Cytotoxicity, pro-oxidant effects and antioxidant depletion in rat lung alveolar macrophages exposed to ultrafine titanium dioxide

Journal of Applied Toxicology

Volumn 18, Issue 5, 1998, Pages 307-312

  Afaq, F ^a   Abidi, P ^a   Matin, R ^a   Rahman, Q ^a  

^a CSIR INDIAN INSTITUTE OF TOXICOLOGY RESEARCH   (India)

Author keywords

Alveolar macrophages; Oxidative stress; Reactive oxygen species; Ultrafine titanium dioxide

Indexed keywords

ACID PHOSPHATASE; ANTIOXIDANT; CELL ENZYME; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; HYDROGEN PEROXIDE; LACTATE DEHYDROGENASE; TITANIUM DIOXIDE;

ANIMAL CELL; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; ENZYME INDUCTION; FEMALE; LIPID PEROXIDATION; LUNG ALVEOLUS MACROPHAGE; LUNG LAVAGE; LUNG TOXICITY; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT;

ANIMALS; COLORING AGENTS; FEMALE; GLUTATHIONE TRANSFERASE; L-LACTATE DEHYDROGENASE; LIPID PEROXIDATION; MACROPHAGES, ALVEOLAR; OXIDATION-REDUCTION; OXIDATIVE STRESS; PARTICLE SIZE; RATS; TITANIUM;

EID: 0031709894     PISSN: 0260437X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-1263(1998090)18:5<307::AID-JAT508>3.0.CO;2-K     Document Type: Article

References (46)

