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Volumn 86, Issue , 2014, Pages 389-396

Lycopene attenuates insulin signaling deficits, oxidative stress, neuroinflammation, and cognitive impairment in fructose-drinking insulin resistant rats

Author keywords

Cognitive deficits; Insulin resistance; Lycopene; Neuroinflammation; Oxidative damage

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; INTERLEUKIN 1BETA; LYCOPENE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHATIDYLINOSITOL 3 KINASE; SOMATOMEDIN C RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; ANTIOXIDANT; CAROTENOID; CYTOKINE; FRUCTOSE; NOOTROPIC AGENT; SWEETENING AGENT;

EID: 84907714566     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2014.07.020     Document Type: Article
Times cited : (85)

References (47)
  • 1
    • 0021318441 scopus 로고
    • Catalase in vitro
    • H. Aebi Catalase in vitro Method Enzymol. 105 1984 121 126
    • (1984) Method Enzymol. , vol.105 , pp. 121-126
    • Aebi, H.1
  • 2
    • 80053092797 scopus 로고    scopus 로고
    • Rosiglitazone decreases peroxisome proliferator receptor-gamma levels in microglia and inhibits TNF-alpha production: New evidences on neuroprotection in a progressive Parkinson's disease model
    • A.R. Carta, L. Frau, A. Pisanu, J. Wardas, and S. Spiga Rosiglitazone decreases peroxisome proliferator receptor-gamma levels in microglia and inhibits TNF-alpha production: new evidences on neuroprotection in a progressive Parkinson's disease model Neurosci. 194 2011 250 261
    • (2011) Neurosci. , vol.194 , pp. 250-261
    • Carta, A.R.1    Frau, L.2    Pisanu, A.3    Wardas, J.4    Spiga, S.5
  • 3
    • 0031889382 scopus 로고    scopus 로고
    • Lycopene: Chemistry, biology, and implications for human health and disease
    • S.K. Clinton Lycopene: chemistry, biology, and implications for human health and disease Nutr. Rev. 56 1998 35 51
    • (1998) Nutr. Rev. , vol.56 , pp. 35-51
    • Clinton, S.K.1
  • 4
    • 28444459842 scopus 로고    scopus 로고
    • Insulin resistance syndrome and Alzheimer's disease: Age- and obesity-related effects on memory, amyloid, and inflammation
    • S. Craft Insulin resistance syndrome and Alzheimer's disease: age- and obesity-related effects on memory, amyloid, and inflammation Neurobiol. Aging 26 2005 65 69
    • (2005) Neurobiol. Aging , vol.26 , pp. 65-69
    • Craft, S.1
  • 5
    • 70349581633 scopus 로고    scopus 로고
    • Insulin resistance and Alzheimer's disease
    • S.M. De la Monte Insulin resistance and Alzheimer's disease BMB Rep. 42 8 2009 475 481
    • (2009) BMB Rep. , vol.42 , Issue.8 , pp. 475-481
    • De La Monte, S.M.1
  • 6
    • 0024464691 scopus 로고
    • Lycopene as the most efficient biological carotenoid singlet oxygen quencher
    • P. Di Mascio, S. Kaiser, and H. Sies Lycopene as the most efficient biological carotenoid singlet oxygen quencher Arch. Biochem. Biophys. 274 1989 532 538
    • (1989) Arch. Biochem. Biophys. , vol.274 , pp. 532-538
    • Di Mascio, P.1    Kaiser, S.2    Sies, H.3
  • 8
    • 58149485983 scopus 로고    scopus 로고
    • Rosiglitazone reverses memory decline and hippocampal glucocorticoid receptor down-regulation in an Alzheimer's disease mouse model
    • L. Escribano, A.M. Simon, A. Perez-Mediavilla, P. Salazar-Colocho, and J. Del Rio Rosiglitazone reverses memory decline and hippocampal glucocorticoid receptor down-regulation in an Alzheimer's disease mouse model Biochem. Biophys. Res. Commun. 379 2009 406 410
