Therapeutic approach to neurodegenerative diseases by medical gases: Focusing on redox signaling and related antioxidant enzymes

Oxidative Medicine and Cellular Longevity

Volumn , Issue , 2012, Pages

  Fujita, Kyota ^a   Yamafuji, Megumi ^a   Nakabeppu, Yusaku ^a   Noda, Mami ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER'S DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL MODEL; ANTIOXIDANT ENZYME; CENTRAL NERVOUS SYSTEMS; COACTIVATORS; COFACTORS; EXPRESSION LEVELS; HEME OXYGENASE-1; HUNTINGTON'S DISEASE; NEURONAL CELL; NEURONAL DEATH; OXIDATIVE DAMAGE; PARKINSON'S DISEASE; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR; PHYTOCHEMICALS; REDOX SIGNALING; SIGNALING PATHWAYS; SUPEROXIDE DISMUTASES; THERAPEUTIC USE; UP-REGULATION;

CARBON MONOXIDE; CELL DEATH; ENZYMES; HYDROGEN; HYDROGEN SULFIDE; OXYGEN; PORPHYRINS; TRANSCRIPTION FACTORS;

NEURODEGENERATIVE DISEASES;

CARBON MONOXIDE; COPPER ZINC SUPEROXIDE DISMUTASE; HEME OXYGENASE 1; HYDROGEN; HYDROGEN SULFIDE; MANGANESE SUPEROXIDE DISMUTASE; NITRIC OXIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR NRF2; ANTIOXIDANT;

DEGENERATIVE DISEASE; ENZYME ACTIVITY; GAS; HUMAN; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; SIGNAL TRANSDUCTION; ANIMAL; ENZYMOLOGY; METABOLISM;

ANIMALS; ANTIOXIDANTS; GASES; HUMANS; NEURODEGENERATIVE DISEASES; OXIDATION-REDUCTION; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 84864944799     PISSN: 19420900     EISSN: 19420994     Source Type: Journal    
DOI: 10.1155/2012/324256     Document Type: Review

References (95)

1. Papa S., Mitochondrial oxidative phosphorylation changes in the life span. Molecular aspects and physiopathological implications Biochimica et Biophysica Acta 1996 1276 2 87 105 (Pubitemid 26308725)
2. Boveris A., Oshino N., Chance B., The cellular production of hydrogen peroxide Biochemical Journal 1972 128 3 617 630
3. Stowe D. F., Camara A. K. S., Mitochondrial reactive oxygen species production in excitable cells: modulators of mitochondrial and cell function Antioxidants and Redox Signaling 2009 11 6 1373 1414
4. Reddy P. H., Mitochondrial medicine for aging and neurodegenerative diseases NeuroMolecular Medicine 2008 10 4 291 315
5. Swerdlow R. H., Khan S. M., A mitochondrial cascade hypothesis for sporadic Alzheimer's disease Medical Hypotheses 2004 63 1 8 20 (Pubitemid 38887104)
6. Beal M. F., Mitochondria take center stage in aging and neurodegeneration Annals of Neurology 2005 58 4 495 505 (Pubitemid 41377212)
7. Wallace D. C., A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine Annual Review of Genetics 2005 39 359 407 (Pubitemid 43011120)
8. Trushina E., McMurray C. T., Oxidative stress and mitochondrial dysfunction in neurodegenerative diseases Neuroscience 2007 145 4 1233 1248 (Pubitemid 46602738)
9. Miura Y., Endo T., Survival responses to oxidative stress and aging Geriatrics and Gerontology International 2010 10 supplement 1 S1 S9
10. Moi P., Chan K., Asunis I., Cao A., Kan Y. W., Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the -globin locus control region Proceedings of the National Academy of Sciences of the United States of America 1994 91 21 9926 9930 (Pubitemid 24311921)
11. Ney P. A., Andrews N. C., Jane S. M., Safer B., Purucker M. E., Weremowicz S., Morton C. C., Goff S. C., Orkin S. H., Nienhuis A. W., Purification of the human NF-E2 complex: cDNA cloning of the hematopoietic cell-specific subunit and evidence for an associated partner Molecular and Cellular Biology 1993 13 9 5604 5612 (Pubitemid 23260662)
12. Andrews N. C., Erdjument-Bromage H., Davidson M. B., Tempst P., Orkin S. H., Erythroid transcription factor NF-E2 is a haematopoietic-specific basic-leucine zipper protein Nature 1993 362 6422 722 728 (Pubitemid 23125974)
13. Igarashi K., Kataoka K., Itoh K., Hayashi N., Nishizawa M., Yamamoto M., Regulation of transcription by dimerization of erythroid factor NF-E2 p45 with small Maf proteins Nature 1994 367 6463 568 572 (Pubitemid 24055517)