1. M. Hedenborg, Titanium dioxide induced chemiluminescence of human polymorphonuclear leukocytes. Int. Arch. Occup. Environ. Health 61, 1-6 (1988).
2. J. Ferin and G. Oberdorster, Biological effects and toxicity assessment of titanium dioxides; anatase and rutile. Am. Ind. Hyg. Assoc. J. 46, 69-72 (1985).
3. R. C. Lindenschmidt, K. E. Driscoll, M. A. Perkins, J. M. Higgins, J. K. Mourer and K. A. Belfiore. The comparison of a fibrogenic and two non-fibrogenic dusts by bronchoalveolar lavage. Toxicol. Appl. Pharmacol. 102, 268-281 (1990).
4. E. M. Ophus, L. E. Rode, B. Gylseth, G. Nicholson and K. Saeed, Analysis of titanium pigments in human lung tissue. Scand. J. Work Environ. Health 5, 290-296 (1979).
5. L. E. Rode, E. M. Ophus and B. Glyseth, Massive pulmonary deposition of rutile after titanium dioxide exposure. Arch. Pathol. Microbiol. Scand. Sect. A 89, 455-461 (1981).
6. G. Oberdorster, J. Ferin, R. Gelein, S. C. Soderholm and J. Finkelstein, Role of the alveolar macrophage in lung injury: studies with ultrafine particles. Environ. Health Perspect. 97, 193-199 (1992).
7. K. E. Driscoll, J. K. Maurer, R. C. Lindenschmidt, D. Romberger, S. I. Rennard and L. Crosby, Respiratory tract responses to dust: relationships between dust burden, lung injury, alveolar macrophages fibronectin release, and the development of pulmonary fibrosis. Toxicol. Appl. Pharmacol. 106, 88-101 (1990).
8. J. Ferin, G. Oberdorster, S. C. Soderholm and R. Gelein, Pulmonary tissue access of ultrafine particles. J. Aerosol Med. 4, 57-68 (1991).
9. C. DuPont, Two-year Inhalation Study in Rats with Titanium Dioxide, Vols I and II, EPA/OTS; DuPont Corp., Doc. No. 88-85008005 (1985).
10. Q. Rahman, J. Norwood, G. Oberdorster and G. Hatch, Rat-human differences in macrophage oxidant production by pollutant particles. In Colloquium on Particulate Air Pollution and Human Mortality and Morbidity, 24-25 January 1994, Irvine, CA, USA.
11. J. M. Petruska, K. O. Leslie and B. T. Mossman, Enhanced lipid peroxidation in lung lavage of rats after inhalation of asbestos. Free Rad. Biol. Med. 11, 425-432 (1991).
12. D.S. Boehme, J. A. Hatchkiss and R. F. Henderson, Glutathione and GSH-dependent enzymes in bronchoalveolar lavage fluid cells in response to ozone. Exp. Mol. Pathol. 56, 37-48 (1992).
13. A. Holian, M. O. Uthman, T. Goltsova, S.D. Brown and R. F. Hamilton, Jr., Asbestos and silica-induced changes in human alveolar macrophage phenotype. Environ. Health Perspect. 105 (Suppl. 5), 1139-1142 (1997).
14. D. W. Kamp, P. Graceffa, W. A. Pryor and S. A. Weitzman. The role of free radicals in asbestos-induced lung diseases. Free Rad. Biol. Med. 12, 293-315 (1992).
15. J. E. Heffner and J. E. Repine, Pulmonary strategies of antioxidant defense. Am. Rev. Respir. Dis. 140, 531-554 (1989).
16. C. W. White and J. E. Repine, Pulmonary antioxidant defense mechanisms. Exp. Lung Res. 8, 81-96 (1985).
17. H. W. Gerarde, Toxicological studies on hydrocarbons. V. Kerosene. Toxicol. Appl. Pharmacol. 1, 462-474 (1959).
18. J. D. Brain, Free cells in the lungs: some aspects of their role, quantitation and regulation. Arch. Intern. Med. 126, 477-487 (1970).
19. J. M. Arif, S. G. Khan, I. Ahmad, L. D. Joshi and Q. Rahman, Effect of kerosene and its soot on the chrysotile-mediated toxicity to the rat alveolar macrophages. Environ. Res. 72, 151-161 (1997).
20. I. D. P. Wotton, Enzymes in blood. In Microanalysis in Medical Biochemistry, pp. 101-118, Churchill, London (1964).
21. D. W. Moss, Acid phosphatases. In Methods of Enzymatic Analysis ed. by H. V. Bergmeyer, Vol. 4, pp. 90-106. Verlag Chemie, Weinheim (1984).
22. J. Mohandas, J. J. Marshall, G. G. Duggin, J. S. Horvath and D. D. Tiller, Differential distribution of glutathione and glutathione related enzymes in rabbit kidney: possible implications in analgesic neuropathy. Cancer Res. 44, 5086-5091 (1984).
23. I. Carlberg and B. Mannervik, Glutathione reductase levels in rat brain. J. Biol. Chem. 250, 5475-5480 (1975).
24. N. Zaheer, K. K. Tiwari and P. S. Krishnan, Exposure and solubilization of hepatic mitochondrial shunt dehydrogenases. Arch. Biochem. Biophys. 109, 646-648 (1965).