    • (2009) Biochem. Biophys. Res. Commun. , vol.379 , pp. 406-410
    • Escribano, L.1    Simon, A.M.2    Perez-Mediavilla, A.3    Salazar-Colocho, P.4    Del Rio, J.5
  • 9
    • 84876407166 scopus 로고    scopus 로고
    • Lycopene inhibits ischemia/reperfusion-induced neuronal apoptosis in gerbil hippocampal tissue
    • K. Fujita, N. Yoshimoto, T. Kato, H. Imada, and G. Mastumoto Lycopene inhibits ischemia/reperfusion-induced neuronal apoptosis in gerbil hippocampal tissue Neurochem Res. 38 3 2013 461 469
    • (2013) Neurochem Res. , vol.38 , Issue.3 , pp. 461-469
    • Fujita, K.1    Yoshimoto, N.2    Kato, T.3    Imada, H.4    Mastumoto, G.5
  • 10
    • 27744486073 scopus 로고    scopus 로고
    • Memory impairment in obese Zucker rats: An investigation of cognitive function in an animal model of insulin resistance and obesity
    • W. Gordon, E.G. Carol, G.P. Gerardo, A.G. Claudia, and R.R. Leah Memory impairment in obese Zucker rats: an investigation of cognitive function in an animal model of insulin resistance and obesity Behav. Neurosci. 119 5 2005 1389 1395
    • (2005) Behav. Neurosci. , vol.119 , Issue.5 , pp. 1389-1395
    • Gordon, W.1    Carol, E.G.2    Gerardo, G.P.3    Claudia, A.G.4    Leah, R.R.5
  • 12
    • 79952439187 scopus 로고    scopus 로고
    • Peripheral insulin-sensitizer drug metformin ameliorates neuronal insulin resistance and Alzheimer's-like changes
    • A. Gupta, B. Bisht, and C.S. Dey Peripheral insulin-sensitizer drug metformin ameliorates neuronal insulin resistance and Alzheimer's-like changes Neuropharmacology 60 2011 910 920
    • (2011) Neuropharmacology , vol.60 , pp. 910-920
    • Gupta, A.1    Bisht, B.2    Dey, C.S.3
  • 13
    • 0016170551 scopus 로고
    • Effect of dietary selenium on erythrocyte and liver glutathione peroxidase in the rats
    • D.G. Hafemen Effect of dietary selenium on erythrocyte and liver glutathione peroxidase in the rats J. Nutr. 104 1974 580 587
    • (1974) J. Nutr. , vol.104 , pp. 580-587
    • Hafemen, D.G.1
  • 14
    • 4043110705 scopus 로고    scopus 로고
    • A potent antioxidant, lycopene, affords neuroprotection against microglia activation and focal cerebral ischemia in rats
    • G. Hsiao, T.H. Fong, N.H. Tzu, K.H. Lin, D.S. Chou, and J.R. Sheu A potent antioxidant, lycopene, affords neuroprotection against microglia activation and focal cerebral ischemia in rats Vivo 18 3 2004 351 356
    • (2004) Vivo , vol.18 , Issue.3 , pp. 351-356
    • Hsiao, G.1    Fong, T.H.2    Tzu, N.H.3    Lin, K.H.4    Chou, D.S.5    Sheu, J.R.6
  • 15
    • 84890493012 scopus 로고    scopus 로고
    • Lycopene metabolite, apo-10'-lycopenoic acid, inhibits diethylnitrosamine-initiated, high fat diet-promoted hepatic inflammation and tumorigenesis in mice
    • B.C. Ip, K.Q. Hu, C. Liu, D.E. Smith, and M.S. Obin Lycopene metabolite, apo-10'-lycopenoic acid, inhibits diethylnitrosamine-initiated, high fat diet-promoted hepatic inflammation and tumorigenesis in mice Cancer Prev. Res. Canprevres 6 12 2013 1304 1316
    • (2013) Cancer Prev. Res. Canprevres , vol.6 , Issue.12 , pp. 1304-1316
    • Ip, B.C.1    Hu, K.Q.2    Liu, C.3    Smith, D.E.4    Obin, M.S.5
  • 16
    • 84864753094 scopus 로고    scopus 로고
    • PPARγ agonist pioglitazone reverses memory impairment and biochemical changes in a mouse model of type 2 diabetes mellitus