14. Igarashi K., Itoh K., Motohashi H., Hayashi N., Matuzaki Y., Nakauchi H., Nishizawa M., Yamamoto M., Activity and expression of murine small Maf family protein MafK The Journal of Biological Chemistry 1995 270 13 7615 7624
15. Rushmore T. H., Pickett C. B., Transcriptional regulation of the rat glutathione S-transferase Ya subunit gene. Characterization of a xenobiotic-responsive element controlling inducible expression by phenolic antioxidants The Journal of Biological Chemistry 1990 265 24 14648 14653
16. Friling R. S., Bensimon A., Tichauer Y., Daniel V., Xenobiotic-inducible expression of murine glutathione S-transferase Ya subunit gene is controlled by an electrophile-responsive element Proceedings of the National Academy of Sciences of the United States of America 1990 87 16 6258 6262
17. Kobayashi M., Yamamoto M., Nrf2-Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species Advances in Enzyme Regulation 2006 46 1 113 140 (Pubitemid 44301353)
18. Johnson J. A., Johnson D. A., Kraft A. D., Calkins M. J., Jakel R. J., Vargas M. R., Chen P. C., The Nrf2-ARE pathway: an indicator and modulator of oxidative stress in neurodegeneration Annals of the New York Academy of Sciences 2008 1147 61 69
19. Innamorato N. G., Rojo A. I., Garca-Yage. J., Yamamoto M., de Ceballos M. L., Cuadrado A., The transcription factor Nrf2 is a therapeutic target against brain inflammation Journal of Immunology 2008 181 1 680 689
20. Hintze K. J., Keck A. S., Finley J. W., Jeffery E. H., Induction of hepatic thioredoxin reductase activity by sulforaphane, both in Hepa1c1c7 cells and in male Fisher 344 rats Journal of Nutritional Biochemistry 2003 14 3 173 179 (Pubitemid 36543004)
21. Ishii T., Itoh K., Sato H., Bannai S., Oxidative stress-inducible proteins in macrophages Free Radical Research 1999 31 4 351 355 (Pubitemid 29452861)
22. Favreau L. V., Pickett C. B., The rat quinone reductase antioxidant response element. Identification of the nucleotide sequence required for basal and inducible activity and detection of antioxidant response element-binding proteins in hepatoma and non-hepatoma cell lines The Journal of Biological Chemistry 1995 270 41 24468 24474
23. Prestera T., Talalay P., Alam J., Ahn Y. I., Lee P. J., Choi A. M., Parallel induction of heme oxygenase-1 and chemoprotective phase 2 enzymes by electrophiles and antioxidants: regulation by upstream antioxidant-responsive elements (ARE) Molecular Medicine 1995 1 7 827 837 (Pubitemid 3013090)
24. Ferrandiz M. L., Devesa I., Inducers of heme oxygenase-1 Current Pharmaceutical Design 2008 14 5 473 486 (Pubitemid 351516852)
25. Kanninen K., Heikkinen R., Malm T., Rolova T., Kuhmonen S., Leinonen H., Yl-Herttuala S., Tanila H., Levonen A. L., Koistinaho M., Koistinaho J., Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer's disease Proceedings of the National Academy of Sciences of the United States of America 2009 106 38 16505 16510
26. Johnson D. A., Andrews G. K., Xu W., Johnson J. A., Activation of the antioxidant response element in primary cortical neuronal cultures derived from transgenic reporter mice Journal of Neurochemistry 2002 81 6 1233 1241 (Pubitemid 34809257)
27. Vargas M. R., Johnson D. A., Sirkis D. W., Messing A., Johnson J. A., Nrf2 activation in astrocytes protects against neurodegeneration in mouse models of familial amyotrophic lateral sclerosis The Journal of Neuroscience 2008 28 50 13574 13581
28. Chen P. C., Vargas M. R., Pani A. K., Smeyne R. J., Johnson D. A., Kan Y. W., Johnson J. A., Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's disease: critical role for the astrocyte Proceedings of the National Academy of Sciences of the United States of America 2009 106 8 2933 2938
