The role of neurotrophins in bipolar disorder

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 56, Issue , 2015, Pages 122-128

  Scola, Gustavo ^a,b   Andreazza, Ana Cristina ^b,c  

^a UNIVERSITY OF TORONTO   (Canada)

^b CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

Bipolar disorder; Glial cell line derived neurotrophic factor; Insulin like growth factor 1; Neurotrophins; Vascular endothelial growth factor

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; GROWTH FACTOR RECEPTOR; NERVE GROWTH FACTOR; NEUROTROPHIN; NEUROTROPHIN 3; NEUROTROPHIN 4; SOMATOMEDIN; VASCULOTROPIN;

ARTICLE; BINDING AFFINITY; BIPOLAR DISORDER; CELL SURVIVAL; DEPRESSION; DISEASE ASSOCIATION; HUMAN; NERVE CELL; NERVE CELL PLASTICITY; NERVE STIMULATION; NEUROPATHOLOGY; NEUROPROTECTION; NONHUMAN; PATHOPHYSIOLOGY; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; METABOLISM;

BIPOLAR DISORDER; HUMANS; NERVE GROWTH FACTORS;

EID: 84907708153     PISSN: 02785846     EISSN: 18784216     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2014.08.013     Document Type: Review

References (81)

1. Airaksinen M.S., Saarma M. The GDNF family: signalling, biological functions and therapeutic value. Nat Rev Neurosci 2002, 3:383-394.
2. Barbosa I.G., Huguet R.B., Neves F.S., et al. Impaired nerve growth factor homeostasis in patients with bipolar disorder. World J Biol Psychiatry 2011, 12:228-232.
3. Barbosa I.G., Huguet R.B., Sousa L.P., et al. Circulating levels of GDNF in bipolar disorder. Neurosci Lett 2011, 502:103-106.
4. Barker P.A. Whither proBDNF?. Nat Neurosci 2009, 12:105-106.
5. Bezchlibnyk Y.B., Xu L., Wang J.F., et al. Decreased expression of insulin-like growth factor binding protein 2 in the prefrontal cortex of subjects with bipolar disorder and its regulation by lithium treatment. Brain Res 2007, 1147:213-217.
6. Boado R.J., Pardridge W.M. Comparison of blood-brain barrier transport of glial-derived neurotrophic factor (GDNF) and an IgG-GDNF fusion protein in the rhesus monkey. Drug Metab Dispos 2009, 37:2299-2304.
7. Bondy C., Lee W.H. Correlation between insulin-like growth factor (IGF)-binding protein 5 and IGF-I gene expression during brain development. J Neurosci 1993, 13:5092-5104.
8. Cassiman D., Denef C., Desmet V.J., et al. Human and rat hepatic stellate cells express neurotrophins and neurotrophin receptors. Hepatology 2001, 33:148-158.
9. Chao M.V. The p75 neurotrophin receptor. J Neurobiol 1994, 25:1373-1385.
10. Chen K.C., Chang L.S. Arachidonic acid-induced apoptosis of human neuroblastoma SK-N-SH cells is mediated through mitochondrial alteration elicited by ROS and Ca(2+)-evoked activation of p38alpha MAPK and JNK1. Toxicology 2009, 262:199-206.
11. Chen S.L., Lee S.Y., Chang Y.H., et al. The BDNF Val66Met polymorphism and plasma brain-derived neurotrophic factor levels in Han Chinese patients with bipolar disorder and schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry 2014, 51C:99-104.
12. Cunha A.B., Frey B.N., Andreazza A.C., et al. Serum brain-derived neurotrophic factor is decreased in bipolar disorder during depressive and manic episodes. Neurosci Lett 2006, 398:215-219.
13. Curtis D., Kalsi G., Brynjolfsson J., et al. Genome scan of pedigrees multiply affected with bipolar disorder provides further support for the presence of a susceptibility locus on chromosome 12q23-q24, and suggests the presence of additional loci on 1p and 1q. Psychiatr Genet 2003, 13:77-84.
14. D'Addario C., Dell'Osso B., Palazzo M.C., et al. Selective DNA methylation of BDNF promoter in bipolar disorder: differences among patients with BDI and BDII. Neuropsychopharmacology 2012, 37:1647-1655.
15. Donovan M.J., Lin M.I., Wiegn P., et al. Brain derived neurotrophic factor is an endothelial cell survival factor required for intramyocardial vessel stabilization. Development 2000, 127:4531-4540.
16. Durbec P., Marcos-Gutierrez C.V., Kilkenny C., et al. GDNF signalling through the Ret receptor tyrosine kinase. Nature 1996, 381:789-793.
17. Fernandes B.S., Gama C.S., Walz J.C., et al. Increased neurotrophin-3 in drug-free subjects with bipolar disorder during manic and depressive episodes. J Psychiatr Res 2010, 44:561-565.
