Elevated levels of plasma brain derived neurotrophic factor in rapid cycling bipolar disorder patients

Psychoneuroendocrinology

Volumn 47, Issue , 2014, Pages 199-211

  Munkholm, Klaus ^a   Pedersen, Bente Klarlund ^a   Kessing, Lars Vedel ^a   Vinberg, Maj ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Biomarkers; Bipolar disorder; Brain derived neurotrophic factor (BDNF); Longitudinal study; Neurotrophin 3 (NT 3)

Indexed keywords

ANTICONVULSIVE AGENT; BRAIN DERIVED NEUROTROPHIC FACTOR; LITHIUM; NEUROLEPTIC AGENT; NEUROTROPHIN 3; SEROTONIN UPTAKE INHIBITOR; BIOLOGICAL MARKER; BRAIN-DERIVED NEUROTROPHIC FACTOR, HUMAN;

ADULT; AFFECT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DEMOGRAPHY; DEPRESSION; DISEASE DURATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HYPOMANIA; LIFESTYLE; LONGITUDINAL STUDY; MALE; MANIA; MEASUREMENT; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAPID CYCLING BIPOLAR DISORDER; STANDARDIZATION; BIPOLAR DISORDER; BLOOD; CASE CONTROL STUDY; DISEASE COURSE; MIDDLE AGED; SEVERITY OF ILLNESS INDEX; UPREGULATION; YOUNG ADULT;

ADULT; AGED; BIOLOGICAL MARKERS; BIPOLAR DISORDER; BRAIN-DERIVED NEUROTROPHIC FACTOR; CASE-CONTROL STUDIES; DISEASE PROGRESSION; FEMALE; HUMANS; MALE; MIDDLE AGED; NEUROTROPHIN 3; SEVERITY OF ILLNESS INDEX; UP-REGULATION; YOUNG ADULT;

EID: 84903727337     PISSN: 03064530     EISSN: 18733360     Source Type: Journal    
DOI: 10.1016/j.psyneuen.2014.05.011     Document Type: Article

References (84)

1. Angst J., Adolfsson R., Benazzi F., Gamma A., Hantouche E., Meyer T.D., Skeppar P., Vieta E., Scott J. The HCL-32: towards a self-assessment tool for hypomanic symptoms in outpatients. J. Affect. Disord. 2005, 88:217-233.
2. Angst J., Gamma A., Bowden C.L., Azorin J.M., Perugi G., Vieta E., Young A.H. Diagnostic criteria for bipolarity based on an international sample of 5635 patients with DSM-IV major depressive episodes. Eur. Arch. Psychiatry Clin. Neurosci. 2012, 262:3-11.
3. Barbosa I.G., Huguet R.B., Mendonca V.A., Neves F.S., Reis H.J., Bauer M.E., Janka Z., Palotas A., Teixeira A.L. Increased plasma levels of brain-derived neurotrophic factor in patients with long-term bipolar disorder. Neurosci. Lett. 2010, 475:95-98.
4. Barbosa I.G., Rocha N.P., de Miranda A.S., Huguet R.B., Bauer M.E., Reis H.J., Teixeira A.L. Increased BDNF levels in long-term bipolar disorder patients. Rev. Bras. Psiquiatr. 2013, 35:67-69.
5. Barbosa I.G., Rocha N.P., Huguet R.B., Ferreira R.A., Salgado J.V., Carvalho L.A., Pariante C.M., Teixeira A.L. Executive dysfunction in euthymic bipolar disorder patients and its association with plasma biomarkers. J. Affect. Disord. 2012, 137:151-155.
6. Berk M., Kapczinski F., Andreazza A.C., Dean O.M., Giorlando F., Maes M., Yucel M., Gama C.S., Dodd S., Dean B., Magalhaes P.V., Amminger P., McGorry P., Malhi G.S. Pathways underlying neuroprogression in bipolar disorder: focus on inflammation, oxidative stress and neurotrophic factors. Neurosci. Biobehav. Rev. 2011, 35:804-817.
7. Bramham C.R., Messaoudi E. BDNF function in adult synaptic plasticity: the synaptic consolidation hypothesis. Prog. Neurobiol. 2005, 76:99-125.
