Abnormality in serum levels of mature brain-derived neurotrophic factor (BDNF) and its precursor proBDNF in mood-stabilized patients with bipolar disorder: A study of two independent cohorts

Journal of Affective Disorders

Volumn 160, Issue , 2014, Pages 1-9

  Södersten, Kristoffer ^a   Pålsson, Erik ^a   Ishima, Tamaki ^b   Funa, Keiko ^c   Landén, Mikael ^a,d   Hashimoto, Kenji ^b   Ågren, Hans ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b CHIBA UNIVERSITY   (Japan)

^c UNIVERSITY OF GOTHENBURG   (Sweden)

^d KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Biomarker; Bipolar disorder; Diagnosis; Mature BDNF; proBDNF; Serum

Indexed keywords

ANTICONVULSIVE AGENT; ANTIDEPRESSANT AGENT; BRAIN DERIVED NEUROTROPHIC FACTOR; GELATINASE B; LITHIUM; NEUROLEPTIC AGENT; BIOLOGICAL MARKER;

ADULT; ARTICLE; BIPOLAR DISORDER; BIPOLAR I DISORDER; BIPOLAR II DISORDER; COHORT ANALYSIS; COMPARATIVE STUDY; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GLOBAL ASSESSMENT OF FUNCTIONING; HUMAN; MAJOR CLINICAL STUDY; MALE; MENTAL PATIENT; MINI MENTAL STATE EXAMINATION; MONTGOMERY ASBERG DEPRESSION RATING SCALE; MOOD; PRECURSOR; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; YOUNG MANIA RATING SCALE; BLOOD; CASE CONTROL STUDY; CROSS-SECTIONAL STUDY; MIDDLE AGED; PSYCHOLOGY;

ADULT; BIOLOGICAL MARKERS; BIPOLAR DISORDER; BRAIN-DERIVED NEUROTROPHIC FACTOR; CASE-CONTROL STUDIES; COHORT STUDIES; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; MALE; MATRIX METALLOPROTEINASE 9; MIDDLE AGED;

EID: 84896531281     PISSN: 01650327     EISSN: 15732517     Source Type: Journal    
DOI: 10.1016/j.jad.2014.01.009     Document Type: Article

References (52)