18. Fernandes B.S., Gama C.S., Ceresér K.M., et al. Brain-derived neurotrophic factor as a state-marker of mood episodes in bipolar disorders: a systematic review and meta-regression analysis. J Psychiatr Res 2011, 45:995-1004.
19. Fournier N.M., Lee B., Banasr M., et al. Vascular endothelial growth factor regulates adult hippocampal cell proliferation through MEK/ERK- and PI3K/Akt-dependent signaling. Neuropharmacology 2012, 63:642-652.
20. Freeman R.S., Burch R.L., Crowder R.J., et al. NGF deprivation-induced gene expression: after ten years, where do we stand?. Prog Brain Res 2004, 146:111-126.
21. Frey B.N., Andreazza A.C., Houenou J., et al. Biomarkers in bipolar disorder: a positional paper from the International Society for Bipolar Disorders Biomarkers Task Force. Aust N Z J Psychiatry 2013, 47(4):321-332.
22. Fujimura H., Altar C.A., Chen R., et al. Brain-derived neurotrophic factor is stored in human platelets and released by agonist stimulation. Thromb Haemost 2002, 87:728-734.
23. Goldberg J.F., Chengappa K.N. Identifying and treating cognitive impairment in bipolar disorder. Bipolar Disord 2009, 11(Suppl. 2):123-137.
24. Götz R., Köster R., Winkler C., et al. Neurotrophin-6 is a new member of the nerve growth factor family. Nature 1994, 372:266-269.
25. Hashimoto K., Shimizu E., Iyo M. Critical role of brain-derived neurotrophic factor in mood disorders. Brain Res Brain Res Rev 2004, 45:104-114.
26. Ho B.C., Milev P., O'Leary D.S., et al. Cognitive and magnetic resonance imaging brain morphometric correlates of brain-derived neurotrophic factor Val66Met gene polymorphism in patients with schizophrenia and healthy volunteers. Arch Gen Psychiatry 2006, 63:731-740.
27. Holm M.M., Nieto-Gonzalez J.L., Vardya I., et al. Mature BDNF, but not proBDNF, reduces excitability of fast-spiking interneurons in mouse dentate gyrus. J Neurosci 2009, 29:12412-12418.
28. Huang E.J., Reichardt L.F. Neurotrophins: roles in neuronal development and function. Annu Rev Neurosci 2001, 24:677-736.
29. Hwang J.P., Tsai S.J., Hong C.J., et al. The Val66Met polymorphism of the brain-derived neurotrophic-factor gene is associated with geriatric depression. Neurobiol Aging 2006, 27:1834-1837.
30. Iga J., Ueno S., Yamauchi K., et al. Gene expression and association analysis of vascular endothelial growth factor in major depressive disorder. Prog Neuropsychopharmacol Biol Psychiatry 2007, 31:658-663.
31. Isung J., Mobarrez F., Nordström P., et al. Low plasma vascular endothelial growth factor (VEGF) associated with completed suicide. World J Biol Psychiatry 2012, 13:468-473.
32. Je H.S., Yang F., Ji Y., et al. Role of pro-brain-derived neurotrophic factor (proBDNF) to mature BDNF conversion in activity-dependent competition at developing neuromuscular synapses. Proc Natl Acad Sci U S A 2012, 109:15924-15929.
33. Jones D.M., Tucker B.A., Rahimtula M., et al. The synergistic effects of NGF and IGF-1 on neurite growth in adult sensory neurons: convergence on the PI 3-kinase signaling pathway. J Neurochem 2003, 86:1116-1128.
34. Kaplan D.R., Miller F.D. Neurotrophin signal transduction in the nervous system. Curr Opin Neurobiol 2000, 10:381-391.
35. Karege F., Bondolfi G., Gervasoni N., et al. Low brain-derived neurotrophic factor (BDNF) levels in serum of depressed patients probably results from lowered platelet BDNF release unrelated to platelet reactivity. Biol Psychiatry 2005, 57:1068-1072.
36. Kauer-Sant'Anna M., Kapczinski F., Andreazza A.C., et al. Brain-derived neurotrophic factor and inflammatory markers in patients with early- vs. late-stage bipolar disorder. Int J Neuropsychopharmacol 2009, 12:447-458.
37. Kempermann G., Kronenberg G. Depressed new neurons-adult hippocampal neurogenesis and a cellular plasticity hypothesis of major depression. Biol Psychiatry 2003, 54:499-503.
38. Kikuchi K., Iga J., Tayoshi S., et al. Lithium decreases VEGF mRNA expression in leukocytes of healthy subjects and patients with bipolar disorder. Hum Psychopharmacol 2011, 26:358-363.
