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Volumn 42, Issue 10, 2014, Pages 1766-1772

Lost in centrifugation: Accounting for transporter protein losses in quantitative targeted absolute proteomics

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN;

EID: 84907579228     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.114.058446     Document Type: Review
Times cited : (37)

References (35)
  • 1
    • 84861513342 scopus 로고    scopus 로고
    • Membrane protein quantification by peptide-based mass spectrometry approaches: Studies on the organic anion-Transporting polypeptide family
    • Balogh LM, Kimoto E, Chupka J, Zhang H, and Lai Y (2012) Membrane protein quantification by peptide-based mass spectrometry approaches: studies on the organic anion-Transporting polypeptide family. Proteomics &Bioinformatics 54:1-5.
    • (2012) Proteomics &Bioinformatics , vol.54 , pp. 1-5
    • Balogh, L.M.1    Kimoto, E.2    Chupka, J.3    Zhang, H.4    Lai, Y.5
  • 2
    • 33845996187 scopus 로고    scopus 로고
    • Scaling factors for the extrapolation of in vivo metabolic drug clearance from in vitro data: Reaching a consensus on values of human microsomal protein and hepatocellularity per gram of liver
    • Barter ZE, Bayliss MK, Beaune PH, Boobis AR, Carlile DJ, Edwards RJ, Houston JB, Lake BG, Lipscomb JC, and Pelkonen OR, et al. (2007) Scaling factors for the extrapolation of in vivo metabolic drug clearance from in vitro data: reaching a consensus on values of human microsomal protein and hepatocellularity per gram of liver. Curr Drug Metab 8:33-45.
    • (2007) Curr Drug Metab , vol.8 , pp. 33-45
    • Barter, Z.E.1    Bayliss, M.K.2    Beaune, P.H.3    Boobis, A.R.4    Carlile, D.J.5    Edwards, R.J.6    Houston, J.B.7    Lake, B.G.8    Lipscomb, J.C.9    Pelkonen, O.R.10
  • 3
    • 57349120552 scopus 로고    scopus 로고
    • Covariation of human microsomal protein per gram of liver with age: Absence of influence of operator and sample storage may justify interlaboratory data pooling
    • Barter ZE, Chowdry JE, Harlow JR, Snawder JE, Lipscomb JC, and Rostami-Hodjegan A (2008) Covariation of human microsomal protein per gram of liver with age: absence of influence of operator and sample storage may justify interlaboratory data pooling. Drug Metab Dispos 36:2405-2409.
    • (2008) Drug Metab Dispos , vol.36 , pp. 2405-2409
    • Barter, Z.E.1    Chowdry, J.E.2    Harlow, J.R.3    Snawder, J.E.4    Lipscomb, J.C.5    Rostami-Hodjegan, A.6
  • 4
    • 0021180138 scopus 로고
    • A new method for the rapid isolation of basolateral plasma membrane vesicles from rat liver: Characterization, validation, and bile acid transport studies
    • Blitzer BL and Donovan CB (1984) A new method for the rapid isolation of basolateral plasma membrane vesicles from rat liver: characterization, validation, and bile acid transport studies. J Biol Chem 259:9295-9301.
    • (1984) J Biol Chem , vol.259 , pp. 9295-9301
    • Blitzer, B.L.1    Donovan, C.B.2
  • 5
    • 0016378181 scopus 로고
    • Subcellular fractionation of rat liver
    • Fleischer S and Kervina M (1974) Subcellular fractionation of rat liver. Methods Enzymol 31: 6-41.
    • (1974) Methods Enzymol , vol.31 , pp. 6-41
    • Fleischer, S.1    Kervina, M.2
  • 7
    • 84872680624 scopus 로고    scopus 로고
    • Absolute abundance and function of intestinal drug transporters: A prerequisite for fully mechanistic in vitro-in vivo extrapolation of oral drug absorption
    • Harwood MD, Neuhoff S, Carlson GL, Warhurst G, and Rostami-Hodjegan A (2013) Absolute abundance and function of intestinal drug transporters: a prerequisite for fully mechanistic in vitro-in vivo extrapolation of oral drug absorption. Biopharm Drug Dispos 34: 2-28.
