Deficiency of cardiomyocyte-specific MicroRNA-378 contributes to the development of cardiac fibrosis involving a transforming growth factor β (TGFβ1)-dependent paracrine mechanism

Journal of Biological Chemistry

Volumn 289, Issue 39, 2014, Pages 27199-27214

  Nagalingam, Raghu S ^a   Sundaresan, Nagalingam R ^b   Noor, Mariam ^a   Gupta, Mahesh P ^b   Solaro, R John ^a   Gupta, Madhu ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PARACRINE; TRANSFORMING GROWTH FACTOR BETA;

ANGIOTENSIN II; MICRORNA; MICRORNA 378; PROTEIN C FOS; PROTEIN C JUN; RAS PROTEIN; TRANSCRIPTION FACTOR AP 1; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; MADH2 PROTEIN, RAT; MADH3 PROTEIN, RAT; MIRN378 MICRORNA, MOUSE; MIRN378 MICRORNA, RAT; MONOMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; N-RAS PROTEIN, MOUSE; SMAD2 PROTEIN; SMAD2 PROTEIN, MOUSE; SMAD3 PROTEIN; SMAD3 PROTEIN, MOUSE; TGFB1 PROTEIN, MOUSE; TGFB1 PROTEIN, RAT;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA CONSTRICTION; ARTICLE; CELL ACTIVATION; CELL PROTECTION; CONTROLLED STUDY; CORRELATIONAL STUDY; CULTURE MEDIUM; CYTOKINE RELEASE; DOWN REGULATION; FIBROBLAST; HEART MUSCLE CELL; HEART MUSCLE FIBROSIS; HEART PROTECTION; HEART STRESS; HEART VENTRICLE HYPERTROPHY; HOMEOSTASIS; INHIBITION KINETICS; MOUSE; MUSCLE HYPERTROPHY; NONHUMAN; PARACRINE SIGNALING; PROTEIN EXPRESSION; PROTEIN FUNCTION; TISSUE DOPPLER IMAGING; TRANSTHORACIC ECHOCARDIOGRAPHY; ANIMAL; BIOSYNTHESIS; CAENORHABDITIS ELEGANS; CELL CULTURE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PATHOLOGY; RAT; SECRETION (PROCESS); SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

ANIMALS; CAENORHABDITIS ELEGANS; CELLS, CULTURED; ENDOMYOCARDIAL FIBROSIS; GENE EXPRESSION REGULATION; MICE; MICRORNAS; MONOMERIC GTP-BINDING PROTEINS; MYOCYTES, CARDIAC; PARACRINE COMMUNICATION; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSCRIPTION FACTOR AP-1; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84907584470     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.580977     Document Type: Article

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