Dysregulation of hydrogen sulfide producing enzyme cystathionine γ-lyase contributes to maternal hypertension and placental abnormalities in preeclampsia

Circulation

Volumn 127, Issue 25, 2013, Pages 2514-2522

  Wang, Keqing ^a,b   Ahmad, Shakil ^a,b   Cai, Meng ^a,b   Rennie, Jillian ^b   Fujisawa, Takeshi ^b   Crispi, Fatima ^c   Baily, James ^b   Miller, Mark R ^b   Cudmore, Melissa ^b   Hadoke, Patrick W F ^b   Wang, Rui ^d   Gratacós, Eduard ^c   Buhimschi, Irina A ^f   Buhimschi, Catalin S ^e   Ahmed, Asif ^a,b  

^a ASTON UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c UNIVERSITY OF BARCELONA   (Spain)

^d LAKEHEAD UNIVERSITY   (Canada)

^e YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f NATIONWIDE CHILDREN S HOSPITAL   (United States)

Author keywords

angiogenesis; fetal development; fms like tyrosine kinase 1; hydrogen sulfide; placental growth factor; preeclampsia; vascular endothelial growth factor

Indexed keywords

CYSTATHIONINE GAMMA LYASE; HYDROGEN SULFIDE; PROPARGYLGLYCINE; SMALL INTERFERING RNA;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; FIRST TRIMESTER PREGNANCY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MATERNAL HYPERTENSION; MOUSE; NONHUMAN; PLACENTA DEVELOPMENT; PLACENTA DISORDER; PREECLAMPSIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REPRODUCTION; TROPHOBLAST; UMBILICAL VEIN ENDOTHELIAL CELL; VASCULARIZATION;

ANGIOGENESIS; FETAL DEVELOPMENT; FMS-LIKE TYROSINE KINASE-1; HYDROGEN SULFIDE; PLACENTAL GROWTH FACTOR; PREECLAMPSIA; VASCULAR ENDOTHELIAL GROWTH FACTOR;

ADOLESCENT; ADULT; ALKYNES; ANIMALS; ANTIGENS, CD; CELLS, CULTURED; CYSTATHIONINE GAMMA-LYASE; DISEASE MODELS, ANIMAL; ENDOTHELIUM, VASCULAR; FEMALE; FETAL DEVELOPMENT; GLYCINE; HUMANS; HYDROGEN SULFIDE; HYPERTENSION; MICE; MICE, INBRED C57BL; MORPHOLINES; NEOVASCULARIZATION, PHYSIOLOGIC; ORGAN CULTURE TECHNIQUES; ORGANOTHIOPHOSPHORUS COMPOUNDS; PLACENTA; PLACENTA DISEASES; PRE-ECLAMPSIA; PREGNANCY; PREGNANCY COMPLICATIONS, CARDIOVASCULAR; PREGNANCY PROTEINS; PREGNANCY, ANIMAL; RECEPTORS, CELL SURFACE; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1; YOUNG ADULT;

EID: 84879528259     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.113.001631     Document Type: Article

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