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Volumn 2, Issue 1, 2013, Pages

Applying systems biology methods to the study of human physiology in extreme environments

Author keywords

[No Author keywords available]

Indexed keywords

ENVIRONMENTAL FACTOR; HUMAN; MATHEMATICAL MODEL; METABOLIC PARAMETERS; METABOLOMICS; NUTRITION; PHYSIOLOGY; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; PROTEOMICS; REVIEW; SYSTEMS BIOLOGY; TWO DIMENSIONAL GEL ELECTROPHORESIS;

EID: 84907630708     PISSN: None     EISSN: 20467648     Source Type: Journal    
DOI: 10.1186/2046-7648-2-8     Document Type: Review
Times cited : (25)

References (77)
  • 2
    • 45149105874 scopus 로고    scopus 로고
    • Fatigue mechanisms determining exercise performance: integrative physiology is systems biology
    • 10.1152/japplphysiol.00088.2008, 18239081
    • Hargreaves M. Fatigue mechanisms determining exercise performance: integrative physiology is systems biology. J Appl Physiol 2008, 104:1541-1542. 10.1152/japplphysiol.00088.2008, 18239081.
    • (2008) J Appl Physiol , vol.104 , pp. 1541-1542
    • Hargreaves, M.1
  • 3
    • 75149129569 scopus 로고    scopus 로고
    • A protocol for generating a high-quality genome-scale metabolic reconstruction
    • 3125167, 20057383
    • Thiele I, Palsson BO. A protocol for generating a high-quality genome-scale metabolic reconstruction. Nat Protoc 2010, 5:93-121. 3125167, 20057383.
    • (2010) Nat Protoc , vol.5 , pp. 93-121
    • Thiele, I.1    Palsson, B.O.2
  • 4
    • 33751361595 scopus 로고    scopus 로고
    • Cambridge: Cambridge University Press
    • Palsson B. Systems Biology 2008, Cambridge: Cambridge University Press.
    • (2008) Systems Biology
    • Palsson, B.1
  • 5
    • 79951973967 scopus 로고    scopus 로고
    • 'Systems biology' in human exercise physiology: is it something different from integrative physiology?
    • 10.1113/jphysiol.2010.201525, 3060583, 21224223
    • Greenhaff PL, Hargreaves M. 'Systems biology' in human exercise physiology: is it something different from integrative physiology?. J Physiol 2011, 589:1031-1036. 10.1113/jphysiol.2010.201525, 3060583, 21224223.
    • (2011) J Physiol , vol.589 , pp. 1031-1036
    • Greenhaff, P.L.1    Hargreaves, M.2
  • 6
    • 0035775725 scopus 로고    scopus 로고
    • A new approach to decoding life: systems biology
    • 10.1146/annurev.genom.2.1.343, 11701654
    • Ideker T, Galitski T, Hood L. A new approach to decoding life: systems biology. Annu Rev Genomics Hum Genet 2001, 2:343-372. 10.1146/annurev.genom.2.1.343, 11701654.
    • (2001) Annu Rev Genomics Hum Genet , vol.2 , pp. 343-372
    • Ideker, T.1    Galitski, T.2    Hood, L.3
  • 7
    • 80053089722 scopus 로고    scopus 로고
    • Systems biology left and right
    • Westerhoff HV. Systems biology left and right. Methods Enzymol 2011, 500:3-11.
    • (2011) Methods Enzymol , vol.500 , pp. 3-11
    • Westerhoff, H.V.1
  • 8
    • 84930191842 scopus 로고    scopus 로고
    • Patient-specific modelling in drug design, development and selection including its role in clinical decision making
    • Shublaq N, Sansom C, Coveney PV. Patient-specific modelling in drug design, development and selection including its role in clinical decision making. Chem Biol Drug Des 2012,
    • (2012) Chem Biol Drug Des
    • Shublaq, N.1    Sansom, C.2    Coveney, P.V.3
  • 9
    • 84877893396 scopus 로고    scopus 로고
    • Systems biology as defined by NIH: an intellectual resource for integrative biology
    • Wanjek C. Systems biology as defined by NIH: an intellectual resource for integrative biology. The NIH Catalyst 2011, 19:1.
    • (2011) The NIH Catalyst , vol.19 , pp. 1
    • Wanjek, C.1
  • 10
    • 77951066659 scopus 로고    scopus 로고
    • Deterministic fallacies and model validation
    • Hawkins DM, Kraker J. Deterministic fallacies and model validation. J Chemom 2010, 24:188-193.