29. Calkins M. J., Jakel R. J., Johnson D. A., Chan K., Yuen W. K., Johnson J. A., Protection from mitochondrial complex II inhibition in vitro and in vivo by Nrf2-mediated transcription Proceedings of the National Academy of Sciences of the United States of America 2005 102 1 244 249 (Pubitemid 40094460)
30. Schipper H. M., Song W., Zukor H., Hascalovici J. R., Zeligman D., Heme oxygenase-1 and neurodegeneration: expanding frontiers of engagement Journal of Neurochemistry 2009 110 2 469 485
31. Ciechanover A., Brundin P., The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg Neuron 2003 40 2 427 446 (Pubitemid 37244106)
32. Shastry B. S., Neurodegenerative disorders of protein aggregation Neurochemistry International 2003 43 1 1 7 (Pubitemid 36246521)
33. Song W., Patel A., Qureshi H. Y., Han D., Schipper H. M., Paudel H. K., The Parkinson disease-associated A30P mutation stabilizes -synuclein against proteasomal degradation triggered by heme oxygenase-1 over-expression in human neuroblastoma cells Journal of Neurochemistry 2009 110 2 719 733
34. Puigserver P., Spiegelman B. M., Peroxisome proliferator-activated receptor- coactivator 1 (PGC-1 ): transcriptional coactivator and metabolic regulator Endocrine Reviews 2003 24 1 78 90 (Pubitemid 36223280)
35. Lin M. T., Beal M. F., Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases Nature 2006 443 7113 787 795 (Pubitemid 44622683)
36. Kelly D. P., Scarpulla R. C., Transcriptional regulatory circuits controlling mitochondrial biogenesis and function Genes and Development 2004 18 4 357 368 (Pubitemid 38316342)
37. Scarpulla R. C., Transcriptional paradigms in mammalian mitochondrial biogenesis and function Physiological Reviews 2008 88 2 611 638 (Pubitemid 351520089)
38. St-Pierre J., Drori S., Uldry M., Silvaggi J. M., Rhee J., Jger S., Handschin C., Zheng K., Lin J., Yang W., Simon D. K., Bachoo R., Spiegelman B. M., Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators Cell 2006 127 2 397 408 (Pubitemid 44572377)
39. Cui L., Jeong H., Borovecki F., Parkhurst C. N., Tanese N., Krainc D., Transcriptional repression of PGC-1 by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration Cell 2006 127 1 59 69 (Pubitemid 44466642)
40. Martin E., Betuing S., Pags C., Cambon K., Auregan G., Deglon N., Roze E., Caboche J., Mitogen- and stress-activated protein kinase 1-induced neuroprotection in Huntington's disease: role on chromatin remodeling at the PGC-1-alpha promoter Human Molecular Genetics 2011 20 12 2422 2434
41. Mudo G., Makela J., Di Liberto V., Transgenic expression and activation of PGC-1alpha protect dopaminergic neurons in the MPTP mouse model of Parkinson's disease Cellular and Molecular Life Sciences 2012 69 7, article 1153
42. Lagouge M., Argmann C., Gerhart-Hines Z., Meziane H., Lerin C., Daussin F., Messadeq N., Milne J., Lambert P., Elliott P., Geny B., Laakso M., Puigserver P., Auwerx J., Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1 Cell 2006 127 6 1109 1122 (Pubitemid 44894520)
43. Zong H., Ren J. M., Young L. H., Pypaert M., Mu J., Birnbaum M. J., Shulman G. I., AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation Proceedings of the National Academy of Sciences of the United States of America 2002 99 25 15983 15987 (Pubitemid 35462735)
44. Jager S., Handschin C., St-Pierre J., Spiegelman B. M., AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1 Proceedings of the National Academy of Sciences of the United States of America 2007 104 29 12017 12022 (Pubitemid 47185622)
45. Outeiro T. F., Marques O., Kazantsev A., Therapeutic role of sirtuins in neurodegenerative disease Biochimica et Biophysica Acta 2008 1782 6 363 369
46. Ho D. J., Calingasan N. Y., Wille E., Dumont M., Beal M. F., Resveratrol protects against peripheral deficits in a mouse model of Huntington's disease Experimental Neurology 2010 225 1 74 84
47. Gao J., Wang W. Y., Mao Y. W., Grff J., Guan J. S., Pan L., Mak G., Kim D., Su S. C., Tsai L. H., A novel pathway regulates memory and plasticity via SIRT1 and miR-134 Nature 2010 466 7310 1105 1109
