Sequence-specific long range networks in PSD-95/Discs large/ZO-1 (PDZ) domains tune their binding selectivity

Journal of Biological Chemistry

Volumn 286, Issue 31, 2011, Pages 27167-27175

  Gianni, Stefano ^a   Haq, S Raza ^b   Montemiglio, Linda C ^a   Jürgens, Maike C ^b   Engström, Åke ^b   Chi, Celestine N ^b   Brunori, Maurizio ^a   Jemth, Per ^b  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOSTERY; AMINO ACID SEQUENCE; BACKBONE INTERACTIONS; BINDING POCKETS; BINDING SELECTIVITY; CELL SCAFFOLDING; DATA SUPPORT; DOUBLE MUTANTS; EXPERIMENTAL DATA; INTRA-DOMAIN; LONG RANGE; MODULAR PROTEINS; PDZ DOMAINS; PEPTIDE LIGAND; PEPTIDE RECOGNITION; PROTEIN-PROTEIN INTERACTIONS; SIDE-CHAINS; SITE DIRECTED MUTAGENESIS;

AMINO ACIDS; COMPLEXATION; LIGANDS; PEPTIDES;

BINDING SITES;

ISOLEUCINE; LEUCINE; LYSINE; PDZ PROTEIN; PDZ2 PROTEIN; PDZ3 PROTEIN; PHENYLALANINE; POSTSYNAPTIC DENSITY PROTEIN 95; PROTEIN ZO1; SERINE; THREONINE; UNCLASSIFIED DRUG; VALINE;

ALLOSTERISM; AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; COMPLEX FORMATION; CONTROLLED STUDY; DISSOCIATION CONSTANT; ENERGY TRANSFER; LIGAND BINDING; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SITE DIRECTED MUTAGENESIS;

INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KINETICS; MEMBRANE PROTEINS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; THERMODYNAMICS;

EID: 79961006047     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.239541     Document Type: Article

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