8. Bus B.A., Molendijk M.L., Penninx B.J., Buitelaar J.K., Kenis G., Prickaerts J., Elzinga B.M., Voshaar R.C. Determinants of serum brain-derived neurotrophic factor. Psychoneuroendocrinology 2011, 36:228-239.
9. Bus B.A., Tendolkar I., Franke B., de Graaf J., den Heijer M., Buitelaar J.K., Oude Voshaar R.C. Serum brain-derived neurotrophic factor: determinants and relationship with depressive symptoms in a community population of middle-aged and elderly people. World J. Biol. Psychiatry 2012, 13:39-47.
10. Chen P.S., Peng G.S., Li G., Yang S., Wu X., Wang C.C., Wilson B., Lu R.B., Gean P.W., Chuang D.M., Hong J.S. Valproate protects dopaminergic neurons in midbrain neuron/glia cultures by stimulating the release of neurotrophic factors from astrocytes. Mol. Psychiatry 2006, 11:1116-1125.
11. Chen S.L., Lee S.Y., Chang Y.H., Chen S.H., Chu C.H., Wang T.Y., Chen P.S., Lee I.H., Yang Y.K., Hong J.S., Lu R.B. The BDNF Val66Met polymorphism and plasma brain-derived neurotrophic factor levels in Han Chinese patients with bipolar disorder and schizophrenia. Prog. Neuropsychopharmacol. Biol. Psychiatry 2014, 51:99-104.
12. (2)max performance in healthy college men. Neurosci. Lett. 2012, 519:78-83.
13. Chou Y.H., Wang S.J., Lirng J.F., Lin C.L., Yang K.C., Chen C.K., Yeh C.B., Liao M.H. Impaired cognition in bipolar I disorder: the roles of the serotonin transporter and brain-derived neurotrophic factor. J. Affect. Disord. 2012, 143:131-137.
14. Coryell W., Solomon D., Turvey C., Keller M., Leon A.C., Endicott J., Schettler P., Judd L., Mueller T. The long-term course of rapid-cycling bipolar disorder. Arch. Gen. Psychiatry 2003, 60:914-920.
15. Coyle J.T., Duman R.S. Finding the intracellular signaling pathways affected by mood disorder treatments. Neuron 2003, 38:157-160.
16. Cunha A.B., Frey B.N., Andreazza A.C., Goi J.D., Rosa A.R., Goncalves C.A., Santin A., Kapczinski F. Serum brain-derived neurotrophic factor is decreased in bipolar disorder during depressive and manic episodes. Neurosci. Lett. 2006, 398:215-219.
17. de Oliveira G.S., Cereser K.M., Fernandes B.S., Kauer-Sant'Anna M., Fries G.R., Stertz L., Aguiar B., Pfaffenseller B., Kapczinski F. Decreased brain-derived neurotrophic factor in medicated and drug-free bipolar patients. J. Psychiatr. Res. 2009, 43:1171-1174.
18. Dias V.V., Brissos S., Frey B.N., Andreazza A.C., Cardoso C., Kapczinski F. Cognitive function and serum levels of brain-derived neurotrophic factor in patients with bipolar disorder. Bipolar Disord. 2009, 11:663-671.
19. Duman R.S., Monteggia L.M. A neurotrophic model for stress-related mood disorders. Biol. Psychiatry 2006, 59:1116-1127.
20. Elfving B., Plougmann P.H., Muller H.K., Mathe A.A., Rosenberg R., Wegener G. Inverse correlation of brain and blood BDNF levels in a genetic rat model of depression. Int. J. Neuropsychopharmacol. 2010, 13:563-572.
21. Fernandes B.S., Gama C.S., Cereser K.M., Yatham L.N., Fries G.R., Colpo G., de Lucena D., Kunz M., Gomes F.A., Kapczinski F. Brain-derived neurotrophic factor as a state-marker of mood episodes in bipolar disorders: a systematic review and meta-regression analysis. J. Psychiatr. Res. 2011, 45:995-1004.
22. Fernandes B.S., Gama C.S., Kauer-Sant'Anna M., Lobato M.I., Belmonte-de-Abreu P., Kapczinski F. Serum brain-derived neurotrophic factor in bipolar and unipolar depression: a potential adjunctive tool for differential diagnosis. J. Psychiatr. Res. 2009, 43:1200-1204.