48. Donmez G., Arun A., Chung C. Y., SIRT1 protects against -synuclein aggregation by activating molecular chaperones The Journal of Neuroscience 2012 32 1 124 132
49. Jiang M., Wang J., Fu J., Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets Nature Medicine 2012 18 153 158
50. Kim D., Nguyen M. D., Dobbin M. M., Fischer A., Sananbenesi F., Rodgers J. T., Delalle I., Baur J. A., Sui G., Armour S. M., Puigserver P., Sinclair D. A., Tsai L. H., SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis The EMBO Journal 2007 26 13 3169 3179 (Pubitemid 47057498)
51. Qin W., Yang T., Ho L., Zhao Z., Wang J., Chen L., Zhao W., Thiyagarajan M., MacGrogan D., Rodgers J. T., Puigserver P., Sadoshima J., Deng H., Pedrini S., Gandy S., Sauve A. A., Pasinetti G. M., Neuronal SIRT1 activation as a novel mechanism underlying the prevention of alzheimer disease amyloid neuropathology by calorie restriction The Journal of Biological Chemistry 2006 281 31 21745 21754 (Pubitemid 44181878)
52. Bonda D. J., Lee H. G., Camins A., Palls M., Casadesus G., Smith M. A., Zhu X., The sirtuin pathway in ageing and Alzheimer disease: mechanistic and therapeutic considerations The Lancet Neurology 2011 10 3 275 279
53. Wareski P., Vaarmann A., Choubey V., Safiulina D., Liiv J., Kuum M., Kaasik A., PGC-1 and PGC-1 regulate mitochondrial density in neurons The Journal of Biological Chemistry 2009 284 32 21379 21385
54. Johnson W. T., Johnson L. A. K., Lukaski H. C., Serum superoxide dismutase 3 (extracellular superoxide dismutase) activity is a sensitive indicator of Cu status in rats Journal of Nutritional Biochemistry 2005 16 11 682 692 (Pubitemid 41456711)
55. McCord J. M., Iron- and manganese-containing superoxide dismutases: structure, distribution, and evolutionary relationships Advances in Experimental Medicine and Biology 1976 74 540 550
56. McCord J. M., Fridovich I., Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein) The Journal of Biological Chemistry 1969 244 22 6049 6055
57. Marklund S. L., Human copper-containing superoxide dismutase of high molecular weight Proceedings of the National Academy of Sciences of the United States of America 1982 79 24 I 7634 7638 (Pubitemid 13173159)
58. Marklund S. L., Extracellular superoxide dismutase in human tissues and human cell lines Journal of Clinical Investigation 1984 74 4 1398 1403 (Pubitemid 15206836)
59. Celsi F., Ferri A., Casciati A., D'Ambrosi N., Rotilio G., Costa A., Volonté C., Carr M. T., Overexpression of superoxide dismutase 1 protects against -amyloid peptide toxicity: effect of estrogen and copper chelators Neurochemistry International 2004 44 1 25 33 (Pubitemid 37101140)
60. Iadecola C., Zhang F., Niwa K., Eckman C., Turner S. K., Fischer E., Younkin S., Borchelt D. R., Hsiao K. K., Carlson G. A., SOD1 rescues cerebral endothelial dysfunction in mice overexpressing amyloid precursor protein Nature Neuroscience 1999 2 2 157 161 (Pubitemid 30491316)
61. Blanchard V., Moussaoui S., Czech C., Touchet N., Bonici B., Planche M., Canton T., Jedidi I., Gohin M., Wirths O., Bayer T. A., Langui D., Duyckaerts C., Tremp G., Pradier L., Time sequence of maturation of dystrophic neurites associated with A deposits in APP/PS1 transgenic mice Experimental Neurology 2003 184 1 247 263 (Pubitemid 37444035)
62. Aucoin J. S., Jiang P., Aznavour N., Tong X. K., Buttini M., Descarries L., Hamel E., Selective cholinergic denervation, independent from oxidative stress, in a mouse model of Alzheimer's disease Neuroscience 2005 132 1 73 86 (Pubitemid 40380716)
63. Tong X. K., Nicolakakis N., Kocharyan A., Hamel E., Vascular remodeling versus amyloid -induced oxidative stress in the cerebrovascular dysfunctions associated with Alzheimer's disease The Journal of Neuroscience 2005 25 48 11165 11174 (Pubitemid 43089561)
