Alpha-1 antitrypsin augmentation therapy corrects accelerated neutrophil apoptosis in deficient individuals

Journal of Immunology

Volumn 193, Issue 8, 2014, Pages 3978-3991

  Hurley, Killian ^a   Lacey, Noreen ^a   O'Dwyer, Ciara A ^a   Bergin, David A ^a   McElvaney, Oliver J ^a   O'Brien, M Emmet ^a   McElvaney, Oisín F ^a   Reeves, Emer P ^a   McElvaney, Noel G ^a  

^a BEAUMONT HOSPITAL   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 1 ANTITRYPSIN; ALPHA 1 ANTITRYPSIN CONCENTRATE; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME; ADAM PROTEIN; LEUKOCYTE ELASTASE; TUMOR NECROSIS FACTOR-ALPHA CONVERTASE;

ADULT; ALPHA 1 ANTITRYPSIN DEFICIENCY; APOPTOSIS; ARTICLE; BACTERICIDAL ACTIVITY; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; FEMALE; FLOW CYTOMETRY; FORCED EXPIRATORY VOLUME; HOMOZYGOTE; HUMAN; HUMAN CELL; IMMUNOREGULATION; IN VIVO STUDY; INFLAMMATION; MAJOR CLINICAL STUDY; MALE; NEUTROPHIL; PROTEIN AGGREGATION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FOLDING; SIGNAL TRANSDUCTION; AGED; ALPHA 1-ANTITRYPSIN DEFICIENCY; BIOSYNTHESIS; COMPLICATION; EMPHYSEMA; ENDOPLASMIC RETICULUM; IMMUNOLOGY; LUNG; LUNG INJURY; METABOLISM; MIDDLE AGED; PATHOLOGY; PROTEOSTASIS DEFICIENCY; PSEUDOMONAS AERUGINOSA;

ADAM PROTEINS; ADULT; AGED; ALPHA 1-ANTITRYPSIN; ALPHA 1-ANTITRYPSIN DEFICIENCY; APOPTOSIS; EMPHYSEMA; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; FEMALE; HUMANS; INFLAMMATION; LEUKOCYTE ELASTASE; LUNG; LUNG INJURY; MALE; MIDDLE AGED; NEUTROPHILS; PROTEIN FOLDING; PROTEOSTASIS DEFICIENCIES; PSEUDOMONAS AERUGINOSA; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84907494138     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1400132     Document Type: Article

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