39. Kim Y.K., Na K.S., Hwang J.A., et al. High insulin-like growth factor-1 in patients with bipolar I disorder: a trait marker?. J Affect Disord 2013, 151:738-743.
40. Kimpinski K., Campenot R.B., Mearow K. Effects of the neurotrophins nerve growth factor, neurotrophin-3, and brain-derived neurotrophic factor (BDNF) on neurite growth from adult sensory neurons in compartmented cultures. J Neurobiol 1997, 33:395-410.
41. Klein A.B., et al. Blood BDNF concentrations reflect brain-tissue BDNF levels across species. Int J Neuropsychopharmacol 2011, 14:347-353.
42. Lang U.E., Hellweg R., Kalus P., et al. Association of a functional BDNF polymorphism and anxiety-related personality traits. Psychopharmacology (Berl) 2005, 180:95-99.
43. Lee B.H., Kim Y.K. Increased plasma VEGF levels in major depressive or manic episodes in patients with mood disorders. J Affect Disord 2012, 136:181-184.
44. Lin P.Y. State-dependent decrease in levels of brain-derived neurotrophic factor in bipolar disorder: a meta-analytic study. Neurosci Lett 2009, 466:139-143.
45. Lin L.F., Doherty D.H., Lile J.D., et al. GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons. Science 1993, 260:1130-1132.
46. Matthews V.B., Aström M.B., Chan M.H., et al. Brain-derived neurotrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMP-activated protein kinase. Diabetologia 2009, 52:1409-1418.
47. Montag C., Weber B., Fliessbach K., et al. The BDNF Val66Met polymorphism impacts parahippocampal and amygdala volume in healthy humans: incremental support for a genetic risk factor for depression. Psychol Med 2009, 39:1831-1839.
48. Mufson E.J., et al. Distribution and retrograde transport of trophic factors in the central nervous system: functional implications for the treatment of neurodegenerative diseases. Prog Neurobiol 1999, 57:451-484.
49. Munkholm K., et al. Elevated levels of plasma brain derived neurotrophic factor in rapid cycling bipolar disorder patients. Psychoneuroendocrinology 2014, 47:199-211.
50. Neves-Pereira M., Mundo E., Muglia P., King N., Macciardi F., Kennedy J.L. The brain-derived neurotrophic factor gene confers susceptibility to bipolar disorder: evidence from a family-based association study. Am J Hum Genet 2002, 71:651-655.
51. Nguyen T.L., Kim C.K., Cho J.H., et al. Neuroprotection signaling pathway of nerve growth factor and brain-derived neurotrophic factor against staurosporine induced apoptosis in hippocampal H19-7/IGF-IR [corrected]. Exp Mol Med 2010, 42:583-595.
52. Nowacka M.M., Obuchowicz E. Vascular endothelial growth factor (VEGF) and its role in the central nervous system: a new element in the neurotrophic hypothesis of antidepressant drug action. Neuropeptides 2012, 46:1-10.
53. Otsuki K., Uchida S., Watanuki T., et al. Altered expression of neurotrophic factors in patients with major depression. J Psychiatr Res 2008, 42:1145-1153.
54. Palomino A., González-Pinto A., Martinez-Cengotitabengoa M., et al. Relationship between negative symptoms and plasma levels of insulin-like growth factor 1 in first-episode schizophrenia and bipolar disorder patients. Prog Neuropsychopharmacol Biol Psychiatry 2013, 44:29-33.
55. Pan W., et al. Transport of brain-derived neurotrophic factor across the blood-brain barrier. Neuropharmacology 1998, 37:1553-1561.
56. Pereira A.C., McQuillin A., Puri V., et al. Genetic association and sequencing of the insulin-like growth factor 1 gene in bipolar affective disorder. Am J Med Genet B Neuropsychiatr Genet 2011, 156:177-187.
57. Poo M.M. Neurotrophins as synaptic modulators. Nat Rev Neurosci 2001, 2:24-32.
58. Ray M.T., Shannon Weickert C., Webster M.J. Decreased BDNF and TrkB mRNA expression in multiple cortical areas of patients with schizophrenia and mood disorders. Transl Psychiatry 2014, 4:389.
59. Riikonen R. Insulin-like growth factor delivery across the blood-brain barrier. Potential use of IGF-1 as a drug in child neurology. Chemotherapy 2006, 52:279-281.
60. Rosa A.R., Frey B.N., Andreazza A.C., et al. Increased serum glial cell line-derived neurotrophic factor immunocontent during manic and depressive episodes in individuals with bipolar disorder. Neurosci Lett 2006, 407:146-150.