    • (2010) J Chemom , vol.24 , pp. 188-193
    • Hawkins, D.M.1    Kraker, J.2
  • 13
    • 80053608521 scopus 로고    scopus 로고
    • Multi-scale modeling in biology: how to bridge the gap between scales?
    • 10.1016/j.pbiomolbio.2011.06.004, 3190585, 21704063
    • Qu Z, Garfinkel A, Weiss JN, Nivala M. Multi-scale modeling in biology: how to bridge the gap between scales?. Prog Biophys Mol Biol 2011, 107:21-31. 10.1016/j.pbiomolbio.2011.06.004, 3190585, 21704063.
    • (2011) Prog Biophys Mol Biol , vol.107 , pp. 21-31
    • Qu, Z.1    Garfinkel, A.2    Weiss, J.N.3    Nivala, M.4
  • 16
    • 80755175374 scopus 로고    scopus 로고
    • In silico studies on the sensitivity of myocardial PCr/ATP to changes in mitochondrial enzyme activity and oxygen concentration
    • 10.1039/c1mb05310h, 22025222
    • Edwards LM, Ashrafian H, Korzeniewski B. In silico studies on the sensitivity of myocardial PCr/ATP to changes in mitochondrial enzyme activity and oxygen concentration. Mol Biosyst 2011, 7:3335-3342. 10.1039/c1mb05310h, 22025222.
    • (2011) Mol Biosyst , vol.7 , pp. 3335-3342
    • Edwards, L.M.1    Ashrafian, H.2    Korzeniewski, B.3
  • 17
    • 0017030517 scopus 로고
    • A general method for numerically simulating the stochastic time evolution of coupled chemical reactions
    • Gillespie DT. A general method for numerically simulating the stochastic time evolution of coupled chemical reactions. J Comput Phys 1976, 22:404-434.
    • (1976) J Comput Phys , vol.22 , pp. 404-434
    • Gillespie, D.T.1
  • 18
    • 84858439602 scopus 로고    scopus 로고
    • Constraining the metabolic genotype-phenotype relationship using a phylogeny of in silico methods
    • 3536058, 22367118
    • Lewis NE, Nagarajan H, Palsson BO. Constraining the metabolic genotype-phenotype relationship using a phylogeny of in silico methods. Nat Rev Microbiol 2012, 10:291-305. 3536058, 22367118.
    • (2012) Nat Rev Microbiol , vol.10 , pp. 291-305
    • Lewis, N.E.1    Nagarajan, H.2    Palsson, B.O.3
  • 19
    • 77957924740 scopus 로고    scopus 로고
    • A detailed genome-wide reconstruction of mouse metabolism based on human Recon 1
    • 10.1186/1752-0509-4-140, 2978158, 20959003
    • Sigurdsson MI, Jamshidi N, Steingrimsson E, Thiele I, Palsson BO. A detailed genome-wide reconstruction of mouse metabolism based on human Recon 1. BMC Syst Biol 2010, 4:140. 10.1186/1752-0509-4-140, 2978158, 20959003.
    • (2010) BMC Syst Biol , vol.4 , pp. 140
    • Sigurdsson, M.I.1    Jamshidi, N.2    Steingrimsson, E.3    Thiele, I.4    Palsson, B.O.5
  • 20
    • 33846910173 scopus 로고    scopus 로고
    • Global reconstruction of the human metabolic network based on genomic and bibliomic data
    • 10.1073/pnas.0610772104, 1794290, 17267599
    • Duarte NC, Becker SA, Jamshidi N, Thiele I, Mo ML, Vo TD, Srivas R, Palsson BO. Global reconstruction of the human metabolic network based on genomic and bibliomic data. Proc Natl Acad Sci U S A 2007, 104:1777-1782. 10.1073/pnas.0610772104, 1794290, 17267599.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 1777-1782
    • Duarte, N.C.1    Becker, S.A.2    Jamshidi, N.3    Thiele, I.4    Mo, M.L.5    Vo, T.D.6    Srivas, R.7    Palsson, B.O.8
  • 21
    • 61449134182 scopus 로고    scopus 로고
    • Identification of potential pathway mediation targets in Toll-like receptor signaling
    • 10.1371/journal.pcbi.1000292, 2634968, 19229310
    • Li F, Thiele I, Jamshidi N, Palsson BO. Identification of potential pathway mediation targets in Toll-like receptor signaling. PLoS Comput Biol 2009, 5:e1000292. 10.1371/journal.pcbi.1000292, 2634968, 19229310.