23. Fernandes B.S., Gama C.S., Walz J.C., Cereser K.M., Fries G.R., Colpo G., Aguiar B., Pfaffenseller B., Kauer-Sant'anna M., Kapczinski F. Increased neurotrophin-3 in drug-free subjects with bipolar disorder during manic and depressive episodes. J. Psychiatr. Res. 2010, 44:561-565.
24. Fujimura H., Altar C.A., Chen R., Nakamura T., Nakahashi T., Kambayashi J., Sun B., Tandon N.N. Brain-derived neurotrophic factor is stored in human platelets and released by agonist stimulation. Thromb. Haemost. 2002, 87:728-734.
25. Fukumoto T., Morinobu S., Okamoto Y., Kagaya A., Yamawaki S. Chronic lithium treatment increases the expression of brain-derived neurotrophic factor in the rat brain. Psychopharmacology (Berl.) 2001, 158:100-106.
26. Galimberti D., Prunas C., Paoli R.A., Dell'osso B., Fenoglio C., Villa C., Palazzo C., Cigliobianco M., Camuri G., Serpente M., Scarpini E., Altamura A.C. Progranulin gene variability influences the risk for bipolar I disorder, but not bipolar II disorder. Bipolar Disord. 2014, 10.1111/bdi.12180.
27. Goldstein B.I., Young L.T. Toward clinically applicable biomarkers in bipolar disorder: focus on BDNF, inflammatory markers, and endothelial function. Curr. Psychiatry Rep. 2013, 15:425.
28. Grande I., Fries G.R., Kunz M., Kapczinski F. The role of BDNF as a mediator of neuroplasticity in bipolar disorder. Psychiatry Investig. 2010, 7:243-250.
29. Grande I., Kapczinski F., Stertz L., Colpo G.D., Kunz M., Cereser K.M., Kauer-Sant'Anna M., Frey B., Vieta E., Magalhaes P.V. Peripheral brain-derived neurotrophic factor changes along treatment with extended release quetiapine during acute mood episodes: an open-label trial in drug-free patients with bipolar disorder. J. Psychiatr. Res. 2012, 46:1511-1514.
30. Grande I., Magalhaes P.V., Chendo I., Stertz L., Fries G.R., Cereser K.M., Cunha A.B., Goi P., Kunz M., Udina M., Martin-Santos R., Frey B.N., Vieta E., Kapczinski F. Val66Met polymorphism and serum brain-derived neurotrophic factor in bipolar disorder: an open-label trial. Acta Psychiatr. Scand. 2013, 10.1111/acps.12192.
31. Hajek T., Carrey N., Alda M. Neuroanatomical abnormalities as risk factors for bipolar disorder. Bipolar Disord. 2005, 7:393-403.
32. Hamilton M. Development of a rating scale for primary depressive illness. Br. J. Soc. Clin. Psychol. 1967, 6:278-296.
33. Huang E.J., Reichardt L.F. Trk receptors: roles in neuronal signal transduction. Annu. Rev. Biochem. 2003, 72:609-642.
34. Huang T.L., Hung Y.Y., Lee C.T., Chen R.F. Serum protein levels of brain-derived neurotrophic factor and tropomyosin-related kinase B in bipolar disorder: effects of mood stabilizers. Neuropsychobiology 2012, 65:65-69.
35. Kapczinski F., Dal-Pizzol F., Teixeira A.L., Magalhaes P.V., Kauer-Sant'Anna M., Klamt F., Moreira J.C., de Bittencourt Pasquali M.A., Fries G.R., Quevedo J., Gama C.S., Post R. Peripheral biomarkers and illness activity in bipolar disorder. J. Psychiatr. Res. 2011, 45:156-161.
36. Kapczinski F., Dias V.V., Kauer-Sant'Anna M., Frey B.N., Grassi-Oliveira R., Colom F., Berk M. Clinical implications of a staging model for bipolar disorders. Expert Rev. Neurother. 2009, 9:957-966.
37. Karege F., Bondolfi G., Gervasoni N., Schwald M., Aubry J.M., Bertschy G. Low brain-derived neurotrophic factor (BDNF) levels in serum of depressed patients probably results from lowered platelet BDNF release unrelated to platelet reactivity. Biol. Psychiatry 2005, 57:1068-1072.
38. Karege F., Schwald M., Cisse M. Postnatal developmental profile of brain-derived neurotrophic factor in rat brain and platelets. Neurosci. Lett. 2002, 328:261-264.
