AP39, a novel mitochondria-targeted hydrogen sulfide donor, stimulates cellular bioenergetics, exerts cytoprotective effects and protects against the loss of mitochondrial DNA integrity in oxidatively stressed endothelial cells in vitro

Nitric Oxide - Biology and Chemistry

Volumn 41, Issue , 2014, Pages 120-130

  Szczesny, Bartosz ^a   Módis, Katalin ^a   Yanagi, Kazunori ^a   Coletta, Ciro ^a   Le Trionnaire, Sophie ^b   Perry, Alexis ^c   Wood, Mark E ^c   Whiteman, Matthew ^b   Szabo, Csaba ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

^b UNIVERSITY OF EXETER MEDICAL SCHOOL   (United Kingdom)

^c UNIVERSITY OF EXETER   (United Kingdom)

Author keywords

Bioenergetics; Cytoprotection; DNA repair; Mitochondria; Oxidative stress

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ANTIOXIDANT; CELL NUCLEUS DNA; CYTOPROTECTIVE AGENT; FLUORESCENT DYE; GLUCOSE OXIDASE; HYDROGEN SULFIDE; LACTATE DEHYDROGENASE; MITOCHONDRIAL DNA; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; [[10 OXO 10 [4 (3 THIOXO 3H 1,2 DITHIOL 5YL)PHENOXY]DECYL]TRIPHENYLPHOSPHONIUM BROMIDE]; HYDROGEN PEROXIDE; ORGANOPHOSPHATE; PROTECTIVE AGENT; THIOKETONE;

ANIMAL CELL; ARTICLE; BIOENERGY; CAPILLARY ENDOTHELIAL CELL; CELL ACTIVITY; CELL PROTECTION; CELL STIMULATION; CELL VIABILITY; CONTROLLED STUDY; DRUG EFFECT; ELECTRON TRANSPORT; IN VITRO STUDY; MITOCHONDRIAL DNA DISORDER; NONHUMAN; OXIDATION; OXIDATIVE STRESS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN MODIFICATION; STIMULATION; ANIMAL; CELL LINE; DNA REPAIR; DRUG EFFECTS; ENDOTHELIUM CELL; INTRACELLULAR SPACE; METABOLISM; MOUSE;

MURINAE;

ANIMALS; CELL LINE; DNA REPAIR; DNA, MITOCHONDRIAL; ENDOTHELIAL CELLS; GLUCOSE OXIDASE; HYDROGEN PEROXIDE; HYDROGEN SULFIDE; INTRACELLULAR SPACE; MICE; ORGANOPHOSPHATES; OXIDATIVE STRESS; PROTECTIVE AGENTS; THIONES;

EID: 84907598666     PISSN: 10898603     EISSN: 10898611     Source Type: Journal    
DOI: 10.1016/j.niox.2014.04.008     Document Type: Article

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