61. Rosa A.R., Singh N., Whitaker E., et al. Altered plasma glutathione levels in bipolar disorder indicates higher oxidative stress; a possible risk factor for illness onset despite normal brain-derived neurotrophic factor (BDNF) levels. Psychol Med 2014, 1-10.
62. Ruiz De Almodovar C., et al. Role and therapeutic potential of VEGF in the nervous system. Physiol Rev 2009, 89:607-648.
63. Rybakowski J.K., Permoda-Osip A., Skibinska M., et al. Single ketamine infusion in bipolar depression resistant to antidepressants: are neurotrophins involved?. Hum Psychopharmacol 2013, 28:87-90.
64. Sariola H. The neurotrophic factors in non-neuronal tissues. Cell Mol Life Sci 2001, 58:1061-1066.
65. Sen S., Duman R., Sanacora G. Serum brain-derived neurotrophic factor, depression, and antidepressant medications: meta-analyses and implications. Biol Psychiatry 2008, 64:527-532.
66. Shaltiel G., Chen G., Manji H.K. Neurotrophic signaling cascades in the pathophysiology and treatment of bipolar disorder. Curr Opin Pharmacol 2007, 1:22-26.
67. Shibata T., Yamagata H., Uchida S., et al. The alteration of hypoxia inducible factor-1 (HIF-1) and its target genes in mood disorder patients. Prog Neuropsychopharmacol Biol Psychiatry 2013, 43:222-229.
68. Sklar P., et al. Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus. Brain-derived neutrophic factor. Mol Psychiatry 2002, 7:579-593.
69. Södersten K., Pålsson E., Ishima T., et al. Abnormality in serum levels of mature brain-derived neurotrophic factor (BDNF) and its precursor proBDNF in mood-stabilized patients with bipolar disorder: a study of two independent cohorts. J Affect Disord 2014, 160:1-9.
70. Squassina A., et al. Insulin-like growth factor 1 (IGF-1) expression is up-regulated in lymphoblastoid cell lines of lithium responsive bipolar disorder patients. Pharmacol Res 2013, 73:1-7.
71. Takebayashi M., Hisaoka K., Nishida A., et al. Decreased levels of whole blood glial cell line-derived neurotrophic factor (GDNF) in remitted patients with mood disorders. Int J Neuropsychopharmacol 2006, 9:607-612.
72. Takebayashi M., Hashimoto R., Hisaoka K., et al. Plasma levels of vascular endothelial growth factor and fibroblast growth factor 2 in patients with major depressive disorders. J Neural Transm 2010, 117:1119-1122.
73. Taylor W.D., Züchner S., McQuoid D.R., et al. Allelic differences in the brain-derived neurotrophic factor Val66Met polymorphism in late-life depression. Am J Geriatr Psychiatry 2007, 15:850-857.
74. Tseng M., Alda M., Xu L., et al. BDNF protein levels are decreased in transformed lymphoblasts from lithium-responsive patients with bipolar disorder. J Psychiatry Neurosci 2008, 33:449-453.
75. Versace A., Andreazza A.C., Young L.T., et al. Elevated serum measures of lipid peroxidation and abnormal prefrontal white matter in euthymic bipolar adults: toward peripheral biomarkers of bipolar disorder. Mol Psychiatry 2013, 19:200-208.
76. Walz J.C., Andreazza A.C., Frey B.N., et al. Serum neurotrophin-3 is increased during manic and depressive episodes in bipolar disorder. Neurosci Lett 2007, 415:87-89.
77. Walz J.C., Magalhães P.V., Giglio L.M., et al. Increased serum neurotrophin-4/5 levels in bipolar disorder. J Psychiatr Res 2009, 43:721-723.
78. Wang Z., et al. Neurotrophic tyrosine kinase receptor type 2 (NTRK2) gene associated with treatment response to mood stabilizers in patients with bipolar I disorder. J Mol Neurosci 2013, 50:305-310.
79. Yatham L.N., Kapczinski F., Andreazza A.C., et al. Accelerated age-related decrease in brain-derived neurotrophic factor levels in bipolar disorder. Int J Neuropsychopharmacol 2009, 12:137-139.
80. Zhang X., Zhang Z., Sha W., et al. Effect of treatment on serum glial cell line-derived neurotrophic factor in bipolar patients. J Affect Disord 2010, 126:326-329.
81. Zheng W.H., Kar S., Quirion R. Insulin-like growth factor-1-induced phosphorylation of transcription factor FKHRL1 is mediated by phosphatidylinositol 3-kinase/Akt kinase and role of this pathway in insulin-like growth factor-1-induced survival of cultured hippocampal neurons. Mol Pharmacol 2002, 62:225-233.