Possible genotoxic mechanisms of nanoparticles: Criteria for improved test strategies

Nanotoxicology

Volumn 4, Issue 4, 2010, Pages 414-420

  Donaldson, Ken ^a   Poland, Craig A ^a   Schins, Roel P F ^b  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b IUF LEIBNIZ RESEARCH INSTITUTE FOR ENVIRONMENTAL MEDICINE   (Germany)

Author keywords

mechanistic toxicology; nanotechnology; Nanotoxicology; occupational health; particle toxicology

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; ASBESTOS; CARBON NANOFIBER; DNA; GLUTATHIONE; NANOPARTICLE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

CHROMOSOME ABERRATION; DNA REPAIR; DNA STRAND BREAKAGE; GENOTOXICITY; HUMAN; MESOTHELIOMA; MICRONUCLEUS TEST; MITOCHONDRIAL RESPIRATION; NANOTOXICOLOGY; OXIDATIVE STRESS; PARTICLE SIZE; PRIORITY JOURNAL; REVIEW; SOOT; STRUCTURE ACTIVITY RELATION; TOXICITY TESTING;

MUTAGENICITY TESTS; MUTAGENS; NANOPARTICLES;

EID: 77957948204     PISSN: 17435390     EISSN: 17435404     Source Type: Journal    
DOI: 10.3109/17435390.2010.482751     Document Type: Review

References (38)