    • (2013) Biopharm Drug Dispos , vol.34 , pp. 2-28
    • Harwood, M.D.1    Neuhoff, S.2    Carlson, G.L.3    Warhurst, G.4    Rostami-Hodjegan, A.5
  • 8
    • 0038364020 scopus 로고    scopus 로고
    • Organelle proteomics: Implications for subcellular fractionation in proteomics
    • Huber LA, Pfaller K, and Vietor I (2003) Organelle proteomics: implications for subcellular fractionation in proteomics. Circ Res 92:962-968.
    • (2003) Circ Res , vol.92 , pp. 962-968
    • Huber, L.A.1    Pfaller, K.2    Vietor, I.3
  • 9
    • 84891867228 scopus 로고    scopus 로고
    • A mechanistic framework for in vitro-in vivo extrapolation of liver membrane transporters: Prediction of drug-drug interaction between rosuvastatin and cyclosporine
    • Jamei M, Bajot F, Neuhoff S, Barter Z, Yang J, Rostami-Hodjegan A, and Rowland-Yeo K (2014) A mechanistic framework for in vitro-in vivo extrapolation of liver membrane transporters: prediction of drug-drug interaction between rosuvastatin and cyclosporine. Clin Pharmacokinet 53:73-87.
    • (2014) Clin Pharmacokinet , vol.53 , pp. 73-87
    • Jamei, M.1    Bajot, F.2    Neuhoff, S.3    Barter, Z.4    Yang, J.5    Rostami-Hodjegan, A.6    Rowland-Yeo, K.7
  • 10
    • 84856492304 scopus 로고    scopus 로고
    • Development of a multiplex UPLC-MRM MS method for quantification of human membrane transport proteins OATP1B1 OATP1B3 and OATP2B1 in in vitro systems and tissues
    • Ji C, Tschantz WR, Pfeifer ND, Ullah M, and Sadagopan N (2012) Development of a multiplex UPLC-MRM MS method for quantification of human membrane transport proteins OATP1B1, OATP1B3 and OATP2B1 in in vitro systems and tissues. Anal Chim Acta 717:67-76.
    • (2012) Anal Chim Acta , vol.717 , pp. 67-76
    • Ji, C.1    Tschantz, W.R.2    Pfeifer, N.D.3    Ullah, M.4    Sadagopan, N.5
  • 11
  • 13
    • 68249101487 scopus 로고    scopus 로고
    • Quantitative expression profile of hepatobiliary transporters in sandwich cultured rat and human hepatocytes
    • Li N, Bi YA, Duignan DB, and Lai Y (2009) Quantitative expression profile of hepatobiliary transporters in sandwich cultured rat and human hepatocytes. Mol Pharm 6:1180-1189.
    • (2009) Mol Pharm , vol.6 , pp. 1180-1189
    • Li, N.1    Bi, Y.A.2    Duignan, D.B.3    Lai, Y.4
  • 14
    • 77953284053 scopus 로고    scopus 로고
    • Improved extrapolation of hepatobiliary clearance from in vitro sandwich cultured rat hepatocytes through absolute quantification of hepatobiliary transporters
    • Li N, Singh P, Mandrell KM, and Lai Y (2010) Improved extrapolation of hepatobiliary clearance from in vitro sandwich cultured rat hepatocytes through absolute quantification of hepatobiliary transporters. Mol Pharm 7:630-641.
    • (2010) Mol Pharm , vol.7 , pp. 630-641
    • Li, N.1    Singh, P.2    Mandrell, K.M.3    Lai, Y.4
  • 16
    • 81855183743 scopus 로고    scopus 로고
    • Development of a highly sensitive method using liquid chromatography-multiple reaction monitoring to quantify membrane P-glycoprotein in biological matrices and relationship to transport function
    • Miliotis T, Ali L, Palm JE, Lundqvist AJ, Ahnoff M, Andersson TB, and Hilgendorf C (2011) Development of a highly sensitive method using liquid chromatography-multiple reaction monitoring to quantify membrane P-glycoprotein in biological matrices and relationship to transport function. Drug Metab Dispos 39:2440-2449.