    • L. Jiang, S. Tang, X. Wang, L. Liu, and Y. Long PPARγ agonist pioglitazone reverses memory impairment and biochemical changes in a mouse model of type 2 diabetes mellitus CNS Neurosci. Ther. 18 2012 659 666
    • (2012) CNS Neurosci. Ther. , vol.18 , pp. 659-666
    • Jiang, L.1    Tang, S.2    Wang, X.3    Liu, L.4    Long, Y.5
  • 17
    • 0016151122 scopus 로고
    • Bromobenzene induced liver necrosis: Protective role of glutathione and evidence for 3, 4-bromobenzenoxide as the hepatotoxic intermediate
    • D.J. Jollow, J.R. Mitchell, N. Zampaglione, and J.R. Gillette Bromobenzene induced liver necrosis: protective role of glutathione and evidence for 3, 4-bromobenzenoxide as the hepatotoxic intermediate Pharmacol. 11 1974 151 169
    • (1974) Pharmacol. , vol.11 , pp. 151-169
    • Jollow, D.J.1    Mitchell, J.R.2    Zampaglione, N.3    Gillette, J.R.4
  • 18
    • 79961208135 scopus 로고    scopus 로고
    • Protective effect of lycopene on oxidative stress and cognitive decline in rotenone induced model of Parkinson's disease
    • H. Kaur, S. Chauhan, and R. Sandhir Protective effect of lycopene on oxidative stress and cognitive decline in rotenone induced model of Parkinson's disease Neurochem Res. 36 2011 1435 1443
    • (2011) Neurochem Res. , vol.36 , pp. 1435-1443
    • Kaur, H.1    Chauhan, S.2    Sandhir, R.3
  • 20
    • 46449094796 scopus 로고    scopus 로고
    • Lycopene attenuates diabetes-associated cognitive decline in rats
    • A. Kuhad, R. Sethi, and K. Chopra Lycopene attenuates diabetes-associated cognitive decline in rats Life Sci. 83 2008 128 134
    • (2008) Life Sci. , vol.83 , pp. 128-134
    • Kuhad, A.1    Sethi, R.2    Chopra, K.3
  • 21
    • 28944446431 scopus 로고    scopus 로고
    • The many faces of PPARgamma
    • M. Lehrke, and M.A. Lazar The many faces of PPARgamma Cell. 123 2005 993 999
    • (2005) Cell. , vol.123 , pp. 993-999
    • Lehrke, M.1    Lazar, M.A.2
  • 23
    • 79957909052 scopus 로고    scopus 로고
    • Effect of pioglitazone on altered expression of Aβ metabolism-associated molecules in the brain of fructose-drinking rats, a rodent model of insulin resistance
    • D. Luo, Y. Hao, L. Hou, M. Wang, S. Xu, and C. Dong Effect of pioglitazone on altered expression of Aβ metabolism-associated molecules in the brain of fructose-drinking rats, a rodent model of insulin resistance Eur. J. Pharmacol. 664 2011 14 19
    • (2011) Eur. J. Pharmacol. , vol.664 , pp. 14-19
    • Luo, D.1    Hao, Y.2    Hou, L.3    Wang, M.4    Xu, S.5    Dong, C.6
  • 24
    • 36549032093 scopus 로고    scopus 로고
    • Peripheral and central neurologic complications in type 2 diabetes mellitus: No association in individual patients
    • S.M. Manschot, G.J. Biessels, G.E. Rutten, R.C. Kessels, and W.H. Gispen Peripheral and central neurologic complications in type 2 diabetes mellitus: no association in individual patients J. Neurol. Sci. 264 2008 157 162
    • (2008) J. Neurol. Sci. , vol.264 , pp. 157-162
    • Manschot, S.M.1    Biessels, G.J.2    Rutten, G.E.3    Kessels, R.C.4    Gispen, W.H.5
  • 25
    • 0021813187 scopus 로고
    • Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
    • D.R. Matthews, J.P. Hosker, A.S. Rudenski, B.A. Naylor, D.F. Treacher, and R.C. Turner Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man Diabetologia 28 7 1985 412 419
    • (1985) Diabetologia , vol.28 , Issue.7 , pp. 412-419