1. C.A. Altar Neurotrophins and depression Trends Pharmacol. Sci. 20 1999 59 62
2. F. Angst, J. Angst, H.H. Stassen, and P.J. Clayton Mortality of patients with mood disorders: follow-up over 34-38 years J. Affective Dis. 68 2002 167 181 (Pubitemid 34628324)
3. K.G. Bath, M.R. Akins, and F.S. Lee BDNF control of adult SVZ neurogenesis Dev. Psychobiol. 54 2012 578 589
4. P. Bekinschtein, C.A. Oomen, L.M. Saksida, and T.J. Bussey Effects of environmental enrichment and voluntary exercise on neurogenesis, learning and memory, and pattern separation: BDNF as a critical variable? Semin. Cell Dev. Biol. 22 2011 536 542
5. R.H. Belmaker Medical progress: bipolar disorder N. Engl. J. Med. 351 2004 476 486
6. C.M. Cassidy, N. Schmitz, and A. Malla Validation of the alcohol use disorders identification test and the drug abuse screening test in first episode psychosis Can. J. Psychiatry 53 2008 26 33 (Pubitemid 351235838)
7. K.M. Conigrave, W.D. Hall, and J.B. Saunders The AUDIT questionnaire: choosing a cut-off score. Alcohol use disorder identification test Addiction 90 1995 1349 1356
8. A.B. Cunha, B.N. Frey, A.C. Andreazza, J.D. Goi, A.R. Rosa, C.A. Goncalves, A. Santin, and F. Kapczinski Serum brain-derived neurotrophic factor is decreased in bipolar disorder during depressive and manic episodes Neurosci. Lett. 398 2006 215 219 (Pubitemid 43673698)
9. G.S. de Oliveira, K.M. Cereser, B.S. Fernandes, M. Kauer-SantAnna, G.R. Fries, L. Stertz, B. Aguiar, B. Pfaffenseller, and F. Kapczinski Decreased brain-derived neurotrophic factor in medicated and drug-free bipolar patients J. Psychiatric Res. 43 2009 1171 1174
10. V.V. Dias, S. Brissos, B.N. Frey, A.C. Andreazza, C. Cardoso, and F. Kapczinski Cognitive function and serum levels of brain-derived neurotrophic factor in patients with bipolar disorder Bipolar Disorders 11 2009 663 671
11. S. Dieni, M. Frotscher, Y.-A. Barde, T. Matsumoto, M. Dekkers, S. Rauskolb, M.S. Ionescu, R. Deogracias, E.D. Gundelfinger, M. Kojima, and S. Nestel BDNF and its pro-peptide are stored in presynaptic dense core vesicles in brain neurons J. Cell Biol. 196 2012 775 788
12. R.S. Duman, G.R. Heninger, and E.J. Nestler A molecular and cellular theory of depression Arch. Gen. Psychiatry 54 1997 597 606 (Pubitemid 27306570)
13. C.J. Ekman, J. Lind, E. Rydén, M. Ingvar, and M. Landén Manic episodes are associated with grey matter volume reduction - a voxel-based morphometry brain analysis Acta Psychiatrica Scand. 122 2010 507 515
14. P. Ernfors, C. Wetmore, L. Olson, and H. Persson Identification of cells in rat brain and peripheral tissues expressing mRNA for members of the nerve growth factor family Neuron 5 1990 511 526 (Pubitemid 20369587)
15. I.M. Ethell, and D.W. Ethell Matrix metalloproteinases in brain development and remodeling: synaptic functions and targets J. Neurosci. Res. 85 2007 2813 2823 (Pubitemid 47523564)
16. B.S. Fernandes, F. Kapczinski, C.S. Gama, K. Maria Ceresér, L.N. Yatham, G.R. Fries, G. Colpo, D. de Lucena, M. Kunz, and F.A. Gomes Brain-derived neurotrophic factor as a state-marker of mood episodes in bipolar disorders: a systematic review and meta-regression analysis J. Psychiatric Res. 45 2011 995 1004
17. M.F. Folstein, S.E. Folstein, and P.R. McHugh "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician J. Psychiatric Res. 12 1975 189 198
18. T.R. Goldstein, M. Keller, B. Birmaher, D. Axelson, B.I. Goldstein, M.K. Gill, C. Esposito-Smythers, N.D. Ryan, M.A. Strober, and J. Hunt Psychosocial functioning among bipolar youth J. Affective Dis. 114 2009 174 183
19. W. Guy Early Clinical Drug Evaluation (ECDEU) Assessment Manual for Psychopharmacology 1976 Department of Health, Education and Welfare
20. R.C. Hall Global assessment of functioning. A modified scale Psychosomatics 36 1995 267 275
21. K. Hashimoto BDNF variant linked to anxiety-related behaviors Bioessays 29 2007 116 119 (Pubitemid 46340246)
22. K. Hashimoto Brain-derived neurotrophic factor as a biomarker for mood disorders: an historical overview and future directions: BDNF as a biomarker of mood disorders Psychiatry Clin. Neurosci. 64 2010 341 357
23. K. Hashimoto Sigma-1 receptor chaperone and brain-derived neurotrophic factor: emerging links between cardiovascular disease and depression Prog. Neurobiol. 100 2013 15 29
24. K. Hashimoto, E. Shimizu, and M. Iyo Critical role of brain-derived neurotrophic factor in mood disorders Brain Res. Rev. 45 2004 104 114 (Pubitemid 38625738)
25. T.L. Huang, Y.Y. Hung, C.T. Lee, and R.F. Chen Serum protein levels of brain-derived neurotrophic factor and tropomyosin-related kinase B in bipolar disorder: effects of mood stabilizers Neuropsychobiology 65 2012 65 69
26. M. Kauer-SantAnna, F. Kapczinski, A.C. Andreazza, D.J. Bond, R.W. Lam, L.T. Young, and L.N. Yatham Brain-derived neurotrophic factor and inflammatory markers in patients with early- vs. late-stage bipolar disorder Int. J. Neuropsychopharmacol. 12 2009 447 458
27. P.Y. Lin State-dependent decrease in levels of brain-derived neurotrophic factor in bipolar disorder: a meta-analytic study Neurosci. Lett. 466 2009 139 143
28. L. Luborsky Clinicians judgments of mental health Arch. Gen. Psychiatry 7 1962 407 417