    • (2011) Drug Metab Dispos , vol.39 , pp. 2440-2449
    • Miliotis, T.1    Ali, L.2    Palm, J.E.3    Lundqvist, A.J.4    Ahnoff, M.5    Andersson, T.B.6    Hilgendorf, C.7
  • 17
    • 84881609555 scopus 로고    scopus 로고
    • Application of permeability-limited physiologically-based pharmacokinetic models: Part I-digoxin pharmacokinetics incorporating P-glycoprotein-mediated efflux
    • Neuhoff S, Yeo KR, Barter Z, Jamei M, Turner DB, and Rostami-Hodjegan A (2013) Application of permeability-limited physiologically-based pharmacokinetic models: part I-digoxin pharmacokinetics incorporating P-glycoprotein-mediated efflux. J Pharm Sci 102: 3145-3160.
    • (2013) J Pharm Sci , vol.102 , pp. 3145-3160
    • Neuhoff, S.1    Yeo, K.R.2    Barter, Z.3    Jamei, M.4    Turner, D.B.5    Rostami-Hodjegan, A.6
  • 18
    • 0000869591 scopus 로고
    • The isolation of a cell membrane fraction from rat liver
    • Neville DM, Jr (1960) The isolation of a cell membrane fraction from rat liver. J Biophys Biochem Cytol 8:413-422.
    • (1960) J Biophys Biochem Cytol , vol.8 , pp. 413-422
    • Neville, D.M.1
  • 19
    • 84872159164 scopus 로고    scopus 로고
    • Quantitative targeted absolute proteomic analysis of transporters, receptors and junction proteins for validation of human cerebral microvascular endothelial cell line hCMEC/D3 as a human blood-brain barrier model
    • Ohtsuki S, Ikeda C, Uchida Y, Sakamoto Y, Miller F, Glacial F, Decleves X, Scherrmann JM, Couraud PO, and Kubo Y, et al. (2013) Quantitative targeted absolute proteomic analysis of transporters, receptors and junction proteins for validation of human cerebral microvascular endothelial cell line hCMEC/D3 as a human blood-brain barrier model. Mol Pharm 10: 289-296.
    • (2013) Mol Pharm , vol.10 , pp. 289-296
    • Ohtsuki, S.1    Ikeda, C.2    Uchida, Y.3    Sakamoto, Y.4    Miller, F.5    Glacial, F.6    Decleves, X.7    Scherrmann, J.M.8    Couraud, P.O.9    Kubo, Y.10
  • 20
    • 84455194082 scopus 로고    scopus 로고
    • Simultaneous absolute protein quantification of transporters, cytochromes P450, and UDP-glucuronosyltransferases as a novel approach for the characterization of individual human liver: Comparison with mRNA levels and activities
    • Ohtsuki S, Schaefer O, Kawakami H, Inoue T, Liehner S, Saito A, Ishiguro N, Kishimoto W, Ludwig-Schwellinger E, and Ebner T, et al. (2012) Simultaneous absolute protein quantification of transporters, cytochromes P450, and UDP-glucuronosyltransferases as a novel approach for the characterization of individual human liver: comparison with mRNA levels and activities. Drug Metab Dispos 40:83-92.
    • (2012) Drug Metab Dispos , vol.40 , pp. 83-92
    • Ohtsuki, S.1    Schaefer, O.2    Kawakami, H.3    Inoue, T.4    Liehner, S.5    Saito, A.6    Ishiguro, N.7    Kishimoto, W.8    Ludwig-Schwellinger, E.9    Ebner, T.10
  • 21
    • 79960116572 scopus 로고    scopus 로고
    • Quantitative targeted absolute proteomicsbased ADME research as a new path to drug discovery and development: Methodology,advantages, strategy, and prospects
    • Ohtsuki S, Uchida Y, Kubo Y, and Terasaki T (2011) Quantitative targeted absolute proteomicsbased ADME research as a new path to drug discovery and development: methodology,advantages, strategy, and prospects. J Pharm Sci 100:3547-3559.
    • (2011) J Pharm Sci , vol.100 , pp. 3547-3559
    • Ohtsuki, S.1    Uchida, Y.2    Kubo, Y.3    Terasaki, T.4
  • 22
    • 0012351964 scopus 로고    scopus 로고
    • Properties of 13C-substituted arginine in stable isotope labeling by amino acids in cell culture (SILAC)
    • Ong SE, Kratchmarova I, and Mann M (2003) Properties of 13C-substituted arginine in stable isotope labeling by amino acids in cell culture (SILAC). J Proteome Res 2:173-181.