25. W. H. Habig, M. J. Pabst and W. B. Jakoby, Glutathione-S-transferase: the first enzymatic step in mercapturic acid formation. J. Biol. Chem. 249, 7130-7139 (1974).
26. V. Sedlack and R. H. Lindsay, Estimation of total protein-bound and non-protein sulfhydryl groups in tissue with Ellman's reagent. Anal. Biochem. 25, 192-205 (1968).
27. F. E. Hunter, J. M. Gebicki, P. E. Hoffsten, J. Weinstein and A. Scott, Swelling and lysis of rat liver mitochondria induced by ferrous ions. J. Biol. Chem. 238, 828-835 (1963).
28. M. Thurman, H. G. Ley and R. Scholz, Hydrogen peroxide formation and role of catalase. Eur. J. Biochem. 25, 420-430 (1972).
29. O. H. Lowry, N. J. Rosebrough, A. L. Farr and R. J. Randall, Protein measurement with Folin phenol reagent. J. Biol. Chem. 193, 265-275 (1951).
30. P. B. Bitterman, L. E. Saltzman, S. Adelberg, V. J. Ferrous and R. G. Crystal, Alveolar macrophage replication: one mechanism for the expansion of the mononuclear phagocyte population in the chronically inflamed lung. J. Clin. Invest. 74, 460-469 (1984).
31. J. R. Spurzem, C. Saltini, W. Rom, J. Winchester and R. G. Crystal, Mechanisms of macrophage accumulation in the lungs of asbestos-exposed subjects. Am. Rev. Respir. Dis. 136, 276-280 (1987).
32. M. P. Absher, L. Trombley, D. R. Hemenway, R. M. Mickey and O. K. Leslie, Biphasic cellular and tissue response of rat lungs after eight-day aerosol exposure to the silicon dioxide cristobalite. Am. J. Pathol. 134, 1243-1251 (1989).
33. C. Churg, K. Zay and K. Li, Mechanisms of mineral dustinduced emphysema. Environ. Health Perspect. 105, 1215-1218 (1997).
34. G. M. Brown, D. M. Brown, J. Slight and K. Donaldson, Persistent biological reactivity of quartz in the lung: raised protease burden compared with a nonpathogenic mineral dust and microbial particle. Br. J. Ind. Med. 48, 61-69 (1991).
35. Y. M. W. Janssen, J. P. Marsh, M. P. Absher, D. Hemenway, P. M. Vacek, K. O. Leslie, P. J. A. Brom and B. T. Mossman, Expression of antioxidant enzymes in rat lungs after inhalation of asbestos and silica. J. Biol. Chem. 267, 10625-10630 (1992).
36. R. M. Schapira, A. J. Ghio, R. M. Effros, J. Morrisey, U. A. Almargn, C. A. Dawson and A. D. Haker, Hydroxyl radical production and lung injury in the rat following silica or titanium dioxide instillation in vivo. Am. J. Respir. Cell Mol. Biol. 12, 220-225 (1995).
37. J. M. Arif, S. G. Khan, M. Ashquin and Q. Rahman, Modulation of macrophage mediated cytotoxicity by kerosene soot: possible role of reactive oxygen species. Environ. Res. 61, 232-238 (1993).
38. T. F. Slater, Free radical mechanism in tissue injury. Biochem. J. 22, 1-15 (1984).
39. L. A. Goodglick and A. B. Kane, Role of reactive oxygen metabolites in crocidolite asbestos toxicity to mouse macrophages. Cancer Res. 46, 5558-5566 (1986).
40. V. Vilim, J. Wilhelm, P. Brzak and J. Hurych, Stimulation of alveolar macrophages by mineral dusts in vitro: luminol-dependent chemiluminescence study. Environ. Res. 42, 246-256 (1995).
41. B. A. Freeman and J. D. Crapo, Free radicals and tissue injury. Lab. Invest. 47, 412-424 (1982).
42. H. Sies, Oxidative stress: introductory remarks. In Oxidative Stress, ed. by H. Sies, pp. 1-8. Academic Press, London (1995).
43. E. M. Perchellet, E. A. Matta, N. L. Abney and J. P. Perchellet, Effect of diverse intracellular thiol delivery agents on glutathione peroxidase activity, the ratio reduced/induction in isolated mouse epidermal cells treated with 12-O-tetradecanoylphorbol-13-acetate. J. Cell. Physiol. 131, 64-73 (1987).
44. J. R. Dunbar, A. J. DeLucia and L. R. Bryant, Glutathione status of isolated rabbit lung: effect of nitrofurantoin and paraquat perfusion with normoxic and hyperoxic ventilation. Biochem. Pharmacol. 33, 1343-1348 (1984).
45. G. S. Vijeyaratnam and B. Corrin, Pulmonary histocytosis stimulating desquamative interstitial pneumonia in rats receiving oraeprindole. J. Pathol. 108, 105-113 (1972).
46. G. A. Loeb, D. C. Skelton, T. D. Coates and H. J. Forman, Role of selenium-dependent glutathione peroxidase in antioxidant defenses in rat alveolar macrophages. Exp. Lung Res. 14, 921-936 (1988).