Improved extrapolation of hepatobiliary clearance from in vitro sandwich cultured rat hepatocytes through absolute quantification of hepatobiliary transporters

Molecular Pharmaceutics

Volumn 7, Issue 3, 2010, Pages 630-641

  Li, Na ^a   Singh, Pratap ^a   Mandrell, Kathy M ^a   Lai, Yurong ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Bile salt export pump (Bsep Abcb11); Biliary clearance; Breast cancer resistance protein (Bcrp Abcg2); In vitro in vivo correlation; Multidrug resistance protein 2 (Mrp2 Abcc2); Sandwich cultured hepatocytes

Indexed keywords

BREAST CANCER RESISTANCE PROTEIN; CEFMETAZOLE; CEFOPERAZONE; CEFPIRAMIDE; ESTRADIOL; MULTIDRUG RESISTANCE PROTEIN 2; OLMESARTAN; PITAVASTATIN; PRAVASTATIN; ROSUVASTATIN; TOPOTECAN; VALSARTAN;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BILE; CONTROLLED STUDY; DRUG CLEARANCE; HEPATOBILIARY SYSTEM; IN VITRO STUDY; IN VIVO STUDY; LIQUID CHROMATOGRAPHY; LIVER CELL; MALE; MATHEMATICS; NONHUMAN; PREDICTION; PRIORITY JOURNAL; RAT; TANDEM MASS SPECTROMETRY;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BILE; CELLS, CULTURED; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, LIQUID; HEPATOCYTES; MALE; MEMBRANE TRANSPORT PROTEINS; MICROSOMES, LIVER; RATS; RATS, SPRAGUE-DAWLEY; TANDEM MASS SPECTROMETRY; TOPOTECAN;

EID: 77953284053     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp9001574     Document Type: Article

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