    • Matthews, D.R.1    Hosker, J.P.2    Rudenski, A.S.3    Naylor, B.A.4    Treacher, D.F.5    Turner, R.C.6
  • 26
    • 0016913961 scopus 로고
    • Sugar substitutes in the diabetic diet
    • H. Mehnert Sugar substitutes in the diabetic diet Int. Z Vitam. Ernahrungsforsch Beih 15 1976 295 324 http://www.nutritionandmetabolism.com/pubmed/783058
    • (1976) Int. Z Vitam. Ernahrungsforsch Beih , vol.15 , pp. 295-324
    • Mehnert, H.1
  • 27
    • 77950955703 scopus 로고    scopus 로고
    • Homologous posttranscriptional regulation of insulin-like growth factor-I receptor level via glycogen synthase kinase-3 and mammalian target of rapamycin in adrenal chromaffin cells: Effect on tau phosphorylation
    • T. Nemoto, S. Satoh, T. Maruta, T. Kanai, N. Yoshikawa, S. Miyazaki, T. Yanagita, and A. Wada Homologous posttranscriptional regulation of insulin-like growth factor-I receptor level via glycogen synthase kinase-3 and mammalian target of rapamycin in adrenal chromaffin cells: effect on tau phosphorylation Neuropharmacology 58 2010 1097 1108
    • (2010) Neuropharmacology , vol.58 , pp. 1097-1108
    • Nemoto, T.1    Satoh, S.2    Maruta, T.3    Kanai, T.4    Yoshikawa, N.5    Miyazaki, S.6    Yanagita, T.7    Wada, A.8
  • 28
    • 30944458833 scopus 로고    scopus 로고
    • Lycopene induces apoptosis in immprtalized fibroblasts exposed to tobacco smoke condensate through arresting cell cycle and down-regulating cyclin D1, pAKT and pBad
    • P. Palozza, A. Sheriff, S. Serini, A. Boninsegna, N. Maggiano, F.O. Ranelletti, G. Calviello, and A. Cittadini Lycopene induces apoptosis in immprtalized fibroblasts exposed to tobacco smoke condensate through arresting cell cycle and down-regulating cyclin D1, pAKT and pBad Apoptosis 10 2005 1445 1456
    • (2005) Apoptosis , vol.10 , pp. 1445-1456
    • Palozza, P.1    Sheriff, A.2    Serini, S.3    Boninsegna, A.4    Maggiano, N.5    Ranelletti, F.O.6    Calviello, G.7    Cittadini, A.8
  • 29
    • 79951669719 scopus 로고    scopus 로고
    • Lycopene prevention of oxysterol-induced proinflammatory cytokine cascade in human macrophages: Inhibition of NF-κB nuclear binding and increase in PPARγ expression
    • P. Palozza, R. Simone, A. Catalano, G. Monego, and M.C. Mele Lycopene prevention of oxysterol-induced proinflammatory cytokine cascade in human macrophages: inhibition of NF-κB nuclear binding and increase in PPARγ expression J. Nutr. Biochem. 22 2011 259 268
    • (2011) J. Nutr. Biochem. , vol.22 , pp. 259-268
    • Palozza, P.1    Simone, R.2    Catalano, A.3    Monego, G.4    Mele, M.C.5
  • 30
    • 0032850599 scopus 로고    scopus 로고
    • Distribution of active synthase kinase-3 beta (GSK-3beta) in brains staged for the Alzheimer disease neurofibrillary changes
    • J.J. Pei, E. Braak, H. Braak, K. Iqbal, I. Grundke-Iqbal, B. Winblad, and R.F. Cowburn Distribution of active synthase kinase-3 beta (GSK-3beta) in brains staged for the Alzheimer disease neurofibrillary changes J. Neuropathol. Exp. Neurol. 58 1999 1010 1019
    • (1999) J. Neuropathol. Exp. Neurol. , vol.58 , pp. 1010-1019
    • Pei, J.J.1    Braak, E.2    Braak, H.3    Iqbal, K.4    Grundke-Iqbal, I.5    Winblad, B.6    Cowburn, R.F.7
  • 32
    • 83555165958 scopus 로고    scopus 로고
    • Protective effects of lycopene against amyloid beta-induced neurotoxicity in cultured rat cortical neurons