29. R. Machado-Vieira, M.O. Dietrich, R. Leke, V.H. Cereser, V. Zanatto, F. Kapczinski, D.O. Souza, L.V. Portela, and V. Gentil Decreased plasma brain derived neurotrophic factor levels in unmedicated bipolar patients during manic episode Biol. Psychiatry 61 2007 142 144 (Pubitemid 46072782)
30. P. Mackin, P. Gallagher, S. Watson, A.H. Young, and I.N. Ferrier Changes in brain-derived neurotrophic factor following treatment with mifepristone in bipolar disorder and schizophrenia Aust. N. Z. J. Psychiatry 41 2007 321 326 (Pubitemid 46705727)
31. M.W. Marlatt, M.C. Potter, P.J. Lucassen, and H. van Praag Running throughout middle-age improves memory function, hippocampal neurogenesis, and BDNF levels in female C57BL/6J mice Dev. Neurobiol. 72 2012 943 952
32. K. Martinowich, H. Manji, and B. Lu New insights into BDNF function in depression and anxiety Nat. Neurosci. 10 2007 1089 1093 (Pubitemid 47339961)
33. P. Monteleone, C. Serritella, V. Martiadis, and M. Maj Decreased levels of serum brain-derived neurotrophic factor in both depressed and euthymic patients with unipolar depression and in euthymic patients with bipolar I and II disorders Bipolar Disorders 10 2008 95 100
34. S.A. Montgomery, and M. Åsberg A new depression scale designed to be sensitive to change Br. J. Psychiatry 134 1979 322 389
35. E.J. Nestler, M. Barrot, R.J. DiLeone, A.J. Eisch, S.J. Gold, and L.M. Monteggia Neurobiology of depression Neuron 34 2002 13 25 (Pubitemid 34270695)
36. A. Palomino, A. Vallejo-Illarramendi, A. Gonzalez-Pinto, A. Aldama, C. Gonzalez-Gomez, F. Mosquera, G. Gonzalez-Garcia, and C. Matute Decreased levels of plasma BDNF in first-episode schizophrenia and bipolar disorder patients Schizophrenia Res. 86 2006 321 322 (Pubitemid 44234056)
37. W. Pan, W.A. Banks, M.B. Fasold, J. Bluth, and A.J. Kastin Transport of brain-derived neurotrophic factor across the blood-brain barrier Neuropharmacology 37 1998 1553 1561 (Pubitemid 28550429)
38. P.T. Pang, and N.H. Woo The yin and yang of neurotrophin action Nat. Rev. Neurosci. 6 2005 603 614 (Pubitemid 41059335)
39. H. Park, and M.M. Poo Neurotrophin regulation of neural circuit development and function Nat. Rev. Neurosci. 14 2013 7 23
40. Q. Peng, N. Masuda, M. Jiang, Q. Li, M. Zhao, C.A. Ross, and W. Duan The antidepressant sertraline improves the phenotype, promotes neurogenesis and increases BDNF levels in the R6/2 Huntingtons disease mouse model Exp. Neurol. 210 2008 154 163
41. M.-m. Poo Neurotrophins as synaptic modulators Nat. Rev. Neurosci. 2 2001 24 32
42. C. Rossi, A. Angelucci, L. Costantin, C. Braschi, M. Mazzantini, F. Babbini, M.E. Fabbri, L. Tessarollo, L. Maffei, N. Berardi, and M. Caleo Brain-derived neurotrophic factor (BDNF) is required for the enhancement of hippocampal neurogenesis following environmental enrichment Eur. J. Neurosci. 24 2006 1850 1856 (Pubitemid 44583469)
43. E. Rydén, C. Johansson, K. Blennow, and M. Landén Lower CSF HVA and 5-HIAA in bipolar disorder type 1 with a history of childhood ADHD J. Neural Transm. 116 2009 1667 1674
44. G.S. Sachs, M.E. Thase, M.W. Otto, M. Bauer, D. Miklowitz, S.R. Wisniewski, P. Lavori, B. Lebowitz, M. Rudorfer, E. Frank, A.A. Nierenberg, M. Fava, C. Bowden, T. Ketter, L. Marangell, J. Calabrese, D. Kupfer, and J.F. Rosenbaum Rationale, design, and methods of the systematic treatment enhancement program for bipolar disorder (STEP-BD) Biol. Psychiatry 53 2003 1028 1042 (Pubitemid 36645233)
45. H.D. Schmidt, and R.S. Duman Peripheral BDNF produces antidepressant-like effects in cellular and behavioral models Neuropsychopharmacology 35 2010 2378 2391
46. D.V. Sheehan, Y. Lecrubier, K.H. Sheehan, P. Amorim, J. Janavs, E. Weiller, T. Hergueta, R. Baker, and G.C. Dunbar The mini-international neuropsychiatric interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10 J. Clin. Psychiatry 59 Suppl 20 1998 22 33 (quiz 34-57) (Pubitemid 29001829)
47. R.L. Spitzer Psychiatric diagnosis: are clinicians still necessary? Compr. Psychiatry 24 1983 399 411 (Pubitemid 13004194)
48. M. Tohen, B.M. Cohen, J. Hennen, J.C.M. Zarate, R.J. Baldessarini, S.M. Strakowski, A.L. Stoll, G.L. Faedda, T. Suppes, and P. Gebre-Medhin Two-year syndromal and functional recovery in 219 cases of first-episode major affective disorder with psychotic features Am. J. Psychiatry 157 2000 220 228 (Pubitemid 30080901)
49. T. Yoshida, M. Ishikawa, M. Iyo, and K. Hashimoto Serum levels of mature brain-derived neurotrophic factor (BDNF) and its precursor proBDNF in healthy subjects Open Clin. Chem. J. 5 2012 7 12
50. T. Yoshida, M. Ishikawa, T. Niitsu, M. Nakazato, H. Watanabe, T. Shiraishi, A. Shiina, T. Hashimoto, N. Kanahara, T. Hasegawa, M. Enohara, A. Kimura, M. Iyo, and K. Hashimoto Decreased serum levels of mature brain-derived neurotrophic factor (BDNF), but not its precursor proBDNF, in patients with major depressive disorder PLoS One 7 2012 e42676
51. R. Yoshimura, Y. Nakano, H. Hori, A. Ikenouchi, N. Ueda, and J. Nakamura Effect of risperidone on plasma catecholamine metabolites and brain-derived neurotrophic factor in patients with bipolar disorders Hum. Psychopharmacol. 21 2006 433 438 (Pubitemid 44660182)
52. R.C. Young, J.T. Biggs, V.E. Ziegler, and D.A. Meyer A rating scale for mania: reliability, validity and sensitivity Br. J. Psychiatry 133 1978 429 435 (Pubitemid 9006756)