39. Kauer-Sant'Anna M., Kapczinski F., Andreazza A.C., Bond D.J., Lam R.W., Young L.T., Yatham L.N. Brain-derived neurotrophic factor and inflammatory markers in patients with early- vs. late-stage bipolar disorder. Int. J. Neuropsychopharmacol. 2009, 12:447-458.
40. Kenna H.A., Reynolds-May M., Stepanenko A., Ketter T.A., Hallmayer J., Rasgon N.L. Blood levels of brain derived neurotrophic factor in women with bipolar disorder and healthy control women. J. Affect. Disord. 2014, 156:214-218.
41. Kieseppa T., Mantyla R., Tuulio-Henriksson A., Luoma K., Mantere O., Ketokivi M., Holma M., Jylha P., Melartin T., Suominen K., Vuorilehto M., Isometsa E. White matter hyperintensities and cognitive performance in adult patients with bipolar I, bipolar II, and major depressive disorders. Eur. Psychiatry 2013, 10.1016/j.eurpsy.2013.08.002.
42. Kim Y.K., Na K.S., Hwang J.A., Yoon H.K., Lee H.J., Hahn S.W., Lee B.H., Jung H.Y. High insulin-like growth factor-1 in patients with bipolar I disorder: a trait marker?. J. Affect. Disord. 2013, 151:738-743.
43. Klein A.B., Williamson R., Santini M.A., Clemmensen C., Ettrup A., Rios M., Knudsen G.M., Aznar S. Blood BDNF concentrations reflect brain-tissue BDNF levels across species. Int. J. Neuropsychopharmacol. 2011, 14:347-353.
44. Krabbe K.S., Mortensen E.L., Avlund K., Pedersen A.N., Pedersen B.K., Jorgensen T., Bruunsgaard H. Brain-derived neurotrophic factor predicts mortality risk in older women. J. Am. Geriatr. Soc. 2009, 57:1447-1452.
45. Kupka R.W., Luckenbaugh D.A., Post R.M., Suppes T., Altshuler L.L., Keck P.E., Frye M.A., Denicoff K.D., Grunze H., Leverich G.S., McElroy S.L., Walden J., Nolen W.A. Comparison of rapid-cycling and non-rapid-cycling bipolar disorder based on prospective mood ratings in 539 outpatients. Am. J. Psychiatry 2005, 162:1273-1280.
46. Lee S.Y., Chen S.L., Chang Y.H., Chu C.H., Huang S.Y., Tzeng N.S., Wang C.L., Lin S.H., Lee I.H., Yeh T.L., Yang Y.K., Lu R.B. The ALDH2 and 5-HT2A genes interacted in bipolar-I but not bipolar-II disorder. Prog. Neuropsychopharmacol. Biol. Psychiatry 2012, 38:247-251.
47. Leonard B., Maes M. Mechanistic explanations how cell-mediated immune activation, inflammation and oxidative and nitrosative stress pathways and their sequels and concomitants play a role in the pathophysiology of unipolar depression. Neurosci. Biobehav. Rev. 2012, 36:764-785.
48. Lipska B.K., Khaing Z.Z., Weickert C.S., Weinberger D.R. BDNF mRNA expression in rat hippocampus and prefrontal cortex: effects of neonatal ventral hippocampal damage and antipsychotic drugs. Eur. J. Neurosci. 2001, 14:135-144.
49. Lommatzsch M., Zingler D., Schuhbaeck K., Schloetcke K., Zingler C., Schuff-Werner P., Virchow J.C. The impact of age, weight and gender on BDNF levels in human platelets and plasma. Neurobiol. Aging 2005, 26:115-123.
50. Lotrich F.E., Butters M.A., Aizenstein H., Marron M.M., Reynolds C.F., Gildengers A.G. The relationship between interleukin-1 receptor antagonist and cognitive function in older adults with bipolar disorder. Int. J. Geriatr. Psychiatry 2013, 10.1002/gps.4048.
51. Lu Y.A., Lee S.Y., Chen S.L., Chen S.H., Chu C.H., Tzeng N.S., Huang S.Y., Kuo P.H., Wang C.L., Lee I.H., Yeh T.L., Yang Y.K., Lu R.B. Gene-temperament interactions might distinguish between bipolar I and bipolar II disorders: a cross-sectional survey of Han Chinese in Taiwan. J. Clin. Psychiatry 2012, 73:339-345.