1. Asharani PV, Low Kah MG, Hande MP, Valiyaveettil S. 2009. Cytotoxicity and genotoxicity of silver nanoparticles in human cells. ACS Nano 3:279-290.
2. Azad N, Rojanasakul Y, Vallyathan V. 2008. Inflammation and lung cancer: Roles of reactive oxygen/nitrogen species. J Toxicol. Environ. Health B Crit Rev 11:1-15.
3. Beyersmann D, Hartwig A. 2008. Carcinogenic metal compounds: Recent insight into molecular and cellular mechanisms. Arch Toxicol 82:493-512.
4. Bhabra G, Sood A, Fisher B, Cartwright L, Saunders M, EvansWH, Surprenant A, Lopez-Castejon G, Mann S, Davis SA, Hails LA, Ingham E, Verkade P, Lane J, Heesom K, Newson R, Case CP. 2009. Nanoparticles can cause DNA damage across a cellular barrier. Nat Nanotechnol 4:876-883.
5. 2 nanoparticles. Exp Cell Res 305:51-62.
6. Doll R. 1955. Mortality from lung cancer in asbestos workers. Br J Ind Med 12:81-86.
7. Driscoll KE, Carter JM, Howard BW, Hassenbein D, Janssen YM, Mossman BT. 1998. Crocidolite activates NF-(kappa)B and MIP-2 gene expression in rat alveolar epithelial cells. Role of mitochrondrial-derived oxidants. Environ Health Perspect 106(Suppl. 5):1171-1174.
8. Duffin R, Tran L, Brown D, Stone V, Donaldson K. 2007. Proinflammogenic effects of low-toxicity and metal nanoparticles in vivo and in vitro: Highlighting the role of particle surface area and surface reactivity. Inhal Toxicol 19:849-856.
9. Fubini B. 1998. Surface chemistry and quartz hazard. Ann Occup Hyg 42:521-530.
10. Gedik CM, Boyle SP, Wood SG, Vaughan NJ, Collins AR. 2002. Oxidative stress in humans: Validation of biomarkers of DNA damage. Carcinogenesis 23:1441-1446.
11. Geiser M, Rothen-Rutlshauser B, Kapp N, Schurch S, Kreyling W, Schulz H, Semmler M, Im HV, Heyder J, Gehr P. 2005. Ultrafine particles cross cellular membranes by non-phagocytic mechanisms in lungs and in cultured cells. Environ Health Perspect. 113:1555-1560.
12. Gonzalez L, Lison D, Kirsch-Volders M. 2008. Genotoxicity of engineered nanomaterials: A critical review. Nanotoxicology 2:252-273.
13. Hesterberg T, Oshimura M, Barrett JC. 1985. Transformation of mammalian cells in culture by asbestos and other mineral dusts: A mechanism involving chromosomal mutation. In: Beck EG, Bignon J, editors. In vitro effects of mineral dusts. NATO ASI Series Vol. G3:185-196.
14. Kagan VE, Tyurina YY, Tyurin VA, Konduru NV, Potapovich AI, Osipov AN, Kisin ER, Schwegler-Berry D, Mercer R, Castranova V, Shvedova AA. 2006. Direct and indirect effects of single walled carbon nanotubes on RAW 264.7 macrophages: Role of iron. Toxicol Lett 165:88-100.
15. Kamp DW, Panduri V,Weitzman SA, Chandel N. 2002. Asbestosinduced alveolar epithelial cell apoptosis: Role of mitochondrial dysfunction caused by iron-derived free radicals. Mol Cell Biochem 234-235:153-160.
16. Kane AB. 1996. Mechanisms of mineral fibre carcinogenesis. In: Kane AB, Boffetta P, Saracci R, Wilbourn JD, editors. Mechanisms of fibre carcinogenesis. IARC Lyon. pp 11-34.
17. Landsiedel R, Kapp MD, Schulz M, Wiench K, Oesch F. 2009. Genotoxicity investigations on nanomaterials: Methods, preparation and characterization of test material, potential artifacts and limitations - many questions, some answers. Mutat Res 681:241-258.
18. Li H, Haberzettl P, Albrecht C, Hohr D, Knaapen AM, Borm PJ, Schins RP. 2007. Inhibition of the mitochondrial respiratory chain function abrogates quartz induced DNA damage in lung epithelial cells. Mutat Res 617:46-57.
19. Li KG, Chen JT, Bai SS, Wen X, Song SY, Yu Q, Li J, Wang YQ. 2009. Intracellular oxidative stress and cadmium ions release induce cytotoxicity of unmodified cadmium sulfide quantum dots. Toxicol In Vitro 23:1007-1013.
20. Li N, Sioutas C, Cho A, Schmitz D, Misra C, Sempf JM, Wang M, Oberley TD, Froines J, Nel A. 2003. Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage. Env Health Perspect 111:455-460.
21. Lu S, Duffin R, Poland C, Daly P, Murphy F, Drost E, MacNee W, Stone V, Donaldson K. 2009. Efficacy of simple short-term in vitro assays for predicting the potential of metal oxide nanoparticles to cause pulmonary inflammation. Environ Health Perspect 117:241-247.
22. Lund LG, Aust AE. 1992. Iron mobilization from crocidolite asbestos greatly enhances crocidolite-dependent formation of DNA single-strand breaks in phi X174 RFIDNA. Carcinogenesis 13:637-642.
23. Lynch I, Dawson KA, Linse S. 2006. Detecting cryptic epitopes created by nanoparticles. Sci STKE e14.
24. Miller BG, Jones AD, Searl A, Buchanan D, Cullen RT, Soutar CA, Davis JM, Donaldson K. 1999. Influence of characteristics of inhaled fibres on development of tumours in the rat lung. Ann Occup Hyg 43:167-179.
25. Nativo P, Prior IA, Brust M. 2008. Uptake and intracellular fate of surface-modified gold nanoparticles. ACS Nano 2:1639-1644.
26. Nel A, Xia T, Madler L, Li N. 2006. Toxic potential of materials at the nanolevel. Science 311:622-627.
27. Oberdörster G, Ferin J, Lehnert BE. 1994. Correlation between particle-size, in-vivo particle persistence, and lung injury. Environ Health Perspect 102(Suppl. 5):173-179.
28. Park EJ, Yi J, Chung KH, Ryu DY, Choi J, Park K. 2008. Oxidative stress and apoptosis induced by titanium dioxide nanoparticles in cultured BEAS-2B cells. Toxicol Lett 180:222-229.
29. Poland CA, Duffin R, Kinloch I, Maynard A, Wallace WA, Seaton A, Stone V, Brown S, MacNee W, Donaldson K. 2008. Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study. Nat Nanotechnol 3:423-428.
30. Robinson JM. 2008. Reactive oxygen species in phagocytic leukocytes. Histochem Cell Biol 130:281-297.
31. Schins RP, Duffin R, Hohr D, Knaapen AM, Shi T, Weishaupt C, Stone V, Donaldson K, Borm PJ. 2002. Surface modification of quartz inhibits toxicity, particle uptake, and oxidative DNA damage in human lung epithelial cells. Chem Res Toxicol 15:1166-1173.
32. Schins RP, Knaapen AM. 2007. Genotoxicity of poorly soluble particles. Inhal Toxicol 19(Suppl. 1):189-198.
33. Schins RPF, Hei TK. 2007. Genotoxic effects of particles. Chapter 16. In: Donaldson K, Borm P, editors. Particle toxicology. Boca Raton, FL: CRC Press. pp 285-298.
34. Tkachenko AG, Xie H, Coleman D, Glomm W, Ryan J, Anderson MF, Franzen S, Feldheim DL. 2003. Multifunctional gold nanoparticle-peptide complexes for nuclear targeting. J Am Chem Soc 125:4700-4701.
35. Unfried K, Albrecht C, von Mikecz A, Grether-Beck S, Schins RPF. 2007. Cellular responses to nanoparticles: Target structures and mechanisms. Nanotoxicology 1:52-71.
36. Vanderven BC, Yates RM, Russell DG. 2009. Intraphagosomal measurement of the magnitude and duration of the oxidative burst. Traffic 10:372-378.
37. Wang F, Gao F, Lan M, Yuan H, Huang Y, Liu J. 2009. Oxidative stress contributes to silica nanoparticle-induced cytotoxicity in human embryonic kidney cells. Toxicol In Vitro 23:808-815.
38. Xu A, Chai Y, Nohmi T, Hei TK. 2009. Genotoxic responses to titanium dioxide nanoparticles and fullerene in gpt delta transgenic MEF cells. Part Fibre Toxicol 6:3.