Fatigue mechanisms determining exercise performance: Integrative physiology is systems biology

Journal of Applied Physiology

Volumn 104, Issue 5, 2008, Pages 1541-1542

  Hargreaves, Mark ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ADENOSINE TRIPHOSPHATE; CALCIUM ION; CARBOHYDRATE; GLUCOSE; GLYCOGEN; NEUROTRANSMITTER;

ATHLETE; BRAIN; CALCIUM TRANSPORT; CARBOHYDRATE INTAKE; CENTRAL NERVOUS SYSTEM; DIET SUPPLEMENTATION; ENERGY METABOLISM; EXCITATION CONTRACTION COUPLING; EXERCISE; FATIGUE; HUMAN; MARATHON RUNNER; MUSCLE FATIGUE; MUSCLE METABOLISM; NEUROTRANSMITTER RELEASE; PHYSICAL PERFORMANCE; PRIORITY JOURNAL; SARCOPLASMIC RETICULUM; SHORT SURVEY; SKELETAL MUSCLE; SPORT; TRAINING; ARTICLE; CARBOHYDRATE METABOLISM; PHYSIOLOGY;

CARBOHYDRATE METABOLISM; CENTRAL NERVOUS SYSTEM; EXERCISE; HUMANS; MUSCLE FATIGUE;

EID: 45149105874     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00088.2008     Document Type: Short Survey

References (25)

1. Amman M, Dempsey JA. Locomotor fatigue modifies central motor drive in healthy humans and imposes a limitation to exercise performance. J Physiol 586: 161-173, 2008.
2. Bainbridge FA. Physiology of Muscular Exercise. London: Longmans, 1919.
3. Bigland-Ritchie B. EMG and fatigue of human voluntary and stimulated contractions. In: Human Muscle Fatigue: Physiological Mechanisms, edited by Porter R, Whelan J. London: Pitman Medical, 1981, p. 130-156.
4. Burgess ML, Robertson RJ, Davis JM, Norris JM. RPE, blood glucose, and carbohydrate oxidation during exercise: effects of glucose feedings. Med Sci Sports Exerc 23: 353-359, 1991.
5. Carter JM, Jeukendrup AE, Jones DA. The effect of a carbohydrate mouth rinse on 1-h cycle time trial performance. Med Sci Sports Exerc 36: 2107-2111, 2004.
6. 2+ release and contractile protein function in intact mouse skeletal muscle. J Physiol 498: 17-29, 1997.
7. Coyle EF, Coggan AR, Hemmert MK, Ivy JL. Muscle glycogen utilization during prolonged strenuous exercise when fed carbohydrate. J Appl Physiol 61: 165-172, 1986.
8. Coyle EF, Hagberg JM, Hurley BF, Martin WH, Ehsani AA, Holloszy JO. Carbohydrate feeding during prolonged strenuous exercise can delay fatigue. J Appl Physiol 55: 230-235, 1983.
9. Davis JM, Bailey SP, Woods JJ, Galiano FJ, Hamilton MT, Bartoli WP. Effects of carbohydrate feedings on plasma tryptophan and branched-chain amino acids during prolonged cycling. Eur J Appl Physiol 65: 513-519, 1992.
10. 2+-cycling responses to prolonged cycling, with and without glucose supplementation. J Appl Physiol 103: 1986-1998, 2007.
11. Gordon B, Kohn LA, Levine SA, Matton M, ScriverWde M, Whiting WB. Sugar content of the blood in runners following a marathon race. JAMA 85: 508-509, 1925.
12. +-ATPase activity during prolonged exercise. Am J Physiol Regul Integr Comp Physiol 293: R354-R362, 2007.
13. Hermansen L, Hultman E, Saltin B. Muscle glycogen during prolonged severe exercise. Acta Physiol Scand 71: 129-139, 1967.
14. Joyner MJ, Saltin B. Exercise physiology and human performance: systems biology before systems biology! (Abstract) J Physiol 586: 9, 2008.
15. McConell G, Snow RJ, Proietto J, Hargreaves M. Muscle metabolism during prolonged exercise in humans: influence of carbohydrate availability. J Appl Physiol 87: 1083-1086, 1999.
16. McKenna MJ, Hargreaves M. Resolving fatigue mechanisms determining exercise performance: integrative physiology at its finest! J Appl Physiol 104: 286-287, 2008.
17. Nybo L. CNS fatigue and prolonged exercise: effect of glucose supplementation. Med Sci Sports Exerc 35: 589-594, 2003.
18. Nybo L, Møller K, Pedersen BK, Nielsen B, Secher NH. Association between fatigue and failure to preserve cerebral energy turnover during prolonged exercise. Acta Physiol Scand 179: 67-74, 2003.
19. Sahlin K, Katz A, Broberg S. Tricarboxylic acid cycle intermediates in human muscle during prolonged exercise. Am J Physiol Cell Physiol 259: C834-C841, 1990.
20. Spencer MK, Yan Z, Katz A. Carbohydrate supplementation attenuates IMP accumulation in human muscle during prolonged exercise. Am J Physiol Cell Physiol 261: C71-C76, 1991.
21. St. Clair Gibson A, Noakes TD. Evidence for complex system integration and dynamic neural regulation of skeletal muscle recruitment during exercise in humans. Br J Sports Med 38: 797-806, 2004.
22. Stephenson DG, Nguyen LT, Stephenson GMM. Glycogen content and excitation-contraction coupling in mechanically skinned muscle fibres of the toad. J Physiol 519: 177-187, 1999.
23. Stewart RD, Duhamel TA, Foley KP, Ouyang J, Smith IC, Green HJ. Protection of muscle membrane excitability during prolonged cycle exercise with glucose supplementation. J Appl Physiol 103: 331-339, 2007.
24. Tatterson AJ, Hahn AG, Martin DT, Febbraio MA. Effects of heat stress on physiological responses and exercise performance in elite cyclists. J Sci Med Sport 3: 186-193, 2000.
25. Taylor JL, Todd G, Gandevia SC. Evidence for a supraspinal contribution to human muscle fatigue. Clin Exp Pharmacol Physiol 33: 400-405, 2006.