52. Machado-Vieira R., Dietrich M.O., Leke R., Cereser V.H., Zanatto V., Kapczinski F., Souza D.O., Portela L.V., Gentil V. Decreased plasma brain derived neurotrophic factor levels in unmedicated bipolar patients during manic episode. Biol. Psychiatry 2007, 61:142-144.
53. Mackin P., Gallagher P., Watson S., Young A.H., Ferrier I.N. Changes in brain-derived neurotrophic factor following treatment with mifepristone in bipolar disorder and schizophrenia. Aust. N. Z. J. Psychiatry 2007, 41:321-326.
54. Malhi G.S., Tanious M., Das P., Coulston C.M., Berk M. Potential mechanisms of action of lithium in bipolar disorder. Current understanding. CNS Drugs 2013, 27:135-153.
55. Manji H.K., Duman R.S. Impairments of neuroplasticity and cellular resilience in severe mood disorders: implications for the development of novel therapeutics. Psychopharmacol. Bull. 2001, 35:5-49.
56. Monteleone P., Serritella C., Martiadis V., Maj M. Decreased levels of serum brain-derived neurotrophic factor in both depressed and euthymic patients with unipolar depression and in euthymic patients with bipolar I and II disorders. Bipolar Disord. 2008, 10:95-100.
57. Munkholm K., Brauner J.V., Kessing L.V., Vinberg M. Cytokines in bipolar disorder vs. healthy control subjects: a systematic review and meta-analysis. J. Psychiatr. Res. 2013, 47:1119-1133.
58. Munkholm K., Vinberg M., Berk M., Kessing L.V. State-related alterations of gene expression in bipolar disorder: a systematic review. Bipolar Disord. 2012, 14:684-696.
59. Munkholm K., Vinberg M., Vedel Kessing L. Cytokines in bipolar disorder: a systematic review and meta-analysis. J. Affect. Disord. 2013, 144:16-27.
60. Pan W., Banks W.A., Fasold M.B., Bluth J., Kastin A.J. Transport of brain-derived neurotrophic factor across the blood-brain barrier. Neuropharmacology 1998, 37:1553-1561.
61. Pan W., Banks W.A., Kastin A.J. Permeability of the blood-brain barrier to neurotrophins. Brain Res. 1998, 788:87-94.
62. Papadimitriou G.N., Calabrese J.R., Dikeos D.G., Christodoulou G.N. Rapid cycling bipolar disorder: biology and pathogenesis. Int. J. Neuropsychopharmacol. 2005, 8:281-292.
63. Parker G., Graham R., Synnott H., Anderson J. Is the DSM-5 duration criterion valid for the definition of hypomania?. J. Affect. Disord. 2014, 156:87-91.
64. Post R.M. Role of BDNF in bipolar and unipolar disorder: clinical and theoretical implications. J. Psychiatr. Res. 2007, 41:979-990.
65. Rasmussen P., Brassard P., Adser H., Pedersen M.V., Leick L., Hart E., Secher N.H., Pedersen B.K., Pilegaard H. Evidence for a release of brain-derived neurotrophic factor from the brain during exercise. Exp. Physiol. 2009, 94:1062-1069.
66. Reis H.J., Nicolato R., Barbosa I.G., Teixeira do Prado P.H., Romano-Silva M.A., Teixeira A.L. Increased serum levels of brain-derived neurotrophic factor in chronic institutionalized patients with schizophrenia. Neurosci. Lett. 2008, 439:157-159.
67. Ricken R., Adli M., Lange C., Krusche E., Stamm T.J., Gaus S., Koehler S., Nase S., Bschor T., Richter C., Steinacher B., Heinz A., Rapp M.A., Borgwardt S., Hellweg R., Lang U.E. Brain-derived neurotrophic factor serum concentrations in acute depressive patients increase during lithium augmentation of antidepressants. J. Clin. Psychopharmacol. 2013, 33:806-809.
68. Sartorius A., Hellweg R., Litzke J., Vogt M., Dormann C., Vollmayr B., Danker-Hopfe H., Gass P. Correlations and discrepancies between serum and brain tissue levels of neurotrophins after electroconvulsive treatment in rats. Pharmacopsychiatry 2009, 42:270-276.