64. Omar R. A., Chyan Y. J., Andorn A. C., Poeggeler B., Robakis N. K., Pappolla M. A., Increased expression but reduced activity of antioxidant enzymes in Alzheimer's disease Journal of Alzheimer's Disease 1999 1 3 139 145
65. Esposito L., Raber J., Kekonius L., Yan F., Yu G. Q., Bien-Ly N., Puolivli J., Scearce-Levie K., Masliah E., Mucke L., Reduction in mitochondrial superoxide dismutase modulates Alzheimer's disease-like pathology and accelerates the onset of behavioral changes in human amyloid precursor protein transgenic mice The Journal of Neuroscience 2006 26 19 5167 5179 (Pubitemid 44315298)
66. Massaad C. A., Washington T. M., Pautler R. G., Klann E., Overexpression of SOD-2 reduces hippocampal superoxide and prevents memory deficits in a mouse model of Alzheimer's disease Proceedings of the National Academy of Sciences of the United States of America 2009 106 32 13576 13581
67. Fujita K., Nakabeppu Y., Noda M., Therapeutic effects of hydrogen in animal models of Parkinson's disease Parkinson's Disease 2011 2011 9
68. Noda M., Fujita K., C. H. Lee, Yoshioka T., The principle and the potential approach to ROS-dependent cytotoxicity by non-pharmaceutical therapies: optimal use of medical gases with antioxidant properties Current Pharmaceutical Design 2011 17 22 2253 2263
69. Von Burg R., Carbon monoxide Journal of Applied Toxicology 1999 19 5 379 386 (Pubitemid 129796566)
70. Sjostrand T., Early studies of CO production Annals of the New York Academy of Sciences 1970 174 1 5 10
71. Maines M. D., The heme oxygenase system: update 2005 Antioxidants and Redox Signaling 2005 7 11-12 1761 1766 (Pubitemid 41768008)
72. Piantadosi C. A., Carbon monoxide, reactive oxygen signaling, and oxidative stress Free Radical Biology and Medicine 2008 45 5 562 569
73. Brancho D., Tanaka N., Jaeschke A., Ventura J. J., Kelkar N., Tanaka Y., Kyuuma M., Takeshita T., Flavell R. A., Davis R. J., Mechanism of p38 MAP kinase activation in vivo Genes and Development 2003 17 16 1969 1978 (Pubitemid 36999324)
74. Kim H. P., Wang X., Zhang J., Suh G. Y., Benjamin I. J., Ryter S. W., Choi A. M. K., Heat shock protein-70 mediates the cytoprotective effect of carbon monoxide: involvement of p38 MAPK and heat shock factor-1 Journal of Immunology 2005 175 2622 2629 (Pubitemid 41113876)
75. Wang B., Cao W., Biswal S., Dore S., Carbon monoxide-activated Nrf2 pathway leads to protection against permanent focal cerebral ischemia Stroke 2011 42 9 2605 2610
76. Thom S. R., Fisher D., Xu Y. A., Notarfrancesco K., Lschiropoulos H., Adaptive responses and apoptosis in endothelial cells exposed to carbon monoxide Proceedings of the National Academy of Sciences of the United States of America 2000 97 3 1305 1310 (Pubitemid 30080854)
77. Carballal S., Trujillo M., Cuevasanta E., Bartesaghi S., Mller M. N., Folkes L. K., Garca-Bereguian M. A., Gutiérrez-Merino C., Wardman P., Denicola A., Radi R., Alvarez B., Reactivity of hydrogen sulfide with peroxynitrite and other oxidants of biological interest Free Radical Biology and Medicine 2011 50 1 196 205
78. Whiteman M., Armstrong J. S., Chu S. H., Jia-Ling S., Wong B. S., Cheung N. S., Halliwell B., Moore P. K., The novel neuromodulator hydrogen sulfide: an endogenous peroxynitrite scavenger? Journal of Neurochemistry 2004 90 3 765 768 (Pubitemid 38989409)
79. Qingyou Z., Junbao D., Weijin Z., Hui Y., Chaoshu T., Chunyu Z., Impact of hydrogen sulfide on carbon monoxide/heme oxygenase pathway in the pathogenesis of hypoxic pulmonary hypertension Biochemical and Biophysical Research Communications 2004 317 1 30 37 (Pubitemid 38401961)
80. Szabo C., Hydrogen sulphide and its therapeutic potential Nature Reviews Drug Discovery 2007 6 11 917 935 (Pubitemid 350042399)
81. Ohsawa I., Ishikawa M., Takahashi K., Watanabe M., Nishimaki K., Yamagata K., Katsura K. I., Katayama Y., Asoh S., Ohta S., Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals Nature Medicine 2007 13 6 688 694 (Pubitemid 46889750)
