Rational engineering of enzyme allosteric regulation through sequence evolution analysis

PLoS Computational Biology

Volumn 8, Issue 7, 2012, Pages

  Yang, Jae Seong ^a   Seo, Sang Woo ^a   Jang, Sungho ^a   Jung, Gyoo Yeol ^a   Kim, Sanguk ^a  

^a Pohang University of Science and Technology (POSTECH)   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BINDING SITES; CATALYST ACTIVITY; COMPLEXATION; ENZYME INHIBITION; ESCHERICHIA COLI; HYDROPHOBICITY; METABOLISM; MOLECULAR BIOLOGY;

ALLOSTERIC INHIBITION; ALLOSTERIC REGULATION; ENZYME-LIGAND COMPLEX; EVOLUTION ANALYSIS; EVOLUTION CHARACTERISTICS; LIGAND-BINDING SITES; METABOLIC FLUX; MOLECULAR EVOLUTION; PHYSICOCHEMICAL CHARACTERISTICS; THREE DIMENSIONAL (3D) STRUCTURES;

LIGANDS;

ADENOSINE PHOSPHATE; FRUCTOSE BISPHOSPHATASE; GLUCOSE 6 PHOSPHATE; ISOLEUCINE; LEUCINE; PHENYLALANINE;

ALLOSTERISM; AMINO ACID COMPOSITION; AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; CONCENTRATION (PARAMETERS); ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ENGINEERING; ENZYME INHIBITION; ENZYME REGULATION; ESCHERICHIA COLI; HYDROGEN BOND; HYDROPHOBICITY; LIGAND BINDING; METABOLIC REGULATION; MICHAELIS CONSTANT; MOLECULAR EVOLUTION; NONHUMAN; PHYSICAL CHEMISTRY; PROTEIN ENGINEERING; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; VELOCITY;

EID: 84864590169     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1002612     Document Type: Article

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