Insulin-like growth factor delivery across the blood-brain barrier. Potential use of IGF-1 as a drug in child neurology

Chemotherapy

Volumn 52, Issue 6, 2006, Pages 279-281

  Riikonen, Raili ^a  

^a UNIVERSITY OF HELSINKI AND HELSINKI UNIVERSITY HOSPITAL   (Finland)

Author keywords

Blood brain barrier; Children; Insulin like growth factor; Neurological diseases; Therapy

Indexed keywords

SOMATOMEDIN C;

ARTICLE; BLOOD BRAIN BARRIER; CELL DEGENERATION; CENTRAL NERVOUS SYSTEM DISEASE; CEREBELLUM; CEREBELLUM ATROPHY; CHILD; DRUG DELIVERY SYSTEM; HUMAN; LIPOFUSCINOSIS; LYMPHATIC LEUKEMIA; NERVE DEGENERATION; NEUROLOGIC DISEASE; PRIORITY JOURNAL; PROTEIN CEREBROSPINAL FLUID LEVEL; PURKINJE CELL; RADIOIMMUNOASSAY; WHITE MATTER;

AUTISTIC DISORDER; BLOOD-BRAIN BARRIER; BRAIN DISEASES; CASE-CONTROL STUDIES; CENTRAL NERVOUS SYSTEM; DISEASE PROGRESSION; HEREDODEGENERATIVE DISORDERS, NERVOUS SYSTEM; HUMANS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 2; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 3; INSULIN-LIKE GROWTH FACTOR I; LEUKEMIA, LYMPHOCYTIC, ACUTE; OPTIC ATROPHY; RADIOIMMUNOASSAY;

EID: 33750256629     PISSN: 00093157     EISSN: None     Source Type: Journal    
DOI: 10.1159/000095957     Document Type: Article

References (5)

1. Sorgel F: The return of Ehrlich's 'Therapia magna sterilisans' and other Ehrlich concepts? Series of papers honouring Paul Ehrlich on the occasion of his 150th birthday. Chemotherapy 2004;50:6-10.
2. Leventhal P, Russel J, Feldman E: IGFs and the nervous system; in Rosenfeld RG, Robers CT Jr (eds): The IGF System: Molecular Biology. Physiology, and Clinical Applications. Totowa, Humana Press, 1999, vol 19, pp 425-444.
3. Pan W, Kastin A: Interactions of IGF-1 with the blood-brain barrier in vivo and in situ. Neuroendocrinology 2000;72:171-178.
4. Norman P: Somatokine. Insmed. Curr Opin Investig Drugs 2003;4:466-471.
5. Riikonen R, Vettenranta K, Riikonen P, Turpeinen U, Pihkala U: Cerebrospinal fluid insulin-like growth factor (IGF-1) and insulin-like growth factor binding protein (IGFBP-2) in children with acute lymphoblastic leukemia. Pediatr Blood Cancer 2004;43:1-5.