    • (2009) PLoS Comput Biol , vol.5
    • Li, F.1    Thiele, I.2    Jamshidi, N.3    Palsson, B.O.4
  • 22
    • 3042816965 scopus 로고    scopus 로고
    • The JAK-STAT signaling network in the human B-cell: an extreme signaling pathway analysis
    • 10.1529/biophysj.103.029884, 1304358, 15240442
    • Papin JA, Palsson BO. The JAK-STAT signaling network in the human B-cell: an extreme signaling pathway analysis. Biophys J 2004, 87:37-46. 10.1529/biophysj.103.029884, 1304358, 15240442.
    • (2004) Biophys J , vol.87 , pp. 37-46
    • Papin, J.A.1    Palsson, B.O.2
  • 23
    • 63549148162 scopus 로고    scopus 로고
    • Genome-scale reconstruction of Escherichia coli's transcriptional and translational machinery: a knowledge base, its mathematical formulation, and its functional characterization
    • 10.1371/journal.pcbi.1000312, 2648898, 19282977
    • Thiele I, Jamshidi N, Fleming RM, Palsson BO. Genome-scale reconstruction of Escherichia coli's transcriptional and translational machinery: a knowledge base, its mathematical formulation, and its functional characterization. PLoS Comput Biol 2009, 5:e1000312. 10.1371/journal.pcbi.1000312, 2648898, 19282977.
    • (2009) PLoS Comput Biol , vol.5
    • Thiele, I.1    Jamshidi, N.2    Fleming, R.M.3    Palsson, B.O.4
  • 25
    • 57549102595 scopus 로고    scopus 로고
    • Genome-scale models of bacterial metabolism: reconstruction and applications
    • 10.1111/j.1574-6976.2008.00146.x, 2704943, 19067749
    • Durot M, Bourguignon PY, Schachter V. Genome-scale models of bacterial metabolism: reconstruction and applications. FEMS Microbiol Rev 2009, 33:164-190. 10.1111/j.1574-6976.2008.00146.x, 2704943, 19067749.
    • (2009) FEMS Microbiol Rev , vol.33 , pp. 164-190
    • Durot, M.1    Bourguignon, P.Y.2    Schachter, V.3
  • 28
    • 33846114132 scopus 로고    scopus 로고
    • BRENDA, AMENDA and FRENDA: the enzyme information system in 2007
    • 10.1093/nar/gkl972, 1899097, 17202167
    • Barthelmes J, Ebeling C, Chang A, Schomburg I, Schomburg D. BRENDA, AMENDA and FRENDA: the enzyme information system in 2007. Nucleic Acids Res 2007, 35:D511-514. 10.1093/nar/gkl972, 1899097, 17202167.
    • (2007) Nucleic Acids Res , vol.35
    • Barthelmes, J.1    Ebeling, C.2    Chang, A.3    Schomburg, I.4    Schomburg, D.5
  • 29
    • 51049107514 scopus 로고    scopus 로고
    • Group contribution method for thermodynamic analysis of complex metabolic networks
    • 10.1529/biophysj.107.124784, 2479599, 18645197
    • Jankowski MD, Henry CS, Broadbelt LJ, Hatzimanikatis V. Group contribution method for thermodynamic analysis of complex metabolic networks. Biophys J 2008, 95:1487-1499. 10.1529/biophysj.107.124784, 2479599, 18645197.
    • (2008) Biophys J , vol.95 , pp. 1487-1499
    • Jankowski, M.D.1    Henry, C.S.2    Broadbelt, L.J.3    Hatzimanikatis, V.4
  • 30
    • 78650541419 scopus 로고    scopus 로고
    • Von Bertalanffy 1.0: a COBRA toolbox extension to thermodynamically constrain metabolic models
    • Fleming RM, Thiele I. von Bertalanffy 1.0: a COBRA toolbox extension to thermodynamically constrain metabolic models. Bioinformatics (Oxford, England) 2011, 27:142-143.