82. Nagata K., Nakashima-Kamimura N., Mikami T., Ohsawa I., Ohta S., Consumption of molecular hydrogen prevents the stress-induced impairments in hippocampus-dependent learning tasks during chronic physical restraint in mice Neuropsychopharmacology 2009 34 2 501 508
83. Gu Y., Huang C. S., Inoue T., Yamashita T., Ishida T., Kang K. M., Nakao A., Drinking hydrogen water ameliorated cognitive impairment in senescence-accelerated mice Journal of Clinical Biochemistry and Nutrition 2010 46 3 269 276
84. Fukuda K. I., Asoh S., Ishikawa M., Yamamoto Y., Ohsawa I., Ohta S., Inhalation of hydrogen gas suppresses hepatic injury caused by ischemia/reperfusion through reducing oxidative stress Biochemical and Biophysical Research Communications 2007 361 3 670 674 (Pubitemid 47238041)
85. Buchholz B. M., Kaczorowski D. J., Sugimoto R., Yang R., Wang Y., Billiar T. R., McCurry K. R., Bauer A. J., Nakao A., Hydrogen inhalation ameliorates oxidative stress in transplantation induced intestinal graft injury American Journal of Transplantation 2008 8 10 2015 2024
86. Nakao A., Kaczorowski D. J., Wang Y., Amelioration of rat cardiac cold ischemia/reperfusion injury with inhaled hydrogen or carbon monoxide, or both Journal of Heart and Lung Transplantation 2010 29 5 544 553
87. Hayashida K., Sano M., Ohsawa I., Shinmura K., Tamaki K., Kimura K., Endo J., Katayama T., Kawamura A., Kohsaka S., Makino S., Ohta S., Ogawa S., Fukuda K., Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury Biochemical and Biophysical Research Communications 2008 373 1 30 35
88. Ohsawa I., Nishimaki K., Yamagata K., Ishikawa M., Ohta S., Consumption of hydrogen water prevents atherosclerosis in apolipoprotein E knockout mice Biochemical and Biophysical Research Communications 2008 377 4 1195 1198
89. Fujita K., Seike T., Yutsudo N., Ohno M., Yamada H., Yamaguchi H., Sakumi K., Yamakawa Y., Kido M. A., Takaki A., Katafuchi T., Tanaka Y., Nakabeppu Y., Noda M., Hydrogen in drinking water reduces dopaminergic neuronal loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease PLoS ONE 2009 4 9
90. Fu Y., Ito M., Fujita Y., Ito M., Ichihara M., Masuda A., Suzuki Y., Maesawa S., Kajita Y., Hirayama M., Ohsawa I., Ohta S., Ohno K., Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson's disease Neuroscience Letters 2009 453 2 81 85
91. Fornai F., Schlter O. M., Lenzi P., Gesi M., Ruffoli R., Ferrucci M., Lazzeri G., Busceti C. L., Pontarelli F., Battaglia G., Pellegrini A., Nicoletti F., Ruggieri S., Paparelli A., Sdhof T. C., Parkinson-like syndrome induced by continuous MPTP infusion: convergent roles of the ubiquitin-proteasome system and -synuclein Proceedings of the National Academy of Sciences of the United States of America 2005 102 9 3413 3418 (Pubitemid 40328059)
92. Setsukinai K. I., Urano Y., Kakinuma K., Majima H. J., Nagano T., Development of novel fluorescence probes that can reliably detect reactive oxygen species and distinguish specific species The Journal of Biological Chemistry 2003 278 5 3170 3175 (Pubitemid 36801227)
93. Liang L. P., Huang J., Fulton R., Day B. J., Patel M., An orally active catalytic metalloporphyrin protects against 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine neurotoxicity in vivo The Journal of Neuroscience 2007 27 16 4326 4333 (Pubitemid 46640723)
94. Sato Y., Kajiyama S., Amano A., Kondo Y., Sasaki T., Handa S., Takahashi R., Fukui M., Hasegawa G., Nakamura N., Fujinawa H., Mori T., Ohta M., Obayashi H., Maruyama N., Ishigami A., Hydrogen-rich pure water prevents superoxide formation in brain slices of vitamin C-depleted SMP30/GNL knockout mice Biochemical and Biophysical Research Communications 2008 375 3 346 350
95. Nakao A., Toyoda Y., Sharma P., Evans M., Guthrie N., Effectiveness of hydrogen rich water on antioxidant status of subjects with potential metabolic syndromean open label pilot study Journal of Clinical Biochemistry and Nutrition 2010 46 2 140 149