    • (2003) J Proteome Res , vol.2 , pp. 173-181
    • Ong, S.E.1    Kratchmarova, I.2    Mann, M.3
  • 23
    • 84890663852 scopus 로고    scopus 로고
    • Interindividual variability in hepatic organic anion-Transporting polypeptides and P-glycoprotein (ABCB1) protein expression: Quantification by liquid chromatography tandem mass spectroscopy and influence of genotype, age, and sex
    • Prasad B, Evers R, Gupta A, Hop CE, Salphati L, Shukla S, Ambudkar SV, and Unadkat JD (2014) Interindividual variability in hepatic organic anion-Transporting polypeptides and P-glycoprotein (ABCB1) protein expression: quantification by liquid chromatography tandem mass spectroscopy and influence of genotype, age, and sex. Drug Metab Dispos 42:78-88.
    • (2014) Drug Metab Dispos , vol.42 , pp. 78-88
    • Prasad, B.1    Evers, R.2    Gupta, A.3    Hop, C.E.4    Salphati, L.5    Shukla, S.6    Ambudkar, S.V.7    Unadkat, J.D.8
  • 24
    • 84878129920 scopus 로고    scopus 로고
    • Interindividual variability in the hepatic expression of the human breast cancer resistance protein (BCRP/ABCG2): Effect of age, sex, and genotype
    • Prasad B, Lai Y, Lin Y, and Unadkat JD (2013) Interindividual variability in the hepatic expression of the human breast cancer resistance protein (BCRP/ABCG2): effect of age, sex, and genotype. J Pharm Sci 102:787-793.
    • (2013) J Pharm Sci , vol.102 , pp. 787-793
    • Prasad, B.1    Lai, Y.2    Lin, Y.3    Unadkat, J.D.4
  • 25
    • 84903585415 scopus 로고    scopus 로고
    • Optimized approaches for quantification of drug transporters in tissues and cells by MRM proteomics
    • Prasad B and Unadkat JD (2014) Optimized approaches for quantification of drug transporters in tissues and cells by MRM proteomics. AAPS J 16:634-648.
    • (2014) AAPS J , vol.16 , pp. 634-648
    • Prasad, B.1    Unadkat, J.D.2
  • 26
    • 84881612960 scopus 로고    scopus 로고
    • Absolute measurement of species differences in sodium taurocholate cotransporting polypeptide (NTCP/Ntcp) and its modulation in cultured hepatocytes
    • Qiu X, Bi YA, Balogh LM, and Lai Y (2013) Absolute measurement of species differences in sodium taurocholate cotransporting polypeptide (NTCP/Ntcp) and its modulation in cultured hepatocytes. J Pharm Sci 102:3252-3263.
    • (2013) J Pharm Sci , vol.102 , pp. 3252-3263
    • Qiu, X.1    Bi, Y.A.2    Balogh, L.M.3    Lai, Y.4
  • 27
    • 39049153805 scopus 로고    scopus 로고
    • The functional consequences of genetic variations in transporter genes encoding human organic anion-Transporting polypeptide family members
    • Seithel A, Glaeser H, Fromm MF, and König J (2008) The functional consequences of genetic variations in transporter genes encoding human organic anion-Transporting polypeptide family members. Expert Opin Drug Metab Toxicol 4:51-64.
    • (2008) Expert Opin Drug Metab Toxicol , vol.4 , pp. 51-64
    • Seithel, A.1    Glaeser, H.2    Fromm, M.F.3    König, J.4
  • 28
    • 0036293772 scopus 로고    scopus 로고
    • Are MDCK cells transfected with the human MDR1 gene a good model of the human intestinal mucosa?
    • Tang F, Horie K, and Borchardt RT (2002) Are MDCK cells transfected with the human MDR1 gene a good model of the human intestinal mucosa? Pharm Res 19:765-772.
