Alteration of the C-terminal ligand specificity of the Erbin PDZ domain by allosteric mutational effects

Journal of Molecular Biology

Volumn 426, Issue 21, 2014, Pages 3500-3508

  Murciano Calles, Javier ^a   McLaughlin, Megan E ^b   Erijman, Ariel ^c   Hooda, Yogesh ^b   Chakravorty, Nishant ^d   Martinez, Jose C ^a   Shifman, Julia M ^c   Sidhu, Sachdev S ^b  

^a UNIVERSITY OF GRANADA   (Spain)

^b UNIVERSITY OF TORONTO   (Canada)

^c HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^d QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

Author keywords

binding cooperativity; computational modeling; phage display; protein engineering; protein interaction domains

Indexed keywords

AMINO ACID; PEPTIDES AND PROTEINS; PROTEIN ERBIN; UNCLASSIFIED DRUG; ERBB2IP PROTEIN, HUMAN; GLUTATHIONE TRANSFERASE; LIGAND; PEPTIDE; PEPTIDE LIBRARY; PROTEIN BINDING; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ALLOSTERISM; ARTICLE; BACTERIOPHAGE; CARBOXY TERMINAL SEQUENCE; CONFORMATIONAL TRANSITION; NONHUMAN; PDZ DOMAIN; PROTEIN BINDING; BINDING SITE; CHEMISTRY; COMPUTER PROGRAM; COMPUTER SIMULATION; GENETICS; HUMAN; METABOLISM; NUCLEOTIDE SEQUENCE; PEPTIDE LIBRARY; PROCEDURES; PROTEIN ENGINEERING; PROTEIN TERTIARY STRUCTURE; SEQUENCE HOMOLOGY;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ALLOSTERIC SITE; COMPUTER SIMULATION; DNA MUTATIONAL ANALYSIS; GLUTATHIONE TRANSFERASE; HUMANS; LIGANDS; PEPTIDE LIBRARY; PEPTIDES; PROTEIN BINDING; PROTEIN ENGINEERING; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; SOFTWARE;

EID: 84907809712     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2014.05.003     Document Type: Article

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