    • (2011) Bioinformatics (Oxford, England) , vol.27 , pp. 142-143
    • Fleming, R.M.1    Thiele, I.2
  • 33
    • 42149149798 scopus 로고    scopus 로고
    • From genome sequence to integrated bioprocess for succinic acid production by Mannheimia succiniciproducens
    • 10.1007/s00253-008-1424-3, 18340442
    • Lee SY, Kim JM, Song H, Lee JW, Kim TY, Jang YS. From genome sequence to integrated bioprocess for succinic acid production by Mannheimia succiniciproducens. Appl Microbiol Biotechnol 2008, 79:11-22. 10.1007/s00253-008-1424-3, 18340442.
    • (2008) Appl Microbiol Biotechnol , vol.79 , pp. 11-22
    • Lee, S.Y.1    Kim, J.M.2    Song, H.3    Lee, J.W.4    Kim, T.Y.5    Jang, Y.S.6
  • 34
    • 0037079023 scopus 로고    scopus 로고
    • Escherichia coli K-12 undergoes adaptive evolution to achieve in silico predicted optimal growth
    • 10.1038/nature01149, 12432395
    • Ibarra RU, Edwards JS, Palsson BO. Escherichia coli K-12 undergoes adaptive evolution to achieve in silico predicted optimal growth. Nature 2002, 420:186-189. 10.1038/nature01149, 12432395.
    • (2002) Nature , vol.420 , pp. 186-189
    • Ibarra, R.U.1    Edwards, J.S.2    Palsson, B.O.3
  • 35
    • 0142152457 scopus 로고    scopus 로고
    • Description and interpretation of adaptive evolution of Escherichia coli K-12 MG1655 by using a genome-scale in silico metabolic model
    • 10.1128/JB.185.21.6400-6408.2003, 219384, 14563875
    • Fong SS, Marciniak JY, Palsson BO. Description and interpretation of adaptive evolution of Escherichia coli K-12 MG1655 by using a genome-scale in silico metabolic model. J Bacteriol 2003, 185:6400-6408. 10.1128/JB.185.21.6400-6408.2003, 219384, 14563875.
    • (2003) J Bacteriol , vol.185 , pp. 6400-6408
    • Fong, S.S.1    Marciniak, J.Y.2    Palsson, B.O.3
  • 36
    • 0034615791 scopus 로고    scopus 로고
    • Theory for the systemic definition of metabolic pathways and their use in interpreting metabolic function from a pathway-oriented perspective
    • 10.1006/jtbi.2000.1073, 10716907
    • Schilling CH, Letscher D, Palsson BO. Theory for the systemic definition of metabolic pathways and their use in interpreting metabolic function from a pathway-oriented perspective. J Theor Biol 2000, 203:229-248. 10.1006/jtbi.2000.1073, 10716907.
    • (2000) J Theor Biol , vol.203 , pp. 229-248
    • Schilling, C.H.1    Letscher, D.2    Palsson, B.O.3
  • 37
    • 1542288938 scopus 로고    scopus 로고
    • Global organization of metabolic fluxes in the bacterium Escherichia coli
    • 10.1038/nature02289, 14985762
    • Almaas E, Kovacs B, Vicsek T, Oltvai ZN, Barabasi AL. Global organization of metabolic fluxes in the bacterium Escherichia coli. Nature 2004, 427:839-843. 10.1038/nature02289, 14985762.
    • (2004) Nature , vol.427 , pp. 839-843
    • Almaas, E.1    Kovacs, B.2    Vicsek, T.3    Oltvai, Z.N.4    Barabasi, A.L.5
  • 38
    • 15844387127 scopus 로고    scopus 로고
    • Candidate metabolic network states in human mitochondria: impact of diabetes, ischemia, and diet
    • 10.1074/jbc.M409072200, 15572364
    • Thiele I, Price ND, Vo TD, Palsson BO. Candidate metabolic network states in human mitochondria: impact of diabetes, ischemia, and diet. J Biol Chem 2005, 280:11683-11695. 10.1074/jbc.M409072200, 15572364.
    • (2005) J Biol Chem , vol.280 , pp. 11683-11695
    • Thiele, I.1    Price, N.D.2    Vo, T.D.3    Palsson, B.O.4
  • 39
    • 33846015888 scopus 로고    scopus 로고
    • Analysis of growth of Lactobacillus plantarum WCFS1 on a complex medium using a genome-scale metabolic model
    • 10.1074/jbc.M606263200, 17062565
    • Teusink B, Wiersma A, Molenaar D, Francke C, de Vos WM, Siezen RJ, Smid EJ. Analysis of growth of Lactobacillus plantarum WCFS1 on a complex medium using a genome-scale metabolic model. J Biol Chem 2006, 281:40041-40048. 10.1074/jbc.M606263200, 17062565.