    • (2002) Pharm Res , vol.19 , pp. 765-772
    • Tang, F.1    Horie, K.2    Borchardt, R.T.3
  • 29
    • 83955163683 scopus 로고    scopus 로고
    • Absolute immunoquantification of the expression of ABC transporters P-glycoprotein, breast cancer resistance protein and multidrug resistance-Associated protein 2 in human liver and duodenum
    • Tucker TG, Milne AM, Fournel-Gigleux S, Fenner KS, and Coughtrie MW (2012) Absolute immunoquantification of the expression of ABC transporters P-glycoprotein, breast cancer resistance protein and multidrug resistance-Associated protein 2 in human liver and duodenum. Biochem Pharmacol 83:279-285.
    • (2012) Biochem Pharmacol , vol.83 , pp. 279-285
    • Tucker, T.G.1    Milne, A.M.2    Fournel-Gigleux, S.3    Fenner, K.S.4    Coughtrie, M.W.5
  • 30
    • 84866708911 scopus 로고    scopus 로고
    • Physiologically based modeling of pravastatin transporter-mediated hepatobiliary disposition and drug-drug interactions
    • Varma MV, Lai Y, Feng B, Litchfield J, Goosen TC, and Bergman A (2012) Physiologically based modeling of pravastatin transporter-mediated hepatobiliary disposition and drug-drug interactions. Pharm Res 29:2860-2873.
    • (2012) Pharm Res , vol.29 , pp. 2860-2873
    • Varma, M.V.1    Lai, Y.2    Feng, B.3    Litchfield, J.4    Goosen, T.C.5    Bergman, A.6
  • 31
    • 84876483882 scopus 로고    scopus 로고
    • Mechanistic modeling to predict the transporter- and enzyme-mediated drug-drug interactions of repaglinide
    • Varma MV, Lai Y, Kimoto E, Goosen TC, El-Kattan AF, and Kumar V (2013) Mechanistic modeling to predict the transporter- and enzyme-mediated drug-drug interactions of repaglinide. Pharm Res 30:1188-1199.
    • (2013) Pharm Res , vol.30 , pp. 1188-1199
    • Varma, M.V.1    Lai, Y.2    Kimoto, E.3    Goosen, T.C.4    El-Kattan, A.F.5    Kumar, V.6
  • 32
    • 84903217760 scopus 로고    scopus 로고
    • Hepatic uptake of atorvastatin: Influence of variability in transporter expression on uptake clearance and drug-drug interactions
    • Vildhede A, Karlgren M, Svedberg EK, Wisniewski JR, Lai Y, Norén A, and Artursson P (2014) Hepatic uptake of atorvastatin: influence of variability in transporter expression on uptake clearance and drug-drug interactions. Drug Metab Dispos 42:1210-1218.
    • (2014) Drug Metab Dispos , vol.42 , pp. 1210-1218
    • Vildhede, A.1    Karlgren, M.2    Svedberg, E.K.3    Wisniewski, J.R.4    Lai, Y.5    Norén, A.6    Artursson, P.7
  • 34
    • 84874849830 scopus 로고    scopus 로고
    • Predicting drug-drug interactions: Application of physiologically based pharmacokinetic models under a systems biology approach
    • Yeo KR, Jamei M, and Rostami-Hodjegan A (2013) Predicting drug-drug interactions: application of physiologically based pharmacokinetic models under a systems biology approach. Expert Rev Clin Pharmacol 6:143-157.
    • (2013) Expert Rev Clin Pharmacol , vol.6 , pp. 143-157
    • Yeo, K.R.1    Jamei, M.2    Rostami-Hodjegan, A.3
  • 35
    • 79956321796 scopus 로고    scopus 로고
    • Liquid chromatography/tandem mass spectrometry based targeted proteomics quantification of P-glycoprotein in various biological samples
    • Zhang Y, Li N, Brown PW, Ozer JS, and Lai Y (2011) Liquid chromatography/tandem mass spectrometry based targeted proteomics quantification of P-glycoprotein in various biological samples. Rapid Commun Mass Spectrom 25:1715-1724.
    • (2011) Rapid Commun Mass Spectrom , vol.25 , pp. 1715-1724
    • Zhang, Y.1    Li, N.2    Brown, P.W.3    Ozer, J.S.4    Lai, Y.5


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