69. Schneck C.D., Miklowitz D.J., Miyahara S., Araga M., Wisniewski S., Gyulai L., Allen M.H., Thase M.E., Sachs G.S. The prospective course of rapid-cycling bipolar disorder: findings from the STEP-BD. Am. J. Psychiatry 2008, 165:370-377.
70. Schulte-Herbruggen O., Jockers-Scherubl M.C., Hellweg R. Neurotrophins: from pathophysiology to treatment in Alzheimer's disease. Curr. Alzheimer Res. 2008, 5:38-44.
71. Sen S., Duman R., Sanacora G. Serum brain-derived neurotrophic factor, depression, and antidepressant medications: meta-analyses and implications. Biol. Psychiatry 2008, 64:527-532.
72. Shaltiel G., Chen G., Manji H.K. Neurotrophic signaling cascades in the pathophysiology and treatment of bipolar disorder. Curr. Opin. Pharmacol. 2007, 7:22-26.
73. Soeiro-de-Souza M.G., Dias V.V., Figueira M.L., Forlenza O.V., Gattaz W.F., Zarate C.A., Machado-Vieira R. Translating neurotrophic and cellular plasticity: from pathophysiology to improved therapeutics for bipolar disorder. Acta Psychiatr. Scand. 2012, 126:332-341.
74. Suwalska A., Sobieska M., Rybakowski J.K. Serum brain-derived neurotrophic factor in euthymic bipolar patients on prophylactic lithium therapy. Neuropsychobiology 2010, 62:229-234.
75. Tang S.W., Chu E., Hui T., Helmeste D., Law C. Influence of exercise on serum brain-derived neurotrophic factor concentrations in healthy human subjects. Neurosci. Lett. 2008, 431:62-65.
76. Trajkovska V., Marcussen A.B., Vinberg M., Hartvig P., Aznar S., Knudsen G.M. Measurements of brain-derived neurotrophic factor: methodological aspects and demographical data. Brain Res. Bull. 2007, 73:143-149.
77. Tramontina J.F., Andreazza A.C., Kauer-Sant'anna M., Stertz L., Goi J., Chiarani F., Kapczinski F. Brain-derived neurotrophic factor serum levels before and after treatment for acute mania. Neurosci. Lett. 2009, 452:111-113.
78. Walz J.C., Andreazza A.C., Frey B.N., Cacilhas A.A., Cereser K.M., Cunha A.B., Weyne F., Stertz L., Santin A., Goncalves C.A., Kapczinski F. Serum neurotrophin-3 is increased during manic and depressive episodes in bipolar disorder. Neurosci. Lett. 2007, 415:87-89.
79. Williams J.B.W. Structural interview guidelines for the Hamilton Depression Rating Scale. The Hamilton Scales 1990, 48-63. Springer, Berlin. P. Bech, A. Coppen (Eds.).
80. Wing J.K., Babor T., Brugha T., Burke J., Cooper J.E., Giel R., Jablenski A., Regier D., Sartorius N. SCAN. Schedules for Clinical Assessment in Neuropsychiatry. Arch. Gen. Psychiatry 1990, 47:589-593.
81. Yoshimura R., Nakano Y., Hori H., Ikenouchi A., Ueda N., Nakamura J. Effect of risperidone on plasma catecholamine metabolites and brain-derived neurotrophic factor in patients with bipolar disorders. Hum. Psychopharmacol. 2006, 21:433-438.
82. Yoshimura R., Sugita-Ikenouchi A., Hori H., Umene-Nakano W., Hayashi K., Katsuki A., Ueda N., Nakamura J. A close correlation between plasma and serum levels of brain-derived neurotrophic factor (BDNF) in healthy volunteers. Int. J. Psychiatry Clin. 2010, 14:220-222.
83. Young R.C., Biggs J.T., Ziegler V.E., Meyer D.A. A rating scale for mania: reliability, validity and sensitivity. Br. J. Psychiatry 1978, 133:429-435.
84. Yucel K., McKinnon M.C., Taylor V.H., Macdonald K., Alda M., Young L.T., MacQueen G.M. Bilateral hippocampal volume increases after long-term lithium treatment in patients with bipolar disorder: a longitudinal MRI study. Psychopharmacology (Berl.) 2007, 195:357-367.