    • (2006) J Biol Chem , vol.281 , pp. 40041-40048
    • Teusink, B.1    Wiersma, A.2    Molenaar, D.3    Francke, C.4    de Vos, W.M.5    Siezen, R.J.6    Smid, E.J.7
  • 40
    • 4644220226 scopus 로고    scopus 로고
    • Genome-scale in silico models of E. coli have multiple equivalent phenotypic states: assessment of correlated reaction subsets that comprise network states
    • 10.1101/gr.2546004, 515326, 15342562
    • Reed JL, Palsson BO. Genome-scale in silico models of E. coli have multiple equivalent phenotypic states: assessment of correlated reaction subsets that comprise network states. Genome Res 2004, 14:1797-1805. 10.1101/gr.2546004, 515326, 15342562.
    • (2004) Genome Res , vol.14 , pp. 1797-1805
    • Reed, J.L.1    Palsson, B.O.2
  • 42
    • 45149111660 scopus 로고    scopus 로고
    • The growing scope of applications of genome-scale metabolic reconstructions using Escherichia coli
    • 10.1038/nbt1401, 3108568, 18536691
    • Feist AM, Palsson BO. The growing scope of applications of genome-scale metabolic reconstructions using Escherichia coli. Nat Biotechnol 2008, 26:659-667. 10.1038/nbt1401, 3108568, 18536691.
    • (2008) Nat Biotechnol , vol.26 , pp. 659-667
    • Feist, A.M.1    Palsson, B.O.2
  • 43
    • 84855929956 scopus 로고    scopus 로고
    • Using the reconstructed genome-scale human metabolic network to study physiology and pathology
    • 10.1111/j.1365-2796.2011.02494.x, 3243107, 22142339
    • Bordbar A, Palsson BO. Using the reconstructed genome-scale human metabolic network to study physiology and pathology. J Intern Med 2012, 271:131-141. 10.1111/j.1365-2796.2011.02494.x, 3243107, 22142339.
    • (2012) J Intern Med , vol.271 , pp. 131-141
    • Bordbar, A.1    Palsson, B.O.2
  • 44
    • 73149122136 scopus 로고    scopus 로고
    • Applications of genome-scale metabolic reconstructions
    • 2795471, 19888215
    • Oberhardt MA, Palsson BO, Papin JA. Applications of genome-scale metabolic reconstructions. Mol Syst Biol 2009, 5:320. 2795471, 19888215.
    • (2009) Mol Syst Biol , vol.5 , pp. 320
    • Oberhardt, M.A.1    Palsson, B.O.2    Papin, J.A.3
  • 45
    • 77958537509 scopus 로고    scopus 로고
    • Insight into human alveolar macrophage and M. tuberculosisinteractions via metabolic reconstructions
    • 2990636, 20959820
    • Bordbar A, Lewis NE, Schellenberger J, Palsson BO, Jamshidi N. Insight into human alveolar macrophage and M. tuberculosisinteractions via metabolic reconstructions. Mol Syst Biol 2010, 6:422. 2990636, 20959820.
    • (2010) Mol Syst Biol , vol.6 , pp. 422
    • Bordbar, A.1    Lewis, N.E.2    Schellenberger, J.3    Palsson, B.O.4    Jamshidi, N.5
  • 47
    • 80054969621 scopus 로고    scopus 로고
    • A multi-tissue type genome-scale metabolic network for analysis of whole-body systems physiology
    • 10.1186/1752-0509-5-180, 3219569, 22041191
    • Bordbar A, Feist AM, Usaite-Black R, Woodcock J, Palsson BO, Famili I. A multi-tissue type genome-scale metabolic network for analysis of whole-body systems physiology. BMC Syst Biol 2011, 5:180. 10.1186/1752-0509-5-180, 3219569, 22041191.
