Toxicity and cytogenetic studies of ultrafine titanium dioxide in cultured rat liver epithelial cells

Toxicology in Vitro

Volumn 11, Issue 4, 1997, Pages 329-331

  Linnainmaa, K ^a   Kivipensas, P ^a   Vainio, H ^a  

^a FINNISH INSTITUTE OF OCCUPATIONAL HEALTH   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

TITANIUM DIOXIDE;

ANIMAL CELL; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CYTOGENETICS; GENOTOXICITY; LIVER CELL CULTURE; MICRONUCLEUS; NONHUMAN; RAT; ULTRAVIOLET RADIATION;

ANIMALIA;

EID: 0030840483     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0887-2333(97)00000-3     Document Type: Article

References (16)

1. 2 particles. Cancer Research 52, 2346-2348.
2. Davis J. M. G., Jones A. D. and Miller B. G. (1991) Experimental studies in rats on the effects of asbestos inhalation coupled with the inhalation of titanium dioxide or quartz. International Journal of Experimental Pathology 72, 501-525.
3. Carter J. M., Hassenbein D., Bertram T. A. and Driscol K. E. (1996) Mutagenic effect on rat lung epithelial cells of particles in vivo and particle-elicited inflammatory cells ex vivo. Toxicologist 30, Abstract No. 247.
4. Eastmond A. and Tucker J. D. (1989) Kinetochore localization in micronucleated cytokinesis-blocked Chinese hamster ovary cells: A new and rapid assay for identifying aneuploidy-inducing agents. Mutation Research 224, 517-525.
5. Gallagher J., Heinrich U., George M., Hendee L., Phillips D. H. and Lewtas J. (1994) Formation of DNA adducts in rat lung following chronic inhalation of diesel emissions, carbon black and titanium dioxide particles. Carcinogenesis 15, 1291-1299.
6. Hayashi M., Sofuni T. and Ishidate M. (1983) An application of acridine orange fluorescent staining to the micronucleus test. Mutation Research 120, 241-247.
7. Heinrich U., Fuhst S., Rittinghausen S., Creutzenberg O., Bellmann B., Koch W. and Levsen K. (1995) Chronic inhalation exposure of Wistar rats and two different strains of mice to diesel engine exhaust, carbon black, and titanium dioxide. Inhalation Toxicology, 533-566.
8. IARC Working Group (1989) IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Vol. 47. Some Organic Solvents, Resin Monomers and Related Compounds, Pigments and Occupational Exposures in Paint Manufacture and Painting. International Agency for Research on Cancer, Lyon.
9. Kubota Y., Shuin T., Kawasaki C., Hosaka M., Kitamura H., Cai R., Sakai H., Hashimoto K. and Fujishima A. (1994) Photokilling of T-24 human bladder cancer with titanium dioxide. British Journal of Cancer 70, 1107-1111.
10. Kumar R. K., O'Grady R., Li W. and Velan G. M. (1992) Mitogenic activity for fibroblasts induced by silica and titanium dioxide particles in vitro and in vivo. International Journal of Experimental Pathology 73, 573-583.
11. Miller B. M., Pujadas E. and Gocke E. (1995) Evaluation of the micronucleus test in vitro using Chinese hamster cells: results of four chemicals weakly positive in the in vivo micronucleus test. Environmental and Molecular Mutagenesis 26, 240-247.
12. Shanbhag A. S., Jacobs J. J., Black J., Galante J. O. and Glant T. T. (1994) Macrophage/particle interactions: effect of size, composition and surface area. Journal of Biomedical Materials Research 28, 81-90.
13. Shelby M. D., Erexson G. L., Hook G. J. and Tice R. R. (1993) Evaluation of a three-exposure mouse bone marrow micronucleus protocol: results with 49 chemicals. Environmental and Molecular Mutagenesis 21, 160-179.
14. Stenbäck F., Rowland J. and Sellukumar A. (1976) Carcinogenicity of benzo(a)pyrene and dusts in the hamster lung (instilled intracheally with titanium oxide, aluminium oxide, carbon and ferric oxide). Oncology 33, 29-34.
15. Stenbäck F., Wasenius V. M. and Rowland J. (1986) Alveolar and interstial changes in silicate-associated lung tumors in Syrian hamsters. In Silica, Silicosis and Cancer: Controversy in Occupational Medicine. Cancer Research Monographs 2. Edited by D. F. Goldsmith, D. M. Winn and C. M. Shy. pp. 199-213. Praeger Publishers, New York.
16. Yegles M., Saint-Etienne L., Renier A., Janson X. and Jaurand M. C. (1993) Induction of metaphase and anaphase/telophase abnormalities by asbestos fibers in rat pleural mesothelial cells in vitro. American Journal of Respiratory Cell Molecular Biology 9, 186-191.