    • M. Qu, L. Li, C. Chen, M. Li, L. Pei, F. Chu, J. Yang, Z. Yu, D. Wang, and Z. Zhou Protective effects of lycopene against amyloid beta-induced neurotoxicity in cultured rat cortical neurons Neurosci. Lett. 505 3 2011 286 290
    • (2011) Neurosci. Lett. , vol.505 , Issue.3 , pp. 286-290
    • Qu, M.1    Li, L.2    Chen, C.3    Li, M.4    Pei, L.5    Chu, F.6    Yang, J.7    Yu, Z.8    Wang, D.9    Zhou, Z.10
  • 33
    • 0036796276 scopus 로고    scopus 로고
    • Role of oxidative stress and antioxidants in neurogenerative diseases
    • A.V. Rao, and B. Balachandran Role of oxidative stress and antioxidants in neurogenerative diseases Nutr. Neurosci. 5 2002 291 309
    • (2002) Nutr. Neurosci. , vol.5 , pp. 291-309
    • Rao, A.V.1    Balachandran, B.2
  • 34
    • 0006460824 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinasemediated regulation of neuronal apoptosis and necrosis by insulin and IGF-I
    • B.R. Ryu, H.W. Ko, I. Jou, J.S. Noh, and B.J. Gwag Phosphatidylinositol 3-kinasemediated regulation of neuronal apoptosis and necrosis by insulin and IGF-I J. Neurobiol. 39 1999 536 546
    • (1999) J. Neurobiol. , vol.39 , pp. 536-546
    • Ryu, B.R.1    Ko, H.W.2    Jou, I.3    Noh, J.S.4    Gwag, B.J.5
  • 35
    • 84899944299 scopus 로고    scopus 로고
    • Orally administered lycopene attenuates diethylnitrosamine-induced hepatocarcinogenesis in rats by modulating Nrf-2/HO-1 and Akt/mTOR pathways
    • K. Sahin, C. Orhan, M. Tuzcu, N. Sahin, S. Ali, I.H. Bahcecioglu, O. Guler, I. Ozercan, N. Ilhan, and O. Kucuk Orally administered lycopene attenuates diethylnitrosamine-induced hepatocarcinogenesis in rats by modulating Nrf-2/HO-1 and Akt/mTOR pathways Nutr. Cancer 66 2014 590 598
    • (2014) Nutr. Cancer , vol.66 , pp. 590-598
    • Sahin, K.1    Orhan, C.2    Tuzcu, M.3    Sahin, N.4    Ali, S.5    Bahcecioglu, I.H.6    Guler, O.7    Ozercan, I.8    Ilhan, N.9    Kucuk, O.10
  • 36
    • 77956227700 scopus 로고    scopus 로고
    • Lycopene prevents 3-nitropropionic acid-induced mitochondrial oxidative stress and dysfunctions in nervous system
    • R. Sandhir, A. Mehrotra, and S.S. Kamboj Lycopene prevents 3-nitropropionic acid-induced mitochondrial oxidative stress and dysfunctions in nervous system Neurochem. Int. 57 5 2010 579 587
    • (2010) Neurochem. Int. , vol.57 , Issue.5 , pp. 579-587
    • Sandhir, R.1    Mehrotra, A.2    Kamboj, S.S.3
  • 37
    • 79956282901 scopus 로고    scopus 로고
    • Lycopene inhibits NF-kB-Mediated IL-8 expression and changes Redox and PPARγ signalling in Cigarette Smoke-Stimulated macrophages
    • R.E. Simone, M. Russo, A. Catalano, G. Monego, and K. Froehlich Lycopene inhibits NF-kB-Mediated IL-8 expression and changes Redox and PPARγ signalling in Cigarette Smoke-Stimulated macrophages PLoS ONE 6 5 2011 e19652
    • (2011) PLoS ONE , vol.6 , Issue.5 , pp. 19652
    • Simone, R.E.1    Russo, M.2    Catalano, A.3    Monego, G.4    Froehlich, K.5
  • 38
    • 27644596252 scopus 로고    scopus 로고
    • Aging affects oxidative state in hippocampus, hypothalamus and adrenal glands of Wistar rats
    • R.I. Siqueira, C. Fochesatto, I.L. Da Silva Torres, C. Dalmaz, and C.A. Netto Aging affects oxidative state in hippocampus, hypothalamus and adrenal glands of Wistar rats Life Sci. 78 2005 271 278
    • (2005) Life Sci. , vol.78 , pp. 271-278
    • Siqueira, R.I.1    Fochesatto, C.2    Da Silva Torres, I.L.3    Dalmaz, C.4    Netto, C.A.5
  • 40
    • 0036759157 scopus 로고    scopus 로고