    • (2011) BMC Syst Biol , vol.5 , pp. 180
    • Bordbar, A.1    Feist, A.M.2    Usaite-Black, R.3    Woodcock, J.4    Palsson, B.O.5    Famili, I.6
  • 50
    • 78049255973 scopus 로고    scopus 로고
    • Probabilistic integrative modeling of genome-scale metabolic and regulatory networks in Escherichia coli and Mycobacterium tuberculosis
    • 10.1073/pnas.1005139107, 2955152, 20876091
    • Chandrasekaran S, Price ND. Probabilistic integrative modeling of genome-scale metabolic and regulatory networks in Escherichia coli and Mycobacterium tuberculosis. Proc Natl Acad Sci U S A 2010, 107:17845-17850. 10.1073/pnas.1005139107, 2955152, 20876091.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 17845-17850
    • Chandrasekaran, S.1    Price, N.D.2
  • 51
    • 44949247269 scopus 로고    scopus 로고
    • Dynamic analysis of integrated signaling, metabolic, and regulatory networks
    • 10.1371/journal.pcbi.1000086, 2377155, 18483615
    • Lee JM, Gianchandani EP, Eddy JA, Papin JA. Dynamic analysis of integrated signaling, metabolic, and regulatory networks. PLoS Comput Biol 2008, 4:e1000086. 10.1371/journal.pcbi.1000086, 2377155, 18483615.
    • (2008) PLoS Comput Biol , vol.4
    • Lee, J.M.1    Gianchandani, E.P.2    Eddy, J.A.3    Papin, J.A.4
  • 52
    • 51749113592 scopus 로고    scopus 로고
    • Integrating metabolic, transcriptional regulatory and signal transduction models in Escherichia coli
    • Covert MW, Xiao N, Chen TJ, Karr JR. Integrating metabolic, transcriptional regulatory and signal transduction models in Escherichia coli. Bioinformatics (Oxford, England) 2008, 24:2044-2050.
    • (2008) Bioinformatics (Oxford, England) , vol.24 , pp. 2044-2050
    • Covert, M.W.1    Xiao, N.2    Chen, T.J.3    Karr, J.R.4
  • 53
    • 84862159118 scopus 로고    scopus 로고
    • Integration of dissolution into physiologically-based pharmacokinetic models III: PK-Sim((R))
    • 10.1111/j.2042-7158.2012.01534.x, 22686345
    • Willmann S, Thelen K, Lippert J. Integration of dissolution into physiologically-based pharmacokinetic models III: PK-Sim((R)). J Pharm Pharmacol 2012, 64:997-1007. 10.1111/j.2042-7158.2012.01534.x, 22686345.
    • (2012) J Pharm Pharmacol , vol.64 , pp. 997-1007
    • Willmann, S.1    Thelen, K.2    Lippert, J.3
  • 54
    • 34547676311 scopus 로고    scopus 로고
    • Optimization based automated curation of metabolic reconstructions
    • Satish Kumar V, Dasika MS, Maranas CD. Optimization based automated curation of metabolic reconstructions. BMC Bioinforma 2007, 8:212.
    • (2007) BMC Bioinforma , vol.8 , pp. 212
    • Satish Kumar, V.1    Dasika, M.S.2    Maranas, C.D.3
  • 55
    • 63549108441 scopus 로고    scopus 로고
    • GrowMatch: an automated method for reconciling in silico/in vivo growth predictions
    • 10.1371/journal.pcbi.1000308, 2645679, 19282964
    • Kumar VS, Maranas CD. GrowMatch: an automated method for reconciling in silico/in vivo growth predictions. PLoS Comput Biol 2009, 5:e1000308. 10.1371/journal.pcbi.1000308, 2645679, 19282964.
    • (2009) PLoS Comput Biol , vol.5
    • Kumar, V.S.1    Maranas, C.D.2
  • 58
    • 84864862895 scopus 로고    scopus 로고
    • Metabolomics reveals increased isoleukotoxin diol (12,13-DHOME) in human plasma after acute Intralipid infusion
    • 10.1194/jlr.P027706, 22715155
    • Edwards LM, Lawler NG, Nikolic SB, Peters JM, Horne J, Wilson R, Davies NW, Sharman JE. Metabolomics reveals increased isoleukotoxin diol (12,13-DHOME) in human plasma after acute Intralipid infusion. J Lipid Res 2012, 53(9):1979-86. 10.1194/jlr.P027706, 22715155.
    • (2012) J Lipid Res , vol.53 , Issue.9 , pp. 1979-1986
    • Edwards, L.M.1    Lawler, N.G.2    Nikolic, S.B.3    Peters, J.M.4    Horne, J.5    Wilson, R.6    Davies, N.W.7    Sharman, J.E.8
  • 59
    • 78651335279 scopus 로고    scopus 로고
    • Systematizing the generation of missing metabolic knowledge
    • 10.1002/bit.22844, 3119652, 20589842
    • Orth JD, Palsson BO. Systematizing the generation of missing metabolic knowledge. Biotechnol Bioeng 2010, 107:403-412. 10.1002/bit.22844, 3119652, 20589842.
