, Li N, Hu R, Liu H, et al. Hepatocyte apoptosis and its molecular mechanisms in mice caused by titanium dioxide nanoparticles. J Hazard Mater 2010;183:874–880.
    • (2010) J Hazard Mater , vol.183 , pp. 874-880
    • Cui, Y.1    Gong, X.2    Duan, Y.3    Li, N.4    Hu, R.5    Liu, H.6
  • 83
    • 79954607728 scopus 로고    scopus 로고
    • P38-Nrf-2 Signaling Pathway of Oxidative Stress in Mice Caused by Nanoparticulate TiO2
    • Wang J, Li N, Zheng L, Wang S, Wang Y, Zhao X, et al. P38-Nrf-2 Signaling Pathway of Oxidative Stress in Mice Caused by Nanoparticulate TiO2. Biol. Trace Elem. Res. 2011;140:186–197.
    • (2011) Biol. Trace Elem. Res , vol.140 , pp. 186-197
    • Wang, J.1    Li, N.2    Zheng, L.3    Wang, S.4    Wang, Y.5    Zhao, X.6
  • 84
    • 0028222754 scopus 로고
    • Titanium dioxide (rutile) particle uptake from the rat GI tract and translocation to systemic organs after oral administration
    • Jani PU, McCarthy DE, Florence AT. Titanium dioxide (rutile) particle uptake from the rat GI tract and translocation to systemic organs after oral administration. Int J Pharm 1994;105:157–168.
    • (1994) Int J Pharm , vol.105 , pp. 157-168
    • Jani, P.U.1    McCarthy, D.E.2    Florence, A.T.3
  • 85
    • 33846131928 scopus 로고    scopus 로고
    • Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administration
    • Wang J, Zhou G, Chen C, Yu H, Wang T, Ma Y, et al. Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administration. Toxicol Lett 2007;168: 176–185.
    • (2007) Toxicol Lett , vol.168 , pp. 176-185
    • Wang, J.1    Zhou, G.2    Chen, C.3    Yu, H.4    Wang, T.5    Ma, Y.6
  • 86
    • 0036850471 scopus 로고    scopus 로고
    • Long-term pulmonary responses of three laboratory rodent species to subchronic inhalation of pigmentary titanium dioxide particles
    • Bermudez E, Mangum JB, Asgharian B, Wong BA, Reverdy EE, Janszen DB, et al. Long-term pulmonary responses of three laboratory rodent species to subchronic inhalation of pigmentary titanium dioxide particles. Toxicol Sci 2002;70:86–97.
    • (2002) Toxicol Sci , vol.70 , pp. 86-97
    • Bermudez, E.1    Mangum, J.B.2    Asgharian, B.3    Wong, B.A.4    Reverdy, E.E.5    Janszen, D.B.6
  • 87
    • 0030296418 scopus 로고    scopus 로고
    • Subchronic inhalation of high concentrations of low toxicity, low solubility participates produces sustained pulmonary inflammation and cellular proliferation
    • Warheit DB, Yuen IS, Kelly DP, Snajdr S, Hartsky MA. Subchronic inhalation of high concentrations of low toxicity, low solubility participates produces sustained pulmonary inflammation and cellular proliferation. Toxicol Lett 1996;88:249–253.
    • (1996) Toxicol Lett , vol.88 , pp. 249-253
    • Warheit, D.B.1    Yuen, I.S.2    Kelly, D.P.3    Snajdr, S.4    Hartsky, M.A.5


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