    • Lack of neurodegeneration in transgenic mice overexpressing mutant amyloid precursor protein is associated with increased levels of transthyretin and the activation of cell survival pathways
    • T.D. Stein, and J.A. Johnson Lack of neurodegeneration in transgenic mice overexpressing mutant amyloid precursor protein is associated with increased levels of transthyretin and the activation of cell survival pathways J. Neurosci. 22 2002 7380 7388
    • (2002) J. Neurosci. , vol.22 , pp. 7380-7388
    • Stein, T.D.1    Johnson, J.A.2
  • 41
    • 55549139200 scopus 로고    scopus 로고
    • Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged rats
    • A.M. Stranahan, E.D. Norman, G. Roy, K.L. Cutler, and R.S. Telljohann Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged rats Hippocampus 18 11 2008 1085 1088
    • (2008) Hippocampus , vol.18 , Issue.11 , pp. 1085-1088
    • Stranahan, A.M.1    Norman, E.D.2    Roy, G.3    Cutler, K.L.4    Telljohann, R.S.5
  • 42
    • 49649112171 scopus 로고    scopus 로고
    • Lycopene inhibits growth human colon cancer cells via suppression of the AKT signaling pathway
    • F.Y. Tang, C.J. Shih, L.H. Cheng, H.J. Ho, and H.J. Chen Lycopene inhibits growth human colon cancer cells via suppression of the AKT signaling pathway Mol. Nutr. Food Res. 52 2008 646 654
    • (2008) Mol. Nutr. Food Res. , vol.52 , pp. 646-654
    • Tang, F.Y.1    Shih, C.J.2    Cheng, L.H.3    Ho, H.J.4    Chen, H.J.5
  • 43
    • 33748983516 scopus 로고    scopus 로고
    • The direct antioxidative and anti-inflammatory effects of peroxisome proliferator-activated receptors ligands are associated with the inhibition of angiotensin converting enzyme expression in streptozotocin-induced diabetic rat aorta
    • H. Toba, S. Miki, and T. Shimizu The direct antioxidative and anti-inflammatory effects of peroxisome proliferator-activated receptors ligands are associated with the inhibition of angiotensin converting enzyme expression in streptozotocin-induced diabetic rat aorta Eur. J. Pharmacol. 549 2006 124 132
    • (2006) Eur. J. Pharmacol. , vol.549 , pp. 124-132
    • Toba, H.1    Miki, S.2    Shimizu, T.3
  • 44
    • 0013914976 scopus 로고
    • Mechanism of lipid peroxide formation in animals
    • E.D. Wills Mechanism of lipid peroxide formation in animals Biochem. J. 99 1965 667 676
    • (1965) Biochem. J. , vol.99 , pp. 667-676
    • Wills, E.D.1
  • 46
    • 58149311349 scopus 로고
    • Determine acetylcholine of whole blood by alkalinity hydroxylammonium and galactose chromatometry
    • H. Yang, W. Wang, and J. Ke Determine acetylcholine of whole blood by alkalinity hydroxylammonium and galactose chromatometry J. Clin. Analy 13 1995 125 126
    • (1995) J. Clin. Analy , vol.13 , pp. 125-126
    • Yang, H.1    Wang, W.2    Ke, J.3
  • 47
    • 84875135190 scopus 로고    scopus 로고
    • Pioglitazone improves cognitive function via increasing insulin sensitivity and strengthening antioxidant defense system in fructose-drinking insulin resistant rats
    • Q. Yin, J. Pei, S. Xu, D. Luo, and S. Dong Pioglitazone improves cognitive function via increasing insulin sensitivity and strengthening antioxidant defense system in fructose-drinking insulin resistant rats PLoS ONE 8 3 2013 e59313
    • (2013) PLoS ONE , vol.8 , Issue.3 , pp. 59313
    • Yin, Q.1    Pei, J.2    Xu, S.3    Luo, D.4    Dong, S.5


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