    • (2010) Biotechnol Bioeng , vol.107 , pp. 403-412
    • Orth, J.D.1    Palsson, B.O.2
  • 60
    • 80053375237 scopus 로고    scopus 로고
    • The human metabolic reconstruction Recon 1 directs hypotheses of novel human metabolic functions
    • 10.1186/1752-0509-5-155, 3224382, 21962087
    • Rolfsson O, Palsson BO, Thiele I. The human metabolic reconstruction Recon 1 directs hypotheses of novel human metabolic functions. BMC Syst Biol 2011, 5:155. 10.1186/1752-0509-5-155, 3224382, 21962087.
    • (2011) BMC Syst Biol , vol.5 , pp. 155
    • Rolfsson, O.1    Palsson, B.O.2    Thiele, I.3
  • 61
    • 79955761880 scopus 로고    scopus 로고
    • Molecular crowding defines a common origin for the Warburg effect in proliferating cells and the lactate threshold in muscle physiology
    • 10.1371/journal.pone.0019538, 3084886, 21559344
    • Vazquez A, Oltvai ZN. Molecular crowding defines a common origin for the Warburg effect in proliferating cells and the lactate threshold in muscle physiology. PLoS One 2011, 6:e19538. 10.1371/journal.pone.0019538, 3084886, 21559344.
    • (2011) PLoS One , vol.6
    • Vazquez, A.1    Oltvai, Z.N.2
  • 63
    • 78650561172 scopus 로고    scopus 로고
    • Metabolic adaptation of skeletal muscle to high altitude hypoxia: how new technologies could resolve the controversies
    • 10.1186/gm117, 2808733, 20090895
    • Murray AJ. Metabolic adaptation of skeletal muscle to high altitude hypoxia: how new technologies could resolve the controversies. Genome Med 2009, 1:117. 10.1186/gm117, 2808733, 20090895.
    • (2009) Genome Med , vol.1 , pp. 117
    • Murray, A.J.1
  • 66
    • 55849092859 scopus 로고    scopus 로고
    • Proteins modulation in human skeletal muscle in the early phase of adaptation to hypobaric hypoxia
    • 10.1002/pmic.200800232, 18937252
    • Vigano A, Ripamonti M, De Palma S, Capitanio D, Vasso M, Wait R, Lundby C, Cerretelli P, Gelfi C. Proteins modulation in human skeletal muscle in the early phase of adaptation to hypobaric hypoxia. Proteomics 2008, 8:4668-4679. 10.1002/pmic.200800232, 18937252.
    • (2008) Proteomics , vol.8 , pp. 4668-4679
    • Vigano, A.1    Ripamonti, M.2    De Palma, S.3    Capitanio, D.4    Vasso, M.5    Wait, R.6    Lundby, C.7    Cerretelli, P.8    Gelfi, C.9
  • 68
    • 80053972002 scopus 로고    scopus 로고
    • Identification of haptoglobin and apolipoprotein A-I as biomarkers for high altitude pulmonary edema
    • 10.1007/s10142-011-0234-3, 21755356
    • Ahmad Y, Shukla D, Garg I, Sharma NK, Saxena S, Malhotra VK, Bhargava K. Identification of haptoglobin and apolipoprotein A-I as biomarkers for high altitude pulmonary edema. Funct Integr Genomics 2011, 11:407-417. 10.1007/s10142-011-0234-3, 21755356.
    • (2011) Funct Integr Genomics , vol.11 , pp. 407-417
    • Ahmad, Y.1    Shukla, D.2    Garg, I.3    Sharma, N.K.4    Saxena, S.5    Malhotra, V.K.6    Bhargava, K.7
  • 69
    • 84930190061 scopus 로고    scopus 로고
    • Studying the effects of hypoxia on mitochondrial metabolism in human heart using a genome-wide metabolic network model
    • Edwards LM, Thiele I. Studying the effects of hypoxia on mitochondrial metabolism in human heart using a genome-wide metabolic network model. Proc Aus Phys Soc 2011, 42:33.
    • (2011) Proc Aus Phys Soc , vol.42 , pp. 33
    • Edwards, L.M.1    Thiele, I.2
  • 70
    • 68749099674 scopus 로고    scopus 로고
    • A multi-level model accounting for the effects of JAK2-STAT5 signal modulation in erythropoiesis
    • 10.1016/j.compbiolchem.2009.07.003, 19660986
    • Lai X, Nikolov S, Wolkenhauer O, Vera J. A multi-level model accounting for the effects of JAK2-STAT5 signal modulation in erythropoiesis. Comput Biol Chem 2009, 33:312-324. 10.1016/j.compbiolchem.2009.07.003, 19660986.
    • (2009) Comput Biol Chem , vol.33 , pp. 312-324
    • Lai, X.1    Nikolov, S.2    Wolkenhauer, O.3    Vera, J.4
  • 72
    • 84858172352 scopus 로고    scopus 로고
    • Computational models of VEGF-associated angiogenic processes in cancer
    • 10.1093/imammb/dqq025, 21266494
    • Stefanini MO, Qutub AA, Mac Gabhann F, Popel AS. Computational models of VEGF-associated angiogenic processes in cancer. Math Med Biol 2012, 29:85-94. 10.1093/imammb/dqq025, 21266494.
    • (2012) Math Med Biol , vol.29 , pp. 85-94
    • Stefanini, M.O.1    Qutub, A.A.2    Mac Gabhann, F.3    Popel, A.S.4
  • 74
    • 77957912885 scopus 로고    scopus 로고
    • Hypoxia-dependent sequestration of an oxygen sensor by a widespread structural motif can shape the hypoxic response - a predictive kinetic model
    • 10.1186/1752-0509-4-139, 2984394, 20955552
    • Schmierer B, Novak B, Schofield CJ. Hypoxia-dependent sequestration of an oxygen sensor by a widespread structural motif can shape the hypoxic response - a predictive kinetic model. BMC Syst Biol 2010, 4:139. 10.1186/1752-0509-4-139, 2984394, 20955552.
    • (2010) BMC Syst Biol , vol.4 , pp. 139
    • Schmierer, B.1    Novak, B.2    Schofield, C.J.3
  • 75
    • 79952199070 scopus 로고    scopus 로고
    • Systems biology of pro-angiogenic therapies targeting the VEGF system
    • 10.1002/wsbm.92, 2990677, 20890966
    • Mac Gabhann F, Qutub AA, Annex BH, Popel AS. Systems biology of pro-angiogenic therapies targeting the VEGF system. Wiley Interdiscip Rev Syst Biol Med 2010, 2:694-707. 10.1002/wsbm.92, 2990677, 20890966.
    • (2010) Wiley Interdiscip Rev Syst Biol Med , vol.2 , pp. 694-707
    • Mac Gabhann, F.1    Qutub, A.A.2    Annex, B.H.3    Popel, A.S.4
  • 76
    • 77956948327 scopus 로고    scopus 로고
    • Gene network analysis to determine the effects of antioxidant treatment in a rat model of neonatal hypoxic-ischemic encephalopathy
    • 10.1007/s12031-010-9337-x, 20191329
    • Kojima T, Ueda Y, Adati N, Kitamoto A, Sato A, Huang MC, Noor J, Sameshima H, Ikenoue T. Gene network analysis to determine the effects of antioxidant treatment in a rat model of neonatal hypoxic-ischemic encephalopathy. J Mol Neurosci 2010, 42:154-161. 10.1007/s12031-010-9337-x, 20191329.
    • (2010) J Mol Neurosci , vol.42 , pp. 154-161
    • Kojima, T.1    Ueda, Y.2    Adati, N.3    Kitamoto, A.4    Sato, A.5    Huang, M.C.6    Noor, J.7    Sameshima, H.8    Ikenoue, T.9
  • 77
    • 74549117769 scopus 로고    scopus 로고
    • Bistability of mitochondrial respiration underlies paradoxical reactive oxygen species generation induced by anoxia
    • 10.1371/journal.pcbi.1000619, 2789320, 20041200
    • Selivanov VA, Votyakova TV, Zeak JA, Trucco M, Roca J, Cascante M. Bistability of mitochondrial respiration underlies paradoxical reactive oxygen species generation induced by anoxia. PLoS Comput Biol 2009, 5:e1000619. 10.1371/journal.pcbi.1000619, 2789320, 20041200.
    • (2009) PLoS Comput Biol , vol.5
    • Selivanov, V.A.1    Votyakova, T.V.2    Zeak, J.A.3    Trucco, M.4    Roca, J.5    Cascante, M.6


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